Journal of Drugs in Dermatology articles from July 2006

Journal of Drugs in Dermatology archives from July 2006

Correction.(Correction notice)
July 1, 2006... The title of the May Laser and Cosmetic News column should have been "Update on Soft Tissue Augmentation."

Cryotherapy in the treatment of keloids.
July 1, 2006... Abstract Background: Despite their benign nature, keloids may constitute a severe aesthetic and, in some cases, functional problem with important repercussions on patients' quality of life. There is no consensus on keloid treatment and no...

Botulinum toxin type A in the treatment of dermatochalasis: an open-label, randomized, dose-comparison study.
July 1, 2006... Abstract Objective: To compare the efficacy and safety of 2 doses of botulinum toxin type A in the treatment of dermatochalasis. Methods: Forty patients with mild to moderate dermatochalasis were randomly assigned to receive 1 of 2...

Anti-inflammatory properties of narrow-band blue light.
July 1, 2006... Abstract Background: Narrow-band blue light (420 nm) has demonstrated safety and efficacy in the treatment of acne vulgaris. It works by exhibiting a phototoxic effect on the heme metabolism of Propionibacterium acnes. Previous studies...

Clinical evaluation of fluid extract of Chamomilla recutita for oral aphthae.
July 1, 2006... Abstract Recurrent aphthous stomatitis is a difficult to treat and quite common chronic inflammatory disease of the oral mucosa. This study evaluates the fluid extract from Chamomilla recutita's safety and effectiveness in pain relief from...

Safety of occluded 4% liposomal lidocaine cream.
July 1, 2006... Abstract The use of topical anesthesia for pain control for dermatologic procedures is widespread. In addition to clinical procedures, such as skin biopsies, lesion removal, and electrocautery, topical anesthesia is used for pain control...

Alefacept in combination with ultraviolet B phototherapy for the treatment of chronic plaque psoriasis: results from an open-label, multicenter study.
July 1, 2006... Abstract Combination therapy for moderate to severe psoriasis is often used to enhance efficacy and minimize treatment-related side effects; however, data are limited on combination therapy with the newer biologic agents. The current study...

Soft tissue augmentation: a review.
July 1, 2006... Abstract The continuing quest for the ideal dermal filler has led to an abundance of injectable agents. The ideal filler should be easy to manufacture, store, and administer. It should also be inexpensive, nontoxic, nonallergenic, natural...

Similar effectiveness of methyl aminolevulinate and 5-aminolevulinate in topical photodynamic therapy for nodular basal cell carcinoma.
July 1, 2006... Abstract Background: Photodynamic therapy (PDT) for basal cell carcinoma (BCC) is a treatment modality that is increasingly used in dermato-oncology. Currently, 2 topical photosensitizers, 5-aminolevulinate (ALA) and methyl aminolevulinate...

Efficacy and safety of a new once-daily topical ketoconazole 2% gel in the treatment of seborrheic dermatitis: a phase III trial.
July 1, 2006... Abstract Background: The first gel formulation of ketoconazole has been tested in 2-week treatment courses. Objective: To evaluate the efficacy and safety of a new, once-daily, 2-week ketoconazole 2% gel treatment in moderate to severe...

Extramammary Paget's disease of the penis and scrotum.(CASE REPORTS)
July 1, 2006... Abstract A 64-year-old Chinese man presented to the Bellevue Hospital Center Department of Dermatology with a 2-year history of an enlarging mass in his suprapubic region, which measured 7 cm x 9 cm and involved the penis and scrotum. A...

Primary mucinous carcinoma with direct histopathologic evidence of lymphatic invasion.(CASE REPORTS)
July 1, 2006... Abstract Background: Primary mucinous carcinoma of the skin is a rare sweat gland neoplasm which occurs most commonly in the periorbital region. Although the tumor has a propensity for local recurrence and regional spread, distant...

Basal cell carcinoma of the nail unit treated with Mohs micrographic surgery: superficial multicentric BCC with jagged borders--a histopathological hallmark for nail unit BCC.(CASE REPORTS)
July 1, 2006... Abstract We present a case of basal cell carcinoma (BCC) of the nail unit with a special emphasis on superficial multicentric histopathologic type with jagged borders that was treated with Mohs micrographic surgery. Nail unit BCCs may not...

Severe refractory cholinergic urticaria treated with danazol.(CASE REPORTS)
July 1, 2006... Abstract Background: Cholinergic urticaria is a form of physical urticaria triggered by a rise in core body temperature. Antihistamines are the mainstay of treatment; however, adequate symptom control can sometimes be difficult to...

Successful treatment of porokeratosis with topical imiquimod in 2 immunosuppressed cases.(CASE REPORTS)
July 1, 2006... Abstract Porokeratosis is a group of cutaneous disorders of keratinization characterized by a predisposition to malignant transformation. The condition, which may be associated with immune suppression, is usually resistant to therapy and...

Solitary subungual neurofibroma: an uncommon finding and a review of the literature.(CASE REPORTS)
July 1, 2006... Abstract We report an uncommon case of solitary subungual neurofibroma on the right first finger of a middle-aged healthy woman. Surgical excision was used for the treatment. Common clinical findings, treatment modalities, and reported...

Laser and cosmetic news.
July 1, 2006... Laser and Cosmetic News is a feature of the journal that covers the latest advances in laser surgery, light technology, phototherapy, and cosmetic surgery. New and emerging therapies, noteworthy publications, and exciting meeting developments...

Photodynamic therapy in the treatment of acne vulgaris.(WASHINGTON WHISPERS)
July 1, 2006... Photodynamic Therapy in the Treatment of Acne Vulgaris Commentary on: Photodynamic therapy of acne vulgaris using 5-aminolevulinic acid versus methyl aminolevulinate. Wiegell SR, et al. J Am Acad Dermatol. 2006;54:647-51. Summary...

Is low-dose isotretinoin efficacious in the treatment of moderate acne vulgaris?(WASHINGTON WHISPERS)
July 1, 2006... Is Low-Dose Isotretinoin Efficacious in the Treatment of Moderate Acne Vulgaris? Commentary on: Low-dose isotretinoin in the treatment of acne vulgaris. Amichai B, et al. J Am Acad Dermatol. 2006;54:644-6. Summary The authors...

Effectiveness of etanercept in the treatment of hidradenitis suppurativa.(WASHINGTON WHISPERS)
July 1, 2006... Effectiveness of Etanercept in the Treatment of Hidradenitis Suppurativa Commentary on: Etanercept: effective in the management of hidradenitis suppurativa. Cusack C, et al. Br J Dermatol. 2006;154:726-9. Summary The authors...

FDA approves Solodyn.(PIPELINE PREVIEWS)
July 1, 2006... Medicis recently announced that the FDA has approved a New Drug Application for Solodyn. Solodyn is an extended release tablet of minocycline HCl. This new drug is approved for treatment in daily dosing of moderate to severe acne. It is...

Phase III clinical trial for Gabapentin GR.(PIPELINE PREVIEWS)
July 1, 2006... Depomed, Inc, recently announced that it has completed a protocol for a Phase III clinical trial for Gabapentin GR extended release tablets for the treatment of postherpetic neuralgia. Enrollment for this randomized, double-blind,...

Phase III clinical trial for treatment of metastatic melanoma.(PIPELINE PREVIEWS)
July 1, 2006... The results of a multicenter, randomized clinical trial for the treatment of metastatic melanoma were recently published in the Annals of Oncology. (1) The study compared treatment with chemotherapy (cisplatin, vindesine, and dacarbazine) to...

Study shows Radiesse corrects nasolabial folds more effectively.(PIPELINE PREVIEWS)
July 1, 2006... A recent study, reported at the Annual Meeting of the American Society for Aesthetic Plastic Surgery (ASAPS), showed that Radiesse, which is composed of calcium hydroxylapatite, is a more effective facial filler for treatment of nasolabial...

Phase I clinical trial of CHIR-265 for melanoma.(PIPELINE PREVIEWS)
July 1, 2006... Chiron Corporation recently announced the beginning of a Phase I clinical trial of CHIR-265 for treatment of melanoma. CHIR-265 is a selective Raf kinase inhibitor (including mutant B-Raf and VEGFR-2) that is orally bioavailable. This compound...

FDA approval for new strengths of Keflex.(PIPELINE PREVIEWS)
July 1, 2006... Advancis Pharmaceutical Corporation recently announced that the FDA approved its request for new strengths of Keflex (cephalexin capsules, USP). Keflex is a first-generation cephalosporin antibiotic that is indicated for the treatment of skin...

FDA approval for Claravis (isotretinoin capsules) in 30 mg strength.(PIPELINE PREVIEWS)
July 1, 2006... Barr Pharmaceuticals, Inc, recently announced that the FDA approved its application to manufacture isotretinoin capsules USP, 30 mg, under its trade name Claravis. Claravis is already manufactured in 10-mg, 20-mg, and 40-mg capsules. This new...

Pemphigus vulgaris.(PIPELINE PREVIEWS)
July 1, 2006... A recent study published in the Archives of Dermatology evaluated adjuvant therapy with oral dexamethasone pulse therapy in the treatment of pemphigus vulgaris. (2) This randomized, multi-center, placebo-controlled trial evaluated 20 patients...

Pilot study of a dietary intervention to prevent acne recurrence.(CLINICAL TRIAL REVIEW)
July 1, 2006... This study is currently recruiting patients. Verified by Harvard School of Public Health. Sponsors and Collaborators: Harvard School of Public Health Department of Dermatology, Leeds General Infirmary, and Breast Cancer Research Foundation. The...

Safety and efficacy study of ICXP007 with compression bandaging for the treatment of non-infected venous leg ulcers.(CLINICAL TRIAL REVIEW)
July 1, 2006... This study is currently recruiting patients. Verified and sponsored by Intercytex. The main purpose of the study is to compare treatment of non-infected venous leg ulcers using ICXP007 combined with 4-layer compression bandaging, placebo...

A study to evaluate the safety and efficacy of efalizumab in adult patients with plaque psoriasis involving the hands and/or feet.(CLINICAL TRIAL REVIEW)
July 1, 2006... This study is currently recruiting patients. Verified and sponsored by Genentech. This is a randomized, double-blind, placebo-controlled study to evaluate the safety and efficacy of SC efalizumab in adult patients (18 years of age and older)...

Metvix PDT versus vehicle PDT with Aktilite CL128 lamp in patients with actinic keratosis on the face and scalp.(CLINICAL TRIAL REVIEW)
July 1, 2006... This study is currently recruiting patients. Verified and sponsored by PhotoCure. The purpose of this study is to compare the efficacy of Photodynamic Therapy (PDT) with methyl aminolevulinate (MAL) cream to PDT with vehicle cream, using the...

Study of ONTAK (denileukin diftitox) in cutaneous T cell lymphoma (CTCL) patients.(CLINICAL TRIAL REVIEW)
July 1, 2006... This study is currently recruiting patients. Sponsored by Ligand Pharmaceuticals. The purpose of this study is to compare the effectiveness of 2 dose levels of ONTAK (denileukin diftitox) in treating patients who have recurrent or persistent...

Curcuminoids for the treatment of chronic psoriasis vulgaris.(CLINICAL TRIAL REVIEW)
July 1, 2006... This study is currently recruiting patients. Verified and sponsored by University of Pennsylvania. The volatile oils (called curcuminoids) of the turmeric root (Curcuma Longa) have anti-inflammatory actions, making them promising candidates for...

Safety and efficacy study of MM-093 in patients with chronic plaque psoriasis.(CLINICAL TRIAL REVIEW)
July 1, 2006... This study is currently recruiting patients. Verified and sponsored by Merrimack Pharmaceuticals. Merrimack is conducting a research study to see if an experimental drug, called MM-093, is safe and effective in the treatment of psoriasis. ...

Topical NF-kappaB Decoy in the treatment of atopic dermatitis.(CLINICAL TRIAL REVIEW)
July 1, 2006... This study is currently recruiting patients. Verified and sponsored by Corgentech. The purpose of this study is to determine whether this topical NF-kappaB Decoy candidate is safe in persons with atopic dermatitis. Preliminary evidence of...

A study of the use of methotrexate in the treatment of chronic idiopathic urticaria.(CLINICAL TRIAL REVIEW)
July 1, 2006... This study is currently recruiting patients. Verified and sponsored by Barnsley Hospital. The purpose of this study is to determine whether methotrexate produces significant improvement in chronic idiopathic urticaria compared with placebo. ...

Use of infliximab for the treatment of pemphigus vulgaris.(CLINICAL TRIAL REVIEW)
July 1, 2006... This study is currently recruiting patients. Verified and sponsored by National Institute of Allergy and Infectious Diseases (NIAID). Pemphigus vulgaris (PV) is a rare skin disorder that causes blistering of the skin and mucous membranes....

The acquisition of blood and skin samples from normal volunteers to support research activities on dermatologic diseases.(CLINICAL TRIAL REVIEW)
July 1, 2006... This study is currently recruiting patients. Verified by National Institutes of Health Clinical Center. Sponsored by National Cancer Institute (NCI). This protocol is concerned with the acquisition of blood, skin, and mucosal samples from...

Randomized controlled 8-week crossover evaluation of compression bandage systems for venous leg ulcers.(CLINICAL TRIAL REVIEW)
July 1, 2006... This study is currently recruiting patients. Verified and sponsored by 3M. The purpose of this study is to evaluate the product performance of a new 2-layer compression bandage for the treatment of venous leg ulcers. Condition ...

The effect of Efudex treatment on photoaged skin.(CLINICAL TRIAL REVIEW)
July 1, 2006... This study is currently recruiting patients. Verified by University of Michigan. Sponsors and collaborators: University of Michigan and Valeant Pharmaceuticals International. The researchers propose that skin improvements may be seen following...

Ultraviolet (UVA) light therapy in the treatment of inflammatory skin conditions.(CLINICAL TRIAL REVIEW)
July 1, 2006... This study is currently recruiting patients. Verified and sponsored by University of Michigan. The purpose of this investigation is to study the effectiveness of longer wavelength UVA1 (340-400 nm) or shorter wavelength UVB (290-320 nm)...

Etanercept for treatment of hidradenitis.(CLINICAL TRIAL REVIEW)
July 1, 2006... This study is currently recruiting patients. Verified and sponsored by University of Pennsylvania. The purpose of this study is to determine whether etanercept is safe and effective for the treatment of hidradenitis. Another purpose of this...

Immunopharmacological effects of Rituximab in atopic dermatitis.(CLINICAL TRIAL REVIEW)
July 1, 2006... This study is currently recruiting patients. Sponsors and Collaborators: University of Bern, Roche, and Swiss National Science Foundation. This study seeks: (1) to determine the efficacy, safety and immunopharmacological effects of Rituximab...

Study of the efficacy, safety, and tolerability of oral CEP-701 in patients with severe psoriasis.(CLINICAL TRIAL REVIEW)
July 1, 2006... This study is currently recruiting patients. Sponsored and verified by Cephalon. A 12-week, exploratory, open-label, nonrandomized, dose-escalation study of the efficacy, safety, and tolerability of oral CEP-701 in patients with severe,...

Efficacy and safety of efalizumab in the treatment of moderate-severe hydradenitis suppurativa.(CLINICAL TRIAL REVIEW)
July 1, 2006... This study is currently recruiting patients. Sponsors and collaborators: New York University School of Medicine and Genentech. The purpose of this study is to determine the effectiveness and safety of efalizumab in treating hydradenitis...

Efficacy and safety of calcipotriol plus betamethasone dipropionate gel in psoriasis vulgaris.(CLINICAL TRIAL REVIEW)
July 1, 2006... This study is currently recruiting patients. Sponsored and verified by LEO Pharma. The objective of the study is to compare the use of calcipotriol plus betamethasone dipropionate gel when either betamethasone dipropionate or calcipotriol is in...

A phase II study on immunogenicity and safety of MVA-BN[R] (IMVAMUNE[TM]) smallpox vaccine in subjects with atopic dermatitis.(CLINICAL TRIAL REVIEW)
July 1, 2006... This study is not yet open for patient recruitment. Sponsors and collaborators: Bavarian Nordic and National Institute of Allergy and Infectious Diseases (NIAID). The purpose of this study is to compare the immunogenicity and safety of an...

Safety and immunogenicity of a Melan-A VLP vaccine in advanced stage melanoma patients.(CLINICAL TRIAL REVIEW)
July 1, 2006... This study is currently recruiting patients. Sponsored and verified by Cytos Biotechnology AG. The purpose of this study is to evaluate a specific cellular immune response in melanoma patients that have been vaccinated with a Melan-A VLP...

Safety and efficacy study of MRE0094 to treat chronic, neuropathic, diabetic foot ulcers.(CLINICAL TRIAL REVIEW)
July 1, 2006... This study is currently recruiting patients. Sponsored and verified by King Pharmaceuticals Research and Development. This is a randomized study of an experimental topical drug for the treatment of chronic, neuropathic, diabetic foot ulcers....

The effect of 0.5% roxithromycin lotion for androgenetic alopecia.(CLINICAL TRIAL REVIEW)
July 1, 2006... This study is currently recruiting patients. Verified and sponsored by Hamamatsu University. The purpose of this study is to explore roxithomycin, a macrolide antibiotic that has immunomodulatory effects, for treatment of androgenetic alopecia....

Efficacy of therapy with spironolactone pills compared to minoxidil lotion in female pattern hair loss.(CLINICAL TRIAL REVIEW)
July 1, 2006... This study is currently recruiting patients. Verified and sponsored by University of British Columbia. Efficacy of therapy with the anti-androgen spironolactone compared to topical minoxidil in female pattern hair loss. Condition ...

The RATIO: registry of infections and lymphoma in patients treated with TNF-[alpha] antagonists.(CLINICAL TRIAL REVIEW)
July 1, 2006... This study is currently recruiting patients. Verified and sponsored by Assistance Publique--Hopitaux de Paris. The RATIO registry is a French registry designed to collect data on opportunistic and severe bacterial infections and lymphoma in...

Study of cetuximab in squamous cell carcinoma of the skin expressing EGFR.(CLINICAL TRIAL REVIEW)
July 1, 2006... This study is currently recruiting patients. Sponsors and collaborators: Centre Hospitalier of Chartres and Hospital of Chartres--France. The purpose of this study is to determine whether cetuximab is effective in the treatment of locally...

The use of Kineret (anakinra) in the treatment of Familial Cold Urticaria.(CLINICAL TRIAL REVIEW)
July 1, 2006... This study is currently recruiting patients. Sponsors and collaborators: Capital District Health Authority, Canada and Atlantic Provinces Dermatology Association. An open-label trial of Kineret (anakinra) induction therapy (100 mg/day) given...