Journal of Drugs in Dermatology articles from January 2006

Journal of Drugs in Dermatology archives from January 2006

A letter from the guest editor.
January 1, 2006... Clinical management of chronic disease is something at which dermatologists excel. The understanding of the subtle variations in the presentation of rosacea, gives the experienced dermatologist the ability to finesse the treatments options by...

Rosacea: clinical presentation and pathophysiology.
January 1, 2006... Abstract Acne rosacea is one of the most common diagnoses seen in the clinical dermatologic practice. The classic presentation of rosacea, acneiform papules, and pustules on a background of telangiectasia, is often easily identified by...

Oral therapy for rosacea.
January 1, 2006... Abstract This article will examine oral therapies utilized in the treatment of rosacea. Important topics include recognizing which types of rosacea can benefit from oral therapy and concerns regarding the emergence of bacterial resistance....

Topical therapies for rosacea.
January 1, 2006... Abstract Therapeutic options for rosacea include topical agents, oral therapies, laser and light treatments, and surgical procedures. Topical therapies play a critical role in the treatment of patients with papulopustular rosacea and...

Treatment of rosacea with herbal ingredients.
January 1, 2006... Abstract Since rosacea is a chronic disease and many patients find prescription therapies unsatisfactory, they frequently turn to herbal ingredients for relief of their persistent facial redness. The most useful and frequently used herbal...

Laser and light therapies for acne rosacea.
January 1, 2006... Abstract Acne rosacea is a multifactorial, somewhat mercurial disorder that can be a challenge to control with standard pharmacologic agents. Laser and light sources have been increasingly utilized, particularly for control of the...

Pattern of development of basal versus squamous cell carcinoma.
January 1, 2006... Abstract Background: Basal cell and squamous cell carcinomas both arise in the epidermis of fair-skinned people in response to ultraviolet light, with the overall frequency of basal cell carcinoma being 4 times that of squamous cell...

Long-pulsed dye laser-mediated photodynamic therapy combined with topical therapy for mild to severe comedonal, inflammatory, or cystic acne.
January 1, 2006... Abstract Background: Acne patients who fail to respond to conventional treatments have been treated with isotretinoin, an effective treatment coming under strict regulation due to the risk of significant side effects. Photodynamic therapy...

Treatment of dysplastic nevi with 5% imiquimod cream, a pilot study.
January 1, 2006... Abstract Objective: To assess the clinical and histologic effects of topical imiquimod therapy on dysplastic nevi, and to determine the feasibility of using in vivo confocal microscopy (CSLM) to non-invasively monitor histological response...

Rebound of psoriasis during treatment with efalizumab.(CASE REPORTS)
January 1, 2006... Abstract Recently, the biologics have emerged as a new class of drugs for systemic therapy of psoriasis with efalizumab (Raptiva[R]) being one of the most recently FDA-approved agents. We report a case of a 34-year-old Caucasian male who...

Bullous reaction to topical methchlorethamine in mycosis fungoides.(CASE REPORTS)
January 1, 2006... Abstract We describe a patient with mycosis fungoides who developed a bulla shortly after the start of topical methchlorethamine. Dermal-epidermal separation has been reported to occur with topical methchlorethamine on histological...

Plantar verrucous carcinoma treated with Mohs micrographic surgery: a case report and literature review.(CASE REPORTS)
January 1, 2006... Abstract Background: Verrucous carcinoma of the foot is a slow-growing tumor that is capable of causing vast local destruction. It is a rare tumor and is frequently misdiagnosed as a plantar wart. Objective: To describe a patient with...

Tinea versicolor clearance with oral isotretinoin therapy.(CASE REPORTS)
January 1, 2006... Abstract We describe the incidental clearance of preexisting tinea versicolor skin infection with the treatment of oral isotretinoin therapy for acne vulgaris. Case Report A 14-year-old Middle Eastern male presented to our clinic...

Lamotrigine-induced erythema multiforme mimicking contact dermatitis.(CASE REPORTS)
January 1, 2006... Abstract Erythema multiforme is an acute, hypersensitivity reaction of the skin often secondary to medications. Lamotrigine is a relatively new anticonvulsant medication approved for seizure and psychiatric disorders. Although the overall...

Exogenous ochronosis.(CASE REPORTS)
January 1, 2006... Abstract We describe a case of a 70-year-old woman who had been using a skin-lightening cream containing hydroquinone for a previous diagnosis of melasma. She presented a hyperpigmentation predominantly on her cheeks and eyebrows. The...

Improved visibility for the Skin Cancer Foundation.(SKIN CANCER FOUNDATION UPDATE)
January 1, 2006... The Foundation recently completed a re-branding initiative to update the look and feel of the organization. The friendlier, more modern graphic identity reflects the idea that sun protection is a lifestyle issue; people view the sun as a...

Fighting the good fight.(SKIN CANCER FOUNDATION UPDATE)
January 1, 2006... At age 34, New Jersey native Wendy Zocks lived the good life in LA. She ran her own public relations firm and loved the sun-fun West Coast culture. She was healthy, single, and fancy-free. Then in February 2001, family and friends convinced...

Skin Sense Award Gala.(SKIN CANCER FOUNDATION UPDATE)
January 1, 2006... The Skin Cancer Foundation held its annual Skin Sense Award Gala on October 11, 2005 at the Pierre Hotel in New York City. Hosted by 20/20's Deborah Roberts, the event raised $625,000. All proceeds will help to expand the Skin Cancer...

New and emerging treatments for acne and photoaging.(LASER AND COSMETIC NEWS)
January 1, 2006... At this year's annual meeting of the American Society for Dermatologic Surgery, which took place in Atlanta, Georgia on October 27-30, 2005, investigators provided new insights into the treatment of the common conditions of acne and photoaging....

A randomized trial of topical 5% 5-fluorouracil (Efudix[R], cream) in the treatment of actinic keratoses comparing daily with weekly treatment.(WASHINGTON WHISPERS)
January 1, 2006... A Randomized Trial of Topical 5% 5-Fluorouracil (Efudix[R], Cream) in the Treatment of Actinic Keratoses Comparing Daily with Weekly Treatment Jury CS, et al. British Journal of Dermatology. 2005;153:808-810. Summary The authors...

Pulse versus continuous terbinafine for onychomycosis: a randomized, double-blind, controlled trial.(WASHINGTON WHISPERS)
January 1, 2006... Pulse versus Continuous Terbinafine for Onychomycosis: A Randomized, Double-Blind, Controlled Trial Warshaw EM, et al. Journal of the American Academy of Dermatology. 2005;53(4): 578-584. Summary The authors present a randomized,...

A randomized, double-blind, placebo-controlled trial of the combined effect of doxycycline hyclate 20-mg tablets and metronidazole 0.75% topical lotion in the treatment of rosacea.(WASHINGTON WHISPERS)
January 1, 2006... A Randomized, Double-Blind, Placebo-Controlled Trial of the Combined Effect of Doxycycline Hyclate 20-mg Tablets and Metronidazole 0.75% Topical Lotion in the Treatment of Rosacea Sanchez J, et al. Journal of the American Academy of...

Low-dose efficacy of botulinum toxin A for axillary hyperhidrosis. A randomized, side-by-side, open-label study.(WASHINGTON WHISPERS)
January 1, 2006... Low-Dose Efficacy of Botulinum Toxin A for Axillary Hyperhidrosis. A Randomized, Side-by-Side, Open-Label Study Heckmann M, et al. Archives of Dermatology. 2005;141:1255-1259. Summary The authors present a randomized, side-by-side,...

Dusa acne treatment.(PIPELINE PREVIEWS)
January 1, 2006... Dusa Pharmaceuticals, Inc., reported that 14/15 patients treated with Levulan followed by pulsed dye laser had complete clearance of their facial acne for a mean duration of 6.4 months. One patient dropped out of the study prior to completion....

Antigenics initiates Phase I clinical trial of AG-707 therapeutic vaccine for genital herpes.(PIPELINE PREVIEWS)
January 1, 2006... Antigenics, Inc., announced the initiation of a Phase I multicenter study to evaluate the safety and immune response of AG-707, a vaccine designed to combat herpes simplex virus type 2 (HSV-2) infections. AG-707 is a recombinant heat shock...

New study demonstrates importance of Elidel in steroid allergic or intolerant patients.(PIPELINE PREVIEWS)
January 1, 2006... A recent randomized, double-blinded vehicle-controlled study demonstrated the importance of Elidel cream for the treatment of facial eczema in patients allergic to or intolerant of topical corticosteroids. The study enrolled 200 patients with...

Oral Zyvox more cost-effective than vancomycin in treatment of skin infections.(PIPELINE PREVIEWS)
January 1, 2006... A recent retrospective analysis comparing costs between treatments with oral Zyvox versus intravenous vancomycin for certain infections, of which 48% were complicated skin infections, demonstrated that treatment with oral Zyvox was more...

CollaGenex starts Phase II Incyclinide trial for acne.(PIPELINE PREVIEWS)
January 1, 2006... CollaGenex announced that it has started a Phase 2 double-blinded, placebo-controlled trial to evaluate the safety and efficacy of Incyclinide, a chemically modified tetracycline, for the treatment of moderate to severe acne. The trial will...

Adolor to start Phase 2 trial for sterile lidocaine patch.(PIPELINE PREVIEWS)
January 1, 2006... Adolor Corporation has started a Phase 2 trial to evaluate the safety and efficacy of its sterile lidocaine patch for post-surgical incision pain. The study is a multicenter randomized double-blind placebo-controlled trial in which 30 patients...

Promising Phase 2 data for oral Rambazole in acne treatment.(PIPELINE PREVIEWS)
January 1, 2006... Barrier Therapeutics, Inc., recently announced positive Phase 2a data for oral Rambazole in the treatment of moderate to severe acne and positive biological activity for topical Rambazole. Rambazole is a novel retinoic acid metabolism-blocking...

HelixBioPharma to conduct trial in Sweden for condyloma acuminata.(PIPELINE PREVIEWS)
January 1, 2006... HelixBioPharma has received approval to conduct a Phase 2 clinical trial of topical interferon alpha-2b for the treatment of condyloma acuminate in patients who are positive for infection with human papilloma virus. The trial will be a...

FDA approves MimyX cream for the treatment of atopic dermatitis.(PIPELINE PREVIEWS)
January 1, 2006... The FDA recently approved Stiefel Laboratories' MimyX cream for the treatment of atopic dermatitis. Unlike traditional topical treatments for atopic dermatitis which target the inflammatory pathway, MimyX cream works by restoring the natural...

Remicade approved in Europe for plaque psoriasis.(PIPELINE PREVIEWS)
January 1, 2006... Centocor, Inc., and Schering-Plough recently announced the approval of Remicade, their chimeric monoclonal antibody to TNF-alpha, for the treatment of moderate to severe plaque psoriasis by the European Union. Remicade was approved for use in...

FDA approves Humira for psoriatic arthritis.(PIPELINE PREVIEWS)
January 1, 2006... The FDA recently approved Humira (adalimumab), a fully humanized monoclonal antibody targeted against TNF-alpha, for the treatment of psoriatic arthritis. Humira is already approved for the treatment of rheumatoid arthritis. FDA approval was...

FDA to review New Drug Application for Oracea.(PIPELINE PREVIEWS)
January 1, 2006... CollaGenex Pharmaceuticals, Inc., announced that the FDA has accepted to review its New Drug Application for Oracea, an oral tetracycline medication developed to treat rosacea. The New Drug Application data was primarily based on two Phase 3...

Taro receives approval for generic bactroban ointment.(PIPELINE PREVIEWS)
January 1, 2006... Taro Pharmaceutical Industries, Ltd., received FDA approval to market mupirocin, a generic version of GlaxoSmithKline's bactroban ointment. This ointment is commonly used to treat mild skin infections due to staphylococcus aureus.

Fougera receives tentative approval for generic metronidazole topical gel 0.75%.(PIPELINE PREVIEWS)
January 1, 2006... Fougera has received tentative FDA approval to develop the first generic version of metronidazole topical gel 0.75%. Galderma's patent on the branded product expires on June 6, 2006. Metronidazole gel is approved for the treatment of rosacea.

Generic Aclovate approved by FDA.(PIPELINE PREVIEWS)
January 1, 2006... Taro Pharmaceuticals Industries, Ltd., received FDA approval to develop and market aclometasone dipropionate cream 0.05%, the generic equivalent to GlaxoSmithKline's Aclovate cream. Taro already markets aclometasone dipropionate ointment.

Clobex spray approved by the FDA.(PIPELINE PREVIEWS)
January 1, 2006... Galderma Laboratories announced that the FDA recently approved Clobex spray (clobetasol propionate 0.05%) for the twice daily treatment of moderate to severe plaque psoriasis in patients over the age of 18. Clobex spray is the only superpotent...

Ceragenix submits 510(k) application to FDA for Epiceram, a skin barrier cream for treatment of eczema and other skin disorders.(PIPELINE PREVIEWS)
January 1, 2006... Ceragenix Pharmaceuticals, Inc. recently submitted a 510(k) application to the FDA for Epiceram, a topical cream developed to reduce pain and pruritus from atopic dermatitis, irritant contact dermatitis, radiation dermatitis, and xerotic skin...

Treatment of melasma with Jessner's solution vs trichloroacetic acid.(CLINICAL TRIAL REVIEW)
January 1, 2006... This study is currently recruiting patients. Sponsored by Emory University. The purpose of this study is determine if there is a difference in the effectiveness of chemical peels using Jessner's solution and trichloroacetic acid (TCA) in the...

Efficacy and tolerability of Solaraze for 3 months vs 6 months in patients with mild to moderate actinic keratosis.(CLINICAL TRIAL REVIEW)
January 1, 2006... This study is currently recruiting patients. Sponsored by University Hospital Tuebingen. The purpose of the study is to evaluate the efficacy and safety of the treatment of actinic keratosis with Solaraze applied twice a day in face and head...

Imatinib in dermatofibrosarcoma protuberans (DFSP).(CLINICAL TRIAL REVIEW)
January 1, 2006... This study is currently recruiting patients. Sponsored by Dermatologic Cooperative Oncology Group. The purpose of this study is to determine whether imatinib is effective in the treatment of primary and recurrent dermatofibrosarcoma protuberans...

Intralesional treatment with interleukin-2 (proleukin) in soft tissue melanoma metastases.(CLINICAL TRIAL REVIEW)
January 1, 2006... This study is currently recruiting patients. Sponsored by University Hospital Tuebingen. In this study the safety and efficacy of IL-2 are evaluated. Condition Intervention Phase Melanoma Drug:...

Safety and efficacy study of ICXP007 with compression bandaging for the treatment of non-infected venous leg ulcers.(CLINICAL TRIAL REVIEW)
January 1, 2006... This study is currently recruiting patients. Sponsored by Intercytex. The main purpose of the study is to compare treatment of non-infected venous leg ulcers using ICXP007 combined with 4-layer compression bandaging, placebo combined with...

Classification and characterization of patients treated with efalizumab for plaque psoriasis.(CLINICAL TRIAL REVIEW)
January 1, 2006... This study is currently recruiting patients. Sponsors and Collaborators: Norwegian University of Science and Technology Serono. The main objectives of the project are to classify patients suffering from plaque psoriasis responding on a given...

Study to determine the maximum tolerated dose and safety of PEP005 Topical Gel.(CLINICAL TRIAL REVIEW)
January 1, 2006... This study is currently recruiting patients. Sponsored by Peplin. The purpose of this study is to determine the maximum tolerated dose (MTD) for PEP005 Topical Gel in patients with actinic keratoses, evaluate patients for clinical safety, and...

A Phase II, randomized study of ACZONE[TM] (dapsone) gel, 5% for papulopustular rosacea.(CLINICAL TRIAL REVIEW)
January 1, 2006... This study is currently recruiting patients. Sponsored by QLT Inc. The purpose of this study is to evaluate the safety and effectiveness of ACZONE gel compared to placebo (inactive substance), MetroGel[R] and a combination of ACZONE gel and...

Phase IV study to gather more information about the safety of ACZONE Gel, 5% in treating subjects with acne who have G6PD deficiency.(CLINICAL TRIAL REVIEW)
January 1, 2006... This study is currently recruiting patients. Sponsored by QLT Inc. The purpose of this study is to gather more information about the safety of ACZONE Gel, 5% in treating subjects with acne who have certain blood disorders. Condition ...

Efficacy of Elidel cream on erosive oral lichen planus.(CLINICAL TRIAL REVIEW)
January 1, 2006... This study is currently recruiting patients. Sponsored by University Hospital Tuebingen. The purpose of this study is to investigate whether topical applied pimecrolimus will lead to improvement of erosive oral lichen planus. This effect will...

Efficacy of calcipotriol plus betamethasone gel versus calcipotriol scalp solution in scalp psoriasis.(CLINICAL TRIAL REVIEW)
January 1, 2006... This study is currently recruiting patients. Sponsored by LEO Pharma. The purpose of this study is to evaluate whether once daily treatment for up to 8 weeks of calcipotriol plus betamethasone dipropionate gel is more effective than twice daily...

Efficacy and safety of calcipotriol plus betamethasone dipropionate ointment in patients with psoriasis vulgaris.(CLINICAL TRIAL REVIEW)
January 1, 2006... This study is currently recruiting patients. Sponsored by LEO Pharma. This study will evaluate the efficacy and safety of calcipotriol plus betamethasone dipropionate ointment compared with calcipotriol ointment in the treatment of patients...

Topical NF-kappa [beta] decoy in the treatment of atopic dermatitis.(CLINICAL TRIAL REVIEW)
January 1, 2006... This study is currently recruiting patients. Sponsored by Corgentech. The purpose of this study is to determine whether this topical NF-kappa [beta] decoy candidate is safe in persons with atopic dermatitis. Preliminary evidence of efficacy...

Pegylated interferon-alpha-2a in patients with malignant melanoma stage IIA-IIIB.(CLINICAL TRIAL REVIEW)
January 1, 2006... This study is currently recruiting patients. Sponsors and Collaborators: University Hospital Tuebingen Dermatologic Cooperative Oncology Group. The purpose of this study is to evaluate the efficacy and safety of adjuvant treatment with...

Ultraviolet B (UVB) light therapy in the treatment of skin conditions with altered dermal matrix.(CLINICAL TRIAL REVIEW)
January 1, 2006... This study is currently recruiting patients. Sponsored by University of Michigan. This research study will evaluate the effectiveness of high dose UVB light therapy in the treatment of keloid (or hypertrophic scar), scleroderma, acne keloidalis...

Study to determine the safety of two applications of PEP005 topical gel to nodular basal cell carcinoma.(CLINICAL TRIAL REVIEW)
January 1, 2006... This study is currently recruiting patients. Sponsored by Peplin. The purpose of this study is to determine whether topical application of PEP005 is safe for the treatment of nodular basal cell carcinoma. Condition Intervention Phase ...

Etanercept for treatment of hidradenitis.(CLINICAL TRIAL REVIEW)
January 1, 2006... This study is currently recruiting patients. Sponsored by University of Pennsylvania. The purpose of this study is to determine whether etanercept is safe and effective for the treatment of hidradenitis. Another purpose of this study is to...

A study of the use of methotrexate in the treatment of chronic idiopathic urticaria.(CLINICAL TRIAL REVIEW)
January 1, 2006... This study is currently recruiting patients. Sponsored by Barnsley Hospital. The purpose of this study is to determine whether methotrexate produces significant improvement in chronic idiopathic urticaria, compared with placebo. Condition...

The effect of 0.5% roxithromycin lotion for androgenetic alopecia.(CLINICAL TRIAL REVIEW)
January 1, 2006... This study is currently recruiting patients. Sponsored by Hamamatsu University. The purpose of this study is exploiting the new drugs for androgenetic alopecia because there are still no effective and safe topical drug for androgenetic...

Standard high-dose alpha interferon vs intermittent high-dose alpha interferon.(CLINICAL TRIAL REVIEW)
January 1, 2006... This study is currently recruiting patients. Sponsored by Dermatologic Cooperative Oncology Group. The study protocol is being conducted to compare intermittent high-dose i.v. administration of interferon alpha-2b with the standard high-dose...

Efficacy study of latanoprost and bimatoprost solutions in promoting eyelash growth in patients with alopecia areata.(CLINICAL TRIAL REVIEW)
January 1, 2006... This study is currently recruiting patients. Sponsored by University of California, San Francisco. This is a single center, randomized, investigator-masked study to determine the efficacy and safety of latanoprost and bimatoprost ophthalmic...

Study of ONTAK (denileukin diftitox) in cutaneous T-cell lymphoma (CTCL) patients.(CLINICAL TRIAL REVIEW)
January 1, 2006... This study is currently recruiting patients. Sponsored by Ligand Pharmaceuticals. The purpose of this study is to compare the effectiveness of 2 dose levels of ONTAK (denileukin diftitox) in treating patients who have recurrent or persistent...