Journal of Drugs in Dermatology articles from March 2007

Journal of Drugs in Dermatology archives from March 2007

Erratum.(Correction notice)
March 1, 2007... In the supplement to the January 2007 issue of the Journal of Drugs in Dermatology, "Poly-L-Lactic Acid: A New Class of Collagen Stimulations," on page 2 an incorrect attribution was published. The statement "Supported by an educational grant...

Letters to the editor.
March 1, 2007... Dear Sirs, I recently read with interest the article by William Abramovits and Mark Boguniewicz (A multicenter, randomized, vehicle-controlled clinical study to examine the efficacy and safety of MAS063DP [Atopiclair[TM]] in the management...

Outcomes associated with the use of biologic agents in moderate to severe psoriasis.
March 1, 2007... Abstract An estimated 2.1% of Americans have psoriasis and approximately 30% of them have moderate to severe psoriasis. Although the disease is not associated with mortality, it has a significant impact on health-related quality of life...

Identification of novel hsp65 RFLPs for Mycobacterium leprae.
March 1, 2007... Abstract Leprosy or Hansen's disease is a chronic infectious disease caused by an acid-fast bacillus, Mycobacterium leprae (M. leprae). The bacilli proliferate in macrophages infiltrating the skin and gain entry to the dermal nerves via...

Xeroderma pigmentosum: beyond skin cancer.(Clinical report)
March 1, 2007... Abstract Xeroderma pigmentosum (XP) is a rare, autosomal-recessive inherited disease that is found worldwide at a frequency of approximately 1:250,000. XP is caused by a deficiency in either nucleotide excision repair (NER) or...

Optimization of narrow-band UVB with a 5% oleic acid cream in the treatment of psoriasis.(Narrow-band ultraviolet Band)
March 1, 2007... Abstract Oleic acid is a monounsaturated fatty acid with a known action of penetration enhancer which has been used for various purposes, such as a tanning increaser. Narrow-band ultraviolet B (UVB) is a also first-line treatment for...

Colloid milium: a review and update.(Clinical report)
March 1, 2007... Abstract Colloid milium (CM) is a rare cutaneous deposition disease with at least 3 distinct subtypes. The exact histogenesis of the condition is still unresolved and awaits definitive elucidation. Electron microscopy and...

Reductions in healthcare resource utilization in psoriatic arthritis patients receiving etanercept therapy: results from the EDUCATE trial.(Clinical report)
March 1, 2007... Abstract The Experience Diagnosing, Understanding Care, and Treatment with Enbrel[R] (EDUCATE) trial is a phase IV, 24-week, multicenter, open-label study of etanercept 50 mg weekly in the treatment of psoriatic arthritis (PsA) in...

A single-center, open-label, prospective pilot study of subcutaneous efalizumab for oral erosive lichen planus.(Clinical report)
March 1, 2007... Abstract Objective: To evaluate the efficacy of efalizumab in the treatment of oral erosive lichen planus. Design: A single-center, open-label, prospective pilot study. The primary efficacy outcome measure was the change in oral...

Treatment of moderate to severe inflammatory acne vulgaris: photodynamic therapy with 5-aminolevulinic acid and a novel Advanced Fluorescence Technology pulsed light source.(Clinical report)
March 1, 2007... Abstract The use of photodynamic therapy (PDT) with 20% 5-aminolevulinic acid (ALA) for the treatment of acne vulgaris has been explored. This study evaluates the safety and efficacy of a new Advanced Fluorescence Technology (AFT) pulsed...

Delayed presentation of impending necrosis following soft tissue augmentation with hyaluronic acid and successful management with hyaluronidase.(CASE REPORTS)(Clinical report)
March 1, 2007... Abstract Soft tissue augmentation is a key element in the successful management of facial rhytids and scars. Injection of hyaluronic acid gels into the dermis is generally well-tolerated with only minimal side effects. Injection necrosis...

Eosinophilic granuloma of the skin: response to intralesional corticosteroid injection.(CASE REPORTS)(Clinical report)
March 1, 2007... Abstract Langerhans cell histiocytosis (LCH) is a histiocytic disorder in which the Langerhans cell is arrested in a premature, partially active state. The disease comprises a spectrum of disorders, the most benign of which is a...

Persistent erythema multiforme and CMV infection.(CASE REPORTS)
March 1, 2007... Abstract Persistent erythema multiforme is a rare disorder with only 23 known cases reported in the literature. Persistent erythema multiforme has been reported in association with Epstein-Barr virus, herpes virus, hepatitis C virus,...

Clinical improvement of pityriasis rubra pilaris with efalizumab in a pediatric patient.(CASE REPORTS)(Clinical report)
March 1, 2007... Abstract Pityriasis rubra pilaris has no single effective therapy and there are some cases resistant to multiple treatments. Psoriasis has clinical and therapeutic response overlaps with pityriasis rubra pilaris and there are several...

Treatment of pityriasis rubra pilaris with pimecrolimus cream 1%.(CASE REPORTS)(Clinical report)
March 1, 2007... Abstract Pityriasis rubra pillaris is an uncommon idiopathic dermatosis considered both a keratinization and an inflammatory disorder. Treatment is largely based on the information presented in case reports. We report the case of a young...

Nokor needle marking: a simple method to maintain orientation during subcision.(SURGICAL PEARL)
March 1, 2007... Pearls is a periodic feature that will present brief tips and words of wisdom on techniques in dermatology. Please submit your pearls to: editor@drugsindermatology.com. Subcision is a simple surgical intervention that may be useful for...

Intertriginous psoriasis: what's safe, what's tolerated, what works.(WASHINGTON WHISPERS)(Clinical report)
March 1, 2007... Intertriginous Psoriasis: What's Safe, What's Tolerated, What Works Commentary on: 1% pimecrolimus, 0.005% calcipotriol, and 1% betamethasone in the treatment of intertriginous psoriasis. Kreuter A, et al. Arch Dermatol....

Rambazole: initial results of a new oral retinoic acid metabolism blocking agent (RAMBA) in psoriasis.(WASHINGTON WHISPERS)(Clinical report)
March 1, 2007... Rambazole: Initial Results of a New Oral Retinoic Acid Metabolism Blocking Agent (RAMBA) in Psoriasis Commentary on: Oral retinoic acid metabolism blocking agent Rambazole for plaque psoriasis: an immunohistochemical study. Bovenschen...

Infliximab: continuous or as needed?(WASHINGTON WHISPERS)(Clinical report)
March 1, 2007... Infliximab: Continuous or as Needed? Commentary on: A randomized comparison of continuous vs. intermittent infliximab maintenance regimens over 1 year in the treatment of moderate-to-severe plaque psoriasis. Mentner A, et al. J Am Acad...

Biafine for wound healing.(PIPELINE PREVIEWS)(Brief article)
March 1, 2007... New data from a recent study indicates that Biafine[R] topical emulsion may be beneficial in wound healing. Biafine is an oil-in-water topical emulsion that recruits macrophages to wound sites while it simultaneously hydrates the affected site....

New kit for rosacea treatment.(PIPELINE PREVIEWS)(Brief article)
March 1, 2007... Galderma Laboratories, LP recently announced the release of a new MetroGel[R] 1% kit for use in the topical therapy of inflammatory lesions of rosacea. The kit includes a 60-gram tube of MetroGel 1% (metronidazole) topical gel as well as a 4 fl...

Sertaconazole nitrate for tinea pedis.(PIPELINE PREVIEWS)(Brief article)
March 1, 2007... Sertaconazole nitrate, the active ingredient of Ertaczo[TM], is indicated for the treatment of tinea pedis. A recent review published in the Archives of Dermatologic Research found evidence that sertaconazole nitrate might be more effective...

FDA approves Olux-E Foam.(PIPELINE PREVIEWS)(Brief article)
March 1, 2007... Stiefel Laboratories recently announced that the FDA has approved Olux-E[TM] (clobetasol propionate) Foam, 0.05% for the treatment of psoriasis and eczema in patients 12 years of age and older. The medication is expected to be available by...

Phase II trial of topical gentamicin for diabetic foot ulcers.(PIPELINE PREVIEWS)(Brief article)
March 1, 2007... Innocoll, Inc recently announced that it has received FDA approval for its Investigational New Drug (IND) application. This IND will permit Innocoll, Inc to begin a phase II clinical study for CollaRx[R] Gentamicin topical antibiotic for the...

FDA approves new indications for Radiesse.(PIPELINE PREVIEWS)(Brief article)
March 1, 2007... BioForm Medical, Inc recently announced that the FDA approved Radiesse[R] for the long-lasting correction of moderate to severe facial wrinkles and folds, as well as for the long-lasting correction of lipoatrophy in patients with HIV. Radiesse...

FDA approval letter for Altabax.(PIPELINE PREVIEWS)(Brief article)
March 1, 2007... GlaxoSmithKline (GSK) recently announced that the FDA has issued an approval letter for the Altabax (retapamulin ointment), 1%. Altabax, a topical antibiotic, will be used for the treatment of secondarily-infected traumatic lesions. These...

Dermatology meetings in march.(Calendar)
March 1, 2007... 3/3-3/9 Skin Disease Education Foundation, 31st Hawaii Dermatology Seminar Grand Wailea Resort, Maui, HI www.sdefderm.com 3/12-3/16 Dermatology for the Practicing Physician Hyatt Sarasota, FL 3/14-3/18 ...

A review of deferasirox, bortezomib, dasatinib, and cyclosporine eye drops: possible uses and known side effects in cutaneous medicine.(SCHOOLS OF PHARMACOLOGY)(Clinical report)
March 1, 2007... Abstract Recently, a number of medications approved for nondermatologic use have proved useful against dermatologic diseases. This article reviews the dermatologic uses and effects of deferasirox, bortezomib, dasatinib, and cyclosporine...

Reconstitution with pimecrolimus cream 1% of steroid-damaged skin in adults with atopic dermatitis.(CLINICAL TRIAL REVIEW)
March 1, 2007... Sponsored by Novartis. Topical steroid use may lead to skin deterioration and spider veins. This study will examine long-term management of atopic dermatitis (AD) over 12 months with pimecrolimus cream 1% and its effect on skin reconstitution...

Study evaluating sirolimus in non-melanoma skin cancer in kidney transplant recipients.(CLINICAL TRIAL REVIEW)
March 1, 2007... Sponsored by Wyeth. The purpose of this study is to determine the effect of sirolimus on the prevention of new non-melanoma skin cancer (NMSC) in kidney transplant recipients. Condition Intervention Phase Kidney...

The effect of Efudex treatment on photoaged skin.(CLINICAL TRIAL REVIEW)
March 1, 2007... Sponsors and Collaborators: University of Michigan and Valeant Pharmaceuticals International. The researchers propose that skin improvements may be seen following a course of Efudex (5-fluorouracil), a FDA-approved topical therapy (applied...

Clinical usefulness of optical skin biopsy.(CLINICAL TRIAL REVIEW)
March 1, 2007... Sponsors and Collaborators: National Taiwan University Hospital, National Science Council, Taiwan, and National Health Research Institutes, Taiwan. In our study, we will evaluate the clinical applications of optical skin biopsy using harmonic...

Topical morphine for analgesia in patients with skin grafts.(CLINICAL TRIAL REVIEW)
March 1, 2007... Sponsored by Rambam Health Care Campus. The purpose of this study is to determine if topically applied morphine onto skin-graft donor wounds is effective. If found to be effective this could be an appealing noninvasive method to treat the pain...

Skin structure infections with suspected or proven MRSA.(CLINICAL TRIAL REVIEW)
March 1, 2007... Sponsored by Pfizer. The purpose of this study is to determine if linezolid is superior to vancomycin in the treatment of complicated skin and soft tissue infections due to MRSA in adult subjects. Condition ...

Common allergens in skin tests for adult atopic dermatitis.(CLINICAL TRIAL REVIEW)
March 1, 2007... Sponsored by National Taiwan University Hospital. To analyze the common allergens revealed by skin tests in adult atopic dermatitis patients. Condition Atopic Dermatitis Study ID Numbers: 9461700672 ClinicalTrials.gov...

Split-thickness skin graft donor site wound healing study.(CLINICAL TRIAL REVIEW)(Brief article)
March 1, 2007... Sponsored by University of Mississippi Medical Center. The purpose of this research study is to discover whether instruments widely used in skin research can be used to measure wound healing in split thickness skin graft donor sites and whether...

The effects of microdermabrasion on skin remodeling.(CLINICAL TRIAL REVIEW)(Brief article)
March 1, 2007... Sponsored by University of Michigan. This research project aims to study the effects of microdermabrasion. Condition Intervention Healthy Skin Procedure: Microdermabrasion Skin Wrinkling Study ID Numbers: Derm 486 ...

Sunless tanning products as a substitute for sunbathing in healthy participants.(CLINICAL TRIAL REVIEW)(Brief article)
March 1, 2007... Sponsors and Collaborators: UMASS Memorial Cancer Center--University Campus and National Cancer Institute (NCI). This phase I/II trial is studying attitudes about the use of sunless tanning products and how well sunless tanning products work as...

Determining the photoadaptation (tolerance) of depigmented skin to targeted phototherapy using UVB in patients with vitiligo.(CLINICAL TRIAL REVIEW)(ultraviolet B)(Brief article)
March 1, 2007... Sponsored by Henry Ford Health System. The purpose of this study is to determine if vitiligo patients develop tolerance (photoadaptation) to ultraviolet light therapy, a type of treatment available for vitiligo. Condition Intervention ...

Comparison of cephalexin versus clindamycin for empiric treatment of suspected CA-MRSA skin infections.(CLINICAL TRIAL REVIEW)(community-acquired methicillin resistant Staphylococcus aureus )(Brief article)
March 1, 2007... Sponsored by Johns Hopkins University. The purpose of this study is to help define the role of antibiotics in the treatment of pediatric skin infections caused by CA-MRSA. We hypothesize that treatment with cephalexin, a penicillin-like...

Oral moxifloxacin versus cefazolin and oral probenecid in the management of skin and soft tissue infections in the emergency Department.(CLINICAL TRIAL REVIEW)(Brief article)
March 1, 2007... Sponsored by University of British Columbia. The purpose of this study is to determine if treatment of moderate cellulitis with an intravenous antibiotic (cefazolin) for 3 to 5 days is as effective as a treatment with an oral antibiotic...

Comparison of Quantiferon-TB gold assay with tuberculin skin testing in patients with chronic liver disease.(CLINICAL TRIAL REVIEW)(tuberculosis)(Brief article)
March 1, 2007... Sponsored by University Health Network, Toronto. The purpose of the study is to estimate the usefulness of the QuantiFERON[R]-TB Gold test for the diagnosis of latent tuberculosis infection in liver transplant candidates by correlating the test...

Phase II randomized study of cultured skin substitutes versus split thickness skin grafts in patients with severe burn injuries.(CLINICAL TRIAL REVIEW)(Brief article)
March 1, 2007... Sponsors and Collaborators: FDA Office of Orphan Products Development and University of Cincinnati. The purpose of this study is to determine the safety and efficacy of biosynthetic skin substitute as a routine therapy for treatment of severe...

Screening patients for NCI protocol eligibility.(CLINICAL TRIAL REVIEW)(National Cancer Institute)(Brief article)
March 1, 2007... Sponsored by National Cancer Institute (NCI). The purpose of this protocol is to provide patients with adequate informed consent to understand that screening tests with minimal health risk will be performed to evaluate their eligibility for a...

Concomitant and sequential radiohormonotherapy in adjuvant breast cancer.(CLINICAL TRIAL REVIEW)(Brief article)
March 1, 2007... Sponsors and Collaborators: Centre Val d'Aurelle--Paul Lamarque and Novartis. This trial will compare grade 2 or greater late skin toxicities of concomitant letrozole-radiotherapy and radiotherapy followed by letrozole as adjuvant therapy for...

Can intravenous vitamin C improve skin hyperpigmentation in long-term hemodialysis patients?(CLINICAL TRIAL REVIEW)(Brief article)
March 1, 2007... Sponsored by National Taiwan University Hospital. The purpose of this study is to determine if intravenous vitamin C will improve skin hyperpigmentation in chronic hemodialysis patients. Condition Intervention Kidney...

Immune response to varicella vaccination in subjects with atopic dermatitis compared to nonatopic controls.(CLINICAL TRIAL REVIEW)(Brief article)
March 1, 2007... Sponsored by National Institute of Allergy and Infectious Diseases (NIAID). This study is examining the immune response to the chickenpox (varicella) vaccination and may provide important information about changes in the body's immune response...

Study evaluating the safety and efficacy of etanercept in patients with psoriatic arthritis treated by dermatologists.(CLINICAL TRIAL REVIEW)(Brief article)
March 1, 2007... Sponsored by Wyeth. The purpose of this study is to evaluate the safety profile and the effectiveness of etanercept under usual care settings in patients with PsA treated by dermatologists. Condition Intervention ...

Isolated limb infusion of chemotherapy in treating patients with melanoma or soft tissue sarcoma of the arm or leg that cannot be removed by surgery.(CLINICAL TRIAL REVIEW)(Brief article)
March 1, 2007... Sponsors and Collaborators: Memorial Sloan-Kettering Cancer Center and National Cancer Institute (NCI). This phase II trial is studying isolated limb infusion of chemotherapy to see how well it works in treating patients with melanoma or soft...