Journal of Drugs in Dermatology articles from February 2006

Journal of Drugs in Dermatology archives from February 2006

Safety update on commonly used psychotropic medications in dermatology.
February 1, 2006... Abstract It is the experience of dermatologists worldwide that a significant proportion of their patient population has underlying psychological components to their dermatologic complaints. Since these patients are often reluctant to see a...

Part 1 of a 2 part article: a comprehensive review of imatinib mesylate (Gleevec) for dermatological diseases.
February 1, 2006... Abstract Imatinib mesylate (Gleevec, also known as STI-571), is an approved oral treatment for patients with chronic myeloid leukemia (CML). It blocks the activity of Abelson cytoplasmic tyrosine kinase (ABL), c-Kit and the...

The position not the presence of the halogen in corticosteroids influences potency and side effects.
February 1, 2006... Abstract Many topical corticosteroids currently on the market contain a halogen substitution at the [C.sub.6], [C.sub.9], or the side-chain [C.sub.21] position of the corticosteroid skeleton. These modifications have enhanced the efficacy...

One-week treatment with 0.5% fluorouracil cream prior to cryosurgery in patients with actinic keratoses: a double-blind, vehicle-controlled, long-term study.
February 1, 2006... Abstract Topical fluorouracil is currently approved for the treatment of actinic keratosis (AK) and is often used prior to or following cryosurgery as interval therapy in patients with severe AK lesions. No randomized, controlled studies...

The use of photodynamic therapy in dermatology: results of a consensus conference.
February 1, 2006... Abstract Photodynamic therapy (PDT) has significant promise in improving outcomes of patients with a variety of cutaneous conditions. A group of experts met to review the principles, indications, and clinical benefits of PDT with...

Bilateral comparison of the efficacy and tolerability of 3% diclofenac sodium gel and 5% 5-fluorouracil cream in the treatment of actinic keratoses of the face and scalp.
February 1, 2006... Abstract Actinic keratoses (AKs) are a common precancerous condition and are said to account for 14% of visits to dermatologists in the US each year. Along with cryotherapy, topical treatments are a mainstay of therapy for these lesions....

The clinical impact of vehicle technology using a patented formulation of benzoyl peroxide 5%/clindamycin 1% gel: comparative assessments of skin tolerability and evaluation of combination use with a topical retinoid.
February 1, 2006... Abstract A major challenge encountered in clinical practice in patients with acne vulgaris is irritation related to topical medications used for treatment. Advances in vehicle technology have improved formulations containing active...

Mechanisms of action of new treatment modalities for actinic keratosis.
February 1, 2006... Abstract Actinic keratosis (AK) constitutes the initial lesion in a disease continuum that can progress to invasive squamous cell carcinoma (SCC). In this article, we describe the mechanisms of action, tolerability, and efficacy of the...

An unusual presentation of refractory cutaneous Langerhans cell histiocytosis in an adult.(CASE REPORTS)
February 1, 2006... Abstract Primary cutaneous adult-onset Langerhans cell histiocytosis is a rare disorder typically characterized by a diffuse papular rash accentuated in a seborrheic distribution. We present a unique case of large plaques and nodules in a...

Infliximab associated new-onset psoriasis.(CASE REPORTS)
February 1, 2006... Abstract Infliximab infusion is not yet FDA-approved for psoriasis but has been reported to be very effective for plaque psoriasis. We report 2 patients without a history of psoriasis who after administration of infliximab for their...

Rapid growth of Merkel cell carcinoma after treatment with rituximab.(CASE REPORTS)
February 1, 2006... Abstract Merkel cell carcinoma is an uncommon neuroendocrine carcinoma of the skin. We report a case of rapid growth of Merkel cell carcinoma after treatment with rituximab, a new anti-CD20 monoclonal antibody, for acquired factor VIII...

The incidence of recurrent herpes simplex and herpes zoster infection during treatment with arsenic trioxide.(CASE REPORTS)
February 1, 2006... Abstract We report the incidence of varicella zoster virus (VZV) and herpes simplex virus (HSV) infection in patients with multiple myeloma and colon cancer who were treated with arsenic trioxide for their disease. In this report, we...

Paraffinomas of the facial area: treatment with systemic and intralesional steroids.(CASE REPORTS)
February 1, 2006... Abstract We present a case of a 32-year-old male patient with a history HIV infection, who administered vitamin E and almond oil into the malar region and chin. On histology the main pathological finding was a foreign body granulomatous...

Poiklodermatous variant of mycosis fungoides.(CASE REPORTS)
February 1, 2006... Abstract Mycosis Fungoides (MF) is a T-cell lymphoma initially presenting in the skin. Many clinical variants exist including follicular, vesicular, poikilodermic, hypo- and hyperpigmented, ichthyosiform and pigmented purpura-like lesions....

Indoor tanning--magnitude of the health issue.(SKIN CANCER FOUNDATION UPDATE)
February 1, 2006... Commercial indoor tanning is unfortunately one of the fastest growing industries in the United States, with sales surpassing $5-7 billion. (1) Reports indicate that between 1986 and 1996 there was a three-fold increase in the percentage of...

Interferon alpha 2b vs. observation in patients with stage IIb/III melanoma.(WASHINGTON WHISPERS)
February 1, 2006... Interferon alpha 2b vs. Observation in Patients with Stage IIb/III Melanoma Eggermont AM, et al. Lancet. 2005;366:1189-1196 Summary The authors present a randomized controlled multicenter trial to evaluate the utility of adjuvant...

Possible mechanisms of how tacrolimus ointment induces repigmentation in patients with vitiligo.(WASHINGTON WHISPERS)
February 1, 2006... Possible Mechanisms of How Tacrolimus Ointment Induces Repigmentation in Patients with Vitiligo Lan CC, et al. Br J Dermatol. 2005;153:498-505. Summary The authors report their findings from in vitro studies of cultured...

Infliximab induction and maintenance therapy for moderate-to-severe psoriasis: a phase III, multicenter, double-blind trial.(WASHINGTON WHISPERS)
February 1, 2006... Infliximab Induction and Maintenance Therapy for Moderate-to-Severe Psoriasis: A Phase III, Multicenter, Double-Blind Trial Reich K, et al. Lancet. 2005;366:1367-1374. Summary The authors present a multicenter, double-blind,...

Lannett Company receives approval for doxycycline monohydrate.(PIPELINE PREVIEWS)
February 1, 2006... Lannett Company, Inc., recently announced that the FDA has approved its Abbreviated New Drug Application for doxycycline monohydrate 50 mg and 100 mg tablets. This product represents a generic version of Doak Dermatologics' Adoxa tablets. This...

Sebazole NDA submitted to FDA.(PIPELINE PREVIEWS)
February 1, 2006... Barrier Therapeutics, Inc.'s New Drug Application for Sebazole, a non-aqueous ketoconazole 2% gel developed for the treatment of seborrheic dermatitis has been accepted for filing by the FDA. The NDA, which was submitted in September 2005, was...

INVANZ approved for complicated foot infection in diabetic patients.(PIPELINE PREVIEWS)
February 1, 2006... Merck & Co., Inc., recently announced that the FDA has approved INVANZ (ertapenem), a once-daily injectable antibiotic, for the treatment of moderate to severe complicated foot infection without osteomyelitis in diabetic patients. INVANZ is a...

Generic azithromycin approved by the FDA.(PIPELINE PREVIEWS)
February 1, 2006... Teva Pharmaceuticals, Inc., has received FDA approval to manufacture generic versions of Pfizer Inc.'s Zithromax. Pfizer is also planning to provide generic versions of Zithromax through its Greenstone Unit.

Zostavax receives favorable reviews from FDA.(PIPELINE PREVIEWS)
February 1, 2006... Merck and Co., Inc., recently announced that the FDA's Vaccines and Related Biological Products Advisory Committee, after reviewing extensive data including the results of the Phase III Shingles Prevention Trial conducted in 38,500 adults,...

Dyax and Genzyme initiate phase III trial of DX-88 for the treatment of hereditary angioedema.(PIPELINE PREVIEWS)
February 1, 2006... Dyax and Genzyme Corporations recently announced the initiation of Phase 3 trials of DX-88, a recombinant plasma kallikrein inhibitor, for the treatment of patients with hereditary angioedema. Patients with hereditary angioedema suffer from...

New class of antibiotic appears promising in the treatment of skin infections.(PIPELINE PREVIEWS)
February 1, 2006... Retapamulin, an antibacterial medication that is part of a new class of antibiotics known as pleuromutilins, demonstrates promising in vitro antimicrobial activity against common skin pathogens Staphylococcal aureus and Streptococcus pyogenes....

HPV vaccines extremely promising in preventing cervical cancer.(PIPELINE PREVIEWS)
February 1, 2006... Recent Phase 3 clinical trial data of Gardasil, a quadrivalent HPV vaccine targeted against HPV type 6, 11, 16, and 18, demonstrated that after 2 years follow-up, none of the patients enrolled in the trial developed cervical intraepithelial...

Schools in Pharmacology.
February 1, 2006... Schools in Pharmacology is a new feature in that will appear periodically. It will explicate the dermatologic uses and side effects of new medications and devices. It follows medications mentioned in the Pipeline Previews into their approval...

Imiquimod 5% cream in plaque-type morphea: a pilot, prospective open-label study.(CLINICAL TRIAL REVIEW)
February 1, 2006... This study is currently recruiting patients. Sponsors and Collaborators: University of Alberta. One morphea plaque will be treated with topical imiquimod 5% cream, and another morphea lesion with vehicle cream. Patients will be asked about side...

Intralesional treatment with interleukin-2 (proleukin) in soft tissue melanom metastases.(CLINICAL TRIAL REVIEW)
February 1, 2006... This study is currently recruiting patients. Sponsored by: University Hospital Tuebingen. In this study the safety and efficacy of IL-2 are evaluated. Condition Intervention Phase Melanoma Drug: Interleukin-2 (Proleukin)...

Effect of Sacchachitin on healing of a chronic wound.(CLINICAL TRIAL REVIEW)
February 1, 2006... This study is currently recruiting patients. Sponsored by: MinSheng General Hospital. In this study, the effects of the Sacchachitin gel, prepared from the waste residue of the fruiting body of Ganoderma tsugae, on the activity of matrix...

Bevacizumab to treat Kaposi's sarcoma in HIV-positive and HIV-negative patients.(CLINICAL TRIAL REVIEW)
February 1, 2006... This study is currently recruiting patients. Sponsored by: National Cancer Institute (NCI). This study will examine the safety and effectiveness of the experimental drug bevacizumab for treating both non-AIDS and AIDS-associated Kaposi's...

Study to evaluate the Leish-111F + MPL-SE vaccine in the treatment of cutaneous leishmaniasis.(CLINICAL TRIAL REVIEW)
February 1, 2006... This study is currently recruiting patients. Sponsors and Collaborators: Infectious Disease Research Institute, Bill and Melinda Gates Foundation. This study will evaluate the safety of the Leish-111f + MPL-SE vaccine in adult patients with...

Efficacy and safety of efalizumab in the treatment of moderate-severe hydradenitis suppurativa.(CLINICAL TRIAL REVIEW)
February 1, 2006... This study is currently recruiting patients. Sponsors and Collaborators: New York University School of Medicine, Genentech. The purpose of this study is to determine the effectiveness and safety of efalizumab in treating hydradenitis...

Leptin to treat lipodystrophy.(CLINICAL TRIAL REVIEW)
February 1, 2006... This study is currently recruiting patients. Sponsored by: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). This study will evaluate the safety and effectiveness of leptin replacement therapy in patients with...

Non-cutting laser therapy in the treatment of acne.(CLINICAL TRIAL REVIEW)
February 1, 2006... This study is currently recruiting patients. Sponsored by: University of Michigan. The purpose of this research project is to study the effect of non-ablative (non-cutting) laser therapy, a technique that uses laser energy to try to improve the...

Treatment of melasma with Jessner's solution vs. trichloroacetic acid.(CLINICAL TRIAL REVIEW)
February 1, 2006... This study is currently recruiting patients. Sponsored by: Emory University. The purpose of this study is determine if there is a difference in the effectiveness between Chemical peels using Jessner's solution and trichloroacetic acid (TCA) in...

Open-label safety study to evaluate imiquimod cream, 5% for large areas of actinic keratosis.(CLINICAL TRIAL REVIEW)
February 1, 2006... This study is currently recruiting patients. Sponsored by: 3M Pharmaceuticals. The purpose of this study is to evaluate the safety of one, two, or three cycles of imiquimod for the treatment of AK. The AK lesions treated can be in adjacent and...

Topical NF-kappa [beta] Decoy in the treatment of atopic dermatitis.(CLINICAL TRIAL REVIEW)
February 1, 2006... This study is currently recruiting patients. Sponsored by: Corgentech. The purpose of this study is to determine whether this topical NF-kappa [beta] Decoy candidate is safe in persons with atopic dermatitis. Preliminary evidence of efficacy...

Infliximab (remicade) to treat dermatomyositis and polymyositis.(CLINICAL TRIAL REVIEW)
February 1, 2006... This study is currently recruiting patients. Sponsored by: National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS). This study will examine whether infliximab is safe and effective for the treatment of dermatomyositis and...

Safety and efficacy study of ICXP007 with compression bandaging for the treatment of non-infected venous leg ulcers.(CLINICAL TRIAL REVIEW)
February 1, 2006... This study is currently recruiting patients. Sponsored by: Intercytex. The main purpose of the study is to compare treatment of non-infected venous leg ulcers using ICXP007 combined with 4-layer compression bandaging, placebo combined with...

The effect of Efudex treatment on photoaged skin.(CLINICAL TRIAL REVIEW)
February 1, 2006... This study is currently recruiting patients. Sponsors and Collaborators: University of Michigan, Valeant Pharmaceuticals International. The researchers propose that skin improvements may be seen following a course of Efudex, (5-fluorouracil), a...

Acyclovir HSV skin, eye, and mouth.(CLINICAL TRIAL REVIEW)
February 1, 2006... This study is currently recruiting patients. Sponsored by: National Institute of Allergy and Infectious Diseases (NIAID). The purpose of this study is to test whether long-term treatment with oral acyclovir improves the outcome for infants with...

Ultraviolet B (UVB) light therapy in the treatment of skin conditions with altered dermal matrix.(CLINICAL TRIAL REVIEW)
February 1, 2006... This study is currently recruiting patients. Sponsored by: University of Michigan. This research study will evaluate the effectiveness of high-dose UVB light therapy in the treatment of keloid (or hypertrophic scar), scleroderma, acne...

Intralesional PV-10 chemoablation of metastatic melanoma.(CLINICAL TRIAL REVIEW)
February 1, 2006... This study is currently recruiting patients. Sponsored by: Provectus Pharmaceuticals. The objective of this study is to investigate the safety of intralesional (IL) PV-10 for the treatment of metastatic melanoma. This study will also include a...

Evaluation of the clinical effectiveness of a Collagen-ORC Antimicrobial matrix in full-thickness, neuropathic diabetic foot ulcers.(CLINICAL TRIAL REVIEW)
February 1, 2006... This study is currently recruiting patients. Sponsored by: Ethicon, Inc. This is a randomized (1:1), prospective, open label, multicenter, comparative study to examine the effectiveness of Collagen-ORC Antimicrobial matrix, a new wound...

Neoadjuvant imatinib in dermatofibrosarcoma protuberans.(CLINICAL TRIAL REVIEW)
February 1, 2006... This study is currently recruiting patients. Sponsored by: Sarcoma Alliance for Research through Collaboration. The purpose of this study is to examine the effect of imatinib on dermatofibrosarcoma protuberans tumors. Condition ...

Terbinafine compared to griseofulvin in children with tinea capitis.(CLINICAL TRIAL REVIEW)
February 1, 2006... This study is currently recruiting patients. Sponsored by: Novartis. This study will evaluate the efficacy and safety of terbinafine in children with tinea capitis. Condition Intervention Phase Tinea Capitis Drug:...

TH9507 in patients with HIV-associated lipodystrophy.(CLINICAL TRIAL REVIEW)
February 1, 2006... This study is currently recruiting patients. Sponsored by: Theratechnologies. This study is aimed at further assessing the efficacy and safety of 2 mg TH9507 in a larger population of HIV patients treated with ART and experiencing an excess of...

Facial lipoatrophy trial.(CLINICAL TRIAL REVIEW)
February 1, 2006... This study is currently recruiting patients. Sponsors and Collaborators: The National centre in HIV Epidemiology and Clinical Research, The University of New South Wales. Condition Intervention Phase HIV-Associated...

Effect of anti-IgE in chronic urticaria.(CLINICAL TRIAL REVIEW)
February 1, 2006... This study is currently recruiting patients. Sponsors and Collaborators: Johns Hopkins University, Genentech. This study is being done to find out if a drug called Xolair (omalizumab), an anti-IgE antibody, is safe and effective for people with...

Efficacy of elidel cream on erosive oral lichen planus.(CLINICAL TRIAL REVIEW)
February 1, 2006... This study is currently recruiting patients. Sponsored by: University Hospital Tuebingen. The purpose of this study is to investigate whether topical applied pimecrolimus will lead to improvement of erosive oral lichen planus. This effect will...

Safety and effectiveness of efalizumab to treat oral lichen planus.(CLINICAL TRIAL REVIEW)
February 1, 2006... This study is currently recruiting patients. Sponsors and Collaborators: Washington University School of Medicine, Genentech. This study is to determine whether efalizumab 1.0 mg/kg given by subcutaneous injection for 12 weeks is effective in...

Etanercept with tacrolimus for psoriasis.(CLINICAL TRIAL REVIEW)
February 1, 2006... This study is currently recruiting patients. Sponsored by: University of Medicine and Dentistry New Jersey. The study is designed to evaluate the efficacy of etanercept 50 mg subcutaneously (SQ) weekly plus tacrolimus 0.1% topical ointment...

Study of reyataz in HIV-infected patients with lipodystrophy syndrome.(CLINICAL TRIAL REVIEW)
February 1, 2006... This study is currently recruiting patients. Sponsored by: BristolMyers Squibb. The purpose of this clinical research study is to learn if HIV-infected subjects with abdominal fat accumulation on their first or second highly active...

Acitretin and etanercept in psoriasis.(CLINICAL TRIAL REVIEW)
February 1, 2006... This study is currently recruiting patients, Sponsored by: Bristol-Myers Squibb. The purpose of this clinical research study is to learn if HIV-infected subjects with abdominal fat accumulation on their first or second highly active...

Study evaluating etanercept and methotrexate in plaque psoriasis.(CLINICAL TRIAL REVIEW)
February 1, 2006... This study is currently recruiting patients. Sponsored by Wyeth. The purpose of this study is to evaluate the efficacy to clear or almost clear the plaques in plaque psoriasis patients, treated with the combination etanercept and methotrexate...

Interferon-alpha 2a vs. cyclosporin a for severe ocular Behcet's disease (INCYTOB).(CLINICAL TRIAL REVIEW)
February 1, 2006... This study is currently recruiting patients. Sponsored by: University Hospital Tuebingen. The purpose of this study is to investigate if interferon-alpha 2a is superior to the standard treatment with cyclosporin A for the treatment of severe...

A study of the use of methotrexate in the treatment of chronic idiopathic urticaria.(CLINICAL TRIAL REVIEW)
February 1, 2006... This study is currently recruiting patients. Sponsors and Collaborators: Barnsley Hospital. The purpose of this study is to determine whether methotrexate produces significant improvement in chronic idiopathic urticaria, compared with placebo....

Efficacy and safety of adalimumab in subjects with moderate to severe chronic plaque psoriasis.(CLINICAL TRIAL REVIEW)
February 1, 2006... This study is currently recruiting patients. Sponsored by: Abbott Laboratories. The purpose of the study is to assess the long-term safety of adalimumab in subjects with moderate to severe chronic plaque psoriasis. Condition Intervention ...

Curcuminoids for the treatment of chronic psoriasis vulgaris.(CLINICAL TRIAL REVIEW)
February 1, 2006... This study is currently recruiting patients. Sponsored by: University of Pennsylvania. The volatile of oils (called curcuminoids) of the turmeric root, however, have anti-inflammatory actions which make them promising candidates for the...

Study of the efficacy, safety and tolerability of oral CEP-701 in patients with severe psoriasis.(CLINICAL TRIAL REVIEW)
February 1, 2006... This study is currently recruiting patients. Sponsored by: Cephalon. A 12-week, exploratory, open-label, non-randomized, dose-escalation study of the efficacy, safety and tolerability of oral CEP-701 in patients with severe, recalcitrant,...

hOKT3gamma1 (Ala-Ala) for the treatment of psoriatic arthritis.(CLINICAL TRIAL REVIEW)
February 1, 2006... This study is currently recruiting patients. Sponsors and Collaborators: National Institute of Allergy and Infectious Diseases (NIAID), Immune Tolerance Network. The purpose of this study is determine whether hOKT3gammal (Ala-Ala) is safe and...

Efficacy of calcipotriol plus betamethasone gel vs. calcipotriol scalp solution in scalp psoriasis.(CLINICAL TRIAL REVIEW)
February 1, 2006... This study is currently recruiting patients. Sponsored by: LEO Pharma. The purpose of this study is to evaluate whether once daily treatment for up to 8 weeks of calcipotriol plus betamethasone dipropionate gel is more effective than twice...

Introduction.
February 1, 2006... For the general dermatologist, implementing photodynamic therapy (PDT) with 5-aminolevulinic acid (ALA) offers a key to new treatment programs in medical dermatology with an added bonus of cosmetic dermatology services. In my...

Broad area photodynamic therapy for treatment of multiple basal cell carcinomas in a patient with nevoid basal cell carcinoma syndrome.(CASE REPORTS)
February 1, 2006... Abstract We report a case of a 73-year-old man with nevoid basal cell carcinoma syndrome who was referred to us with multiple basal cell carcinomas on his face and chest. The patient underwent photodynamic therapy utilizing a 1-hour...

Photodynamic therapy for the treatment of erythema, papules, pustules, and severe flushing consistent with rosacea.(CASE REPORTS)
February 1, 2006... Abstract We report a case of a 45-year-old woman who presented with facial erythema, papules, pustules, and severe flushing consistent with rosacea. The patient had failed standard pharmacologic treatments. The patient's flushing was so...

Treatment of hyperpigmentation-melasma with photodynamic therapy.(CASE REPORTS)
February 1, 2006... Abstract Hyperpigmentation-melasma was treated in a 31-year-old female with the application of aminolevulinic acid HCL 20%-single use Levulan[R] Kerastick[R] followed by exposure to 10 J/[cm.sup.2] of nonlaser blue light. The results have...

Photodynamic therapy for perioral dermatitis.
February 1, 2006... Abstract Background: Treatment of perioral dermatitis (POD) consists of topical steroids, oral antibiotics, and topical antibiotics. Objective: To evaluate the safety and efficacy of photodynamic therapy (PDT) with topical...

Current treatments of actinic keratosis.
February 1, 2006... Abstract Actinic keratosis (AK) lesions should be treated because they may evolve into lesions clinically indistinguishable from those of invasive squamous cell carcinoma which require expensive therapy. Treatment options for AK include...