Journal of Drugs in Dermatology articles from August 2008

Journal of Drugs in Dermatology archives from August 2008

From the Editor-in-Chief.(EDITORIAL)(Editorial)
August 1, 2008... Six years ago, I started the Journal of Drugs in Dermatology (JDD) and I can tell you that it is an exciting time to be a part of this new journal. Already in 2008, the JDD has experienced unsurpassed growth and is making big strides towards...

From the Co-Editor-in-Chief.(Editorial)
August 1, 2008... Why one more journal? The answer is timeliness. Dermatology continues to develop novel therapies and treatments at a rapid pace. Dermatologists are particularly quick to adopt new therapies and need current information in order to assess the...

Doxycycline plus Levamisole: combination treatment for severe nodulocystic acne.(ORIGINAL ARTICLES)
August 1, 2008... ABSTRACT: Background: Levamisole is an agent without much potential use alone, but through immunomodulation, may synergistically improve the efficacy of other drugs like doxycycline in the treatment of acne vulgaris. Objective: The goal of...

Long-term safety of mycophenolate mofetil and cyclosporine: a review.(ORIGINAL ARTICLES)
August 1, 2008... ABSTRACT: The prevailing notion in dermatology is that mycophenolate mofetil (MMF) is safer than cyclosporine (CsA), but that CsA has greater efficacy. This literature review evaluates the available long-term safety data of MMF and CsA....

Prevalence of community-acquired methicillin-resistant Staphylococcus aureus in a private dermatology office.(ORIGINAL ARTICLES)
August 1, 2008... ABSTRACT: Background: The prevalence of community-acquired methicillin-resistant Staphlocococus aureus (CA-MRSA) skin and soft tissue infection (SSTI) in private practice dermatology office is largely unknown and the prescribing of antibiotic...

Evaluating the tolerability and efficacy of etanercept compared to triamcinolone acetonide for the intralesional treatment of keloids.(ORIGINAL ARTICLES)
August 1, 2008... ABSTRACT: Background: Tumor necrosis factor-alpha (TNF-[alpha]) is a proinflammatory and profibrotic cytokine that inhibits degradation of collagen and glycosaminoglycans. Etanercept, a recombinant TNF-[alpha] receptor fusion protein, may...

The effectiveness of liquid bandage as an adhesive and antimicrobial agent.(ORIGINAL ARTICLES)
August 1, 2008... INTRODUCTION A useful dressing for wounds not only facilitates healing but also has antimicrobial properties. A new Food and Drug Administration (FDA)-approved occlusive dressing (Elastic Skin Liquid Bandage, Medpak, LLC) first introduced...

A case series of 48 patients treated with Thalidomide.(ORIGINAL ARTICLES)(Clinical report)
August 1, 2008... ABSTRACT: Introduction: Thalidomide is approved by the Food and Drug Administration (FDA) for erythema nodosum leprosum, but has been used in many other dermatological conditions that are refractory to standard therapy. Methods: The...

Low risk of postinflammatory hyperpigmentation in skin types 4 and 5 after treatment with Fractional C[O.sub.2] laser device.(ORIGINAL ARTICLES)
August 1, 2008... ABSTRACT: Background/Objective: Hyperpigmentation occurs in more than 37% of dark-skinned subjects treated with a fully ablative C[O.sub.2] laser device. This study assessed the risk of postinflammatory hyperpigmentation (PHI) in subjects with...

The use of acellular, fetal bovine dermal matrix for acute, full-thickness wounds.(ORIGINAL ARTICLES)
August 1, 2008... ABSTRACT: Background: Skin substitutes may be used as part of the management of acute surgical wounds. The ideal skin substitute should be biocompatible, inexpensive, free of potential pathogens, easy to store, prepare, and utilize. ...

Nevus lipomatosus cutaneous superficialis of the groin arising in the fifth decade of life.(CASE REPORTS)(Case study)
August 1, 2008... ABSTRACT: Nevus lipomatosus cutaneous superficialis (NLCS) is a rare malformation characterized by ectopic adipose tissue in the dermis. The lesson is usually present from birth or noticed in the first 2 decades of life. It occurs as sessile or...

Successful treatment of Metastatic Crohn's disease with cyclosporine.(CASE REPORTS)(Case study)
August 1, 2008... ABSTRACT: Metastatic Crohn's disease refers to cutaneous granulomatous lesions that are noncontiguous to the gastrointestinal tract. The treatment of cutaneous Crohn's disease is challenging. A patient with metastatic Crohn's disease whose...

Reticulated phototoxic eruption in a patient on long-term diltiazem therapy.(CASE REPORTS)
August 1, 2008... ABSTRACT: Ditiazem hydrochloride is a commonly prescribed medication in the treatment of cardiovascular disease. A case of diltiazem-induced hyperpigmentation in a patient after significant sun exposure is reported. The morphological appearance...

Moxifloxacin as the likely cause of drug-induced Linear immunoglobulin a bullous dermatosis.(CASE REPORTS)
August 1, 2008... ABSTRACT: Linear immunoglobulin A bullous dermatosis (LABD) is an immune-mediated subepidermal blistering disease that can be triggered by drug exposures, most notably, vancomycin. The authors report of a case of a 72-year-old man who developed...

Development of systemic lupus erythematosus in a patient with rheumatoid arthritis following treatment conversion of infliximab to adalimumab.(CASE REPORTS)
August 1, 2008... ABSTRACT: Systemic lupus erythematosus (SLE)-like syndromes and the development of lupus-related autoantibodies are known to occur during treatment with certain medications. Here a case of complete SLE conversion in a patient with rheumatoid...

Treatments for genital warts.(NEWS, VIEWS & REVIEWS)
August 1, 2008... INTRODUCTION Anogenital warts, or condyloma acuminata, are a common manifestation of sexually transmitted human papillomavirus (HPV) infections, and represent a significant public health concern. Multiple medical and surgical treatment...

Pipeline previews.(FEATURES)(briefs)
August 1, 2008... V.A.C. Therapy for Acute Wounds Kinetic Concepts Inc recently announced the completion of a 2-phase clinical study of the safety and efficacy of V.A.C.[R] therapy for wound healing in Japan. The study compared V.A.C. therapy to standard...

Connective tissue disorders.(CLINICAL TRIAL REVIEW)
August 1, 2008... UVA1 Light for Scleroderma and Similar Conditions Sponsored by the University of Michigan.The purpose of this investigation is to evaluate the effectiveness of high-does UVA1 irradiation in the treatment of fibrosing conditions of the skin,...

Tretinoin microsphere gel in facial acne vulgaris: a meta-analysis.
August 1, 2008... ABSTRACT: Background: Acne vulgaris can persist beyond adolescence into the fourth decade of life or later; most patients have a combination of inflammatory and noninflammatory lesions. Objective: To determine whether tretinoin microsphere...

Tretinoin microsphere gel in younger acne patients.
August 1, 2008... ABSTRACT: Background: Facial acne is common in adolescents and can have a significant psychosocial impact. Treatments prescribed should not add stress by causing excessive localized irritation. Objective: To determine whether the lowest...

Cumulative irritation potential of topical retinoid formulations.
August 1, 2008... ABSTRACT: Background: Localized irritation can limit treatment success with topical retinoids such as tretinoin and adapalene. The factors that influence irritant reactions have been shown to include individual skin sensitivity, the particular...

Photographic assessment of Tretinoin Microsphere gel in moderate Acne.
August 1, 2008... ABSTRACT: Background: True objective measures for assessing responsiveness to acne treatments are lacking. Photographic documentation can therefore be a valuable adjunct to treatment assessment. Objectives: To photographically document the...