Journal of Drugs in Dermatology articles from April 1 2009

Journal of Drugs in Dermatology archives from April 1 2009

Biologic survival.(ORIGINAL ARTICLES)
April 1, 2009... ABSTRACT Background: The results of long-term studies on the efficacy and safety profiles of the biologics for patients with psoriasis are starting to appear in the literature. Not only are the results promising for the biologics as a...

The science and art of dermal fillers for soft-tissue augmentation.(ORIGINAL ARTICLES)(Report)
April 1, 2009... ABSTRACT Our expanding understanding of the physiological and immunological conditions of the skin and, in particular, the aging face, has prompted a growing field of aesthetic technology. Restorative procedures are taking advantage of...

LCD plus NB-UVB reduces time to improvement of psoriasis vs. NB-UVB alone.(ORIGINAL ARTICLES)(narrowband ultraviolet B)(coal tar solution)(Report)
April 1, 2009... ABSTRACT Background: Use of coal tar with narrowband (NB) ultraviolet B (UVB) light (the Goeckerman regimen) is an effective treatment for plaque psoriasis that has become impractical in outpatient care mainly due to the inconvenience and...

The efficacy of topical 2% green tea lotion in mild-to-moderate acne vulgaris.(ORIGINAL ARTICLES)(Report)
April 1, 2009... ABSTRACT Background: Botanical extracts and preparations have been used in different pathological conditions with success. An important group of phytochemical phenolic compounds are the catechins found in green tea. Acne is a widely...

Telemedicine: current status in developed and developing countries.(ORIGINAL ARTICLES)
April 1, 2009... ABSTRACT Background: Many developed countries, including the United States, have made it a priority to incorporate telemedicine into their healthcare systems. Worldwide, this concept has been adopted by countries in effort to provide...

Histological comparison of 1064 nm Nd: YAG and 1320 nm Nd: YAG laser lipolysis using an ex vivo model.(ORIGINAL ARTICLES)(Report)
April 1, 2009... ABSTRACT Background: Body contouring with liposuction including laser liposuction is one of the most commonly performed cosmetic procedures. Laser lipolysis is generally well tolerated with high patient satisfaction rates. Laser lipoplasty...

Tolerability of clindamycin/tretinoin gel vs. Tretinoin microsphere gel and adapalene gel.(ORIGINAL ARTICLES)(Report)
April 1, 2009... ABSTRACT Background: Newer agents and formulations seek to improve the tolerability of topical retinoid therapy. Recently, a gel containing crystalline clindamycin 1.2% and tretinoin 0.025% (CLIN/RA) was approved by the U.S. Food and Drug...

Disfiguring scarring following mesotherapy-associated mycobacterium cosmeticum infection.(CASE REPORTS)
April 1, 2009... ABSTRACT Mesotherapy is a popular procedure that poses risks that include scarring, contour changes and bacterial infections. The benefits of the procedure remain to be objectively delineated in a placebo-controlled, blinded study. Despite...

Hair depigmentation during chemotherapy with dasatinib, a dual Bcr-Abl/Src family tyrosine kinase inhibitor.(CASE REPORTS)(Report)
April 1, 2009... ABSTRACT Hair depigmentation has been shown to occur with disruption of the interaction between the ligand stem cell factor (SCF) with its class III receptor tyrosine kinase c-kit, also called the stem cell factor receptor. This article...

Follow-up of psoriatic arthritis mutilans patients treated with anti-TNF-alpha therapy.(CASE REPORTS)(tumor necrosis factor)(Report)
April 1, 2009... ABSTRACT Psoriatic arthritis (PsA) is a chronic inflammatory joint disease associated with psoriasis. Arthritis mutilans is a rare clinical form of PsA in which osteolysis and destructive changes in the joints lead to irreversible...

The genetics of psoriasis.(NEWS, VIEWS & REVIEWS)(Report)
April 1, 2009... INTRODUCTION Psoriasis is a common skin disease afflicting millions of people a year. Although the exact etiology of psoriasis is unknown, it is a multifactorial disease involving both genetic and environmental components. The...

Safety and efficacy of the use of botox on acne.(ACNE)(Author abstract)
April 1, 2009... Sponsed by DeNova Research. This 90 day trial will include botox injections at baseline/screening visit. Photos will be taken throughout the study and patients will be evaluated by masked injector evaluator and a masked evaluator. Patients will...

Dapsone gel 5% and tazarotene cream 0.1% versus tazarotene cream 0.1% monotherapy for facial acne vulgaris.(ACNE)(Brief article)
April 1, 2009... Sponsed by Allergan. This 12-week randomized, single blind study will evaluate facial acne vulgaris characterized by the following: 30-100 facial inflammatory lesions; and 25-100 facial non-inflammatory lesions; stable disease, non-rapidly...

Dapsone gel 5% and tretinoin gel 0.025% versus tretinoin gel 0.025% monotherapy for facial acne vulgaris.(ACNE)(Author abstract)
April 1, 2009... Sponsered by Allergan. This evaluation will study facial acne vulgaris characterized by the following: 30-100 facial inflammatory lesions; and, 25-100 facial non-inflammatory lesions; stable disease, non-rapidly regressing facial acne vulgaris;...

Safety and efficacy study of Clindamycin Phosphate 1.2% and Tretinoin 0.025% Gel to treat rosacea.(ACNE ROSACEA)(Report)
April 1, 2009... Sponsored by Massachusetts General Hospital; Medics Pharmacetical Corporation. This double-blind, placebo-controlled, pilot study will measure the absolute change in inflammatory lesion counts (papules and pustules) from baseline to week 12...

Efficacy of topical cyclosporin for ocular rosacea.(ACNE ROSACEA)(Brief article)
April 1, 2009... Sponsored by Ophthalmic Consultants of Long Island; Allergan. This double-blind, randomized study will evaluate patients from 18 to 65 years old with a diagnosis of acne rosacea active ocular rosacea based on lid findings of meibomian gland...

Treatment of patients with blepharitis and facial rosacea.(ACNE ROSACEA)(Brief article)
April 1, 2009... Sponsered by CollaGenex Pharmaceuticals. This double-blind, parallel assignment will measure the change in ocular surface disease index, as well as the change in bulbar conjunctival hyperemia. The purpose of this study is to determine the...

Safety study of AMG 157 in healthy subjects and subjects with atopic dermatitis.(ATOPIC DERMATITIS)(Brief article)
April 1, 2009... Sponsored by Amgen. This study is a phase 1 single dose escalation study of AMG 157 in healthy subjects and subjects with moderate to severe atopic dermatitis. It will measure subject incidence of treatment-emergent adverse events, clinically...

The impact of treating staphylococcus aureus infection and colonization on the clinical severity of atopic dermatitis.(ATOPIC DERMATITIS)(Report)(Brief article)
April 1, 2009... Sponsored by Children's Memorial Hospital; Society for Pediatric Dermatology; Johnson & Johnson. Staphylococcus aureus (S. aureus) infection is perceived not only as a common secondary complication of atopic dermatitis (AD), but also as a...

Study to evaluate the safety and efficacy of Alefacept (Amevive) in subjects with moderate to severe atopic dermatitis.(ATOPIC DERMATITIS)(Brief article)
April 1, 2009... Sponsored by Rush University Medical Center; Astellas Pharma US, Inc. Atopic dermatitis is a chronic inflammatory skin disease associated with cutaneous hyper-reactivity to environmental triggers that are generally innocuous to healthy,...

Efficacy of therapy with the spironolactone pills compared to minoxidil lotion in female pattern hair loss.(ALOPECIA)(Brief article)
April 1, 2009... Sponsored by the University of British Columbia. This study evaluates the efficacy of therapy with the anti-androgen spironolactone compared to topical minoxidil in female pattern hair loss. It will evalute patients with the following criteria:...

Imiquimod in children with plaque morphea.(CONNECTIVE TISSUE DISORDERS)(Brief article)
April 1, 2009... Sponsored by The Hospital for Sick Children. Morphea is very hard to treat. In a small number of adult patients, Imiquimod has proven to be beneficial in decreasing the thickness of the morphea plaques, while improving their appearance. There...

A pilot study of etanercept in dermatomyositis.(DERMATOMYOSITIS)(Brief article)
April 1, 2009... Sponsored by Brigham and Women's Hospital; National Institute of Neurological Disorders and Stroke (NINDS). Dermatomyositis (DM) is an autoimmune disorder that affects skin and muscle. Autoimmune disorders are diseases in which the immune...

Rituximab for the treatment of refractory adult and juvenile dermatomyositis (DM) and adult polymyositis (PM).(DERMATOMYOSITIS)(Brief article)
April 1, 2009... Sponsered by National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS); Genentech; Biogen Idec. Rituximab is a man-made antibody used to treat certain types of cancer. This study will determine whether rituximab is an...

Treatment of cutaneous lupus erythematosus (CLE) with the 595 nm flashlamp pulsed dye laser.(CUTANEOUS LUPUS ERYTHEMATOSUS)(Brief article)
April 1, 2009... Sponsored by the University of Pennsylvania. The purpose of using the 595 nm Vbeam Perfecta[TM] flashlamp-excited, pulsed dye laser in this study is to help improve study patients' skin disease. Cutaneous lupus erythematosus (CLE) often...

Evaluation of lenalidomide (Revlimid [R]) to treat subjects with Cutaneous Lupus Erythematosus (CLE).(CUTANEOUS LUPUS ERYTHEMATOSUS)(Brief article)
April 1, 2009... Sponsored by University of Pennsylvania; Celgene Corporation. This study is being conducted to evaluate the safety and effectiveness of lenalidomide (Revlimid[R]) in subjects with Cutaneous Lupus Erythematosus (CLE).The study drug will be used...

Safety study of clinical and immune effects of PDE-4 inhibitor in cutaneous lupus patients.(CUTANEOUS LUPUS ERYTHEMATOSUS)(Brief article)
April 1, 2009... Sponsored by New York University School of Medicine; Celgene Corporation. Discoid cutaneous lupus is the most common cutaneous manifestation of lupus erythematosus, a chronic, immune mediated disease of unknown etiology. Treatment of cutaneous...

The safety and efficacy of etanercept (Enbrel [R]) for the treatment of Discoid Lupus Erythematosus.(CUTANEOUS LUPUS ERYTHEMATOSUS)(Brief article)
April 1, 2009... Sponsored by Florida Academic Dermatology Centers. The purpose of this 20-week study is to assess the safety and efficacy of etanercept (Enbrel[R]) for the treatment of Discoid Lupus Erythematosus. The proportion of patients responding to study...

Study of light treatment and laser treatment for melasma.(MELASMA)(Brief article)
April 1, 2009... Sponsored by Northwestern University. The purpose of this study is to determine the efficacy of light treatment and laser treatment for melasma. These treatment options have not been thoroughly explored in the treatment of melasma. By studying...

Treatment of melasma with Jessner's solution Vs. trichloroacetic acid.(MELASMA)(Brief article)
April 1, 2009... Sponsored by Emory University. Melasma is an acquired discoloration of the skin characterized by brown patches. Chemical peels using agents such as Jessner's solution and trichloroacetic acid (TCA) are commonly used to treat melasma. A chemical...

Study of acid peel and laser for the treatment of melasma.(MELASMA)(Brief article)
April 1, 2009... Sponsored by Northwestern University. The objective of this study is to evaluate laser treatment and acid peel for the treatment of melasma. Patients considered for the study will be those in good health, between 18 and 75 years old, with a...

Introduction.(Editorial)
April 1, 2009... The Cosmetic Bootcamp was established to present information that is cutting edge and relevant to assist the board-certified core physician in establishing and growing a cosmetic practice with improved patient outcomes and experience as the...

A grading system for the malar crease region and its implications for treatment of this region with soft-tissue augmentation products.(ORIGINAL ARTICLES)
April 1, 2009... ABSTRACT Facial aging is one of the most common problems patients present to dermatologic surgeons. Aging of the mid-face is typically a significant factor in the overall appearance of the face. Mid-facial descent and volume loss manifest...

The beer hand scale: a validated scale to grade dorsal hand aging and response to treatments.(ORIGINAL ARTICLES)(Report)
April 1, 2009... ABSTRACT A validated scale is presented to provide an objective measurement tool to evaluate dorsal hand aging. Representative cases are utilized to demonstrate the various stages of the rating scale. Various modalities for hand...

Advances in collagen fillers.(ORIGINAL ARTICLES)
April 1, 2009... INTRODUCTION Collagen has been recognized as the major building block of dermal structures and has, since the advent of collagen-filler technology, always been considered an important source for soft-tissue injectable implants. Collagen...

Advanced techniques for Sculptra.(ORIGINAL ARTICLES)(Report)
April 1, 2009... ABSTRACT Poly-L-lactic acid (PLLA) is one of several products known as bioactivators that have a unique mechanism of action, stimulating fibroblasts to produce collagen causing an increase in volume. This mechanism of action has important...

Combination therapy of the aging hand using non-ablative fractional resurfacing, radiofrequency & calcium hydroxylapatite.(ORIGINAL ARTICLES)(Report)
April 1, 2009... ABSTRACT The aging hand poses a number of therapeutic challenges for rejuvenation and multiple factors are involved, including; dyschromia, lentigines, textural anomalies, volume loss, laxity and the visibility of superficial veins. As...

Introduction of a validated rating scale for the management of lip fullness and aging options.(ORIGINAL ARTICLES)
April 1, 2009... ABSTRACT Lip fullness declines with aging. Injectable dermal fillers, most commonly hyaluronic acid and collagen-derived, are used to treat the border of the upper and lower lip to enhance lip contour and definition, although in the U.S....