Journal of Drugs in Dermatology articles from March 2008

Journal of Drugs in Dermatology archives from March 2008

Increase in collagen turnover induced by intradermal injection of carbon dioxide in rats.
March 1, 2008... Introduction Human tissue changes with age. In the skin, these modifications are more easily recognized. (1,2) The modifications to the collagen and elastin system cause wrinkles, atrophy, grooves, ptosis, and laxity. These are the most...

Dermatological implications of skeletal aging: a focus on supraperiosteal volumization for perioral rejuvenation.
March 1, 2008... Introduction Facial beauty and attractiveness are important cross-cultural social concepts as they tend to dictate how individuals are judged and treated. (1) Research has shown that facial beauty is perceived and processed rapidly by the...

Botulinum toxin type A versus topical 20% aluminum chloride for the treatment of moderate to severe primary focal axillary hyperhidrosis.
March 1, 2008... Introduction Severe hyperhidrosis affects 2.8% of the population and can be socially unacceptable and emotionally devastating. (1) Approximately 1.4% of the US population has axillary hyperhidrosis, with one-third having severe axillary...

Histological and clinical studies on the effects of low to medium level infrared light therapy on human and mouse skin.
March 1, 2008... Introduction Phototherapy of the skin has been used for many years, but its exact mechanism of action is still not clear. (1) Nonablative laser or intense pulsed light (IPL) therapies have been reported to require thermal damage of the...

Lip augmentation and rejuvenation using a novel, porcine collagen-derived filler.
March 1, 2008... Introduction There are no universal ideas about the aesthetics of lips, as they vary with cultural beliefs, time, and individual preferences. (1) In an attempt to improve their appearance, many women, prompted by the changes that occur...

Utilization of narrow-band ultraviolet light B Therapy and Etanercept for the Treatment of Psoriasis (UNITE): efficacy, safety, and patient-reported outcomes.
March 1, 2008... Introduction Psoriasis is a chronic, systemic, debilitating inflammatory disease involving the skin, and potentially the joints in patients with psoriatic arthritis. (1) It has an important impact on patient wellbeing, potentially...

A pilot study to determine the safety and efficacy of monochromatic excimer light in the treatment of vitiligo.
March 1, 2008... Introduction Vitiligo is a chronic depigmentary disorder characterized by the loss of melanin and decreased melanocytes in the epidermis of affected skin. This defect results in well-circumscribed white macules or patches, which tend to...

Hydrocortisone butyrate 0.1% lotion in the treatment of atopic dermatitis in pediatric subjects.
March 1, 2008... Introduction Topical corticosteroids have become the cornerstone of treatment for a variety of inflammatory dermatoses, including atopic dermatitis (AD), eczema, and psoriasis. A wide selection of topical corticosteroid products is...

Skin rejuvenation in Asian skin: the analysis of clinical effects and basic mechanisms of intense pulsed light.
March 1, 2008... Introduction Photoaging is the result of chronic ultraviolet (UV) light exposure characterized by both epidermal and dermal skin changes. The visible signs of photodamage include coarse skin texture, wrinkles, pigmentation alterations,...

Fast and easy treatment for reduction of the Tyndall effect secondary to cosmetic use of hyaluronic acid.(CASE REPORTS)
March 1, 2008... Introduction Evaluation of the aging face includes the assessment of volume loss due to thinning skin, fat atrophy, and fat pad descent and protrusion. Today's treatment options include a variety of filler substances. One common product...

Erythromelalgia of the ears: an unusual variant and response to therapy.(CASE REPORTS)(Case study)
March 1, 2008... Introduction Erythromelalgia is an idiopathic condition characterized by episodes of erythematous, warm, burning acral skin, which is exacerbated by heat and relieved by cold. Erythromelalgia can be primary or secondary to various...

Basal cell carcinoma of the vulva presenting as unilateral pruritus.(CASE REPORTS)
March 1, 2008... Introduction Basal cell carcinoma (BCC) is the most common human malignancy and has been reported to account for a vast majority of all nonmelanoma skin cancers. Although it may occur in association with certain rare genetic disorders such...

Inguinal hyperhidrosis misdiagnosed as urinary incontinence: treatment with botulinum toxin A.(CASE REPORTS)(Case study)
March 1, 2008... Case Report A 34-year-old Hispanic female presented with a chief complaint of excessive wetness in the underpants. The patient had a history of excessive sweating on her nose as well. Her condition had been imminent for 20 years with onset...

2008 dermatology conferences and conventions.(Calendar)
March 1, 2008... January 7th Annual Caribbean Dermatology Symposium January 15-19, 2008 St Thomas, US Virgin Islands www.caribederm.org American Society of Cosmetic Surgery 24th Annual Scientific Meeting (ASCS) January 17-20, 2008...

Somatic stem cells in dermatology.(LASER AND COSMETIC NEWS)
March 1, 2008... The reprogramming of somatic stem cells derived from adult human skin into a pluripotent stem cell state has recently been achieved. Fibroblasts isolated from adult human skin were transduced using retroviral vectors carrying 4 key...

Cutaneous clues to drug addiction.(NEWS, VIEWS, AND REVIEWS)
March 1, 2008... Introduction Drug addiction may be suspected or diagnosed on the basis of skin findings alone. The astute dermatologist may recognize cutaneous patterns, and characteristic skin changes, including burns, scars, or other reaction patterns,...

Flo-Pred approved by the FDA.(PIPELINE PREVIEWS)(food and drug administration)(Brief article)
March 1, 2008... Taro Pharmaceutical Industries Ltd recently announced that the FDA has granted approval to a new drug application for Flo-Pred[TM] (prednisolone acetate oral suspension). Flo-Pred will be available as the equivalent of 5 mg/5 ml and 15 mg/5 ml...

Over-the-counter cetirizine hydrochloride tablets.(PIPELINE PREVIEWS)(Brief article)
March 1, 2008... Perrigo Company recently reported that the FDA has granted final approval for the manufacturing and marketing of over-the-counter cetirizine hydrochloride tablets (5 mg and 10 mg). This product will be available under store brand labels, and is...

Phase III trial for Isolagen Therapy completed.(PIPELINE PREVIEWS)(Brief article)
March 1, 2008... Isolagen, Inc has announced that injection treatments have been completed in its phase III double-blind, randomized, placebo-controlled, clinical trials: IT-A-005 and IT-A-006. All patients who have completed treatments may now advance to the...

Microcyn[R] for mildly infected diabetic foot ulcers.(PIPELINE PREVIEWS)
March 1, 2008... The phase II clinical study, which evaluated Microcyn[R] Technology for the treatment of mildly infected diabetic foot ulcers, was recently completed. This phase II randomized, controlled trial, which was undertaken by Oculus Innovative...

PV-10 for metastatic melanoma.(PIPELINE PREVIEWS)(Brief article)
March 1, 2008... A phase II clinical trial for PV-10 (Provecta[TM]) in the treatment of stage III and stage IV metastatic melanoma has begun a recruitment expansion to a second trial center. Provecta is an anticancer medication that has received orphan drug...

FDA approval for Humira for psoriasis.(PIPELINE PREVIEWS)(Brief article)
March 1, 2008... The FDA recently granted approval to Abbott to market Humira[R] for the treatment of adult patients with moderate to severe chronic plaque psoriasis. Humira had previously been approved to treat rheumatoid arthritis, ankylosing spondylitis, and...

Cefuroxime axetil for oral suspension.(PIPELINE PREVIEWS)(Brief article)
March 1, 2008... Ranbaxy Pharmaceuticals Inc recently announced that it has received FDA approval to manufacture and market cefuroxime axetil for oral suspension USP, 125 mg/5 mL and 250 mg/5 mL. This is the generic equivalent of Cefin[R], which is manufactured...

EpiCept NP-1 cream for diabetic peripheral neuropathy.(PIPELINE PREVIEWS)(Brief article)
March 1, 2008... EpiCept[TM] Corporation recently announced promising initial results from a phase II trial of EpiCept NP-1 cream for the treatment of diabetic peripheral neuropathy. EpiCept NP-1 cream is a topical cream combination of 4% amitriptyline and 2%...

Comparison study of topical acne regimens.(ACNE)(Brief article)
March 1, 2008... Sponsored by: University Medical Products. This study will compare the effectiveness of the 2 acne treatment regimens, AcneFree and Proactiv, for the treatment of moderately severe acne vulgaris of the face and neck. It will also compare the...

A study to evaluate psoriasis outcomes and safety events in patients with chronic moderate to severe plaque psoriasis (RESPONSE).(PSORIASIS)(Brief article)
March 1, 2008... Sponsored by: Genentech. This is a multicenter, prospective, 5-year surveillance study of approximately 5000 Raptiva-treated patients and approximately 500 non-Raptiva treated patients (formerly 2500 comparison patients who were treated with a...

A safety and efficacy study of a topical gel for the treatment of mild to moderate psoriasis.(PSORIASIS)(Brief article)
March 1, 2008... Sponsors and Collaborators: Manhattan Pharmaceuticals Therapeutics, Inc. The primary objective of the study is to assess the tolerability and efficacy of a parathyroid hormone peptide gel [PTH (1-34)] 0.10% or 0.05% in the treatment of mild to...

Prospective study using remicade in psoriasis patients with an inadequate response to etanercept (PSUNRISE).(PSORIASIS)(Brief article)
March 1, 2008... Sponsored by: Centocor, Inc. The purpose of this study is to test the safety and effectiveness of infliximab in patients with plaque psoriasis who have been receiving the drug etanercept for treatment of their plaque psoriasis for at least 4...

Efficacy and safety of cyclosporine a microemulsion in maintenance patients with chronic plaque psoriasis.(PSORIASIS)(Brief article)
March 1, 2008... Sponsored by: Novartis. The study will evaluate the efficacy of cyclosporine, when administered twice a week compared to continuous administration, in patients with chronic plaque psoriasis. Condition Intervention ...

Safety and efficacy study of CF101 to treat psoriasis.(PSORIASIS)(Brief article)
March 1, 2008... Sponsored by: Can-Fite BioPharma. This study will test the hypothesis that CF101, an agonist to the A3 adenosine receptor, which is under development to treat other immune-mediated inflammatory diseases, will provide clinical benefits in the...

The effect of light emitting diodes on scar appearance.(SCARRING)(Brief article)
March 1, 2008... Sponsored by: Northwestern University. The goal of this project is to examine the ability of light exposure to improve the appearance of cutaneous scars. Condition Intervention Cutaneous Scars Device: no intervention ...

Photochemical tissue bonding.(SCARRING)(Brief article)
March 1, 2008... Sponsored by: Massachusetts General Hospital. The broad aim of this study is to evaluate the efficacy of photochemical tissue bonding (PTB) for the closure of skin excisions. The study will test the hypothesis that full thickness skin excisions...

Photodynamic therapy using silicon phthalocyanine 4 in treating patients with actinic keratosis, Bowen's disease, skin cancer, or stage I or stage II mycosis fungoides.(SKIN CANCER)(Brief article)
March 1, 2008... Sponsors and Collaborators: Case Comprehensive Cancer Center and National Cancer Institute (NCI). This phase I trial is studying the side effects and best dose of photodynamic therapy using silicon phthalocyanine 4 in treating patients with...

Combination chemotherapy followed by donor stem cell transplant in treating young patients with epidermolysis bullosa at high risk of developing squamous cell skin cancer.(SKIN CANCER)(Brief article)
March 1, 2008... Sponsored by: University of Minnesota. This clinical trial is studying how well combination chemotherapy followed by donor stem cell transplant works in treating young patients with epidermolysis bullosa at high risk of developing squamous cell...

Photodynamic therapy in treating patients with skin cancer.(SKIN CANCER)(Brief article)
March 1, 2008... Sponsors and Collaborators: Roswell Park Cancer Institute and National Cancer Institute (NCI). This randomized phase II trial is studying how well photodynamic therapy that includes aminolevulinic acid works in treating patients with skin...

Chemotherapy and total-body irradiation followed by autologous lymphocyte infusion, aldesleukin, and autologous stem cell transplant in treating patients with metastatic melanoma.(SKIN CANCER)(Brief article)
March 1, 2008... Sponsored by: National Cancer Institute (NCI). This phase II trial is studying how well chemotherapy and total-body irradiation followed by autologous lymphocyte infusion, aldesleukin, and autologous stem cell transplant work in treating...

Comparison of cephalexin versus clindamycin for empiric treatment of suspected CA-MRSA skin infections.(SKIN INFECTION)(Brief article)
March 1, 2008... Sponsored by: Johns Hopkins University. The purpose of this study is to help define the role of antibiotics in the treatment of pediatric skin infections caused by community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA). It...

A randomized clinical trial to prevent recurrent CA-MRSA infection (PRIMO).(SKIN INFECTION)(Brief article)
March 1, 2008... Sponsors and Collaborators: Los Angeles Biomedical Research Institute Kaiser Permanente. This clinical trial tests the hypotheses that 1) body decolonization of patients with recurrent community-associated methicillin-resistant Staphyloccus...

A study for patients with complicated skin and skin structure infections (SIMPLIFI).(SKIN INFECTION)(Brief article)
March 1, 2008... Sponsored by: Targanta Therapeutics Corporation. Two Phase III trials to demonstrate the efficacy and safety of oritavancin in the treatment of complicated skin and skin structure infections (cSSSI) have been completed. Condition ...

Study comparing the safety and efficacy of tigecycline with ampicillin-sulbactam or amoxicillin-clavulanate to treat skin infections.(SKIN INFECTION)(Brief article)
March 1, 2008... Sponsored by: Wyeth. The purpose of this study is to compare the safety and efficacy of the antibiotic tigecycline with other antibiotics, ampicillin-sulbactam, and amoxicillin-clavutanate in the treatment of a complicated skin and/or skin...

Efficacy study of antiseptic preoperative scrubs in prevention of postoperative wound infections.(SKIN INFECTION)(Brief article)
March 1, 2008... Sponsored by: Baylor College of Medicine. Most cases of infection of clean-contaminated wounds (wounds without gross spillage of organisms from the gastrointestinal tract) are thought to originate from the skin. Therefore, it is conceivable...

TheraGauze alone and Regranex gel 0.01% plus TheraGauze in the treatment of Wagner stage I diabetic foot ulcers.(WOUND HEALING)(Brief article)
March 1, 2008... Sponsored by: Soluble Systems LLC. Patients will be randomized to receive TheraGauze alone or with Regranex to treat diabetic foot ulcer condition. The purpose of the study is provide the sponsor with pilot information regarding the ability of...

Study of thymosin beta 4 in patients with pressure ulcers.(WOUND HEALING)(Brief article)
March 1, 2008... Sponsored by: RegeneRx Biopharmaceuticals Inc. The purpose of this study is to evaluate the safety, tolerability and effectiveness of thymosin beta 4 administered topically in patients with pressure ulcers. Condition Intervention ...

Effectiveness of dermaPACE Device and standard treatment compared to standard treatment alone for diabetic foot ulcers.(WOUND HEALING)(Brief article)
March 1, 2008... Sponsored by: SANUWAVE Inc. The purpose of this study is to compare the safety and effectiveness of the dermaPACE Device to sham application, when administered in conjunction with standard treatments used in the treatment of diabetic foot...