Journal of Drugs in Dermatology articles from August 2007

Journal of Drugs in Dermatology archives from August 2007

Printer erratum.(Journal of Drugs in Dermatology)(Brief article)
August 1, 2007... There was a problem with the color balance with the printing of the July 2007 issue of the Journal of Drugs in Dermatology and we sincerely apologize for any inconvenience this may have caused. We have been assured by our printer that steps are...

The treatment of actinic keratoses with a combination of 5-fluorouracil and imiquimod creams.
August 1, 2007... Abstract Background: 5-fluorouracil (5-FU) and imiquimod creams are accepted topical therapies for actinic keratosis (AK). Both are associated with a prolonged course of treatment with an inflammatory response that may preclude the...

Vitamins and minerals: their role in nail health and disease.
August 1, 2007... Abstract Nail health and appearance are global concerns. We investigated the use of biotin vitamin E, alpha-tocopherol, vitamin C (ascorbic acid), vitamin A, retinoids, retinol, retinal, silicon, zinc, iron, copper, selenium, and vitamin...

Clinical evaluation of a handheld self-treatment device for hair removal.(no!no! Thermicon from Radiancy Inc.)
August 1, 2007... Abstract Background and Objectives: Laser- and light-based methods for hair removal, though effective, are expensive and may be associated with adverse effects. Our objective was to evaluate the efficacy and safety of a thermal, handheld...

Excimer laser for psoriasis: a review of theories regarding enhanced efficacy over traditional UVB phototherapy.
August 1, 2007... Abstract Background: Fiber-optically targeted ultraviolet B (UVB) therapy has been shown to clear plaques of psoriasis in a significantly fewer number of treatments and reduce overall cumulative UVB dose than traditional UVB phototherapy....

A new combination technique of local anesthesia for full-face dermabrasion.
August 1, 2007... Abstract We present a safer, more efficient, and more effective technique for full-face dermabrasion utilizing a combination of regional nerve block anesthesia, refrigerant spray cryoanesthesia, and local infiltration anesthesia. This...

A novel method to inject hyaluronic acid: the Fern Pattern Technique.
August 1, 2007... Abstract Nonanimal Stabilized Hyaluronic Acid (NASHA) has proven itself as one of the safest, most versatile dermal fillers with a high patient and physician satisfaction. The authors describe a novel technique to inject Restylane (NASHA)...

Pilot investigation of the hydrating effects of topical acne medications.
August 1, 2007... Abstract Topical therapies are effective in managing acne vulgaris but are associated with local adverse effects such as irritation and dryness. This 4-week pilot study compared skin hydration in 36 healthy adult women randomized to...

Enhanced efficacy of photodynamic therapy after fractional resurfacing: fractional photodynamic rejuvenation.
August 1, 2007... Abstract Background and Objectives: Conventional ablative resurfacing is the gold standard for removing signs of cutaneous photodamage. Despite the excellent results one can achieve with this technique, it is accompanied with significant...

Allergic contact dermatitis to mafenide acetate: a case series and review of the literature.(CASE REPORTS)(Case study)
August 1, 2007... Abstract Burn patients with extensive involvement of body surface area (BSA >30%) represent a challenge in wound treatment. Multiple topical agents may be used for cleansing, barrier protection, and antimicrobial control leading to...

Treatment of locally metastatic melanoma: a novel approach.(CASE REPORTS)(Case study)
August 1, 2007... Abstract We report a case of an 83-year-old female with locally metastatic melanoma treated with imiquimod and tazarotene. The patient originally presented to our dermatology clinic with local metastases of malignant melanoma after having...

Mycosis fungoides in a patient with ankylosing spondylitis during infliximab therapy.(CASE REPORTS)(Case study)
August 1, 2007... Abstract Immunosuppressive therapies, in particular cyclosporine, are known to induce the development of lymphoproliferative malignancies. In general, the lymphomas that occur in the setting of impaired immune function are B cell...

Combination of a new radiofrequency device and blue light for the treatment of acne vulgaris.(CASE REPORTS)(Accent from Alma Lasers Inc., blue light from DUSA Pharmaceuticals Inc. )(Case study)
August 1, 2007... Abstract Acne vulgaris is the most common skin disease treated by physicians. Current topical and oral treatments may have short-and long-term negative consequences. Since radiofrequency (RF) energy has been shown to reduce sebum...

Recalcitrant rosacea successfully treated with multiplexed pulsed dye laser.(CASE REPORTS)(Case study)
August 1, 2007... Abstract There are few treatments that address both papulopustular and telangiectatic components of rosacea. We present a case of rosacea that was unresponsive to treatment with antibiotics. We report the novel use of a new laser...

Radiesse nodule of the lips from a distant injection site: report of a case and consideration of etiology and management.(CASE REPORTS)(Case study)
August 1, 2007... Abstract Radiesse was approved for cosmetic use by the US FDA in December of 2006. Prior to this approval it had been widely used off-label for a variety of areas including lip augmentation. With increased use, complications including...

Fractional technology: a review and clinical approaches.(AESTHETIC PRACTICE TRENDS)(Buyers guide)
August 1, 2007... Introduction Energy-based systems have evolved greatly over the past several years, and many new medical devices have been introduced into the dermatologist's armamentarium, some of which are truly revolutionary. Fractional...

News, views, and reviews.(on Psoriasis)
August 1, 2007... Sexy and 17: [T.sub.H]17 Effector T Cells and Psoriasis Psoriasis is classically believed to be a disease of chronic skin inflammation driven by a T helper type 1 ([T.sub.H]1) cellular immune response. Recently, a novel and distinct lineage...

FDA approves doxycycline tablets, 150 mg.(PIPELINE PREVIEWS)(Mylan Laboratories Inc.)(Brief article)
August 1, 2007... Mylan Laboratories Inc recently announced that it has received FDA approval for doxycycline tablets, 150 mg. This medication will be the equivalent generic version of Par Pharmaceutical's doxycycline tablets, 150 mg which are currently marketed...

Altargo approved in Europe.(PIPELINE PREVIEWS)(GlaxoSmithKline PLC)(Brief article)
August 1, 2007... GlaxoSmithKline recently announced that the European Commission has granted approval to Altargo[R] (retapamulin ointment, 1%) for the treatment of impetigo and infected small wounds caused by Staphylococcus aureus and Streptococcus pyogenes....

Azithromycin tablets approved by the FDA.(PIPELINE PREVIEWS)(Mylan Laboratories Inc.)(Brief article)
August 1, 2007... Mylan Laboratories Inc recently announced that its Abbreviated New Drug Application for Azithromycin tablets, 250 and 500 mg, has been approved by the FDA. These tablets are the generic equivalent of Pfizer's Zithromax[R] Tablets. They will be...

Generic Zyrtec approved by the FDA.(PIPELINE PREVIEWS)(Caraco Pharmaceutical Laboratories Ltd.)(Brief article)
August 1, 2007... Caraco Pharmaceutical Laboratories, Ltd recently announced that its product, Cetirizine HC1, 5 and 10 mg Immediate Release tablets, has been tentatively approved by the FDA. This medication is the generic equivalent of Pfizer Inc's product,...

Telavancin to be marketed in Europe.(PIPELINE PREVIEWS)(Theravance Inc.)(Brief article)
August 1, 2007... Theravance Inc recently announced that the European Medicines Agency has approved the marketing application for telavancin in the treatment of complicated skin and soft tissue infections in adults. Telavancin is an injectable antibiotic that is...

Xyzal receives FDA approval.(PIPELINE PREVIEWS)(Sanofi-Aventis S.A., UCB S.A. )(Brief article)
August 1, 2007... UCB and sanofi-aventis recently announced that Xyzal[R] (levocetirizine dihydrochloride) has been granted FDA approval. Xyzal is an antihistamine that can be used to treat chronic idiopathic urticaria in patients aged 6 years and older. This...

Liarozole for treatment of lamellar ichthyosis.(PIPELINE PREVIEWS)(Barrier Therapeutics Inc.)(Brief article)
August 1, 2007... Barrier Therapeutics, Inc recently announced results from its phase II/III trial of liarozole in the treatment of lamellar ichthyosis. The randomized, double-blind, placebo-controlled dose-ranging study, enrolled 64 patients and randomized them...

Phase III trial for postherpetic neuralgia completes enrollment.(PIPELINE PREVIEWS)(NeurogesX Inc.)
August 1, 2007... NeurogesX, Inc recently announced that its phase III clinical trial for NGX-4010 has completed its enrollment. NGX-4010 is a dermal patch that is being evaluated for the treatment of postherpetic neuralgia. NeurogesX has already completed prior...

Phase III trial for C1-esterase inhibitor for hereditary angioedema.(PIPELINE PREVIEWS)(Lev Pharmaceuticals Inc.)(Brief article)
August 1, 2007... Lev Pharmaceuticals, Inc recently announced that its phase III trial of C1-esterase inhibitor (C1-INH) for hereditary angioedema (HAE) has been completed. The clinical trial evaluated the safety and efficacy of C1-INH replacement therapy in...

Differin Gel 0.3% receives FDA approval.(PIPELINE PREVIEWS)(Galderma Laboratories Inc.)(Brief article)
August 1, 2007... Galderma Laboratories, LP, recently announced that its product, Differin[R] (adapalene) Gel, 0.3%, has received approval from the FDA. This new product is a higher concentration of its current product, Differin Gel, 0.1%. Differin Gel is a...

Upcoming dermatology meetings.(Brief article)(Calendar)
August 1, 2007... Domestic 8/22-8/26 Pacific Dermatologic Association 59th Annual Meeting Loews Coronado Bay Resort, San Diego, CA pda@hp-assoc.com 9/27-9/30 Women's and Pediatric Dermatology Seminar Grand Hyatt San Francisco, San...

Comparison study of topical acne regimens.(ACNE)(Acne Free and Proactiv compared)(Brief article)
August 1, 2007... Sponsored by University Medical Products. This study will compare the effectiveness of the 2 acne treatment regimens, Acne Free[R] and Proactiv[R], for the treatment of moderately severe acne vulgaris of the face and neck. It will also compare...

The development and evaluation of an "E-Visit" program for the management of acne.(ACNE)(Massachusetts General Hospital)(Brief article)
August 1, 2007... Sponsored by Massachusetts General Hospital. The purpose of this study is to test the efficacy, timeliness, and user satisfaction of an online "E-Visit" application that uses store-and-forward technology for acne patients requiring dermatologic...

A multicenter, randomized, double-blind, parallel-group study to demonstrate the efficacy and safety of adapalene/benzoyl peroxide topical gel in subjects with acne vulgaris.(ACNE)(Galderma Laboratories Inc.)(Brief article)
August 1, 2007... Sponsored by Galderma. This is a multicenter, randomized, double-blind, parallel group study with 12 weeks of treatment of acne vulgaris. The primary objective is to demonstrate the superiority in efficacy and assess safety of adapalene/benzoyl...

The treatment of acne vulgaris with radiofrequency device.(ACNE)(Alma Lasers)(Brief article)
August 1, 2007... Sponsored by Alma Lasers. A radiofrequency emitting device, normally used for Thermage[R] treatments, will be used on 22 mild to moderate acne patients' faces. The aim of the study is to check whether radiofrequency heating of subcutaneous...

Efficacy and safety of azithromycin SR compared with minocycline in acne.(ACNE)(Pfizer Inc.)(Brief article)
August 1, 2007... Sponsored by Pfizer. The primary objective of this study is to evaluate the clinical efficacy of azithromycin micropheres treatment in outpatients with moderate to severe inflammatory acne compared with first-line treatment minocycline after 8...

Optical imaging of skin cancers for margin delineation of nonmelanoma skin cancers.(SKIN CANCER)(Brief article)
August 1, 2007... Sponsors and Collaborators: MD Anderson Cancer Center and National Institute of Dental and Craniofacial Research (NIDCR). The primary objective of this exploratory laboratory study is to evaluate the ability of optical imaging technologies such...

Photodynamic therapy using silicon phthalocyanine 4 in treating patients with actinic keratosis, Bowen's disease, skin cancer, or stage I or stage II mycosis fungoides.(SKIN CANCER)(Case Comprehensive Cancer Center, National Cancer Institute )(Brief article)
August 1, 2007... Sponsors and Collaborators: Case Comprehensive Cancer Center and National Cancer Institute (NCI). This phase I trial is studying the side effects and best dose of photodynamic therapy using silicon phthalocyanine 4 in treating patients with...

Evaluation of pigmented skin lesions with MelaFind system.(SKIN CANCER)(Brief article)
August 1, 2007... Sponsored by Electro-Optical Sciences. The purpose of this clinical trial is to demonstrate that MelaFind[R] a new instrument that uses machine vision for noninvasive early detection of cutaneous pigmented malignant melanoma, is safe and...

Chemotherapy and total-body irradiation followed by autologous lymphocyte infusion, aldesleukin, and autologous stem cell transplant in treating patients with metastatic melanoma.(SKIN CANCER)(National Cancer Institute)(Table)(Brief article)
August 1, 2007... Sponsored by National Cancer Institute (NCI). This phase II trial is studying how well chemotherapy and total-body irradiation followed by autologous lymphocyte infusion, aldesleukin, and autologous stem cell transplant work in treating...

Complete lymph node dissection or observation in treating patients with localized melanoma and sentinel node metastasis who have undergone sentinel lymphadenectomy.(SKIN CANCER)(Brief article)
August 1, 2007... Sponsors and Collaborators: John Wayne Cancer Institute at Saint John's Health Center and National Cancer Institute (NCI). This randomized phase III trial is studying complete lymph node dissection to see how well it works compared to...

Early diagnosis of melanoma using expression profiling and noninvasive sampling of skin cells (DermTech).(SKIN CANCER)(University of California (Davis))(Brief article)
August 1, 2007... Sponsored by University of California, Davis. This study is divided into distinct sample collection and analysis phases. In the sample collection phase, investigators will tape strip lesions that are designated for biopsy because they are...

High-resolution MRI scans to look for spread of melanoma to nearby lymph nodes.(SKIN CANCER)(magnetic resonance imaging)(Brief article)
August 1, 2007... Sponsored by Redwood Regional Medical Group. The study is designed to see if a high-resolution MRI scan of lymph node areas near where a melanoma has been removed from the skin, can pick up the spread of melanoma to those lymph nodes with a...

The effect of Efudex treatment on photoaged skin.(PHOTOAGING)(Valeant Pharmaceuticals International, University of Michigan )(Brief article)
August 1, 2007... Sponsors and Collaborators: University of Michigan and Valeant Pharmaceuticals International. The researchers propose that skin improvements may be seen following a course of Efudex, (5-fluorouracil), an FDA-approved topical therapy (applied...

Comparison of Metvix photodynamic therapy with its vehicle in the treatment of photoaged skin.(PHOTOAGING)(Brief article)
August 1, 2007... Sponsored by Galderma. Metvix[R] photodynamic therapy is a procedure currently marketed in several countries in Europe (eg, the UK and Spain) and in Australia, for the treatment of benign forms of skin cancer (eg, actinic keratosis). The aim of...

The effects of microdermabrasion on skin remodeling.(PHOTOAGING)(Brief article)
August 1, 2007... Sponsored by University of Michigan. This research project aims to study the effects of microdermabrasion. We are interested in determining how this procedure works at rebuilding the skin following microdermabrasion. Condition ...

Study to compare the safety and effectiveness of a non-FDA-approved device (DGE) and an FDA-approved device for the correction of nasolabial folds (NLFs).(WRINKLES)(Dermal Gel Extra, Genzyme Biosurgery, Mentor Corp.)(Brief article)
August 1, 2007... Sponsors and Collaborators: Genzyme and Mentor Corporation. The purpose of this research study is to evaluate the effects (good and bad) of DGE Injectable Gel (manufactured by Genzyme Biosurgery) with an FDA-approved dermal filler in the...

Study of the safety, tolerability, and efficacy of BCT194 in healthy volunteers and patients with psoriasis.(PSORIASIS)(Novartis AG)(Brief article)
August 1, 2007... Sponsored by Novartis. The purpose of this study is to assess the local tolerability of a single topical administration of BCT194 in healthy volunteers and, potentially, to evaluate the safety, tolerability, and efficacy of multiple topical...

Safety and effectiveness of CNTO 1275 compared to etanercept for moderate to severe plaque psoriasis.(PSORIASIS)(Centocor Inc.)(Brief article)
August 1, 2007... Sponsored by Centocor, Inc. The purpose of this research study is to compare the effects (good and/or bad) of CNTO 1275 or etanercept on moderate to severe plaque psoriasis. Condition Intervention Phase Psoriasis...

Efficacy and safety of cyclosporine a microemulsion in maintenance patients with chronic plaque psoriasis.(PSORIASIS)(Novartis AG)(Brief article)
August 1, 2007... Sponsored by Novartis. The study will evaluate the efficacy of cyclosporine twice weekly compared to continuous administration in patients with chronic plaque psoriasis. Condition Intervention Phase Chronic...

Skin structure infections with suspected or proven MRSA.(SKIN INFECTION)(methicillin resistant staphylococcus aureus)(Brief article)
August 1, 2007... Sponsored by Pfizer. To determine if linezolid is superior to vancomycin in the treatment of complicated skin and soft tissue infections due to MRSA in adult subjects. Study ID Numbers: A5951002 ClinicalTrials.gov Identifier:...

Topical SB-275833 ointment for impetigo.(SKIN INFECTION)(GlaxoSmithKline PLC)(Brief article)
August 1, 2007... Sponsored by GlaxoSmithKline. The goal of this study is to determine if topical SB-275833 ointment, 1%, is as safe and effective as topical sodium fusidate ointment, 2%, for the treatment of impetigo in adults and children as young as 9 months...