Journal of Drugs in Dermatology articles from April 2006

Journal of Drugs in Dermatology archives from April 2006

Metronidazole in the treatment of rosacea: do formulation, dosing, and concentration matter?
April 1, 2006... Abstract Background: Topical metronidazole is commonly used in the management of rosacea. No consensus on the optimal formulation, concentration, or dosing regimen exists. Purpose: To assess the relative efficacy of metronidazole...

Sun protection strength of a hydroquinone 4%/retinol 0.3% preparation containing sunscreens.
April 1, 2006... Abstract Background: Dyschromias are common and significantly impact patients' quality of life. Formulas containing hydroquinone 4% are effective in these conditions. Since exposure to ultraviolet radiation (UVR) can worsen disease and...

Short-term safety assessment of clobetasol propionate 0.05% shampoo: hypothalamic-pituitary-adrenal axis suppression, atrophogenicity, and ocular safety in subjects with scalp psoriasis.
April 1, 2006... Abstract Clobetasol propionate is known to be a very effective treatment for psoriasis; however, its use is limited by potent corticosteroid class related side effects such as hypothalamic-pituitary-adrenal (HPA) axis suppression and...

Topical tacrolimus for the treatment of psoriasis on the face, genitalia, intertriginous areas and corporal plaques.
April 1, 2006... Abstract Tacrolimus is an immunosuppressive drug that has proved effective in the treatment of psoriasis when administered systemically. Topically. Topically, it seems only useful in thin psoriasis plaques located on the face, genitalia,...

Alefacept in the treatment of psoriatic nail disease: a proof of concept study.
April 1, 2006... Abstract Nail psoriasis can be debilitating and as therapeutic options are limited, it can be notoriously difficult to treat. As there are many new medications currently undergoing clinical trials in psoriasis, questions have arisen...

The utility of benzoyl peroxide in hydrophase base (Brevoxyl[R]) in the treatment of acne vulgaris.
April 1, 2006... Abstract Available for more than 5 decades, benzoyl peroxide has been a "workhorse" of acne therapy. The benefits of this agent include reduction in Propionibacterium acnes (P. acnes) with decrease in inflammatory lesions, efficacy as both...

Photodynamic therapy induces less pain in patients treated with methyl aminolevulinate compared to aminolevulinic acid.
April 1, 2006... Abstract Photodynamic therapy (PDT) with topical application of either aminolevulinic acid (ALA) or methyl aminolevulinate (MAL) is increasingly used for the treatment of actinic keratoses (AKs). Although PDT is a well-tolerated treatment,...

An intra-individual randomized safety and efficacy comparison of clobetasol propionate 0.05% spray and its vehicle in the treatment of plaque psoriasis.
April 1, 2006... Abstract Background: Plaque psoriasis affects about 2% of the US population. A new and unique spray formulation of clobetasol propionate (CP) 0.05% was developed to provide advantages over the currently available treatment formulations....

Uncontrollable prurigo nodularis effectively treated by roxithromycin and tranilast.(CASE REPORTS)
April 1, 2006... Abstract Treatment of prurigo nodularis (PN) is often very difficult even with strong corticosteroid dressing and other available means. Macrolide roxithromycin (RXM) is used in consideration of its immunosuppressive effects in treating...

Recurrent injection site reactions from interferon beta 1-b.(CASE REPORTS)
April 1, 2006... Abstract Recombinant human interferon beta-1b is an immune-modulatory drug used for a variety of conditions including multiple sclerosis (MS). Skin reactions to therapeutic use of injectable interferon beta-1b are relatively common,...

Epidermal growth factor receptor (EGFR) inhibitor associated skin eruption.(CASE REPORTS)
April 1, 2006... Abstract EGFR Inhibitors are used to treat Non-Small-Cell Lung Cancer (NSCLC) and colorectal cancer (CRC). A common side effect of EGFR Inhibitors is a follicular/pustular skin eruption. We report a case of gefitinib (Iressa) associated...

Non-sarcoidal, non-tuberculoid granuloma in common variable immunodeficiency.(CASE REPORTS)
April 1, 2006... Abstract Sarcoidal (non-caseating) or tuberculoid granulomas are cutaneous manifestations of common variable immunodeficiency (CVID). In this case report, we describe a patient with CVID but with non-sarcoidal, non-tuberculoid granuloma....

Dapsone in the treatment of persistent erythema multiforme.(CASE REPORTS)
April 1, 2006... Abstract Erythema multiforme (EM) is usually an acute and self-limited inflammatory reaction of the skin and mucous membranes. Attacks may be sporadic or recurrent, and generally last for 1 to 3 weeks. Rarely, an episode of EM may fail to...

Nicolau syndrome: a report of 2 cases.(CASE REPORTS)
April 1, 2006... Abstract Nicolau syndrome or embolia cutis medicamentosa is a very rare, but well recognized complication of intramuscular injections which clinically presents with extensive necrosis of the injected skin area. Intra-arterial or...

The PINE study of epidural steroids and local anaesthetics to prevent postherpetic neuralgia: a randomised controlled trial.(WASHINGTON WHISPERS)
April 1, 2006... The PINE Study of Epidural Steroids and Local Anaesthetics to Prevent Postherpetic Neuralgia: A Randomised Controlled Trial van Wijck AJM, et al. Lancet. 2006;367:219-224. Summary The authors present a multicenter, open-treatment,...

A randomized, double-blind, vehicle-controlled, bilateral comparison trial of bexarotene gel 1% versus vehicle gel in combination with narrowband UVB phototherapy for moderate to severe psoriasis vulgaris.(WASHINGTON WHISPERS)
April 1, 2006... A Randomized, Double-Blind, Vehicle-Controlled, Bilateral Comparison Trial of Bexarotene Gel 1% versus Vehicle Gel in Combination with Narrowband UVB Phototherapy for Moderate to Severe Psoriasis Vulgaris Magliocco MA, et al. J Am Acad...

Etanercept and clinical outcomes, fatigue, and depression in psoriasis: double-blind placebo-controlled randomised phase III trial.(WASHINGTON WHISPERS)
April 1, 2006... Etanercept and Clinical Outcomes, Fatigue, and Depression in Psoriasis: Double-Blind Placebo-Controlled Randomised Phase III Trial Tyring S, et al. Lancet. 2006;367:29-35. Summary The authors report a drug manufacturer-sponsored,...

Two randomized, double-blind, controlled trials of 2219 subjects to compare the combination clindamycin/tretinoin hydrogel with each agent alone and vehicle for the treatment of acne vulgaris.(WASHINGTON WHISPERS)
April 1, 2006... Two Randomized, Double-Blind, Controlled Trials of 2219 Subjects to Compare the Combination Clindamycin/Tretinoin Hydrogel with each Agent Alone and Vehicle for the Treatment of Acne Vulgaris Leyden JJ, et al. J Am Acad Dermatol....

GSK to seek FDA approval for HPV vaccine Cervarix.(PIPELINE PREVIEWS)
April 1, 2006... GlaxoSmithKline announced recently that it will submit Cervarix, its human papillomavirus (HPV) vaccine, to the FDA for approval by the end of 2006. Cervarix is a bivalent HPV vaccine targeted against HPV strains 16 and 18. These 2 strains are...

FDA considers postponing deadline for iPledge program.(PIPELINE PREVIEWS)
April 1, 2006... In March 2004, the FDA recommended the iPledge program in attempts to reduce the number of pregnancies in women taking the acne medication isotretinoin. iPledge mandates that all prescribers, women patients, pharmacists, and prescription drug...

FDA approves Clarinex-D[R] 12 Hour.(PIPELINE PREVIEWS)
April 1, 2006... The FDA recently approved Clarinex-D 12 Hour (deslorati-dine 2.5 mg and pseudoephedrine sulfate, USP 120 mg) Extended Release Tablets for the treatment of seasonal allergic rhinitis, including nasal congestion, in patients aged 12 years or...

GlaxoSmithKline's topical antibiotic retapamulin accepted for FDA review.(PIPELINE PREVIEWS)
April 1, 2006... GlaxoSmithKline recently announced that the FDA has started to review its new drug application for retapamulin, a new class of topical antibiotics known as pleuromutilins developed to treat uncomplicated skin and skin structure infections...

Garenoxacin accepted for FDA review.(PIPELINE PREVIEWS)
April 1, 2006... Schering-Plough Corporations recently announced that the FDA has accepted for review its New Drug Application for garenoxacin. Garenoxacin is a broad-spectrum quinolone antibiotic, which in Phase III trials demonstrated activity against...

Gardasil to receive priority review from FDA.(PIPELINE PREVIEWS)
April 1, 2006... Merck & Co., recently announced that the FDA has accepted it Biologics License Application for Gardasil and that the application will be given priority review. Gardasil is a quadrivalent human papillomavirus types 6,11,16, and 18, recombinant...

Vusion approved by the FDA for diaper dermatitis complicated by candidiasis.(PIPELINE PREVIEWS)
April 1, 2006... The FDA recently approved Barrier Therapeutics, Inc., Vusion ointment for the treatment of diaper dermatitis complicated by candidal infection in infants 4 weeks and older. It is estimated that over 40% of cases of "diaper rash" are complicated...

FDA mandates new warnings for Tequin.(PIPELINE PREVIEWS)
April 1, 2006... Bristol-Myers Squibb, Co., has announced new FDA approved labeling changes to its quinolone antibiotic Tequin (gatifloxacin). Tequin is indicated for treatment of pneumonia, bronchitis, uncomplicated gonorrhea, and infections of the skin,...

Schools of Pharmacology.
April 1, 2006... Schools in Pharmacology is a new feature that will appear periodically. It will explicate the dermatologic uses and side effects of new medications and devices. It follows medications mentioned in the Pipeline Previews into their approval and...

CYA versus MMF for treatment of moderate to severe psoriasis.(CLINICAL TRIAL REVIEW)
April 1, 2006... This study is currently recruiting patients. Verified by University Hospital Muenster. Sponsors and Collaborators: University Hospital Muenster and Hoffmann-La Roche. This clinical trial was initiated to compare the safety and effectiveness of...

Common allergens in skin tests for adult atopic dermatitis.(CLINICAL TRIAL REVIEW)
April 1, 2006... This study is currently recruiting patients. Sponsored and verified by National Taiwan University Hospital. This study analyzes the common allergens revealed by skin tests in adult atopic dermatitis patients. Condition Atopic...

Treatment of melasma with Jessner's solution versus trichloroacetic acid.(CLINICAL TRIAL REVIEW)
April 1, 2006... This study is currently recruiting patients. Sponsored and Verified by Emory University. Melasma is an acquired discoloration of the skin characterized by brown patches. Chemical peels using agents such as Jessner's solution and trichloroacetic...

A phase II randomized study of ACZONE (dapsone) gel 5% for papulopustular rosacea.(CLINICAL TRIAL REVIEW)
April 1, 2006... This study is currently recruiting patients. Sponsored and verified by QLT Inc. The purpose of this study is to evaluate the safety and effectiveness of ACZONE gel compared to placebo (inactive substance), MetroGel and a combination of ACZONE...

Imatinib in dermatofibrosarcoma protuberans (DFSP).(CLINICAL TRIAL REVIEW)
April 1, 2006... This study is currently recruiting patients. Sponsored and verified by Dermatologic Cooperative Oncology Group. The purpose of this study is to determine whether imatinib is effective in the treatment of primary and recurrent...

Phase IV study to gather more information about the safety of ACZONE Gel 5% in treating subjects with acne who have G6PD deficiency.(CLINICAL TRIAL REVIEW)
April 1, 2006... This study is currently recruiting patients. Sponsored and verified by QLT Inc. The purpose of this study is to gather more information about the safety of ACZONE Gel 5% in treating subjects with acne who have certain blood disorders. The...

Efficacy of elidel cream on erosive oral lichen planus.(CLINICAL TRIAL REVIEW)
April 1, 2006... This study is currently recruiting patients. Sponsored and verified by University Hospital Tuebingen. The purpose of this study is to investigate whether topically applied pimecrolimus will lead to improvement of erosive oral lichen planus....

Intralesional treatment with interleukin-2 (proleukin) in soft tissue melanoma metastases.(CLINICAL TRIAL REVIEW)
April 1, 2006... This study is currently recruiting patients. Sponsored and verified by University Hospital Tuebingen. The intra-/perilesional application of interleukin-2 seems to be a safe and effective treatment of skin and soft tissue metastases in...

Efficacy and safety of calcipotriol plus betamethasone dipropionate ointment in patients with psoriasis vulgaris.(CLINICAL TRIAL REVIEW)
April 1, 2006... This study is currently recruiting patients. Sponsored and verified by LEO Pharma. This study will evaluate the efficacy and safety of calcipotriol plus betamethasone dipropionate ointment compared with calcipotriol ointment in the treatment of...

Topical NF-kappa B Decoy in the treatment of atopic dermatitis.(CLINICAL TRIAL REVIEW)
April 1, 2006... This study is currently recruiting patients. Sponsored and Verified by Corgentech. The purpose of this study is to determine whether this topical NF-kappa B Decoy candidate is safe in persons with atopic dermatitis. Preliminary evidence of...

Ultraviolet B (UVB) light therapy in the treatment of skin conditions with altered dermal matrix.(CLINICAL TRIAL REVIEW)
April 1, 2006... This study is currently recruiting patients. Sponsored and verified by University of Michigan. This research study will evaluate the effectiveness of high dose UVB light therapy in the treatment of keloid (or hypertrophic scar), scleroderma,...

Pegylated interferon-alpha-2a in patients with malignant melanoma stage IIA-IIIB.(CLINICAL TRIAL REVIEW)
April 1, 2006... This study is currently recruiting patients. Verified by University Hospital Tuebingen. Sponsors and Collaborators: University Hospital Tuebingen and Dermatologic Cooperative Oncology Group. The purpose of this study is to evaluate the efficacy...

Curcuminoids for the treatment of chronic psoriasis vulgaris.(CLINICAL TRIAL REVIEW)
April 1, 2006... This study is currently recruiting patients. Sponsored and Verified by University of Pennsylvania. Turmeric (Curcuma Longa) is member of the ginger family and is best known for its culinary use as the major component of curry powder. The...

Safety and efficacy study of MM-093 in patients with chronic plaque psoriasis.(CLINICAL TRIAL REVIEW)
April 1, 2006... This study is currently recruiting patients. Sponsored and verified by Merrimack Pharmaceuticals. Merrimack is conducting a research study to see if an experimental drug, called MM-093, is safe and effective in the treatment of psoriasis....

A study of the use of methotrexate in the treatment of chronic idiopathic urticaria.(CLINICAL TRIAL REVIEW)
April 1, 2006... This study is currently recruiting patients. Sponsored and verified by Barnsley Hospital April. The purpose of this study is to determine whether methotrexate produces significant improvement in chronic idiopathic urticaria, compared with...

Etanercept for treatment of hidradenitis.(CLINICAL TRIAL REVIEW)
April 1, 2006... This study is currently recruiting patients. Sponsored and verified by University of Pennsylvania. This study is being done to test a drug called etanercept (Enbrel). Etanercept has been approved by the US FDA for the treatment of chronic...

Immunopharmacological effects of Rituximab in atopic dermatitis.(CLINICAL TRIAL REVIEW)
April 1, 2006... This study is currently recruiting patients. Verified by University of Bern. Sponsors and Collaborators: University of Bern, Roche, Swiss National Science Foundation. Primary Study Objective: to determine the efficacy, safety and...

Study of cetuximab in squamous cell carcinoma of the skin expressing EGFR.(CLINICAL TRIAL REVIEW)
April 1, 2006... This study is currently recruiting patients. Sponsored and verified by Centre Hospitalier of Chartres. The purpose of this study is to determine whether cetuximab is effective in the treatment of locally advanced or metastatic squamous cell...

Standard palliative care versus standard palliative care plus polychemotherapy in metastasized malignant melanoma.(CLINICAL TRIAL REVIEW)
April 1, 2006... This study is currently recruiting patients. Sponsored and verified by Dermatologic Cooperative Oncology Group. The purpose of this multicenter study is to examine whether the proposed randomized treatment regime results in a significantly...

Study of the efficacy, safety and tolerability of oral CEP-701 in patients with severe psoriasis.(CLINICAL TRIAL REVIEW)
April 1, 2006... This study is currently recruiting patients. Sponsored and verified by Cephalon. A 12-week, exploratory, open-label, nonrandomized, dose-escalation study of the efficacy, safety and tolerability of oral CEP-701 in patients with severe,...

Efficacy and safety of calcipotriol plus betamethasone dipropionate gel in psoriasis vulgaris.(CLINICAL TRIAL REVIEW)
April 1, 2006... This study is currently recruiting patients. Sponsored and verified by LEO Pharma. The objective of the study is to compare the use of calcipotriol plus betamethasone dipropionate gel with betamethasone dipropionate in the gel vehicle,...

The effect of 0.5% roxithromycin lotion for androgenetic alopecia.(CLINICAL TRIAL REVIEW)
April 1, 2006... This study is currently recruiting patients. Sponsored and verified by Hamamatsu University. The purpose of this study is exploiting the new drugs for androgenetic alopecia because there are still no effective and safe topical drug for...

Standard high-dose alpha interferon versus intermittent high-dose alpha interferon.(CLINICAL TRIAL REVIEW)
April 1, 2006... This study is currently recruiting patients. Sponsored and verified by Dermatologic Cooperative Oncology Group. The study protocol is being conducted to compare intermittent high-dose I.V. administration of interferon alpha-2b with the standard...

Efficacy study of latanoprost and bimatoprost solutions in promoting eyelash growth in patients with alopecia areata.(CLINICAL TRIAL REVIEW)
April 1, 2006... This study is currently recruiting patients. Sponsored and verified by the University of California, San Francisco. This is a single-center, randomized, investigator-masked study to determine the efficacy and safety of latanoprost and...

The impact of treating staphylococcus aureus infection and colonization on the clinical severity of atopic dermatitis.(CLINICAL TRIAL REVIEW)
April 1, 2006... This study is currently recruiting patients. Verified by Children's Memorial Hospital. Sponsors and Collaborators: Children's Memorial Hospital, Society for Pediatric Dermatology, and Johnson & Johnson. Staphylococcus aureus (S. aureus)...

Study of ONTAK (denileukin diftitox) in cutaneous T-cell lymphoma (CTCL) patients.(CLINICAL TRIAL REVIEW)
April 1, 2006... This study is currently recruiting patients. Sponsored and verified by Ligand Pharmaceuticals. The purpose of this study is to compare the effectiveness of 2 dose levels of ONTAK (denileukin diftitox) in treating patients who have recurrent or...

Study of ONTAK (denileukin diftitox) in previously treated cutaneous T-cell lymphoma patients.(CLINICAL TRIAL REVIEW)
April 1, 2006... This study is currently recruiting patients. Sponsored and verified by Ligand Pharmaceuticals. The purpose of this study is to provide an opportunity for patients who exhibit progressive disease while receiving placebo on the companion 93-04-11...

Comparison of excision versus punch incision in the treatment of epidermal cysts.(CLINICAL TRIAL REVIEW)
April 1, 2006... This study is currently recruiting patients. Sponsored and verified by Emory University. The purpose of this trial is to compare 2 standard of care treatments for removing epidermal cysts. Surgical excision removes the entire cyst but requires...