Journal of Drugs in Dermatology articles from June 2003

Journal of Drugs in Dermatology archives from June 2003

Letter from a senior editor.(Letter to the Editor)(Editorial)
June 1, 2003... In last issue's letter from our esteemed Editor-in-Chief, he justifiably expressed his pride in the respect and admiration for the state of dermatology in the 21st Century. However, he notes progress only in procedural dermatology and credits...

What's new in fillers?
June 1, 2003... Abstract This article is an in-depth review of various materials and products that have been used for the augmentation of soft tissue in the past, and covers several new products, methods, and techniques that may provide new options for...

Treatment of Rosacea with intense pulsed light.
June 1, 2003... Abstract Rosacea is a chronic disease that affects millions of men and women. Topical and oral antibiotics are effective, yet often leave individuals with treatment plateau associated erythema and persistent flushing. We investigated the...

The National Psoriasis Foundation Psoriasis Score (NPF-PS) System versus the Psoriasis Area Severity Index (PASI) and Physician's Global Assessment (PGA): a comparison.
June 1, 2003... Abstract The Psoriasis Area and Severity Index (PASI) and Physician Global Assessment (PGA) are commonly used, but fail to measure quality of life and the patient's perception of well-being. In response to these limitations, the National...

Use and abuse of topical corticosteroids in infections of the skin and related structures.
June 1, 2003... Abstract Topical corticosteroids have improved the management of many inflammatory skin diseases, such as psoriasis and atopic dermatitis. However, these medications are associated with certain adverse effects that are potentially serious....

Drug eruptions: approaching the diagnosis of drug-induced skin diseases.
June 1, 2003... Abstract Adverse drug reactions are a major problem in drug therapy, and cutaneous drug reactions account for a large proportion of all adverse drug reactions. Cutaneous drug reactions are also a challenging diagnostic problem since they...

The upper lip lift using the 'bull's horn' approach.(Focus on: lip lifts)
June 1, 2003... Abstract Our lift lip technique consists of an excision of the white part of the upper lip directly beneath the nose in the shape of a 'bull's-horn', with advancement of the inferior border of the incision to the area directly beneath the...

Use of digital dermoscopy to monitor melanocytic lesions: risks and benefits.(Skin Cancer Foundation Update)
June 1, 2003... For patients who develop multiple melanocytic skin lesions, it is often not feasible to obtain a biopsy for every lesion. Digital dermoscopy, an evolving computer-based version of traditional dermoscopy, provides a noninvasive alternative to...

Erythema gyratum repens in a case of resolving psoriasis.(Case Reports)
June 1, 2003... Abstract Erythema gyratum repens (EGR) is a rare skin syndrome often associated with internal malignancies, and thus considered paraneoplastic (1). There are cases of erythema gyratum repens in the literature associated with other...

Generalized eruptive keratoacanthoma of Grzybowski.(Case Reports)
June 1, 2003... Abstract We describe the case of a 71-year-old woman with a six-year history of generalized eruptive keratoacanthomas on the extremities. We review the diagnostic clinical and histologic features of the rare Grzybowski variant of...

Minocycline-induced immune thrombocytopenia presenting as Schamberg's disease.(Case Reports)
June 1, 2003... Abstract Minocycline hydrochloride, a synthetic tetracycline, is a systemic antibiotic that has received much attention over the past several years. Currently, minocycline is considered the most widely prescribed oral antibiotic in the...

Fluticasone-associated cutaneous allergic granulomatous vasculitis.(Case Reports)
June 1, 2003... Introduction: Churg-Strauss syndrome (CSS) is a multisystem vasculitis of unknown etiology first described in 1951 using autopsy specimens from patients with a history of asthma, tissue eosinophilia, and systemic vasculitis (1). The...

A case of sarcoidosis mimicking rhinophyma.(Case Reports)
June 1, 2003... ********** Case Report: A 54-year-old African-American man was seen at an outside hospital center and referred to our institution for laser surgery in October 2002 with a diagnosis of presumed rhinophyma. The patient described a...

Dyshidrotic-like spongiotic dermatitis after intravenous immunoglobulin therapy.(Case Reports)
June 1, 2003... Abstract Intravenous immunoglobulin (IVIG) therapy has been used to treat a variety of immune mediated disorders. Cutaneous reactions to IVIG are rare and have only been anecdotally described. We describe three cases with dyshidrotic-like...

Pipeline previews.(new drug profiles)
June 1, 2003... New Drug Application 19-941/S14, S15 Approval Date: 1/27/03 Name: EMLA Anesthetic Disc Applicant: AstraZeneca LP OTC/RX status: RX Indication of Use: Topical anesthetic New Drug...

Topical ALA-PDT more effective than 5-FU in treatment of Bowen's Disease.(Washington Whispers)(5-aminolaevulinic acid photodynamic therapy)(Brief Article)
June 1, 2003... The purpose of this randomized, two-center study was to compare the efficacy and tolerability of photodynamic therapy (PDT) and topical 5-fluorouracil (5-FU) in Bowen's Disease (BD). PDT involves the activation of a photosensitizing agent by...

Case-report of Minocycline-induced CNS-pulmonary hypersensitivity syndrome.(Washington Whispers)(Brief Article)
June 1, 2003... Minocycline is widely used by dermatologists for the treatment of acne vulgaris. Well-known side effects include gastrointestinal upset, photosensitivity, tissue hyperpigmentation, rash, vestibular symptoms, fever, and eosinophilia. Less common...

Sulodexide shows promise in the treatment of oral erosive/ulcerative lichen planus.(Washington Whispers)(Brief Article)
June 1, 2003... This open non-randomized trial compared the effect of heparinoid sulodexide systemically compared with topical cyclosporine on chronic oral erosive/ulcerative lichen planus. Sulodexide is composed of 80% heparin and 20% dermatan sulfate....

Carbon dioxide laser in the treatment of Zoon's balanitis.(Washington Whispers)(Author Abstract)
June 1, 2003... Fifteen patients are described with Zoon's balanitis, a chronic benign inflammatory process usually involving the glans penis. It is characterized clinically by bright, smooth-surfaced, erythematous plaques in the male genital mucosa. The...

Addition of folic acid and vitamin B12 does not enhance the efficacy of NB-UVB in the treatment of vitiligo.(Washington Whispers)(Author Abstract)
June 1, 2003... This randomized study compares the use of narrow-band UVB (NB-UVB) (311 nm) alone versus NB-UVB with the addition of oral folic acid and vitamin B12. The lack of these vitamins in some vitiligo patients has prompted investigation into their...

Growth factors in urticarial lesions.(Washington Whispers)(Author Abstract)
June 1, 2003... Tissue sections from patients with urticaria and healthy controls were studied for the immunohistochemical expression of known mast cell growth factors (stem cell factor, SCF; nerve growth factor, NGF). Levels of inhibitory...

Combination calcipotriol/betamethasone shows more rapid onset of action than monotherapy in the treatment of psoriasis.(Washington Whispers)(Author Abstract)
June 1, 2003... This double-blind, randomized study compares the effectiveness of betamethasone dipropionate ointment and calcipotriol ointment alone as compared to the use of a combination ointment. 1,106 patients were randomozed to twice-daily treatments...

Case report of recalcitrant epidermodysplasia verruciformis in HIV patient.
June 1, 2003... A 38-year-old HIV-positive man presented with an extensive eruption on the forearms and neckline, also involving the trunk, arms, and thighs. Physical examination showed erythematous papules with the appearance of flat warts. Common warts were...

Moisturizers enhance skin capacitance but do not change mechanical properties.(Washington Whispers)(Author Abstract)
June 1, 2003... This single-blind study assesses the effects of moisturizers on skin capacitance, distensibility, hysteresis, and elasticity. Nineteen healthy volunteers applied moisturizer once daily to one arm, twice daily to the other arm, and an area...

Case report of metastatic melanoma visualized with N-isopropyl-P[123I]-iodoamphetamine.(Washington Whispers)
June 1, 2003... A 70-year-old Japanese man presented with a 35x40 mm, brown-black nodule with an irregular surface, irregular border, and color variegation on the right side of the hard palate. Two-bean sized lymph nodes were palpable on the right neck....

Treatment of Steatocystoma multiplex with C[O.sup.2] laser therapy.(Washington Whispers)
June 1, 2003... Steatocystoma multiplex is a condition characterized by the presence of multiple dermal cysts containing sebaceous glands. Clinically, patients develop numerous elastic or firm flesh to yellow-colored nodular cystic formations between 0.2 and 2...

PCR detects mycobacterial infection in AFB-negative tissue.(Washington Whispers)
June 1, 2003... The aim of this study was to determine whether Mycobacteria tuberculosis or atypical mycobacteria could be identified in specimens from patients with a diagnosis of granulomatous dermatitis who had negative finding for AFB. Thirty-eight...

Vaccine therapy in treating patients with primary stage II melanoma.(Clinical Trial Review)
June 1, 2003... Sponsored by: EORTC Melanoma Cooperative Group Rationale: Vaccines may make the body build an immune response to kill tumor cells. It is not yet known whether vaccine therapy is more effective than observation alone for melanoma. ...

Study to compare the efficacy and safety of CC-5013 vs. placebo in subjects with metastatic malignant melanoma.(Clinical Trial Review)
June 1, 2003... Sponsored by: Celgene Corporation, ICON Clinical Research Purpose: Subjects are randomized to one of two treatment arms. All subjects are screened for eligibility within 28 days prior to randomization. The study consists of a treatment...

Chemotherapy and photodynamic therapy in treating patients with cutaneous T-cell lymphoma.(Clinical Trial Review)
June 1, 2003... Sponsored by: Millennix Rationale: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Photodynamic therapy uses light and drugs that make cancer cells more sensitive to light to...

To study the efects of CD25 and low dose Cyclosporin in the treatment of active psoriasis vulgaris.(Clinical Trial Review)
June 1, 2003... Sponsored by: Protein Design Labs Purpose: This study compares the efficacy and analyzes the cellular effects of anti-TAC (Daclizumab) and Cyclosporine in the treatment of psoriasis vulgaris. This is a three-armed study-Daclizumab alone,...

Bioengineered skin and wound healing.(Clinical Trial Review)
June 1, 2003... Sponsored by: National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) Purpose: This study will look at whether a graft of bioengineered skin (BSC), known commercially as Apligraf, stimulates the healing process in a...

Conditioning, the placebo effect, and psoriasis.(Clinical Trial Review)
June 1, 2003... Sponsored by: National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) Purpose: The goal of this study is to show that people with psoriasis who are maintained on corticosteroid cream part of the time and an inactive...

Temozolomide with or without radiation therapy to the brain in treating patients with stage IV melanoma that is metastatic to the brain.(Clinical Trial Review)
June 1, 2003... Sponsored by: EORTC Melanoma Cooperative Group Rationale: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells. It is...

Determine the effect of administering Periostat [R] twice daily patients with acne rosacea.
June 1, 2003... Sponsored by: CollaGenex Pharmaceuticals Purpose: The purpose of this study is to determine whether Periostat [R] (doxycycline hyclate) 20 mg tablets taken twice daily is effective in reducing the red and white heads and overall redness...

Open label study of OnTAK (denileukin diftitox) in previously treated cutaneous T-cell lymphoma patients.(Clinical Trial Review)
June 1, 2003... Sponsored by: Ligand Pharmaceuticals Purpose: The purpose of this study is to provide an opportunity for patients who exhibit progressive disease while receiving placebo on the companion 93-04-11 study to receive ONTAK. It is also designed...

Randomized double-blind study of OnTAK (denileukin diftitox) in cutaneous T-cell lymphoma (CTCL) patients.(Clinical Trial Review)
June 1, 2003... Sponsored by: Ligand Pharmaceuticals Purpose: The purpose of this study is to compare the effectiveness of two dose levels of ONTAK (denileukin diftitox) in treating patients who have recurrent or persistent cutaneous T-cell lymphoma. ...