Journal of Drugs in Dermatology articles from July 2007

Journal of Drugs in Dermatology archives from July 2007

Erratum.(Correction notice)
July 1, 2007... In the supplement to the June 2007 issue, the disclosures of conflicts of interest were omitted for some of the authors. Neil Sadick MD, the guest-editor and co-author of all 5 articles, received consulting and research funding from the...

A new approach to comparing efficacy results from clinical trials of topical acne vulgaris treatments.
July 1, 2007... Abstract Clinicians must evaluate a voluminous amount of information from clinical trials when choosing among the growing number of topical acne treatments. This article describes a simple way to evaluate and broadly compare the efficacy...

Repair of partial and complete earlobe clefts: a review of 21 methods.
July 1, 2007... Abstract Background: Partially or completely spilt earlobes are a common reason for patient presentation to the cosmetic surgeon. Methods: In this article, we review the different techniques of repairing both partial and complete cleft...

Neoplastic skin lesions in Iranian renal transplant recipients: the role of immunosuppressive therapy.
July 1, 2007... Abstract Background: Immunosuppressive therapy is believed to be one of the most important risk factors in the development of skin cancer in renal transplant recipients. Objective: Our purpose was to determine the types of neoplastic...

Melanoma in situ with epidermal effacement: a compelling adjunctive finding.
July 1, 2007... Abstract Since many studies have shown the discordant diagnoses of melanocytic lesions among pathologists despite the existence of an established histologic criteria, we sought to refine the histologic criteria by finding an additional...

A single-arm, open-label efficacy and tolerability study of diclofenac sodium 3% gel for the treatment of actinic keratosis of the upper and lower lip.(Solaraze)
July 1, 2007... Abstract Objectives and Methods: This study is an evaluation of patients diagnosed with actinic keratosis (AK) lesions of the upper and lower lip (both cutaneous and mucosal surfaces), with at least one lesion on the vermilion (mucosal)...

A novel hydrogel vehicle formulated for the treatment of atopic dermatitis.(Clinical report)
July 1, 2007... Abstract Atopic dermatitis (AD) is a chronic cyclical inflammatory skin disease that is increasing in incidence. Twenty percent of those affected with AD are infants and young children. Despite the development of newer nonsteroidal topical...

Novel eye cream containing a mixture of human growth factors and cytokines for periorbital skin rejuvenation.
July 1, 2007... Abstract Evidence of the signs associated with skin aging often first appears in the periorbital area and includes wrinkles, eyelid bags, circles around the eye, or a "tired" look. This multicenter study aimed to investigate a novel eye...

Successful adjuvant treatment of recalcitrant mucous membrane pemphigoid with anti-CD20 antibody rituximab.(CASE REPORTS)
July 1, 2007... Abstract Rituximab is a humanized monoclonal antibody directed against CD20-positive B cells and originally developed for the treatment of non-Hodgkins lymphoma. We report a case of severe mucous membrane pemphigoid responsive to rituximab...

Successful treatment of Hailey-Hailey disease with acitretin.(CASE REPORTS)
July 1, 2007... Abstract Hailey-Hailey disease is an autosomal dominant skin condition characterized by waxing and waning painful and pruritic vesicles and plaques affecting the intertriginous areas. Its pathogenesis involves inherited abnormalities in a...

Subacute annular generalized pustular psoriasis treated with etanercept and cyclosporine combination.(CASE REPORTS)
July 1, 2007... Abstract We present a case of a 36-year-old man with a 20-year history of stable plaque psoriasis admitted to our inpatient dermatology unit with subacute annular pustular psoriasis. Two weeks prior to admission the patient's dermatologist...

Alopecia induced by lopinavir plus ritonavir therapy in an HIV patient.(CASE REPORTS)
July 1, 2007... Abstract The most commonly reported side effects related to lopinavir/ritonavir are diarrhea, vomiting, headache, nausea, and increased serum triglycerides and cholesterol levels. About 4% of the patients prescribed lopinavir/ritonavir...

Exacerbation of myasthenia gravis during imiquimod treatment.(CASE REPORTS)
July 1, 2007... Abstract Myasthenia gravis is an autoimmune neuromuscular disease that can be exacerbated by interferon. We report a case of imiquimod-related exacerbation of myasthenia gravis. Introduction Imiquimod (Aldara[TM]) is indicated for...

Serum sickness-like reaction to cefuroxime: a case report and review of the literature.(CASE REPORTS)
July 1, 2007... Abstract We report a case of a 34-year-old woman who received cefuroxime, a second-generation cephalosporin, as treatment for mastitis. She subsequently developed a serum sickness-like reaction (SSLR) with a generalized pruritic rash,...

Fractional laser resurfacing.(LASER AND COSMETIC NEWS)(Column)
July 1, 2007... Laser and Cosmetic News covers the latest advances in laser surgery, light technology, phototherapy, and cosmetic surgery. New and emerging therapies, noteworthy publications, and exciting meeting developments will be highlighted. Controversies...

Pruritus: therapeutic challenges, new treatment approaches.(NEWS, VIEWS, AND REVIEWS)
July 1, 2007... The focus of this month's column is itching. While the causes of pruritus are many, patients may continue to suffer in the absence of a treatable etiology. Up to 50% of patients with itching may suffer without an identifiable cause. For those...

FDA approval letter for CIP-Isotretinoin.(PIPELINE PREVIEWS)(Cipher Pharmaceuticals)(Brief article)
July 1, 2007... Cipher Pharmaceuticals, Inc recently announced that its New Drug Application for CIP-Isotretinoin has received an approval letter from the FDA. CIP-Isotretinoin is a new formulation of the medication isotretinoin that is approved for the...

Phase II study of incyclinide discontinues cohort.(PIPELINE PREVIEWS)(CollaGenex Pharmaceuticals Inc.)(Brief article)
July 1, 2007... CollaGenex Pharmaceuticals, Inc recently announced that it has discontinued enrollment and treatment of enrolled patients in the 40 mg cohort of its phase II trial of incyclinide for the treatment of acne. This announcement follows the...

Positive results for ABT-874 in the treatment of psoriasis.(PIPELINE PREVIEWS)(Abbott Laboratories. Pharmaceutical Products Div.)(Brief article)
July 1, 2007... Results of a recent phase II study of ABT-874, the investigational treatment for psoriasis, were positive. ABT-874 is targeted to selectively inhibit proteins responsible for inflammation such as interleukin-12 and interleukin-23. This phase II...

Oracea[R] for the treatment of rosacea.(PIPELINE PREVIEWS)(USP capsules)(Brief article)
July 1, 2007... A recent report in the Journal of the American Academy of Dermatology evaluated 2 randomized phase III clinical trials that aimed to study the efficacy and safety of anti-inflammatory dose doxycycline (Oracea[R], 40 mg doxycycline, USP...

Phase II study of sapacitabine for advanced cutaneous T cell lymphoma.(PIPELINE PREVIEWS)(Cyclacel Pharmaceuticals Inc.)(Brief article)
July 1, 2007... Cyclacel Pharmaceuticals, Inc recently announced that it has started a multicenter randomized phase II clinical trial of sapacitabine (CYC682) for the treatment of advanced cutaneous T cell lymphoma (CTCL). Sapacitabine is an orally available...

Brevoxyl[R] Acne Wash Kit.(PIPELINE PREVIEWS)(Stiefel Laboratories Inc.)(Brief article)
July 1, 2007... Stiefel Laboratories, Inc recently announced that its new Brevoxyl[R] Acne Wash Kit is now available. This kit contains Brevoxyl Creamy Wash (benzoyl peroxide 4% or 8%) and SFC[TM] Lotion. SFC Lotion is a soap-free, fragrance-free cleanser. The...

New data on Gardasil[R].(PIPELINE PREVIEWS)(Brief article)
July 1, 2007... The New England Journal of Medicine recently published results from 2 phase III studies of Gardasil[R] (Quadrivalent Human Papillomavirus [Types 6, 11, 16, 18] Recombinant Vaccine). In one study, Gardasil exhibited 100% protection against...

Tentative FDA approval for Ranbaxy.(PIPELINE PREVIEWS)(Ranbaxy Pharmaceuticals Inc.)(Brief article)
July 1, 2007... Ranbaxy Pharmaceuticals Inc recently announced that it has received tentative FDA approval to manufacture and market the antihistamine fexofenadine hydrochloride tablets 30 mg, 60 mg, and 180 mg. The product will be launched after final...

Positive survey results for Cloderm[R] Cream 0.1%.(PIPELINE PREVIEWS)(Coria Laboratories Ltd.)(Brief article)
July 1, 2007... Coria Laboratories, Ltd recently announced positive results from a nationwide survey regarding Cloderm[R] (clocortolone pivalate) Cream 0.1%, a mid-potency topical steroid. The survey was mailed to dermatologists nationwide and 2,927...

FDA approves Perlane[R].(PIPELINE PREVIEWS)(Medicis Pharmaceutical Corp.)(Brief article)
July 1, 2007... Medicis recently announced that the FDA has granted approval for Perlane for use as a dermal filler in the treatment of moderate to severe facial rhytides. Perlane is a product that contains hyaluronic acid and is similar to Restylane[R], which...

Dermatology meetings in July.(Brief article)(Calendar)
July 1, 2007... 7/10-7/13 British Association of Dermatologists 87th Annual Meeting Birmingham, UK www.bad.org.uk/healthcare/meetings/FINAL_PROGRAMME_2007.pdf 7/12-7/15 Society for Pediatric Dermatology 33rd Annual Meeting Chicago, IL ...

A brief primer on treatments of cutaneous T cell lymphoma, newly approved or late in development.(SCHOOLS OF PHARMACOLOGY)
July 1, 2007... Abstract Dermatologists use a variety of treatments for cutaneous T cell lymphoma (CTCL) or mycosis fungoides, in particular topical corticosteroids, psoralen and ultraviolet A phototherapy (PUVA) or ultraviolet B (UVB) phototherapy....

Safety and efficacy of daptomycin for the treatment of complicated skin and skin-structure infections.(CLINICAL TRIAL REVIEW)(Brief article)
July 1, 2007... Sponsored by Novartis. This study will evaluate the safety and efficacy of daptomycin against complicated skin and skin-structure infections in adults. Condition Intervention Phase Staphylococcal Skin...

Study comparing the safety and efficacy of tigecycline with ampicillin-sulbactam or amoxicillin-clavulanate to treat skin infections.(CLINICAL TRIAL REVIEW)(Wyeth)(Brief article)
July 1, 2007... Sponsored by Wyeth. The purpose of this study is to compare the safety and efficacy of the antibiotic tigecycline with other antibiotics, ampicillin-sulbactam, and amoxicillin-clavulanate in the treatment of a complicated skin and/or skin...

ZD1839 (Iressa[R]) for recurrent or metastatic squamous cell carcinoma of the skin.(CLINICAL TRIAL REVIEW)(AstraZeneca PLC and Anderson Cancer Center do trials)(Brief article)
July 1, 2007... Sponsors and Collaborators: MD Anderson Cancer Center and AstraZeneca. The purpose of this study is to explore the activity of ZD1839 administered to patients with squamous cell carcinoma (SCC) of the skin who have locoregional recurrence...

Study of the combination of a cyanoacrylate and surgical solutions in reducing skin flora contamination.(CLINICAL TRIAL REVIEW)(Brief article)
July 1, 2007... Sponsored by Kimberly-Clark Corporation. The purpose of this study is to determine if there is a qualitative reduction in microbial skin flora postsurgery compared to presurgery when a cyanoacrylate based microbial sealant is used in...

Efficacy and safety of daptomycin versus vancomycin or teicoplanin for treatment of complicated skin and soft tissue infections.(CLINICAL TRIAL REVIEW)(Novartis AG)(Brief article)
July 1, 2007... Sponsored by Novartis. This study will evaluate the efficacy and safety of daptomycin compared to vancomycin or teicoplanin for the treatment of complicated skin and soft tissue infections. Condition Intervention ...

Study of cetuximab in squamous cell carcinoma of the skin expressing EGFR.(CLINICAL TRIAL REVIEW)(epidermal growth factor receptor)(Centre Hospitalier of Chartres and Hospital of Chartres-France do the research)(Brief article)
July 1, 2007... Sponsors and Collaborators: Centre Hospitalier of Chartres and Hospital of Chartres-France. The purpose of this study is to determine whether cetuximab is effective in the treatment of locally advanced or metastatic squamous cell carcinoma of...

Comparison of cephalexin versus clindamycin for empiric treatment of suspected CA-MRSA skin infections.(CLINICAL TRIAL REVIEW)(community acquired methicillin resistant staphylococcus aureus)(Brief article)
July 1, 2007... Sponsored by Johns Hopkins University. The purpose of this study is to help define the role of antibiotics in the treatment of pediatric skin infections caused by CA-MRSA. We hypothesize that treatment with cephalexin, a penicillin-like...

Topical imiquimod compared with surgery in treating patients with basal cell skin cancer.(CLINICAL TRIAL REVIEW)(Brief article)
July 1, 2007... Sponsored by Queen's Medical Centre. This randomized phase III trial is studying how well topical imiquimod works compared to surgery in treating patients with basal cell skin cancer. Condition Intervention Phase...

Mycophenolate mofetil in systemic sclerosis.(CLINICAL TRIAL REVIEW)(Boston University, Aspreva Pharmaceuticals)(Brief article)
July 1, 2007... Sponsors and Collaborators: Boston University and Aspreva Pharmaceuticals. This is a research study of an investigational product called mycophenolate mofetil (MMF). The study is designed to establish the safety and potential benefit of MMF....

CellCept[R] (mycophenolate mofetil) in pemphigus vulgaris.(CLINICAL TRIAL REVIEW)(Roche Holding Ltd., Aspreva Pharmaceuticals )(Brief article)
July 1, 2007... Sponsors and Collaborators: Aspreva Pharmaceuticals as part of the Roche-Aspreva Collaboration Agreement. This study will test the safety and efficacy of adjunct mycophenolate mofetil in association with reduced corticosteroids to achieve...

Photodynamic therapy using silicon phthalocyanine 4 in treating patients with actinic keratosis, bowen's disease, skin cancer, or stage I or stage II mycosis fungoides.(CLINICAL TRIAL REVIEW)(National Cancer Institute)(Brief article)
July 1, 2007... Sponsors and Collaborators: Case Comprehensive Cancer Center and National Cancer Institute (NCI). This phase I trial is studying the side effects and best dose of photodynamic therapy using silicon phthalocyanine 4 in treating patients with...

Study of 30% salicylic acid peel versus Q-switched Nd:Yag laser for the treatment of melasma in ethnic skin.(CLINICAL TRIAL REVIEW)(Northwestern University)(Brief article)
July 1, 2007... Sponsored by Northwestern University. The purpose of this study is to determine the efficacy of 30 % salicylic acid peel versus Q-switched Nd:Yag laser for the treatment of melasma in ethnic skin. Condition Intervention Melasma ...

Ultraviolet (UVA and UVB) light therapy in the treatment of inflammatory skin conditions.(CLINICAL TRIAL REVIEW)(University of Michigan)(Brief article)
July 1, 2007... Sponsored by University of Michigan. The purpose of this investigation is to study the effectiveness of longer wavelength UVA1 (340-400 nm) or shorter wavelength ultraviolet B (UVB, 290-320 nm) irradiation in the treatment of inflammatory skin...

Photodynamic therapy in treating patients with skin cancer.(CLINICAL TRIAL REVIEW)(Roswell Park Cancer Institute, National Cancer Institute)(Brief article)
July 1, 2007... Sponsors and Collaborators: Roswell Park Cancer Institute and National Cancer Institute (NCI). This randomized phase II trial is studying how well photodynamic therapy that includes aminolevulinic acid works in treating patients with skin...

Infliximab (Remicade[R]) to treat dermatomyositis and polymyositis.(CLINICAL TRIAL REVIEW)(National Institute of Arthritis and Musculoskeletal and Skin Diseases )(Brief article)
July 1, 2007... Sponsored by National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS). This study will examine whether infliximab (Remicade[R]) is safe and effective for the treatment of dermatomyositis and polymyositis. Condition ...

Study of etanercept (Enbrel[R]) in the treatment of pemphigus vulgaris.(CLINICAL TRIAL REVIEW)(Brief article)
July 1, 2007... Sponsors and Collaborators: Massachusetts General Hospital Brigham and Women's Hospital and Stanford University. The purpose of the study is to find out about the effectiveness and safety of an investigational drug called etanercept (Enbrel[R])...

Clobetasol versus pimecrolimus for vulvar lichen sclerosus.(CLINICAL TRIAL REVIEW)(Novartis AG, Center for Vulvovaginal Disorders)(Brief article)
July 1, 2007... Sponsors and Collaborators: Center for Vulvovaginal Disorders and Novartis. Lichen sclerosus (LS) is a skin condition of the external genitals (vulva) of women. This study is designed to compare the effectiveness and safety of a topical...

A small clinical study: photodynamic therapy to treat hidradenitis suppurativa.(CLINICAL TRIAL REVIEW)(DUSA Pharmaceuticals Inc., University of Kansas )(Brief article)
July 1, 2007... Sponsors and Collaborators: University of Kansas and DUSA Pharmaceuticals. This study will investigate the efficacy of photodynamic therapy (PDT), which is the therapeutic use of photochemical reactions, in treating hidradenitis suppurativa...

Efficacy and safety of omalizumab in bullous pemphigoid.(CLINICAL TRIAL REVIEW)(Genentech Inc.)(Brief article)
July 1, 2007... Sponsors and Collaborators: University of Iowa and Genentech. The primary objective is to test the safety and efficacy of Xolair[R] (omalizumab) in the treatment of the autoimmune blistering disease, bullous pemphigoid. Condition ...

Treatment of alopecia areata of the scalp with intradermal injections of botulinum toxin.(CLINICAL TRIAL REVIEW)(Brief article)
July 1, 2007... Sponsored by University of British Columbia. The purpose of this study is to examine prospectively the safety and efficacy of botulinum toxin A (Botox[R]) injections in the treatment of patients with alopecia areata of the scalp. ...