Journal of Drugs in Dermatology articles from July 2005

Journal of Drugs in Dermatology archives from July 2005

A letter from the editor.
July 1, 2005... On May 16, the Women's Dermatologic Society hosted "Swing into Sun Safety Media Day," at Chelsea Piers in New York City. The event, sponsored by Dermik Laboratories and Fujisawa Healthcare, offered free skin cancer screenings and golf tips from...

The diminishing value of the Physicians' Desk Reference and drug package inserts as a medical and legal standard of medical usage of pharmaceutical drugs.(LETTERS TO THE EDITOR)(Letter to the Editor)
July 1, 2005... In the legal arena, the Physician's Desk Reference (PDR) is often held to be the standard for medical usage of pharmaceutical drugs. (1) It is used by attorneys as a resource to support testimony that a certain adverse effect can occur with a...

A double-blinded, placebo-controlled study of Botox[R] for the treatment of subjects with chin rhytids.
July 1, 2005... Abstract Background: Botox has been used primarily for treating rhytids of the upper face. Its use in the lower part of the face has been reported by several authors but there is a relative scarcity of information regarding the use of...

Brown recluse spider envenomation: dermatologic application of hyperbaric oxygen therapy.
July 1, 2005... Abstract Envenomation from the brown recluse (Loxosceles recluse) spider commonly proceed on one of three clinical pathways. The majority of bites (90%) result in nothing more than a local reaction. They are essentially self-limiting,...

A review of the chemopreventive and chemotherapeutic effects of topical and oral retinoids for both cutaneous and internal neoplasms.
July 1, 2005... Abstract Retinoids, a group of compounds encompassing Vitamin A and its analogs, have been shown to inhibit tumor growth in laboratory studies. Based on these findings, a number of clinical trials have been conducted to investigate the...

Comparison of intense pulsed light to 595-nm long-pulsed pulsed dye laser for treatment of hypertrophic surgical scars: a pilot study.
July 1, 2005... Abstract Background: The short-pulsed pulsed dye laser (PDL) has been previously reported to improve the appearance of hypertrophic scars. Prolonged purpura following treatment led to the development of the newer long-pulsed pulsed dye...

Topical anesthetics for cosmetic and laser dermatology.
July 1, 2005... Abstract Many effective and simple topical anesthetic products are available today and commonly used in medical and non-medical settings. The increased use of topical anesthetics, especially by non-physicians in the medical and non-medical...

New histopathological classification of actinic keratosis (incipient intraepidermal squamous cell carcinoma).
July 1, 2005... Abstract Actinic keratoses are common, sun-induced lesions that have historically been regarded as "premalignant." Evidence supports their inclusion along a continuum with squamous cell carcinoma. We propose a classification analogous to...

Blood pressure levels decrease during Mohs micrographic surgery.
July 1, 2005... Abstract Background: A common practice is not to operate on patients with elevated blood pressure (BP) levels to avoid cardiovascular and cerebrovascular complications. We therefore designed a study to evaluate the effect of prolonged...

Topical metronidazole combination therapy in the clinical management of rosacea.
July 1, 2005... Abstract Metronidazole was the first topical agent approved by the US Food and Drug Administration for the treatment of rosacea. Several controlled studies have confirmed the efficacy and safety of topical metronidazole 0.75% gel, lotion...

Ciclopirox topical solution, 8% combined with oral terbinafine to treat onychomycosis: a randomized, evaluator-blinded study.
July 1, 2005... Abstract This randomized, evaluator-blind, 3-arm parallel, comparator controlled, multicenter pilot study evaluated the safety and efficacy of ciclopirox nail lacquer topical solution, 8% in combination with oral terbinafine for the...

Cutaneous small vessel vasculitis due to famciclovir therapy.(CASE REPORTS)
July 1, 2005... Abstract Cutaneous hypersensitivity vasculitis is often idiopathic, but may be the result of therapeutic drugs. It is important to be aware of previously unreported drugs that may be associated with this complication. We report a case of...

Mitozantrone-induced onycholysis associated with subungual abscesses, paronychia, and pyogenic granuloma.(CASE REPORTS)
July 1, 2005... Abstract Chemotherapeutic agents may induce a wide variety of adverse mucocutaneous effects, including nail changes. We present a case of atypical onycholysis, associated with subungual abscess formation, paronychia and pyogenic granuloma...

Suicidal ideation in the dermatology clinic.(CASE REPORTS)
July 1, 2005... Abstract Many dermatology patients have significant psychiatric comorbidities, including depression and suicidal ideation. In light of the isotretinoin controversy, the relevance of this subject has never been greater. Therefore, it is...

Acne fulminans in Marfan syndrome.(CASE REPORTS)
July 1, 2005... Abstract We report on a 12-year-old boy suffering from acne fulminans in combination with Marfan syndrome. The trigger for acne induction seemed to be a testosterone therapy. The particular therapeutic problems in the present case are...

Verapamil-induced subacute cutaneous lupus erythematosus.(CASE REPORTS)
July 1, 2005... Abstract Calcium-channel blockers (CCB), including verapamil, nifedipine, and diltiazem, are one of the most widely prescribed class of drugs in the treatment of cardiovascular disease. In the last several years, CCBs have been linked with...

Flaps & grafts workshop.
July 1, 2005... New York, Sept 10th & 11th Learn from the Leading Expert Perry Robins, MD [ILLUSTRATION OMITTED] For the past 22 years, Dr. Robins has developed new techniques for teaching and learning reconstructive closure of surgical...

Treatment of nevirapine-associated DRESS syndrome with intravenous immune globulin (IVIG).(CASE REPORTS)
July 1, 2005... Abstract Drug rash with eosinophilia and systemic symptoms (DRESS) syndrome is an adverse drug reaction most commonly associated with aromatic antiepileptic agents. It is characterized by the triad of skin eruption, fever, and systemic...

Laser News.
July 1, 2005... At the spring meeting of the American Society for Laser Medicine and Surgery in Orlando, Florida, the budding developments in lasers were presented. In the past 2 years, radiofrequency for skin and tissue tightening was the major topic, but...

Imiquimod cream 5% for recalcitrant cutaneous warts in immunosuppressed individuals.(WASHINGTON WHISPERS)
July 1, 2005... Imiquimod Cream 5% for Recalcitrant Cutaneous Warts in Immunosuppressed Individuals Harwood CA, MD et al. British Journal of Dermatology. 2005;152:122-129. Summary The authors present an open-label, left versus right comparison...

Treatment of female pattern hair loss with oral antiandrogens.(WASHINGTON WHISPERS)
July 1, 2005... Treatment of Female Pattern Hair Loss with Oral Antiandrogens Sinclair R, MD, et al. British Journal of Dermatology. 2005;152:466-473. Summary The authors present an open intervention study to assess if antiandrogen therapy is...

Intralesional 5-fluorouracil in the treatment of keloids: an open clinical and histopathologic study.(WASHINGTON WHISPERS)
July 1, 2005... Intralesional 5-Fluorouracil in the Treatment of Keloids: An Open Clinical and Histopathologic Study Kontochristopoulos G, MD, et al. Journal of the American Academy of Dermatology. 2005;52(3): 474-479. Summary The authors present...

Dosing with 5% imiquimod cream 3 times per week for the treatment of actinic keratosis.(WASHINGTON WHISPERS)
July 1, 2005... Dosing with 5% Imiquimod Cream 3 Times per Week for the Treatment of Actinic Keratosis Korman N, MD, et al. Archives of Dermatology. 2005;141:467-473. Summary The authors present 2 phase 3, multi-center, randomized, double-blind,...

Cumulative irritation potential of adapalene 0.1% cream and gel compared with tretinoin microsphere 0.04% and 0.1%.(WASHINGTON WHISPERS)
July 1, 2005... Cumulative Irritation Potential of Adapalene 0.1% Cream and Gel Compared with Tretinoin Microsphere 0.04% and 0.1% Dosik JS, MD, et al. Cutis. 2005;75(4):238-243. Summary The authors present an investigator-blinded, single-center,...

Restylane gel.(PIPELINE PREVIEWS)
July 1, 2005... The FDA recently accepted Medicis' pre-market approval application for Restylane Injectable Gel. Restylane is a transparent hyaluronic acid gel that is indicated for rhytides, especially near the nasolabial folds. This hyaluronic acid gel...

OTC topical steroids for psoriasis.(PIPELINE PREVIEWS)
July 1, 2005... Psoriasis Cure Now, a nonprofit advocacy group, recently asked two FDA Advisory Committees to provide over-the-counter status to some topical steroids which are currently only available via prescription. They argued that topical steroid...

Community acquired staphylococcus aureus infections: is vaccination the answer?(PIPELINE PREVIEWS)
July 1, 2005... In the past, infections with methicillin resistant staphylococcus aureus (MRSA) were typically seen in hospitalized or nursing home patients; however, in the late 1990s a new strain of MRSA was emerging: community acquired MRSA. Infections with...

Aczone and acne.(PIPELINE PREVIEWS)
July 1, 2005... Aczone, a 5% topical dapsone gel, demonstrates promise as a new treatment for acne vulgaris. Co-developed by QLT USA and Fujisawa Healthcare, aczone is currently awaiting FDA approval in the United States. Phase III trials which included 496...

Clarinex-D 24 Hour extended release tablets approved by the FDA.(PIPELINE PREVIEWS)
July 1, 2005... The FDA has recently approved Clarinex-D 24 Hour (desloratadine 5 mg and pseudoephedrine sulfate USP 240 mg) extended release tablets to treat nasal and non-nasal symptoms of seasonal allergic rhinitis in patients 12 years of age or older....

DNA repair lotion dimericine awaiting FDA approval.(PIPELINE PREVIEWS)
July 1, 2005... It has long been known that the bacterial enzyme T4 endonuclease V, in vitro, has demonstrated the ability to repair damaged DNA strands. Recently, Applied Genetics Inc. (AGI) Dermatics developed a mechanism by which to make this enzyme...

Fraxel Laser approved for skin resurfacing.(PIPELINE PREVIEWS)
July 1, 2005... The Fraxel Laser, Reliant Technologies product which has already gained FDA approval for soft tissue coagulation and treatment of periorbital rhytids and pigmented lesions, was recently granted 510(k) FDA clearance for non-ablative skin...

Serrano SA ends clinical trials for onercept and canvaxin.(PIPELINE PREVIEWS)
July 1, 2005... Serrano SA recently ended its clinical trials on onercept, a drug developed to treat psoriasis and canvaxin, a drug developed to treat Stage IV melanoma. Studies on onercept were halted after two patients receiving the medication developed...

Phase II trials of HPV vaccine look promising.(PIPELINE PREVIEWS)
July 1, 2005... Currently in Phase II trials, Merck's experimental HPV vaccine (Gardasil) which targets strains 16, 18, 6, and 11, those subtypes most likely to cause cervical cancer and genital warts, appears promising. Preliminary data reports that this...

Herpes zoster vaccine.(PIPELINE PREVIEWS)
July 1, 2005... Over 800,000 Americans suffer from herpes zoster per year, many of whom go on to develop post-herpetic neuralgia, the persistent chronic nerve pain sequella of this disease. Over 90% of the adult population has been exposed to the varicella...

FDA approves chlorhexidine gluconate 2% cloth.(PIPELINE PREVIEWS)
July 1, 2005... Chlorhexidine gluconate is often used as an antiseptic to clean non-mucosal surfaces prior to skin surgery. The FDA recently approved Sage pharmaceutical's chlorhexidine gluconate 2% cloth for pre-operative skin preparation. Like other...

Bioengineered skin and wound healing.(CLINICAL TRIAL REVIEW)
July 1, 2005... This study is currently recruiting patients. Sponsored by National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS). This study will look at whether a graft of bioengineered skin (BSC), known commercially as Apligraf[R],...

Comparison of telavancin and vancomycin for complicated skin and skin structure infections with a focus on methicillin-resistant staphylococcus aureus (ATLAS 1).(CLINICAL TRIAL REVIEW)
July 1, 2005... This study is currently recruiting patients. Sponsored by Theravance. Study 0017 compares the safety and effectiveness of an investigational drug, telavancin, and an approved drug, vancomycin, for the treatment of complicated skin and skin...

Celecoxib in preventing skin cancer.(CLINICAL TRIAL REVIEW)
July 1, 2005... This study is currently recruiting patients. Sponsors and collaborators: Herbert Irving Comprehensive Cancer Center. Randomized phase II trial to study the effectiveness of celecoxib in preventing skin cancer in participants exposed to...

The acquisition of blood and skin samples from normal volunteers to support research activities on dermatologic diseases.(CLINICAL TRIAL REVIEW)
July 1, 2005... This study is currently recruiting patients. Sponsored by National Cancer Institute (NCI). This protocol is concerned with the acquisition of blood, skin, and mucosal samples from normal volunteers to support the basic science research...

ZD1839 (iressa) for recurrent or metastatic SCC of the skin.(CLINICAL TRIAL REVIEW)
July 1, 2005... This study is currently recruiting patients. Sponsored by M.D. Anderson Cancer Center. Patients will receive 250 mg ZD1839 daily by mouth (1 course = 4 weeks). Patients will receive 6 courses of treatment. A patient may continue to receive...

The effects of microdermabrasion on skin remodeling.(CLINICAL TRIAL REVIEW)
July 1, 2005... This study is currently recruiting patients. Sponsored by University of Michigan. This research project aims to study the effects of microdermabrasion, a technique causing minimal injury used to improve the appearance of fine lines, wrinkles,...

Characterizing serum protein patterns in selected skin diseases.(CLINICAL TRIAL REVIEW)
July 1, 2005... This study is currently recruiting patients. Sponsored by National Cancer Institute (NCI). The purpose of this study is to determine whether computer-aided analysis of proteins found in the blood can distinguish between the serum protein...

Oral acyclovir for neonatal HSV disease of the skin, eyes, and mouth.(CLINICAL TRIAL REVIEW)
July 1, 2005... This study is currently recruiting patients. Sponsored by National Institute of Allergy and Infectious Diseases (NIAID). The purpose of this study is to test whether long-term treatment with oral acyclovir improves the outcome for infants with...

Skin Incision Study.(CLINICAL TRIAL REVIEW)
July 1, 2005... This study is currently recruiting patients. Sponsored by Queensland Centre for Gynaecological Cancer. The Skin Incision Study evaluates the efficacy of skin closure methods: skin staples and subcuticular sutures at 6 weeks and at 3 months...

Study of psoriatic arthritis.(CLINICAL TRIAL REVIEW)
July 1, 2005... This study is currently recruiting patients. Sponsored by National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS). This study will examine the genetic and immune factors involved in the cause and development of psoriatic...

Tetracycline in preventing skin rash in patients who are receiving drugs such as gefitinib and cetuximab for cancer.(CLINICAL TRIAL REVIEW)
July 1, 2005... This study is currently recruiting patients. Sponsors and collaborators: North Central Cancer Treatment Group. This randomized clinical trial is studying tetracycline to see how well it works compared to placebo in preventing skin rash in...

Infliximab (Remicade[R]) to treat dermatomyositis and polymyositis.(CLINICAL TRIAL REVIEW)
July 1, 2005... This study is currently recruiting patients. Sponsored by National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS). This study will examine whether infliximab (Remicade) is safe and effective for the treatment of...

Skin response to sunlight.(CLINICAL TRIAL REVIEW)
July 1, 2005... This study is currently recruiting patients. Sponsored by National Cancer Institute (NCI). This study will explore the relationship between skin cancer and ultraviolet (UV) radiation exposure by measuring gene expression patterns in skin that...

The research registry for neonatal lupus.(CLINICAL TRIAL REVIEW)
July 1, 2005... This study is currently recruiting patients. Sponsored by National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS). Women with lupus and other related disorders produce certain antibodies in the blood. Some women have these...

Etanercept for treatment of hidradenitis.(CLINICAL TRIAL REVIEW)
July 1, 2005... This study is currently recruiting patients. Sponsors and collaborators: University of Pennsylvania Amgen. The purpose of this study is to determine whether etanercept is safe and effective for the treatment of hidradenitis. Another purpose of...

Cell infusions and interleukin-2 to treat metastatic melanoma.(CLINICAL TRIAL REVIEW)
July 1, 2005... This study is currently recruiting patients. Sponsored by National Cancer Institute (NCI). This study will examine the effectiveness of treating advanced melanoma with special tumor-fighting cells taken from the patient's tumor and grown in the...

Leptin to treat lipodystrophy.(CLINICAL TRIAL REVIEW)
July 1, 2005... This study is currently recruiting patients. Sponsored by National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). This study will evaluate the safety and effectiveness of leptin replacement therapy in patients with...

Cause and natural course of pediatric-onset mastocytosis.(CLINICAL TRIAL REVIEW)
July 1, 2005... This study is currently recruiting patients. Sponsored by National Institute of Allergy and Infectious Diseases (NIAID). This study will evaluate children with mastocytosis, a disease of excessive mast cells in tissues such as skin and bone...

Genetic analysis of familial keloids.(CLINICAL TRIAL REVIEW)
July 1, 2005... This study is currently recruiting patients. Sponsored by National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). The purpose of this study is to identify the gene or genes responsible for keloid formation. Keloids are raised...

To study the effects of CD25 and low dose Cyclosporin in the treatment of active psoriasis vulgaris.(CLINICAL TRIAL REVIEW)
July 1, 2005... This study is currently recruiting patients. Sponsored by Protein Design Labs. This study compares the efficacy and analyzes the cellular effects of anti-TAC (Daclizumab) and Cyclosporine in the treatment of psoriasis vulgaris. This is a...

To study the use of humanized CD25 in preventing the relapse of psoriasis vulgaris.(CLINICAL TRIAL REVIEW)
July 1, 2005... This study is currently recruiting patients. Sponsored by Protein Design Labs. This study is designed to study disease relapse after NBUVB and how the administration of Daclizumab/placebo alters disease relapse. Condition Treatment or...

Utilization of narrow band ultraviolet B (UVB) light therapy and etanercept for the treatment of psoriasis.(CLINICAL TRIAL REVIEW)
July 1, 2005... This study is currently recruiting patients. Sponsored by Amgen. The purpose of this study is to evaluate the safety and effectiveness of combination therapy with etanercept and narrow-band (NB) UVB phototherapy for the treatment of psoriasis...

Monoclonal antibody treatment for systemic lupus erythematosus.(CLINICAL TRIAL REVIEW)
July 1, 2005... This study is currently recruiting patients. Sponsored by National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS). This study will examine the safety and effects of the monoclonal antibody MRA in patients with systemic...

Copper histidine therapy for Menkes diseases.(CLINICAL TRIAL REVIEW)
July 1, 2005... This study is currently recruiting patients. Sponsored by National Institute of Neurological Disorders and Stroke (NINDS). The purpose of this study is to continue to evaluate the effects of early in copper histidine Menkes disease patients and...

Preliminary testing of new treatment for chronic leg wounds.(CLINICAL TRIAL REVIEW)
July 1, 2005... This study is currently recruiting patients. Sponsors and collaborators: National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) and National Gene Vector Laboratory. The long-term goal of this study is to evaluate a new...

Conditioning, the placebo effect, and psoriasis.(CLINICAL TRIAL REVIEW)
July 1, 2005... This study is currently recruiting patients. Sponsored by National Institute of Arthritis and Musculoskeletal and Skin. This study uses the psychological principle known as classical conditioning to try to improve the standard treatment of...

Alopecia areata registry.(CLINICAL TRIAL REVIEW)
July 1, 2005... This study is currently recruiting patients. Sponsored by National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS). Alopecia areata is the loss of hair in oval patches that can proceed to loss of all hair (alopecia totalis...

New technologies for in vivo diagnoses of early melanoma.(SKIN CANCER FOUNDATION UPDATE)
July 1, 2005... Unaided visual inspection is not enough to detect and diagnose all cutaneous melanomas. Numerous instruments are being utilized or investigated to increase diagnostic sensitivity and specificity and improve in vivo differentiation of melanoma...