Journal of Drugs in Dermatology articles from November 2007

Journal of Drugs in Dermatology archives from November 2007

Letter from the guest editor.
November 1, 2007... The Aesthetic Aesthetics comes from the Greek [alpha][iota][sigma] [theta][eta][tau][iota][kappa][eta] (aisthetike) meaning "sensation" from [alpha]l[sigma][theta][eta][sigma][iota][mu] (aisthesin) or "sense." This sense is something...

Botanical ingredients in cosmeceuticals.
November 1, 2007... Abstract During the last 10 to 15 years, complementary and alternative medicine (CAM) has become increasingly popular in the US. Within this realm of health care, oral and topical herbal supplements have become some of the most frequently...

Juvederm: a hyaluronic acid dermal filler.
November 1, 2007... Abstract Over the past decade, the use of nonsurgical products and devices to correct facial contour defects and signs of skin aging has exploded with new lasers, toxins for muscle relaxation, and dermal fillers revolutionizing aesthetic...

Nonablative skin tightening with a variable depth heating 1310-nm wavelength laser in combination with surface cooling.
November 1, 2007... Abstract A near-infrared laser with the ability to target different depths within skin has been developed and evaluated for the application of facial and neck skin tightening in a pilot clinical study. The device consists of a combination...

Use of topical lidocaine for cosmetic dermatologic procedures.
November 1, 2007... Abstract Topical anesthetic agents are frequently used by dermatologists to decrease the pain associated with a variety of cutaneous procedures, including laser surgery, soft tissue augmentation, and other cosmetic surgical treatments....

Plasma skin regeneration technology.
November 1, 2007... Abstract Plasma skin regeneration is a novel type of skin rejuvenation technology developed over the last 3 years. Plasma is the fourth state of matter in which electrons are stripped from atoms to form an ionized gas. Although high...

Treatment of photoaging with a very superficial Er:YAG laser in combination with a broadband light source.(Erbium)(Yttrium Aluminium Garnet )
November 1, 2007... Abstract Background and Objective: Studies documenting improvement following combined laser and light-based devices are needed. The objective of this study was to evaluate clinical, histological, and ultrastructural changes in photodamaged...

Fractionated delivery systems for difficult to treat clinical applications: acne scarring, melasma, atrophic scarring, striae distensae, and deep rhytides.
November 1, 2007... Abstract Fractional resurfacing or laser therapy (FLT) represents a technology that seeks to address the limitations of both ablative resurfacing and nonablative treatments. Many companies now offer versions of fractionated erbium or...

Photodynamic therapy update 2007.
November 1, 2007... Abstract The use of photodynamic therapy (PDT) in the US has shown record growth in 2007 with more clinicians utilizing PDT for more clinical entities than ever before. Research endeavors utilizing PDT in published clinical manuscripts...

Evaluating the efficacy in improving facial photodamage with a mixture of topical antioxidants.
November 1, 2007... Abstract This study evaluates the efficacy and tolerability of an investigational study cream composed of 3 ingredients (green and white teas, mangosteen, and pomegranate extract), Vitaphenol[TM] Skin Cream (La Jolla Spa MD, La Jolla CA),...

Botulinum toxin type a enhances the outcome of fractional resurfacing of the cheek.(CASE REPORTS)
November 1, 2007... Abstract Fractional resurfacing and fractionally ablative (C[O.sub.2]) resurfacing have become increasingly popular in recent years. They hold the promise of delivering skin rejuvenation with fewer risks and less downtime than traditional...

Nanotechnology.(LASER AND COSMETIC NEWS)
November 1, 2007... Laser and Cosmetic News covers the latest advances in laser surgery, light technology, phototherapy, and cosmetic surgery. New and emerging therapies, noteworthy publications, and exciting meeting developments will be highlighted. Controversies...

Upcoming dermatology meetings.
November 1, 2007... Domestic 11/8-11/11 8th Las Vegas Dermatology Seminar The Venetian, Las Vegas, NV www.sdefderm.com 11/29-12/1 ASCDAS 6th Annual Meeting and Exhibition The Wynn Las Vegas Resort, Las Vegas, NV info@ascdas.org...

The yin and yang of cathelicidins: how the innate immune system drives skin disease.(NEWS, VIEWS, AND REVIEWS)
November 1, 2007... Initially Described in the 1990s Initially described in the early 1990s, cathelicidins are antimicrobial peptides found in vertebrates like mammals, birds, and fish. In humans, they are expressed by keratinocytes and neutrophils, as well...

Orphan Drug Designation for ALS-357.(PIPELINE PREVIEWS)(Brief article)
November 1, 2007... Advanced Life Sciences Holdings, Inc recently announced that it has received an Orphan Drug Designation for its product, ALS-357. The Orphan Drug Designation applies to the use of ALS-357 in the treatment of metastatic melanoma. ALS-357 is a...

Generic Famvir[R] tablets approved.(PIPELINE PREVIEWS)(Brief article)
November 1, 2007... The FDA has recently granted approval to Teva Pharmaceutical Industries, Ltd to market its generic equivalent of Novartis's Famvir (Famciclovir) tablets, 125 mg, 250 mg, and 500 mg. In addition, Teva has been granted a 180-day period of...

NGX-4010 and postherpetic neuralgia.(PIPELINE PREVIEWS)(NeurogesX, Inc introduced new synthetic capsaicin)(Brief article)
November 1, 2007... NeurogesX, Inc recently announced positive results from its second phase III clinical trial for NGX-4010 in the treatment of postherpetic neuralgia. NGX-4010 is a non-narcotic, locally-acting dermal patch that contains synthetic capsaicin. The...

Microcyn[R] Technology for diabetic foot ulcers.(PIPELINE PREVIEWS)(Brief article)
November 1, 2007... Oculus Innovative Sciences, Inc recently announced updates in its phase II clinical trial of Microcyn Technology in the treatment of mildly infected diabetic foot ulcers. Phase III trials are currently being planned. Microcyn Technology...

IL-2 and metastatic melanoma.(PIPELINE PREVIEWS)(interleukin-2)(Brief article)
November 1, 2007... A recent report suggests that a small number of patients with metastatic melanoma who have been refractory to biochemotherapy may respond to high-dose bolus interleukin-2 (IL-2). Twenty-six patients with refractory metastatic melanoma were...

Second-generation smallpox vaccine .(PIPELINE PREVIEWS)(Acambis,Inc.'s ACAM2000 approved)
November 1, 2007... The FDA recently granted approval for a second-generation smallpox vaccine, ACAM2000. This vaccine is approved for the vaccination of people at high risk for exposure to smallpox and could be used in at-risk populations during a bioter-rorist...

A phase II study of ASC-J9 cream in acne vulgaris.(ACNE)(AndroScience Corp developed new product)(Author abstract)
November 1, 2007... Sponsored by AndroScience Corp. The purpose of this study is to evaluate if topical ASC-J9 cream is effective in treating acne. Condition Intervention Phase Acne Drug: ASC-J9 cream Phase II Vulgaris Drug: placebo...

Comparison efficacy of azithromycin with doxycycline in the treatment of acne vulgaris.(ACNE)(Brief article)
November 1, 2007... Sponsored by Shaheed Beheshti Medical University. The purpose of this study is to compare the efficacy and adverse side effect occurrence of doxycycline and azithromycin in the management of moderate acne vulgaris. Condition Intervention...

Treatment of alopecia areata of the scalp with intradermal injections of botulinum toxin.(ALOPECIA)(Brief article)
November 1, 2007... Sponsored by University of British Columbia. The purpose of this study is to examine prospectively the safety and efficacy of botulinum toxin A (Botox) injections in the treatment of patients with alopecia areata of the scalp. Condition...

A study to assess the efficacy and safety of dutasteride 0.5 mg once daily for 6 months in the treatment of male subjects with androgenetic alopecia.(ALOPECIA)(Brief article)
November 1, 2007... Sponsored by GlaxoSmithKline. The aim of this phase III study is to compare the efficacy, safety, and tolerability of dutasteride (0.5 mg) with placebo for 6 months in Korean male subjects with androgenetic alopecia in the vertex region, types...

Efficacy of therapy with the spironolactone pills compared to minoxidil lotion in female pattern hair loss.(ALOPECIA)(Brief article)
November 1, 2007... Sponsored by University of British Columbia. This study evaluates the efficacy of therapy with the antiandrogen spironolactone compared to topical minoxidil in female pattern hair loss. Condition Intervention Phase...

Imiquimod in children with plaque morphea.(CONNECTIVE TISSUE DISORDERS)(Brief article)
November 1, 2007... Sponsored by the Hospital for Sick Children. This is a pilot study to assess the potential efficacy and relative safety of imiquimod in children with plaque morphea. Condition Intervention Phase Scleroderma,...

Single-blind study determining the efficacy of polypodium leucotomos extract supplement in decreasing UVA premutagenic and photoaging markers (heliocare).(PHOTOAGING)(ultraviolet-A)(Brief article)
November 1, 2007... Sponsored by University of Miami. The purpose of this study is to determine if taking a dose of the study medication, called Polypodium leucotomos, prevents some of the changes in the skin caused by the adverse effects of ultraviolet-A. ...

A study to evaluate psoriasis outcomes and safety events in patients with chronic moderate to severe plaque psoriasis (response).(PSORIASIS)(Brief article)
November 1, 2007... Sponsored by Genentech. This is a multicenter, prospective, 5-year surveillance study of approximately 5,000 Raptiva[R]-treated patients and approximately 500 non-Raptiva treated patients (formerly 2,500 comparison patients who were treated...

PSUNRISE--prospective study using Remicade in psoriasis patients with an inadequate response to etanercept.(PSORIASIS)(Brief article)
November 1, 2007... Sponsored by Centocor, Inc. The purpose of this study is to test the safety and effectiveness of infliximab in patients with plaque psoriasis who have been receiving the drug etanercept for treatment of their plaque psoriasis for at least 4...

Study of the safety and effectiveness of CNTO 1275 compared to etanercept for the treatment of moderate to severe plaque psoriasis.(PSORIASIS)(Brief article)
November 1, 2007... Sponsored by Centocor, Inc. The purpose of this research study is to compare the effects (good and/or bad) of CNTO 1275 or etanercept on moderate to severe plaque psoriasis. Condition Intervention Phase Psoriasis...

Efficacy and safety of cyclosporine a microemulsion in maintenance patients with chronic plaque psoriasis.(PSORIASIS)(Brief article)
November 1, 2007... Sponsored by Novartis. The study will evaluate the efficacy of cyclosporine when administered twice a week compared to continuous administration in patients with chronic plaque psoriasis. Condition Intervention ...

Psoriasis longitudinal assessment and registry (PSOLAR).(PSORIASIS)(Brief article)
November 1, 2007... Sponsored by Centocor, Inc. The purpose of this study is to evaluate the safety of infliximab in patients with chronic severe plaque psoriasis as well as the clinical outcomes, quality of life, and comorbidities for patients who receive...

Photodynamic therapy using silicon phthalocyanine 4 in treating patients with actinic keratosis, Bowen's disease, skin cancer, or stage I or stage II mycosis fungoides.(SKIN CANCER)(Brief article)
November 1, 2007... Sponsors and Collaborators: Case Comprehensive Cancer Center and National Cancer Institute (NCI). This phase I trial is studying the side effects and best dose of photodynamic therapy using silicon phthalocyanine 4 in treating patients with...

Photodynamic therapy in treating patients with skin cancer.(SKIN CANCER)(Brief article)
November 1, 2007... Sponsors and Collaborators: Roswell Park Cancer Institute and National Cancer Institute (NCI). This randomized phase II trial is studying how well photodynamic therapy that includes aminolevulinic acid works in treating patients with skin...

Topical tazarotene in treating patients with basal cell skin cancer and basal cell nevus syndrome.(SKIN CANCER)
November 1, 2007... Sponsors and Collaborators: University of California, San Francisco and National Cancer Institute (NCI). This phase II trial is studying topical tazarotene to see how well it works in treating patients with basal cell skin cancer and basal cell...

Lovastatin in treating patients at high risk of recurrent melanoma.(SKIN CANCER)
November 1, 2007... Sponsors and Collaborators: Chao Family Comprehensive Cancer Center and National Cancer Institute (NCI). This randomized phase II trial is studying lovastatin to see how well it works compared to a placebo in treating patients at high risk of...

A study with ASP2151 in subjects with recurrent episodes of genital herpes.(SKIN INFECTION)
November 1, 2007... Sponsored by Astellas Pharma Inc. This is a study of ASP2151 in subjects with recurrent outbreaks of genital herpes. Condition Intervention Phase Herpes Genitalis Drug: ASP2151 Phase II Drug:...

A randomized trial to evaluate the suppressive effect of high-dose acyclovir versus valacyclovir on persons with HSV-2.(SKIN INFECTION)(herpes simplex virus)
November 1, 2007... Sponsors and Collaborators: University of Washington and National Institutes of Health (NIH). The purpose of the research study is to evaluate the effectiveness of high-dose acyclovir compared to valacyclovir for the reduction of HSV-2...

Safety, pharmacokinetics, and efficacy study of NB-001 to treat recurrent herpes labialis.(SKIN INFECTION)(NanoBio Corporation)
November 1, 2007... Sponsored by NanoBio Corporation. The purpose of this study is to determine the safety and efficacy of topical applications of NB-001 as compared to placebo for the treatment of recurrent herpes labialis. Condition Intervention...

Study of a Bupivacaine patch (Eladur[TM]) to treat postherpetic neuralgia.(SKIN INFECTION)
November 1, 2007... Sponsored by Durect. This study will test the safety and efficacy of treating postherpetic neuralgia patients with the analgesic patch, Bupivacaine TTS (Eladur). Condition Intervention Phase Postherpetic Drug:...