Journal of Drugs in Dermatology articles from May 2006

Journal of Drugs in Dermatology archives from May 2006

Correction.(Correction notice)
May 1, 2006... The table of contents in the March issue incorrectly stated the authors of "Crusted Scabies: A Clinical Review." They were Kjetil Kristoffer Guldbakke MD and Amor Khachemoune MD CWS.

New roles for systemic retinoids.
May 1, 2006... Abstract Acitretin, the only oral retinoid indicated for the treatment of psoriasis, has shown activity when used in combination, rotational, and sequential therapy regimens with other therapies. When used with phototherapy, significantly...

Haptens as drugs: contact allergens are powerful topical immunomodulators.
May 1, 2006... Abstract For the past 40 years, dermatologists have safely used contact sensitizers such as dinitrochlorobenzene (DNCB), diphenylcyclopropenone (DPCP), and squaric acid dibutylester (SADBE) for the treatment of warts, alopecia areata, and...

Topical 5% 5-fluorouracil cream in the treatment of plantar warts: a prospective, randomized, and controlled clinical study.
May 1, 2006... Abstract Topical 5-fluorouracil (5-FU) is an antineoplastic antimetabolite that inhibits DNA and RNA synthesis, thereby preventing cell replication and proliferation. This mechanism of action may allow topical 5-FU to be utilized in the...

The mechanism of lithium and beta-blocking agents in inducing and exacerbating psoriasis.
May 1, 2006... Abstract Documentation of psoriatic eruptions occurring with the initiation of various pharmacotherapy agents has been reported in the literature. Two such agents include lithium and beta-blocking drugs. By understanding the mechanism by...

Poly-L-lactic acid: an overview.
May 1, 2006... Abstract In August 2004, the US Food and Drug Administration approved a poly-L-lactic acid (PLLA)-based injectable medical device for restoration and/or correction of the signs of facial fat loss (lipoatrophy) in people with human...

A multicenter efficacy and tolerability evaluation of benzoyl peroxide in a 10% urea vehicle for the treatment of acne vulgaris.
May 1, 2006... Abstract Background: Acne vulgaris is a common skin disease that affects 70% to 96% of individuals. Topical benzoyl peroxide has been used successfully for acne treatment; however, it may be accompanied by drying and or flaking skin. The...

Evaluation of a nonsurgical, muscle-stimulating system to elevate soft tissues of the face and neck.
May 1, 2006... Abstract Non-invasive procedures for tissue tightening and elevation are new frontiers in dermasurgery. Current methods for achieving a "nonsurgical face-lift" include radiofrequency and infrared light devices which disrupt non-covalent...

Effective treatment of head louse with pediculicides.
May 1, 2006... Abstract Of the pediculicides on the market, most are not 100% ovicidal and don't have a residual activity of more than 2 days. Therefore, at least 2 treatments are necessary to control the entire louse population. In order for a...

Treatment of giant keratoacanthoma with intralesional 5-fluorouracil.(CASE REPORTS)
May 1, 2006... Abstract Giant keratoacanthomas measure greater than 2 cm and have a predilection for the nose and eyelids. As a result, they often present a significant therapeutic challenge. A 36-year old woman was referred for evaluation of a 4.0 x 4.0...

Autosensitization dermatitis associated with propolis-induced allergic contact dermatitis.(CASE REPORTS)
May 1, 2006... Abstract Propolis is a beehive product known for its anti-inflammatory properties. With its growing use, propolis-induced contact dermatitis is increasing. While the dermatitis mostly occurs on areas directly exposed to propolis, our case...

Local immune modulator (imiquimod 5% cream) as adjuvant treatment after incomplete mohs micrographic surgery for large, mixed type basal cell carcinoma: a report of 3 cases.(CASE REPORTS)
May 1, 2006... Abstract Background: Surgical excision, including Mohs micrographic surgery, is the treatment of first choice for basal cell carcinoma (BCC). Occasionally, the Mohs procedure has to be ceased prematurely for unforeseen reasons. ...

Nasal reconstruction using 20 mg/ml cross-linked hyaluronic acid.(CASE REPORTS)
May 1, 2006... Abstract According to American Society for Aesthetic Plastic Surgery (ASAPS), 200,924 people had rhinoplasties in 2005. (1) Patients typically have surgical rhinoplasty to correct unsightly noses resulting from trauma, surgery, or...

Facial edema induced by isotretinoin use: a case and a review of the side effects of isotretinoin.(CASE REPORTS)
May 1, 2006... Abstract Isotretinoin (13-cis-retinoic acid) is a retinoid that is used to treat cystic acne, comedonal acne, and other diseases. For the treatment of acne, isotretinoin is dosed at 0.5 to 2 mg/kg daily for 5 months with a target total...

Trachyonychia: case report and review of the literature.(CASE REPORTS)
May 1, 2006... Abstract Trachyonychia is the term used to describe nail plate roughness, pitting, and ridging that may affect 1 to 20 nails. Alopecia areata, psoriasis, lichen planus, atopic dermatitis, ichthyosis vulgaris, as well as other skin...

Laser and cosmetic news.
May 1, 2006... Laser and Cosmetic News covers the latest advances in laser surgery, light technology, phototherapy, and cosmetic surgery. New and emerging therapies, noteworthy publications, and exciting meeting developments will be highlighted. Controversies...

Levocetirizine in the treatment of chronic idiopathic urticaria: a randomized, double-blind, placebo-controlled study.(WASHINGTON WHISPERS)
May 1, 2006... Levocetirizine in the Treatment of Chronic Idiopathic Urticaria: A Randomized, Double-Blind, Placebo-Controlled Study Nettis E., et al. British Journal of Dermatology. 2006; 154:533-538. Summary The authors present a randomized,...

A randomized, multicenter, double-blind, placebo-controlled phase 2 trial of ISA247 in patients with chronic plaque psoriasis.(WASHINGTON WHISPERS)
May 1, 2006... A Randomized, Multicenter, Double-blind, Placebo-Controlled Phase 2 Trial of ISA247 in Patients with Chronic Plaque Psoriasis Bissonnette R, MD, et al. Journal of the American Academy of Dermatology. 2006;54:472-478. Summary The...

Efficacy and safety of 3- and 5-injection patterns (30 and 50 U) of botulinum toxin A (Dysport) for the treatment of wrinkles in the glabella and the central forehead region.(WASHINGTON WHISPERS)
May 1, 2006... Efficacy and Safety of 3- and 5-Injection Patterns (30 and 50 U) of Botulinum Toxin A (Dysport) for the Treatment of Wrinkles in the Glabella and the Central Forehead Region Rzany B, MD, et al. Arch Dermatol. 2006;142:320-326. Summary...

Phase I clinical trial of PTK0796 for treatment of skin infections.(PIPELINE PREVIEWS)
May 1, 2006... Merck and Paratek recently announced a collaboration in the initiation of a Phase I clinical trial for the new antibiotic PTK0796. This drug will be used for the treatment of methicillin-resistant Staphylococcus aureus (MRSA) infections, as...

FDA approves Fast Track for PPI-0903.(PIPELINE PREVIEWS)
May 1, 2006... The FDA recently approved Cerexa's PPI-0903 for Fast Track to expedite the review and subsequent development of this drug. PPI-0903 is a new cephalosporin antibiotic which is intended for treatment of complicated skin and skin structure...

Broader indication approved by the FDA for VANOS.(PIPELINE PREVIEWS)
May 1, 2006... Medicis recently announced that the FDA has approved additional indications for their topical corticosteroid VANOS. VANOS is a Class I corticosteroid that was initially released in the spring of 2005 and approved by the FDA for treatment of...

Phase IV study shows Differin effective in combination acne therapy.(PIPELINE PREVIEWS)
May 1, 2006... The M.O.R.E. (Measuring Outcomes in A Real World Experience) Trial, a Phase IV study was recently presented at the 64th Annual Meeting of the American Academy of Dermatology (AAD). The M.O.R.E. Trial studied the efficacy of the topical...

Phase III study demonstrates positive results for Remicade.(PIPELINE PREVIEWS)
May 1, 2006... The EXPRESS II Trial (The Evaluation of Infliximab for Psoriasis Efficacy and Safety Study), a Phase III study, was recently presented at the 64th Annual Meeting of the American Academy of Dermatology (AAD). The data demonstrated that patients...

Study shows Botox superior to Dysport in duration of effect and patient satisfaction.(PIPELINE PREVIEWS)
May 1, 2006... A recent study comparing 2 distinct formulations of botulinum toxin type A was presented at the 64th Annual Meeting of the American Academy of Dermatology (AAD). Botox Cosmetic, marketed by Allergan, Inc. (Vistabel/Vistabex in Europe), was...

Preliminary data announced from Phase III study of ISA247 for psoriasis.(PIPELINE PREVIEWS)
May 1, 2006... Isotechnika, Inc., recently revealed preliminary results from its Phase III trial for its immunosuppressant ISA247. The current data set includes 193 patients who have received treatment with ISA247 for a total of 48 weeks. The patients were...

Remicade for treatment of psoriatic arthritis is approved in Australia.(PIPELINE PREVIEWS)
May 1, 2006... Schering-Plough Corporation recently announced that the Therapeutic Goods Administration of the Department of Health and Ageing in Australia has approved Remicade for treatment of active psoriatic arthritis in patients whose disease has not...

Effect of chlorhexidine skin cleansing on skin flora.(CLINICAL TRIAL REVIEW)
May 1, 2006... This study is currently recruiting patients. Verified by Johns Hopkins Bloomberg School of Public Health. Given the potential of skin cleansing with chlorhexidine as a safe, feasible, and cost-effective intervention for reducing neonatal death...

Photodynamic therapy in treating patients with skin cancer.(CLINICAL TRIAL REVIEW)
May 1, 2006... This study is currently recruiting patients. Verified by National Cancer Institute (NCI). Sponsors and Collaborators: Roswell Park Cancer Institute and National Cancer Institute (NCI). This randomized Phase II trial is studying how well...

The effects of microdermabrasion on skin remodeling.(CLINICAL TRIAL REVIEW)
May 1, 2006... This study is currently recruiting patients. Verified and sponsored by University of Michigan. This research project aims to study the effects of microdermabrasion, a technique causing minimal injury used to improve the appearance of fine...

Common allergens in skin tests for adult atopic dermatitis.(CLINICAL TRIAL REVIEW)
May 1, 2006... This study is currently recruiting patients. Verified and sponsored by National Taiwan University Hospital. The purpose of this study is to analyze the common allergens revealed by skin tests in adult atopic dermatitis patients. Condition...

Treatment of cutaneous ulcers with a novel biological dressing.(CLINICAL TRIAL REVIEW)
May 1, 2006... This study is currently recruiting patients. Verified and sponsored by Centre Hospitalier Affilie, Universitaire de Quebec. The aim of the study is to evaluate the effect of a biological dressing on the healing process of venous ulcers. The...

Infliximab (Remicade[R]) to treat dermatomyositis and polymyositis.(CLINICAL TRIAL REVIEW)
May 1, 2006... This study is currently recruiting patients. Verified and sponsored by National Institutes of Health Clinical Center. This study will examine whether infliximab (Remicade) is safe and effective for the treatment of dermatomyositis and...

Etanercept for treatment of hidradenitis.(CLINICAL TRIAL REVIEW)
May 1, 2006... This study is currently recruiting patients. Verified and sponsored by University of Pennsylvania. The purpose of this study is to determine whether etanercept is safe and effective for the treatment of hidradenitis. Another purpose of this...

Treatment of melasma with Jessner's solution versus trichloroacetic acid.(CLINICAL TRIAL REVIEW)
May 1, 2006... This study is currently recruiting patients. Verified and sponsored by Emory University. The purpose of this study is determine if there is a difference in the effectiveness between chemical peels using Jessner's solution and trichloroacetic...

Efalizumab for eczema.(CLINICAL TRIAL REVIEW)
May 1, 2006... This study is currently recruiting patients. Verified by University of Medicine and Dentistry New Jersey. Sponsors and collaborators: University of Medicine and Dentistry New Jersey and Genentech. The purpose of this study is to demonstrate a...

A study of valacyclovir to suppress HSV and HIV shedding in co-infected persons.(CLINICAL TRIAL REVIEW)
May 1, 2006... This study is currently recruiting patients. Verified by University of Washington. Sponsors and Collaborators: University of Washington, GlaxoSmithKline, and National Institutes of Health (NIH). The primary objective of this research study is...

The impact of treating Staphylococcus aureus infection and colonization on the clinical severity of atopic dermatitis.(CLINICAL TRIAL REVIEW)
May 1, 2006... This study is currently recruiting patients. Verified by Children's Memorial Hospital. Sponsors and Collaborators: Children's Memorial Hospital, Society for Pediatric Dermatology and Johnson & Johnson. A randomized investigator-blinded...

A study of HSV testing among pregnant women.(CLINICAL TRIAL REVIEW)
May 1, 2006... This study is currently recruiting patients. Verified by University of Washington. Sponsors and Collaborators: University of Washington and National Institutes of Health (NIH). The objective of the study is to evaluate the acceptance and effect...

Study of atopic dermatitis in pediatrics.(CLINICAL TRIAL REVIEW)
May 1, 2006... This study is currently recruiting patients. Verified by GlaxoSmithKline. Sponsors and Collaborators: GlaxoSmithKline and UCB. The purpose of this study is to compare cetirizine dry syrup to ketotifen dry syrup in the change in the severity of...

Histamine pharmacogenetics in children with atopic dermatitis.(CLINICAL TRIAL REVIEW)
May 1, 2006... This study is currently recruiting patients. Verified by National Institute of Child Health and Human Development (NICHD). Sponsors and Collaborators: National Institute of Child Health and Human Development (NICHD) and American College of...

Valacyclovir+temovate gel for the treatment of herpes labialis.(CLINICAL TRIAL REVIEW)
May 1, 2006... This study is currently recruiting patients. Verified by University of Utah. Sponsors and Collaborators: University of Utah and GlaxoSmithKline. A randomized study comparing the combination of valacyclovir and temovate gel versus placebo for...

A safety and tolerability study of valaciclovir oral suspension in infants and children.(CLINICAL TRIAL REVIEW)
May 1, 2006... This study is currently recruiting patients. Verified and sponsored by GlaxoSmithKline. Limited data are available on valaciclovir use in children and valaciclovir is not currently approved for use in pediatrics. The marketed formulation of...

Post-burn pruritus study: study to determine the pruritic benefits of ondansetron versus diphenhydramine in burn patients undergoing wound healing.(CLINICAL TRIAL REVIEW)
May 1, 2006... This study is currently recruiting patients. Verified and sponsored by United States Army Institute of Surgical Research. The purpose of this study is to see if a drug called ondansetron (Zofran) controls itching from healing burn wounds as...

A short course of neoadjuvant Gleevec (imatinib mesylate) in dermatofibrosarcoma protuberans.(CLINICAL TRIAL REVIEW)
May 1, 2006... This study is currently recruiting patients. Verified and sponsored by University of Michigan Cancer Center. The goal of this research study is to see if Gleevec can be used to treat a rare type of tissue tumor, dermatofibrosarcoma protuberans...

Study of cutaneous disease accompanied with pruritus in pediatrics.(CLINICAL TRIAL REVIEW)
May 1, 2006... This study is currently recruiting patients. Verified by GlaxoSmithKline. Sponsored by GlaxoSmithKline and UCB. The purpose of this study is to assess the safety of long-term use of cetirizine dry syrup in children with various types of...

Clinical and basic investigations into hermansky-pudlak syndrome.(CLINICAL TRIAL REVIEW)
May 1, 2006... This study is currently recruiting patients. Verified by National Institutes of Health Clinical Center. Sponsored by National Human Genome Research Institute (NHGRI). The purpose of this study is to perform research into the medical...

Studies in porphyria I: characterization of enzyme defects.(CLINICAL TRIAL REVIEW)
May 1, 2006... This study is currently recruiting patients. Verified by National Center for Research Resources (NCRR). Sponsored by National Center for Research Resources (NCRR) and the University of Texas. The objectives of this study are to characterize...

An observational study of the use and safety of Raptiva during pregnancy for androgenetic alopecia.(CLINICAL TRIAL REVIEW)
May 1, 2006... This study is currently recruiting patients. Verified and sponsored by Genentech. The Raptiva Pregnancy Registry is a prospective observational study established to obtain data on pregnancy outcomes of women who are exposed to Raptiva. ...