Journal of Drugs in Dermatology articles from January 2008

Journal of Drugs in Dermatology archives from January 2008

Versatility of azelaic acid 15% gel in treatment of inflammatory acne vulgaris.
January 1, 2008... Abstract Azelaic acid (AzA) 15% gel is approved for the treatment of rosacea in the US, but also has approval for the treatment of acne vulgaris in many European countries where it has demonstrated success. Two randomized, multicenter,...

Pharmacoeconomic analysis of the treatment of multiple actinic keratoses.
January 1, 2008... Abstract Actinic keratosis (AK) is common and lesions may progress to squamous cell carcinoma. The choice of therapy depends mainly on 2 factors: the efficacy of therapeutic options and the number of lesions present. Cryotherapy alone is...

In vivo determination of the skin atrophy potential of the super-high-potency topical corticosteroid fluocinonide 0.1% cream compared with clobetasol propionate 0.05% cream and foam, and a vehicle.
January 1, 2008... Abstract Purpose: Prolonged topical corticosteroid use is often associated with atrophic skin changes. This trial compared signs of skin atrophy related to 3 super-high-potency corticosteroids: fluocinonide 0.1% cream, clobetasol...

Oral erythromycin is ineffective in the treatment of pityriasis rosea.(Clinical report)
January 1, 2008... Abstract Background: Despite the availability of various medical treatments for pityriasis rosea, a large percentage of patients fail to achieve satisfactory results. Erythromycin is reported to be effective in the treatment of pityriasis...

Healthcare utilization and costs of patients with rosacea in an insured population.
January 1, 2008... Abstract Background: Rosacea is a chronic, relapsing dermatologic condition that affects an estimated 14 million people in the US. However, there is little data in the literature on the healthcare utilization and costs of patients with...

Primary cutaneous cryptococcosis during therapy with methotrexate and adalimumab.(CASE REPORTS)(Case study)
January 1, 2008... Abstract Primary cutaneous infection with Cryptococcus neoformans is uncommon, but can occur following an inoculation injury to the skin. Tumor necrosis factor-alpha (TNF-[alpha]) is important in the immune response to Cryptococcus, and...

Fractional laser resurfacing for thermal burns.(CASE REPORTS)
January 1, 2008... Abstract Fractional resurfacing may be an effective treatment for burn scars because of its unique healing properties and depth of penetration. This case report shows the successful use of fractional resurfacing to treat burn scars....

Radiation recall reaction induced by levofloxacin.(CASE REPORTS)(Case study)
January 1, 2008... Abstract We present a case of a 55-year-old female with breast cancer who developed radiation recall dermatitis (RRD) 3 years later after administration of levofloxacin. A vast majority of cases occur after administration of...

Acneiform eruption following anti-TNF-alpha treatment: a report of three cases.(CASE REPORTS)(Case study)
January 1, 2008... Abstract Tumor necrosis factor-alpha (TNF-[alpha]) antagonists are used to treat many autoimmune disorders including Crohn's disease, ulcerative colitis, rheumatoid arthritis, and more recently, psoriasis. The adverse effects of the...

Multifocal scalp abscess with subcutaneous fat necrosis and scarring alopecia as a complication of scalp mesotherapy.(CASE REPORTS)
January 1, 2008... Abstract Over the past several years, there has been a growing interest in the treatment method termed mesotherapy. Marketed for nonsurgical fat melting, skin rejuvenation, and hair regrowth, this technique has become increasingly popular...

Zyrtec[R] for use without a prescription.(PIPELINE PREVIEWS)
January 1, 2008... McNeil Consumer Healthcare announced the recent FDA approval for Zyrtec (cetirizine HCl) to be used without a prescription for both adults and children. The medication will be widely available in stores throughout the United States in January...

Isolagen Therapy[TM] for acne scars.(PIPELINE PREVIEWS)(Brief article)
January 1, 2008... Isolagen[TM], Inc. recently reported that it has initiated a Phase III clinical trial to evaluate Isolagen Therapy for its use in the treatment of acne scars. In this study, two randomized, double-blind, placebo-controlled trials will assess...

M-Vax[R] in metastatic melanoma.(PIPELINE PREVIEWS)(Brief article)
January 1, 2008... AVAX Technologies, Inc. recently announced the initiation of a Phase III trial for M-Vax in the treatment of metastatic melanoma. This Phase III, double-blind, randomized, multicenter trial will enroll up to 387 patients over a 2 year period....

Cloderm[R] cream in pump delivery system.(PIPELINE PREVIEWS)(Brief article)
January 1, 2008... Coria Laboratories has recently announced that Cloderm (clocortolone pivalate) Cream, 0.1% is now available in a pump delivery system. The pump precisely controls the amount of cream that is dispensed with each administration. The container...

Minoxidil foam for androgenetic alopecia.(PIPELINE PREVIEWS)(Brief article)(Clinical report)
January 1, 2008... A recent report in the Journal of the American Academy of Dermatology describes a multicenter, randomized, placebo-controlled, double-blind clinical trial of 5% minoxidil topical foam in the treatment of androgenetic alopecia in men. This trial...

Genasense[R] therapy in advanced melanoma.(PIPELINE PREVIEWS)(Brief article)
January 1, 2008... Genta Inc recently announced promising data regarding Genasense (oblimersen sodium) Injection plus Temodar[R] (temozolomide) and Abraxane[R] (paclitaxel protein-bound particles for injectable suspension) in the treatment of advanced metastatic...

Phase III trial for golimumab for psoriatic arthritis.(PIPELINE PREVIEWS)(Brief article)
January 1, 2008... A recent Phase III trial which evaluated golimumab (CNTO 148), Centocor Inc and Schering-Plough Corporation's newest human anti-tumor necrosis factor-alpha monoclonal antibody (anti-TNF-alpha), showed significant improvement in psoriatic...

Parabens toxicity to skin and other organs.(LASER AND COSMETIC NEWS)
January 1, 2008... Laser and Cosmetic News covers the latest advances in laser surgery, light technology, phototherapy, and cosmetic surgery. New and emerging therapies, noteworthy publications, and exciting meeting developments will be highlighted. Controversies...

No nonsense dermoscopy: self-assessment.(Technical report)
January 1, 2008... This new periodic column will help clinicians evaluate their own proficiency and gain new techniques in the general principles of dermoscopy. Introduction Dermoscopy is the standard of care in many countries around the world and has...

Could skin be the fountain of youth? The use of skin as the origin of induced stem cells.(NEWS, VIEWS, AND REVIEWS)
January 1, 2008... Abstract Amidst the ban on federal funding for most stem cell research, recent developments have been made in generating stem cells without using human embryos. One novel approach is to reprogram mature adult cells into pluripotent stem...

Does endometriosis increase a women's melanoma risk?(NEWS, VIEWS, AND REVIEWS)
January 1, 2008... Abstract Case-control and cohort studies have suggested an association between melanoma and endometriosis. A prospective study of over 90,000 patients in the French national health care system, is the largest study to evaluate the...

Study of light treatment and laser treatment for melasma.(MELASMA)(Brief article)
January 1, 2008... Sponsored by Northwestern University. The purpose of this study is to determine the efficacy of light treatment and laser treatment for melasma. Condition Intervention Melasma Procedure: Light Treatment Procedure:...

Treatment of melasma with Jessner's solution vs. trichloroacetic acid: a comparison of clinical efficacy.(MELASMA)(Brief article)
January 1, 2008... Sponsored by Emory University. Chemical peels using agents such as Jessner's solution and trichloroacetic acid (TCA) are commonly used to treat melasma. The purpose of this study is to determine if there is a difference in the effectiveness of...

Study of acid peel and laser for the treatment of melasma.(MELASMA)(Brief article)
January 1, 2008... Sponsored by Northwestern University. The objective of this study is to evaluate laser treatment and acid peel for the treatment of melasma. Condition Intervention Melasma Procedure: Laser Treatment Procedure: Acid...

Alternating treatment for melasma with Tri-Luma Cream and glycolic acid peels.(MELASMA)(Brief article)
January 1, 2008... Sponsored by Galderma Laboratories LP. The primary objective of this study is designed to document the effectiveness of Tri-Luma[R] Cream alternating with glycolic acid peels for melasma. Condition Intervention Phase ...

Zinc sulfate in the treatment of rosacea: a randomized, controlled trial.(PHOTOAGING)(Brief article)
January 1, 2008... Sponsored by St. Mary's Duluth Clinic Health System. The purpose of the study is to determine whether oral zinc sulfate treatment is an effective treatment for facial rosacea. Study ID Numbers: 09-05-03 ClinicalTrials.gov Identifier:...

Efficacy of topical cyclosporin for ocular rosacea.(PHOTOAGING)(Brief article)
January 1, 2008... Sponsors and Collaborators: Ophthalmic Consultants of Long Island and Allergan. The purpose of this study is to determine whether Restasis[R] (topical cyclosporin) is effective in the treatment of ocular rosacea. Condition Intervention...

Treatment of patients with blepharitis and facial rosacea.(PHOTOAGING)(Brief article)
January 1, 2008... Sponsored by CollaGenex Pharmaceuticals. The purpose of this study is to determine the safety and efficacy of sub-antimicrobial dose doxycycline in the treatment of patients who have both blepharitis and facial rosacea. Condition ...

Treatment of acne scarring with subdermal manipulation.(PHOTOAGING)(Brief article)
January 1, 2008... Sponsored by Northwestern University. The purpose of this study is to look at the efficacy of subdermal manipulation in the improvement of acne scar appearance. Condition Intervention Phase Acne Scarring...

An evaluation of an injected filler for correction of wrinkles.(PHOTOAGING)(Brief article)
January 1, 2008... Sponsored by Northwestern University. The purpose of this study is to determine whether an injectable filler into wrinkles can result in safe, aesthetically-pleasing, and long-lasting correction. Condition Intervention ...

Single-blind study determining the efficacy of Polypodium leucotomos extract supplement in decreasing UVA premutagenic and photoaging markers.(PHOTOAGING)(Brief article)
January 1, 2008... Sponsored by the University of Miami. The purpose of this study is to determine if taking a dose of the study medication, called Polypodium leucotomos (PL), prevents some of the changes in the skin caused by the adverse effects of UVA, a type...

Comparison of Metvix photodynamic therapy (PDT) with tts vehicle in the treatment of photoaged skin.(PHOTOAGING)(Brief article)
January 1, 2008... Sponsored by Galderma. The purpose of this study is to assess whether Metvix[R] PDT will be effective in correcting the effects related to photodamage and whether it will be well-tolerated. Condition Intervention Phase ...

Effects of TNF-alpha antagonism (etanercept) in patients with the metabolic syndrome and psoriasis.(PSORIASIS)(tumor necrosis factor)(Brief article)
January 1, 2008... Sponsors and Collaborators: Massachusetts General Hospital and Amgen. People with psoriasis have significantly higher rates of obesity, diabetes, heart failure, and high blood pressure than the general public. The purpose of this study is to...

Curcuminoids for the treatment of chronic psoriasis vulgaris.(PSORIASIS)(Brief article)
January 1, 2008... Sponsored by the University of Pennsylvania. The purpose of this study is to determine the safety and to estimate the efficacy of oral Curcuminoid C3 Complex[R] in patients with chronic psoriasis vulgaris. Condition Intervention ...

Psunrise--prospective study using Remicade[R] in psoriasis patients with an inadequate response to etanercept.(PSORIASIS)(Brief article)
January 1, 2008... Sponsored by Centocor Inc. The purpose of this study is to test the safety and effectiveness of infliximab in patients with plaque psoriasis who have been receiving the drug etanercept for treatment of their plaque psoriasis for at least four...

Efficacy and safety of cyclosporine a microemulsion in maintenance patients with chronic plaque psoriasis.(PSORIASIS)(Brief article)
January 1, 2008... Sponsored by Novartis. The study will evaluate the efficacy of cyclosporine when administered twice a week compared to continuous administration, in patients with chronic plaque psoriasis. Condition Intervention ...

Safety and efficacy study of CF101 to treat psoriasis.(PSORIASIS)(Brief article)
January 1, 2008... Sponsored by Can-Fite BioPharma. This study will test the hypothesis that CF101, which is under development to treat other immune-mediated inflammatory diseases, will provide clinical benefits in the treatment of chronic plaque psoriasis. ...

T4N5 liposomal lotion in preventing the recurrence of nonmelanoma skin cancer in patients who have undergone a kidney transplant.(SKIN CANCER)(Brief article)
January 1, 2008... Sponsors and Collaborators: Lurleen Wallace Comprehensive Cancer at the University of Alabama-Birmingham and National Cancer Institute (NCI). The purpose of this randomized phase II trial is to study how well T4N5 liposomal lotion works in...

Topical tazarotene in treating patients with basal cell skin cancer and basal cell nevus syndrome.(SKIN CANCER)(Brief article)
January 1, 2008... Sponsors and Collaborators: The Children's Hospital and Research Center, Oakland and National Cancer Institute (NCI). The purpose of this phase II trial is studying topical tazarotene to see how well it works in treating patients with basal...

Difluoromethylornithine (DFMO) chemoprevention of skin cancer in organ transplant recipients.(SKIN CANCER)(Brief article)
January 1, 2008... Sponsored by the University of Wisconsin. The purposes of this study are to determine if DFMO at 500 mg daily will be well-tolerated for 12 months and not affect organ transplant viability; will inhibit 12-O-tetradecanoylphorbol-13-acetate...

Spectral Diagnosis of cutaneous malignancy.(SKIN CANCER)(Brief article)
January 1, 2008... Sponsors and Collaborators: MD Anderson Cancer Center and the University of Texas. The purpose of this study is to determine the spectroscopic features of skin lesions in vivo, develop the Spectral Diagnosis (SD) system to distinguish between...

Melanoma detection by oblique-incidence optical spectroscopy.(SKIN CANCER)(Brief article)
January 1, 2008... Sponsored by the MD Anderson Cancer Center. The purpose of this study is to establish a statistically significant database to contain demographic information, clinical diagnoses, clinical images, OIR images, histopathologic diagnoses, and...

Introduction.
January 1, 2008... Approximately 1 million cases of basal cell carcinoma (BCC) are expected to occur in the US this year. The current standard treatment of superficial BCC, curettage and desiccation (C & D) alone, is associated with scarring and recurrences....

Scientific rationale: combining imiquimod and surgical treatments for basal cell carcinomas.
January 1, 2008... Abstract The number of basal cell carcinomas (BCCs) occurring in the US in 2007 has been conservatively estimated to be 1 million. Surgical extirpation alone is the standard for the treatment for BCCs, which results in scarring and is...

A 36-month clinical experience of the effectiveness of curettage and imiquimod 5% cream in the treatment of basal cell carcinoma.
January 1, 2008... Abstract Background: Electrodesiccation and curettage is commonly used for the treatment of basal cell carcinomas (BCCs). Does the addition of imiquimod 5% cream improve clearance rates and cosmetic outcomes? Objective: To evaluate a...

Imiquimod 5% cream following curettage without electrodesiccation for basal cell carcinoma: preliminary report.
January 1, 2008... Abstract Background: Using more than one therapeutic approach in the treatment of basal cell carcinomas (BCCs) has the potential to enhance cure rates. Materials and Methods: In this study, 57 nodular and superficial BCCs were...

Antiangiogenesis in the treatment of skin cancer.
January 1, 2008... Abstract Angiogenesis is the formation of new capillary blood vessels from existing vasculature. Cancers are dependent upon angiogenesis for their growth. Inhibition of angiogenesis can slow, halt, or regress tumors. Angiogenesis...