Journal of Drugs in Dermatology articles from May 2007

Journal of Drugs in Dermatology archives from May 2007

Histologic patterns of melanocytic nevi: a proposal for a new classification.(Clinical report)
May 1, 2007... Abstract A new classification of melanocytic nevi is presented that may incorporate 1 of 3 anatomic patterns, 1 of 12 architectural patterns, and 1 of 3 cellular patterns in the diagnosis. In this scheme, the patterns are easy to...

Managing rosacea: a review of the use of metronidazole alone and in combination with oral antibiotics.
May 1, 2007... Abstract Background: Rosacea is an extremely common chronic dermatosis affecting an estimated 14 million Americans. Rosacea is most commonly managed with topical metronidazole, sometimes in combination with oral antibiotics. Purpose:...

Phase II clinical trial of bexarotene gel 1% in psoriasis.(Clinical report)
May 1, 2007... Abstract We report the results of a nonrandomized, open-label pilot trial investigating the safety, tolerability, and efficacy of bexarotene gel 1% in treating chronic mild to moderate plaque psoriasis. Twenty-four adults with mild to...

Treatment of all basal cell carcinoma variants including large and high-risk lesions with 5% imiquimod cream: histological and clinical changes, outcome, and follow-up.
May 1, 2007... Abstract Forty-one patients with 47 basal cell carcinomas (BCCs; 15 superficial, 26 nodular, and 6 sclerodermiform) were treated with 5% imiquimod cream once daily 5 times a week for 6 weeks in an open-label clinical trial. The overall...

Retrospective analysis of pimecrolimus cream 1% for treatment of facial vitiligo.
May 1, 2007... Abstract Objective: To explore the effectiveness of pimecrolimus cream 1% used twice daily (BID) for the treatment of facial vitiligo. Methods: Patients who had used pimecrolimus cream 1% monotherapy BID for at least 3 months and who...

Absorption and efficacy of miconazole nitrate 0.25% ointment in infants with diaper dermatitis.(Clinical report)
May 1, 2007... Abstract Background: The potential for toxicity from systemic absorption of topical miconazole in infants is a concern. Objective: To assess the relative safety of 0.25% miconazole based on the amount absorbed through the skin of...

Generalized urticaria with use of diphencyprone in the treatment of warts.
May 1, 2007... Abstract Generalized urticaria is an adverse and serious side effect of diphencyprone. We report a case in order to advise of the possibility of associated type I hypersensitivity reaction (urticaria), which could progress to a more severe...

Treatment of Zoon's balanitis with imiquimod 5% cream.(Case study)
May 1, 2007... Abstract We report a case of a 43-year-old uncircumcised Caucasian, diabetic man with a 4-year history of Zoon's balanitis unresponsive to topical steroids, in whom control of the disease was achieved with topical imiquimod. A...

The first reported case of lichen planus following inactivated influenza vaccination.(Case study)
May 1, 2007... Abstract Lichen planus (LP) is an idiopathic, inflammatory, pruritic dermatosis of unknown origin. An increased prevalence of a wide range of diseases such as viral hepatitis C, hepatitis B, primary sclerosing cholangitis, and primary...

Cystic sebaceous carcinoma: is it a constant pathognomic marker for Muir-Torre syndrome?
May 1, 2007... Abstract Sebaceous carcinoma (SC) is a rare and aggressive cutaneous neoplasm. It may arise in ocular or extraocular sites. Approximately 25% of all reported cases of SC are extraocular. Cystic presentation of sebaceous neoplasm is rare....

Dermatology meetings in May.
May 1, 2007... 5/9-5/12 68th Annual Meeting of the Society of Investigative Dermatology Los Angeles, CA http://sidnet.org/Annual_Meeting.asp 5/12 4th Annual Scientific Meeting of the Australasian Society for Dermatology Research ...

Cellulitis as a postprocedural complication of topical 5-aminolevulinic acid photodynamic therapy in the treatment of actinic keratosis.
May 1, 2007... Abstract Background: Actinic keratoses (AKs) are a common premalignant tumor of the skin. Several treatment modalities exist for broad-area therapy. Photodynamic therapy (PDT) is one such treatment modality. Disruption of squamous...

Sequelae from inadvertent long-term use of potent topical steroids.(Case study)
May 1, 2007... Abstract We report a case of a 53-year-old African American woman with an unusual example of striae caused by topical steroid usage and discuss the widespread usage of these products. Introduction The sale of prescription strength...

Pediatric adherence to topical medication can be very poor.(atopic dermatitis)
May 1, 2007... Pediatric Adherence to Topical Medication Can Be Very Poor Commentary on: Stealth monitoring of adherence to topical medication: Adherence is very poor in children with atopic dermatitis. Krejci-Manwaring J, et al. J Am Acad Dermatol....

Patients with photosensitive diseases do not apply adequate sunscreen.(NEWS, VIEWS, AND REVIEWS)
May 1, 2007... Patients with Photosensitive Diseases Do Not Apply Adequate Sunscreen Commentary on: Sunscreen application by photosensitive patients is inadequate for protection. Azurdia RM, et al. Br J Dermatol. 1999;140:255-258. Summary ...

Post-transplant sunscreen use is poor.(NEWS, VIEWS, AND REVIEWS)
May 1, 2007... Post-Transplant Sunscreen Use Is Poor Commentary on: Sunscreen use before and after transplantation and assessment of risk factors associated with skin cancer development in renal transplant recipients. Moloney FJ, et al. Arch...

Beyond skin: the dynamics on nonadherence in other chronic diseases.(NEWS, VIEWS, AND REVIEWS)
May 1, 2007... Beyond Skin: The Dynamics on Nonadherence in Other Chronic Diseases Commentary on: Gaps in treatment among users of osteoporosis medications: the dynamics of noncompliance. Brookhart MA, et al. Am J Med. 2007;120:251-256. Summary...

Xolegel[TM] receives marketing approval in Canada.(PIPELINE PREVIEWS)(Brief article)
May 1, 2007... Barrier Therapeutics, Inc recently announced that it has received marketing approval for Xolegel in Canada. Xolegel (ketoconazole, topical gel, 2%) is approved for the treatment of seborrheic dermatitis in immunocompetent adults and children...

OrCel[R] in the treatment of venous ulcers.(PIPELINE PREVIEWS)(Brief article)
May 1, 2007... Ortec International, Inc recently announced that it has started the process of filing its Pre-Market Approval supplement application to the FDA to request approval to market its product OrCel. OrCel is a tissue-engineered product for the...

Generic prednicarbate approved by the FDA.(PIPELINE PREVIEWS)(Food and Drug Administration)(Brief article)
May 1, 2007... The FDA recently granted an approval for a first-time generic formulation for prednicarbate 0.1% ointment for topical treatment. The medication is used to treat corticosteroid-responsive dermatoses and their pruritic manifestations. It is a...

Dapsone gel for treatment of acne vulgaris.(PIPELINE PREVIEWS)(Brief article)
May 1, 2007... Two recently published randomized, double-blind studies demonstrated the safety and efficacy of dapsone gel 5% for the treatment of acne vulgaris. Dapsone gel 5% is a new aqueous formulation of dapsone. The 2 studies were 12-week clinical...

Efalizumab for severe atopic dermatitis.(PIPELINE PREVIEWS)(Brief article)
May 1, 2007... A recent study demonstrated that efalizumab may be a potential treatment for recalcitrant atopic eczema. The safety and efficacy of efalizumab was assessed in an investigator-initiated, prospective, open-label, pilot study of 10 patients with...

Herpes simplex virus test kit.(PIPELINE PREVIEWS)(drug approval Focus Diagnostics, Inc.)(Brief article)
May 1, 2007... The FDA recently granted clearance to Focus Diagnostics, Inc for release of a herpes simplex virus (HSV) test kit. The test kit (Plexus HerpeSelect 1 and 2 IgG test kit) contains an assay that finds and differentiates between immunoglobulin G...

Phase II study of incyclinide for treatment of acne.(PIPELINE PREVIEWS)(Brief article)
May 1, 2007... CollaGenex Pharmaceuticals, Inc recently announced positive results from a phase II dose-finding study of the safety and therapeutic range of incyclinide for the treatment of acne. The phase II study was a double-blind, placebo-controlled trial...

Skin Flaps in Facial Surgery.(Book review)
May 1, 2007... Skin Flaps in Facial Surgery by Daniel Buchen MD McGraw Hill Medical Publishing; 2006 $129.00, 300 pages. ISBN: 007145943X For the physician looking for a review of facial surgical repairs, Dr. Daniel Buchen's new text...

Dermatology: A Pictorial Review.(Brief article)(Book review)
May 1, 2007... Dermatology: A Pictorial Review by Asra Ali McGraw Hill Medical Publishing; 2006 $65.95, 486 pages. ISBN: 0071422935 Asra Ali's Dermatology: A Pictorial Review is a well-written, concise, and easy to read pictorial review of...

ZD1839 (Iressa) for recurrent or metastatic squamous cell carcinoma of the skin.(CLINICAL TRIAL REVIEW)(Brief article)
May 1, 2007... Sponsors and Collaborators: MD Anderson Cancer Center and AstraZeneca. The purpose of this study is to explore the activity of ZD1839 administered to patients with squamous cell carcinoma of the skin who have locoregional recurrence and/or...

TD-1792 in Gram-positive complicated skin and skin structure infection.(CLINICAL TRIAL REVIEW)(Brief article)
May 1, 2007... Sponsored by Theravance. The purpose of this study is to determine whether TD-1792 is safe and effective when used to treat complicated skin and skin structure infections caused by Gram-positive bacteria. Condition ...

Study evaluating sirolimus in nonmelanoma skin cancer in kidney transplant recipients.(CLINICAL TRIAL REVIEW)(Brief article)
May 1, 2007... Sponsored by Wyeth. The purpose of this study is to determine the effect of sirolimus on the prevention of new nonmelanoma skin cancer (NMSC) in kidney transplant recipients. Condition Intervention Phase Graft vs....

Study of cetuximab in squamous cell carcinoma of the skin expressing EGFR.(CLINICAL TRIAL REVIEW)(epidermal growth factor receptor)(Brief article)
May 1, 2007... Sponsors and Collaborators: Centre Hospitalier of Chartres and Hospital of Chartres-France. The purpose of this study is to determine whether cetuximab is effective in the treatment of locally advanced or metastatic squamous cell carcinoma of...

Skin structure infections with suspected or proven MRSA.(CLINICAL TRIAL REVIEW)(methicillin-resistant Staphylococcus aureus)(Brief article)
May 1, 2007... Sponsored by Pfizer. The purpose of this study is to determine if linezolid is superior to vancomycin in the treatment of complicated skin and soft tissue infections due to methicillin-resistant staphylococcus aureus (MRSA) in adult subjects....

Comparison of Metvix PDT with its vehicle in the treatment of photoaged skin.(CLINICAL TRIAL REVIEW)
May 1, 2007... Sponsored by Galderma. The aim of the study is to assess whether Metvix[R] PDT--a procedure currently marketed in several countries in Europe (including UK and Spain) and in Australia, for the treatment of benign forms of skin cancer (eg,...

T4N5 liposomal lotion in preventing the recurrence of nonmelanoma skin cancer in patients who have undergone a kidney transplant.(CLINICAL TRIAL REVIEW)
May 1, 2007... Sponsors and Collaborators: Lurleen Wallace Comprehensive Cancer at University of Alabama-Birmingham and National Cancer Institute (NCI). This randomized phase II trial is studying how well T4N5 liposomal lotion works in preventing the...

The effects of microdermabrasion on skin remodeling.(CLINICAL TRIAL REVIEW)
May 1, 2007... Sponsored by University of Michigan. This research project aims to study the effects of microdermabrasion. We are interested in determining how this procedure works at rebuilding the skin following microdermabrasion. Condition ...

Study of recombinant human thrombin for bleeding during autologous skin grafting.(CLINICAL TRIAL REVIEW)
May 1, 2007... Sponsored by ZymoGenetics. The purpose of this study is to evaluate whether rhThrombin is safe when used for controlling bleeding during skin graft surgery. Condition Intervention Phase Surgical Hemostasis Drug:...

Trial of Zesteem (estradiol) in healing of split thickness skin graft donor sites.(CLINICAL TRIAL REVIEW)
May 1, 2007... Sponsored by Renovo. This trial will assess the effects of Zesteem (estradiol) on the healing of split thickness skin graft donor sites in patients aged 18 to 85 years old. Condition Intervention Phase Burn ...

The use of silver leaf dressing in the prevention of radiotherapy induced skin reactions.(CLINICAL TRIAL REVIEW)
May 1, 2007... Sponsors and Collaborators: British Columbia Cancer Agency and Canadian Breast Cancer Foundation. The hypothesis is that silver leaf nylon dressing reduces the percentage of patients developing brisk erythema and moist desquamation while...

Photodynamic therapy in treating patients with skin cancer.(CLINICAL TRIAL REVIEW)
May 1, 2007... Sponsors and Collaborators: Roswell Park Cancer Institute and National Cancer Institute (NCI). This randomized phase II trial is studying how well photodynamic therapy that includes aminolevulinic acid works in treating patients with skin...

LMB-2 immunotoxin and vaccine therapy in treating patients with metastatic melanoma that cannot be removed by surgery.(CLINICAL TRIAL REVIEW)
May 1, 2007... Sponsored by National Cancer Institute (NCI). This phase II trial is studying how well giving LMB-2 immunotoxin together with vaccine therapy works in treating patients with metastatic melanoma that cannot be removed by surgery. Condition...

Metvix PDT versus vehicle PDT with Aktilite CL128 lamp in patients with actinic keratosis on the face and scalp.(CLINICAL TRIAL REVIEW)
May 1, 2007... Sponsored by PhotoCure. The purpose of this study is to compare the efficacy of photodynamic therapy (PDT) with methyl aminolevulinate (MAL) cream to PDT with vehicle cream, using the LED light source Aktilite CL128, in the treatment of...

Chemotherapy and total-body irradiation followed by autologous lymphocyte infusion, aldesleukin, and autologous stem cell transplant in treating patients with metastatic melanoma.(CLINICAL TRIAL REVIEW)
May 1, 2007... Sponsored by National Cancer Institute (NCI). This phase II trial is studying how well chemotherapy and total-body irradiation followed by autologous lymphocyte infusion, aldesleukin, and autologous stem cell transplant, work in treating...

Mometasone furoate in preventing radiation dermatitis in patients undergoing radiation therapy to the breast or chest wall for invasive breast cancer or ductal carcinoma in situ.(CLINICAL TRIAL REVIEW)
May 1, 2007... Sponsors and Collaborators: North Central Cancer Treatment Group and National Cancer Institute (NCI). This randomized phase III trial is studying mometasone furoate to see how well it works compared to a placebo in preventing radiation...

A study to evaluate the safety and efficacy of abatacept in patients with diffuse systemic sclerosis (scleroderma).(CLINICAL TRIAL REVIEW)
May 1, 2007... Sponsors and Collaborators: Stanford University and Bristol-Myers Squibb. The purpose of this study is to determine if treatment with abatacept, a new therapy recently approved for the treatment of rheumatoid arthritis, may reduce the...

Adesleukin with or without vaccine therapy in treating patients with locally advanced or metastatic melanoma.(CLINICAL TRIAL REVIEW)
May 1, 2007... Sponsors and Collaborators: Center for Cancer Care at Goshen Health System and National Cancer Institute (NCI). The purpose of this randomized phase III trial is to compare the effectiveness of aldesleukin with or without vaccine therapy in...

Topical 5-ALA photodynamic therapy for the treatment of verruca vulgaris.(CLINICAL TRIAL REVIEW)
May 1, 2007... Sponsored by National Taiwan University Hospital. The purpose of this clinical trial is to develop topical ALA-PDT as an alternative treatment for warts but without the unwanted side effects of pain and burning. Condition Phase ...

Chemotherapy plus biological therapy in treating patients with metastatic melanoma.(CLINICAL TRIAL REVIEW)
May 1, 2007... Sponsored by National Cancer Institute (NCI). This phase II trial is studying how well giving chemotherapy together with biological therapy works in treating patients with metastatic melanoma that has not responded to previous therapy. ...