Journal of Drugs in Dermatology articles from January 2007

Journal of Drugs in Dermatology archives from January 2007

Erratum.(Correction notice)
January 1, 2007... In the September 2006 issue, regarding "Treatment considerations for inflammatory acne: clinical evidence for adapalene 0.1% in combination therapies" by Thiboutot DM, Gollnick HP. J Drugs Dermatol. 2006;5(8):785-94. Table 2. Cutaneous...

Letter from the guest editor.
January 1, 2007... It is a pleasure to serve as guest editor for this very special issue of the Journal of Drugs in Dermatology, which is dedicated to dermatology in deeply pigmented patients. We are deeply indebted to the authors who have performed a service for...

Sunscreen use and usefulness in African-Americans.
January 1, 2007... Abstract Sunscreen use in the African-American population is much less than in Caucasians. Its use in African-Americans varies based on factors such as sex, age, skin type, socioeconomic status, occupation, aesthetic issues, and medical...

Dermatosis papulosis nigra: treatment options.
January 1, 2007... Abstract Dermatosis papulosis nigra (DPN) is a very prevalent skin condition among certain ethnic groups, especially African-Americans and Afro-Caribbeans. The histology is not significantly different from that of seborrheic keratosis. DPN...

Insight into skin lightening cosmeceuticals for women of color.(Disease/Disorder overview)(Clinical report)
January 1, 2007... Abstract The changing face of America highlights the importance of understanding dermatologic conditions of skin of color. Hyperpigmentation is the most common and distressing condition afflicting this unique subset of the population....

Comparison of adverse events of laser and light-assisted hair removal systems in skin types IV-VI.(Clinical report)
January 1, 2007... Abstract Photoepilation, utilizing lasers and noncoherent light sources, is designed to irradiate as much of the follicular unit as possible, with melanin as the target chromophore. Wavelength absorption should generate energy sufficient...

Soft tissue augmentation in skin of color: market growth, available fillers, and successful techniques.
January 1, 2007... Abstract In recent years, people of color have become an increasingly important market force for the cosmetics industry. Product lines have been expanded to accommodate a broader spectrum of skin colors and marketing strategies have been...

Cultural and ethnic differences in the acceptance or rejection of liposuction instrumentation entrance marks.
January 1, 2007... Abstract The acceptance of visible marks on the skin as a result of surgical procedures varies by the necessity of the procedure (ie, cosmetic or not) and by the cultural interpretation of those sequelae. As liposuction has become the most...

Hair removal with the 3-msec alexandrite laser in patients with skin types IV-VI: efficacy, safety, and the role of topical corticosteroids in preventing side effects.
January 1, 2007... Abstract Background: Laser hair removal targets melanin in the hair shaft. The abundance of melanin in the epidermis of patients with dark skin color has always been regarded as hazardous due to the increased incidence of side effects in...

Surgical therapy of acne scars in pigmented skin.(CASE REPORTS)
January 1, 2007... Abstract Problem: Surgical therapy of moderate or severe acne scars in African-Americans, Hispanics, and other individuals with darkly pigmented skin. Challenges: Dyspigmentation in more darkly complected individuals following...

Selected dermatoses in children of color.(CASE REPORTS)(Disease/Disorder overview)(Clinical report)
January 1, 2007... Abstract Three conditions, erythema dyschromicum perstans (EDP), granulomatous periorificial dermatitis (GPD), and Kawasaki disease (KD) are seen more frequently in children of color. EDP and GPD are benign and self-limited dermatoses;...

Laser and light-based treatment of cellulite.(LASER AND COSMETIC NEWS)
January 1, 2007... Laser and Cosmetic News covers the latest advances in laser surgery, light technology, phototherapy, and cosmetic surgery. New and emerging therapies, noteworthy publications, and exciting meeting developments will be highlighted. Controversies...

Cutaneous side effects of cetuximab and erlotinib.(WASHINGTON WHISPERS)(Clinical report)
January 1, 2007... Cutaneous Side Effects of Cetuximab and Erlotinib Commentary on: Description and management of cutaneous side effects during cetuximab or erlotinib treatments: A prospective study of 30 patients. Roe E, MD, et al. J Am Acad Dermatol....

Treatment options for the papulopustular eruption of gefitinib.(WASHINGTON WHISPERS)
January 1, 2007... Treatment Options for the Papulopustular Eruption of Gefitinib Commentary on: Treatment of gefitinib-associated folliculitis. Matheis P, et al. J Am Acad Dermatol. 2006;55:710-713. Summary The authors present a case series of...

FDA approves generic Sulfacetamide.(PIPELINE PREVIEWS)
January 1, 2007... Fougera recently announced that the FDA has approved the first generic Sulfacetamide Sodium Topical Suspension USP 10%. This medication is used for the topical treatment of acne. This new formulation is already available and is marketed in 4-fl...

Humira received expanded FDA approval in treatment of psoriatic arthritis.(PIPELINE PREVIEWS)
January 1, 2007... The FDA recently expanded the indications in its approval for Humira (adalimumab) in the treatment of psoriatic arthritis. Humira is a TNF-alpha blocker and represents the only fully human monoclonal antibody that is approved in the US for the...

Adalimumab in the treatment of moderate to severe psoriasis.(PIPELINE PREVIEWS)(Clinical report)
January 1, 2007... A recently published multicenter, randomized, double-blind, placebo-controlled study examined the safety and efficacy of adalimumab in patients with moderate-to-severe plaque-type psoriasis. In this study, 147 patients received adalimumab at 40...

FDA approves Mylan's doxycycline tablets.(PIPELINE PREVIEWS)
January 1, 2007... The FDA recently approved the Abbreviated New Drug Application for Mylan Laboratories Inc's doxycycline tablets in 50 mg, 75 mg and 100 mg. This medication is a generic equivalent of Doak Dermatologic's Adoxa tablets.

ArteFill approved by the FDA.(PIPELINE PREVIEWS)
January 1, 2007... Artes Medical recently announced that the FDA has approved its product ArteFill as the first nonresorbable injectable filler to correct nasolabial fold rhytides. ArteFill is the first product that is a permanent support structure for continuing...

Topical tacrolimus for the treatment of lichen sclerosus.(PIPELINE PREVIEWS)
January 1, 2007... The results of a Phase II multicenter clinical trial that assessed the safety and efficacy of topical tacrolimus ointment 0.1% in the treatment of lichen sclerosus were recently published in the British Journal of Dermatology. In the...

Transacin for post-herpetic neuralgia.(PIPELINE PREVIEWS)
January 1, 2007... NeurogesX Inc recently announced positive results from a trial of Transacin (NGX-4010) for the treatment of post-herpetic neuralgia. Transacin is a physician-administered, high-concentration trans-capsaicin dermal patch. This Phase III...

FDA approves Noxafil for oropharyngeal candidiasis.(PIPELINE PREVIEWS)
January 1, 2007... Schering-Plough Corporation recently announced that its product Noxafil has been approved by the FDA for the treatment of Oropharyngeal Candidiasis. Noxafil Oral Suspension, or posaconazole, is a triazole antifungal that had previously been...

Additional positive results for telavancin.(PIPELINE PREVIEWS)
January 1, 2007... Theravance Inc recently announced new positive results from its clinical trials evaluating the safety and efficacy of telavancin. Telavancin is a rapidly bactericidal injectable antibiotic which is indicated for the treatment of complicated...

FDA approves Zolinza for treatment of cutaneous T cell lymphoma.(PIPELINE PREVIEWS)
January 1, 2007... Merck & Co, Inc recently reported that the FDA approved Zolinza (vorinostat) in the treatment of patients with cutaneous T-cell lymphoma. Zolinza inhibits the enzyme his-tone deacetylase, although its exact anticancer activity remains unknown....

A comparison of available and investigational antibiotics for complicated skin infections and treatment-resistant Staphylococcus aureus and Enterococcus.(SCHOOLS OF PHARMACOLOGY)(Concert review)
January 1, 2007... Abstract This article compares vancomycin, teicoplanin, quinupristin-dalfopristin, linezolid, daptomycin, tigecyline, dalbavancin, telavancin, ceftobiprole, oritavancin, and ramoplanin for the treatment of complicated skin and skin...

Ceftobiprole in the treatment of resistant Staphylococcus aureus skin and skin structure infections.(CLINICAL TRIAL REVIEW)
January 1, 2007... Sponsored by Johnson and Johnson Pharmaceutical Research and Development, L.L.C. The purpose of this study is to compare the clinical cure rate of ceftobiprole medocaril versus a comparator in the treatment of patients with complicated skin and...

Study comparing the safety and efficacy of tigecycline with ampicillin-sulbactam or amoxicillin-clavulanate to treat skin infections.(CLINICAL TRIAL REVIEW)
January 1, 2007... Sponsored by Wyeth. The purpose of this study is to compare the safety and efficacy of the antibiotic tigecycline with other antibiotics, ampicillin-sulbactam, and amoxicillin-clavutanate in the treatment of a complicated skin and/or skin...

Celecoxib in preventing skin cancer.(CLINICAL TRIAL REVIEW)
January 1, 2007... Sponsors and Collaborators: Herbert Irving Comprehensive Cancer Center and National Cancer Institute (NCI). The purpose of this study is to conduct a randomized phase II trial to study the effectiveness of celecoxib in preventing skin cancer in...

Reconstitution with pimecrolimus cream 1% of steroid-damaged skin in adults with atopic dermatitis.(CLINICAL TRIAL REVIEW)
January 1, 2007... Sponsored by Novartis. This study will examine long-term management of atopic dermatitis (AD) over 12 months with pimecrolimus cream 1% and its effect on skin reconstitution of steroid-damaged skin and disease control. Condition ...

The effect of Efudex treatment on photoaged skin.(CLINICAL TRIAL REVIEW)
January 1, 2007... Sponsors and Collaborators: University of Michigan and Valeant Pharmaceuticals International. The researchers propose that skin improvements may be seen following a course of Efudex, (5-fluorouracil), a FDA-approved topical therapy (applied...

Effect of bosentan on skin fibrosis in patients with systemic sclerosis.(CLINICAL TRIAL REVIEW)
January 1, 2007... Sponsored by Heinrich-Heine University, Duesseldorf. The purpose of this study is to evaluate the effect of bosentan treatment on skin fibrosis and its functionality in patients with systemic sclerosis. Condition Intervention...

Topical morphine for analgesia in patients with skin grafts.(CLINICAL TRIAL REVIEW)
January 1, 2007... Sponsored by Rambam Health Care Campus. The purpose of this study is to topically apply morphine onto skin-graft donor wounds. If found to be effective this treatment modality could be an appealing noninvasive method to treat the pain of this...

Comparing skin disinfectants before labor epidural analgesia.(CLINICAL TRIAL REVIEW)
January 1, 2007... Sponsored by University of British Columbia. The purpose of this study is to compare the current standard skin disinfectant solution for labor epidurals used at BC Women's Hospital to another common skin disinfectant and to the skin...

T4N5 liposomal lotion in preventing the recurrence of nonmelanoma skin cancer in patients who have undergone a kidney transplant.(CLINICAL TRIAL REVIEW)
January 1, 2007... Sponsors and Collaborators: University of Alabama at Birmingham and National Cancer Institute (NCI). This randomized phase II trial is studying how well T4N5 liposomal lotion works in preventing the recurrence of nonmelanoma skin cancer in...

Atopic dermatitis-like skin disease in pediatric heart transplant patients.(CLINICAL TRIAL REVIEW)
January 1, 2007... Sponsored by Maria K. Hordinsky, MD. The skin disease found in pediatric heart transplant patients represents an atopic dermatitis-like rash that is refractory to systemic immunomodulation. Condition Intervention Phase...

Gefitinib in treating patients who are undergoing surgery and/or radiation therapy for locally advanced or recurrent squamous cell skin cancer.(CLINICAL TRIAL REVIEW)
January 1, 2007... Sponsors and Collaborators: M.D. Anderson Cancer Center and National Cancer Institute (NCI). This phase II trial is studying how well gefitinib works in treating patients who are undergoing surgery and/or radiation therapy for locally advanced...

The acquisition of blood and skin samples from normal volunteers to support research activities on dermatologic diseases.(CLINICAL TRIAL REVIEW)
January 1, 2007... Sponsored by National Cancer Institute (NCI). This protocol is concerned with the acquisition of blood, skin, and mucosal samples from normal volunteers to support the basic science research activities of the Dermatology Branch. Condition...

Common allergens in skin tests for adult atopic dermatitis.(CLINICAL TRIAL REVIEW)
January 1, 2007... Sponsored by National Taiwan University Hospital. The purpose of this study is to analyze the common allergens revealed by skin tests in adult atopic dermatitis patients. Condition Atopic Dermatitis Study ID Numbers: 9461700672...

The effects of microdermabrasion on skin remodeling.(CLINICAL TRIAL REVIEW)
January 1, 2007... Sponsored by University of Michigan. This research project aims to study the effects of microdermabrasion. We are interested in determining how this procedure works at rebuilding the skin following microdermabrasion. Condition ...

T cell repertoire analysis of immune mediated skin diseases.(CLINICAL TRIAL REVIEW)
January 1, 2007... Sponsored by University of California, Davis. This study is designed to identify the cells of the immune system that cause skin disease such as psoriasis and mycosis fungoides. Blood samples from many patients will be compared in hopes of...

Sunless tanning products as a substitute for sunbathing in healthy participants.(CLINICAL TRIAL REVIEW)
January 1, 2007... Sponsors and Collaborators: UMASS Memorial Cancer Center (University Campus) and National Cancer Institute (NCI). This phase I/II trial is studying attitudes about the use of sunless tanning products and how well sunless tanning products work...

Hematopoietic stem cell support in patients with autoimmune bullous skin disorders.(CLINICAL TRIAL REVIEW)
January 1, 2007... Sponsored by Northwestern University. This study is designed to examine whether treating patients with high dose cyclophosphamide (a drug which reduces the function of the immune system) together with antithymocyte globulin (a protein that...

Determining the photoadaptation (tolerance) of depigmented skin to targeted phototherapy using UVB in patients with vitiligo.(CLINICAL TRIAL REVIEW)
January 1, 2007... Sponsored by Henry Ford Health System. The purpose of this study is to determine if vitiligo patients develop tolerance to ultraviolet light therapy, a type of treatment available for vitiligo. Condition Intervention Vitiligo...

Study of recombinant human Thrombin for bleeding during autologous skin grafting.(CLINICAL TRIAL REVIEW)
January 1, 2007... Sponsored by ZymoGenetics. The purpose of this study is to evaluate whether Thrombin is safe when used for controlling bleeding during skin graft surgery. Condition Intervention Phase Surgical Hemostasis Drug:...

Skin cancer in individuals of African, Asian, Latin-American, and American-Indian descent: differences in incidence, clinical presentation, and survival compared to Caucasians.(Disease/Disorder overview)
January 1, 2007... Abstract Skin cancer most commonly affects Caucasians and rarely affects individuals of African, Asian, Latin-American, and American-Indian descent. Although skin cancer is rare in these groups, the diagnosis may be associated with...