Bioscience Technology articles from October 2005

Bioscience Technology archives from October 2005

Microfluidics loom large.(EDITOR'S Note)
October 1, 2005... Mirofluidics-based analytical instrumentation is making its way into the life science research laboratory at the same time that the technology seeks other practical applications, including uses in "personalized" diagnostic and therapeutic...

Mouse genes off the shelf.(NEWS & Trends)(Brief Article)
October 1, 2005... Geneservice Ltd. and RZPD German Resource Center for Genome Research have announced an agreement with Kabushiki Kaisha Dnaform of Japan for the distribution of the Mouse Genome Encyclopedia DNABook. The book offers a collection of complete...

Program standardizes research.(NEWS & Trends)(Invitrogen Corp. introduces Vector NTI Open Access policy and the online Vector NTI User Community)(Brief Article)
October 1, 2005... Invitrogen Corp. has launched its Vector NTI Open Access policy and the online Vector NTI User Community, which allow researchers in not-for-profit labs to use the software at no cost. Vector NTI DNA and protein sequence analysis program...

NHLBI funds new centers for cell-based therapy.(NEWS & Trends)(National Heart, Lung, and Blood Institute)(Brief Article)
October 1, 2005... The National Heart, Lung, and Blood Institute has awarded the first three grants in a new research program on cell-based therapy of heart, lung, and blood diseases. Specialized Centers for Cell-Based Therapy for Heart, Lung, and Blood...

Cell lines for pathway analysis.(EDITOR'S Choice: OCTOBER'S TECHNOLOGY)
October 1, 2005... Invitrogen Corp. has announced new products in the CellSensor Cell Lines. Cell lines encoding ISRE, c-fos, AP-1, HRE, SIE and GAS response elements have been added to the existing products. The cell lines facilitate rapid and reliable...

Pipetting system for small laboratories.(EDITOR'S Choice: OCTOBER'S TECHNOLOGY)
October 1, 2005... CyBi-SmartWell, designed for newcomers to automation in small to medium sized laboratories, is a precise 96 channel liquid handling device. A library of ready to use test routines enables reagent, sample and mother-daughter plate transfers,...

Digital In Vivo molecular imaging.(EDITOR'S Choice: OCTOBER'S TECHNOLOGY)
October 1, 2005... KODAK Image Station In-Vivo FX system, available immediately, features cooled CCD camera technology and selectable multi-wavelength illumination for quantitative imaging of luminescent, fluorescent, and radiographic labeled biomolecules in...

Automated ELISA assay workstation.(EDITOR'S Choice: OCTOBER'S TECHNOLOGY)
October 1, 2005... The DSX workstation finds use in a number of applications--clinical diagnostics, assay design, ADME tox and drug discovery--in any lab performing ELISA assays. The automated instrument processes up to four 96-well microplates and up to 12...

Three-dimensional biophotonic imaging.(EDITOR'S Choice: OCTOBER'S TECHNOLOGY)
October 1, 2005... The IVIS 3D biophotonic imaging system provides full three-dimensional diffuse tomographic analysis of bioluminescent light sources in living animals as well as two-dimensional multi-view fluorescent imaging capabilities. The system captures...

Nanoliter pipettor.(EDITOR'S Choice: OCTOBER'S TECHNOLOGY)
October 1, 2005... Nano25 8-channel pipettor (Hudson Control Group, Inc.) offers transfer volumes ranging from 25 nl to 10 ml. Real-time documented confirmation is provided for all aspirated and dispensed volumes. Each channel offers individual volume control....

Protein interaction analysis systems.(EDITOR'S Choice: OCTOBER'S TECHNOLOGY)
October 1, 2005... The Biacore A100 facilitates array-based protein interaction analysis. Data from the system, which monitors entire interactions in real time and without the use of labels, provides insights into protein interactions for better understanding of...

Comet Assay.(EDITOR'S Choice: OCTOBER'S TECHNOLOGY)(Brief Article)
October 1, 2005... Comet Assay IV interactive video-based software system measures the DNA damage detected using single cell gel electrophoresis (SCGE). A high-definition video camera attached to a microscope provides real-time cell scoring by transferring a live...

Microfluidic analyzers: slow, steady progress.(Cover Story)
October 1, 2005... Once a sidebar of the nanotechnology revolution, microfluidics-based analysis chips have come of age through periods of hype, apathy and finally, commercialization. Originally called "laboratory-on-a-chip" in the United States and "micrototal...

Thermal cyclers.(BIOANALYTICAL INSTRUMENTS)
October 1, 2005... Mastercycler ep family thermal cyclers feature ESP-heated lids for fast. precise annealing and block homogeneity. A user may choose from Mastercycler ep gradient for 96-ml x 0.2-ml tubes or 1 PCR plate with a gradient range up to 20 C:...

Small molecule MS system.(BIOANALYTICAL INSTRUMENTS)
October 1, 2005... LTQ Orbitrap hybrid mass spectrometer is offered for small molecule research, drug discovery, proteomics, metabolite identification, and metabolomics. Automated Data Dependent [MS.sup.n] acquisition with accurate mass analysis combines with...

Biomolecule characterization.(BIOANALYTICAL INSTRUMENTS)
October 1, 2005... Viscotek Model 802 DLS dynamic light scattering instrument incorporates patented Single Mode Fibre (SMF) technology to provide fast and accurate characterization of biomolecules in solution determining qualities such as stability conformation...

High flow rate LC.(BIOANALYTICAL INSTRUMENTS)
October 1, 2005... NanoLC-1D Plus liquid chromatography system for nanospray mass spec analysis is configured with a third pump for rapid sample loading in proteomics and biomarker discovery applications. Operation of the third pump is incorporated in software,...

Single tube luminometer.(BIOANALYTICAL INSTRUMENTS)
October 1, 2005... FB15 Sirius single tube luminometer is offered with built-in printer and on-board software for data evaluation in stand alone mode. Flash and glow luminescence measurement provides sensitivity of 1000 molecules of firefly luciferase. The system...

Bio-spectrophotometer.(BIOANALYTICAL INSTRUMENTS)
October 1, 2005... U-0080D Bio-spectrophotometer diode array instrument has a built-in DNA/RNA application program, and can also be used as a standard spectrophotometer. Sample volumes as small as 1 microliter are quantitatively analyzed. The nucleic acid...

Add-on FT-Raman module.(BIOANALYTICAL INSTRUMENTS)(Brief Article)
October 1, 2005... RAM II add-on FT-Raman module can be coupled to proprietary multi-range FT-IR spectrometers. It is equipped with standard 1064-nm excitation for suppression of fluorescence. Configurations with a 976- or a 785-nm laser are available to offer...

Autosampler for GPC/SEC.(BIOANALYTICAL INSTRUMENTS)
October 1, 2005... PL-GPC 50 integrated GPC/SEC platform (Polymer Laboratories Inc.) is now offered with an optional the PL-AS RT Autosampler, for automated sample handling and increased sample throughput. Sample injection via a flushed fixed loop provides...

Digital imaging for microbiology.(BIOANALYTICAL INSTRUMENTS)
October 1, 2005... The BIOMIC [V.sup.3] System utilizes touch-screen technology to instantly read and interpret standard disk diffusion testing within 2005 CLSI guidelines. The system also reads many brands of ID Kits and CHROMagar plates by color digital image...

Biomolecule purification.(BIOANALYTICAL INSTRUMENTS)
October 1, 2005... Offered for the rapid purification of proteins, nucleic acids, carbohydrates and other biomolecules, the 2D ElectroPrep dialysis tank can, in three minutes, dialyze a sample simultaneously into multiple MWCO fractions. Alternatively, the system...

Multimode detectors.(BIOANALYTICAL INSTRUMENTS)
October 1, 2005... Two software packages and a verification system are available for Beckman Coulter DTX Series multimode detectors. The new enhancements--Multimode Analysis Software, Accounts and Permissions Software and Multimode Check Plate--can be implemented...

Radio-HPLC detector.(BIOANALYTICAL INSTRUMENTS)
October 1, 2005... The new b-RAM Model 4, for radio-HPLC measurements, features a 6" W x 13" deep footprint. Leak-proof cell design uses on internal fittings. The latest version of the instrument incorporates a system for automatically recording cell parameters...

Magnetic pen provides purification.(GENOMICS)
October 1, 2005... The PickPen streamlines target molecule capture and waste solution removal between processing steps and enhances purity and recovery. The pen-like magnetic device is available with a single magnetic tip, with 8-tip multi-sample processing...

Array for genome regulatory region analysis.(GENOMICS)
October 1, 2005... ChIP-on-chip microarrays (Agilent Technologies, Inc.) analyze activity at regulatory regions of genomes. The technology, also known as location analysis, provides insight into key mechanisms of embryonic stem cells and illnesses such as cancer,...

Microarraying platform.(GENOMICS)
October 1, 2005... QArray2 high throughput microarray platform is offered for both DNA and protein arrays. High-resolution linear drives combine with a high precision-low friction 48-pin printing head to ensure array regularity and high-speed printing of slides....

High capacity array hybridization.(GENOMICS)
October 1, 2005... Used with the Model 777 Microarray Oven from SciGene, this carousel hybridizes 96 Affymetrix GeneChip microarrays. The carousel is designed for reliable high speed rotation. Arrays are easily inserted and removed, yet are held firmly in place...

MicroRNA assays.(GENOMICS)
October 1, 2005... TaqMan microRNA Assays detect and quantitate mature human microRNA expression levels. MicroRNAs play a regulatory role in cell differentiation, developmental biology and diseases such as cancer. The assays allow discrimination between mature...

Drug, disease mediation assay.(GENOMICS)
October 1, 2005... ArrayPlate qNPA technology facilitates measurement of how drugs act and diseases are mediated at the level of whole cells, tissues, or organisms. Resources are focused, with results obtained in days. The platform does not require extraction,...

P53 protein microarray.(GENOMICS)
October 1, 2005... Panorama Human p53 microarray is based on technology that ensures that the protein is correctly folded and confers full functionality. The array contains wild type human p53 and 49 variants. Each p53 variant contains a mutation or single...

Phenotype microarray panels.(GENOMICS)
October 1, 2005... Phenotype MicroArrays (PM), offered for cell-based assays used with mammalian cell lines, have been optimized for use in a variety of human cell lines, including: liver cell lines (HepG2, C3A), leukemia cell lines (CRF-CEM, HL60), a colon...

Detect alternative splicing.(GENOMICS)
October 1, 2005... SpliceArrays combine exon and junction probes for specific detection of the two possible molecular species resulting from each splice event. Microarrays detect reference and alternatively spliced transcripts of human genes for: GPCRs,...

Western blotting detection kits.(GENOMICS)
October 1, 2005... The Visualizer EC Western Blot Detection Kit is a luminal peroxidase formulation offering high signal-to-noise ratios and sensitivity and low background. The product incorporates a high glow reaction chemiluminescent substrate that is both...

Human Druggabble Genome siRNA Set.(GENOMICS)
October 1, 2005... Human Druggable Genome siRNA Set V2.0 enables gone silencing studies of 6992 potential human druggable targets. The siRNAs are designed using the HiPerformance siRNA Design Algorithm, ensuring maximum silencing and minimum risk of nonspecific...

Transfection reagent.(GENOMICS)
October 1, 2005... Cationic polyethylenimine (PEI) derived transfection reagent is optimized for the delivery of genes to fragile primary cells, such as human umbilical vein endothelial cells (HUVEC) and vascular endothelial cells of various origins. The...

Genotypic analysis software.(GENOMICS)
October 1, 2005... Exemplar Genotyping Analysis Suite 2.2 analyzes data from genotyping experiments as well as clinical/environmental data. The software facilitates an understanding of the relationships between medical affectations, genes and environment. These...

Mouse expression arrays.(GENOMICS)(Brief Article)
October 1, 2005... Two new Sentrix BeadChips enable multi-sample whole-genome or RefSeq-based expression profiling of multi mouse samples. The chips enable profiling of over 47,000 mouse RNA transcripts and variants for the purpose of gene discovery, gene...

Dissolution and pipetting under argon.(HIGH THROUGHPUT SCREENING)
October 1, 2005... MOSS 2002 modular sample preparation system's eight independent spacing tips provide high speed movement in x, y and z axes. Weighing technology combines with software to automate library sample, weighing and dissolution with assay and storage...

Protein purification system.(HIGH THROUGHPUT SCREENING)
October 1, 2005... Vivapure 8-to-96 well cobalt-chelate kit simultaneously purities multiple His-tagged proteins by Immobilized Metal Affinity Chromatography. Membrane-based hardware is included for all process steps: lysate filtration, protein purification,...

Nanoliter picking, dispensing.(HIGH THROUGHPUT SCREENING)
October 1, 2005... X1 nanoliter version of the mosquito liquid handling system pipettes through the 50n1-1.2 ml range, with CVs of < 10% at 50 nl, and can pierce aluminum and PET plate seals with a cycle time of 5 seconds. Precise sampling of individual wells in...

Hydrophobic sitting drop plate for membrane protein research.(HIGH THROUGHPUT SCREENING)
October 1, 2005... CrystalQuick Plus combines the optical properties of a flat crystallization well bottom with hydrophobic surface features to render a format conducive to crystallography of cell membrane proteins. The plate surface effectively prevents drop...

Generation of labeled cRNA targets for microarray expression analysis: for scientists working with small amounts of biopsy tissue samples, rare primary cells, or laser-captured single cells, the difficult question remains as, how to use the little amount of RNA (either poly (A)+ RNA or total RNA) to generate biologically meaningful and reproducible microarray data?(APPLICATION Note)
October 1, 2005... DNA microarray technology is used in the study of differential gene expression. In comparison to quantitative PCR, one of the significant challenges presented by DNA microarrays is having sufficient amounts of high quality RNA sample that can...

Pipetting system.(NEW Technology)
October 1, 2005... WellAware Pipetting Aid, an error-free pipetting system, is a software driven system that can be used for microplate transpositions, serial dilutions, reformatting microplates, cherry-picking, and most custom protocols. WellAware guides users...

Cell-based screening plates.(NEW Technology)
October 1, 2005... NUNC 96-well and 384-well CC3 plates are used in screening a variety of cell lines and primary cells, including HEK, PC-12, BHK, CHO, cancer cells, primary neuronal cells and retinal explants. The CC3 surface mimics positively charged...

CAMP phosphodiesterase assay.(NEW Technology)
October 1, 2005... PDELight HTS cAMP phosphodiesterase assay kit can be used with all cAMP-dependent phosphodiesterases to produce rapid, quality data suitable for I[C.sub.50] determinations of screen compounds. The signal is a long lasting luminescence with a...

High-throughput monoclonal antibody purification.(NEW Technology)
October 1, 2005... AKTAxpress MAb and HiTrap MabSelect SuRe provide high throughput, automated, multi-step purification of monoclonal antibodies. AKTAxpress MAb is a software modification to AKTAxpress--a modular system for high-throughput purification of protein...

Particle suspension, reduction.(NEW Technology)
October 1, 2005... The Reactron particle suspension, distribution and reduction system offers reactor capacities from 1 to 200 liters. Most systems are built to specific requirements. Huber circulators provide heating or cooling. Caron Products & Services,...

Purify microbial DNA.(NEW Technology)
October 1, 2005... WaterMaster DNA Purification Kit provides the liquid reagents needed to purify microbial DNA from any water source after passage through a filter. DNA can be purified from bacteria and eukaryotes, and can be used for restriction digests, PCR,...

Stackable shaking cabinets.(NEW Technology)
October 1, 2005... Up to three Certomat BS-1 environmental shaking cabinets can be stacked without any reduction in shaking speeds. Erlenmeyer flasks of up to six-liter capacity are accomodated. Key parameters--speed, temperature and light, time cycles--are user...

Transfection kit.(NEW Technology)
October 1, 2005... TransIT-mRNA Transfection Kit delivers both mRNA and viral RNA of various lengths to a range of cell types. Transfection of mRNA leads to high level protein expression with minimal cytotoxicity. This kit has been optimized for use in the...

Centrifugal concentrators.(NEW Technology)(Brief Article)
October 1, 2005... The miVac range of centrifugal concentrators offers methods for drying aqueous and alcohol-based samples are included in all models. The units as a group provide capacity for 6 to 12 stacked shallow-well microplates or 64 to 200 micro...

Structure activity relationship service.(NEW Technology)
October 1, 2005... Service utilizes NMR spectroscopy techniques, such as Saturation Transfer Detection (STD) and Water-LOGSY, to study receptor-ligand interactions. NMR spectroscopy offers versatility and high-throughput capabilities, and provides atomic level...

Platelet aggregometer.(NEW Technology)(Brief Article)
October 1, 2005... Platelet aggregometer has eight channels. Software allows the device to perform various assays or generate a number of dose response curve points in about the same time as is required to perform a single assay or obtain a single data point....

Full DNA Polymerases.(NEW Technology)
October 1, 2005... Taq Full DNA Polymerases efficiently and conveniently amplify DNA from any template and are recommended for any general PCR amplification procedure. The DNA polymerase can generate the highest yields from any DNA template, including rare ones,...

High-pressure syringe pump.(NEW Technology)
October 1, 2005... KDS 410 high pressure syringe pump works with syringe capacities of 10 ml to 140 ml with flow from 1 nl/min to 145.5 ml/min. The pump can be triggered remotely by a foot pedal or a switch, and can communicate with a computer through the RS 232...

Apoptosis antibodies.(NEW Technology)
October 1, 2005... New antibodies are offered for studying ER stress-related apoptosis, including antibodies to ATF6, BAP31, Caspase-12, CHOP, TRAF2 and BiP/GRP78. New TR ligands are also available for inflammation research, along with monoclonal antibodies to...

Biotinylated polyclonals against scavenger receptors.(NEW Technology)(Brief Article)
October 1, 2005... Biotinylated affinity-purified polyclonal antibodies against Human SREC-I/SR-FI and Mouse LOX-1 sacenger receptors are available. Scavenger receptors are made of structurally distinct proteins that share a common functional role in innate...

Solid Phase Extraction.(NEW Technology)(Brief Article)
October 1, 2005... Polymeric Solid Phase Extraction (SPE) materials are offered for use in sample preparation, synthesis and purification, including pre and post HPLC applications. Utilizing StratoSpheres resins, these macroporous-based SPE materials offer high...

Heating circulators.(NEW Technology)(Brief Article)
October 1, 2005... Heating circulators in the 8100 Series are available with three different controllers, integrated simplex or duplex pump, and a 13 liter reservoir. The units require only about 1.1 square feet of bench space. Model 8112 has a programmable...

Dialysis and electroelution system.(NEW Technology)(Brief Article)
October 1, 2005... D-Tube Dialyzers dialyze sample volumes from 10 to 3000 ml. Screw-cap tubes with an integrated regenerated cellulose membrane, they are easy to load and unload. They can also be used to electroelute DNA, RNA, protein or protein-DNA complexes...

Dynamic light scattering protein crystallization.(NEW Technology)
October 1, 2005... The DynaPro product line offers tools for characterizing unfractionated samples via dynamic light scattering (DLS). The automated DynaPro Titan Plate Reader provides rapid screening of unfractionated samples for applications such as...

Refrigerators and freezers.(NEW Technology)
October 1, 2005... SANYO SR-Series refrigerators and freezers are offered in both 23 cu/ft (single door) and 49 cu/ft (double door) models with stainless steel interior and exterior surfaces, microprocessor controls and digital temperature displays. Applications...

Screening Sets for ELISA development.(NEW Technology)(Brief Article)
October 1, 2005... Screening Sets, for development of 5 colorimetric ELISA plates each, are currently available for human IFNg, IL-1b, IL-6, IL-8 and TNFa; bovine IFNg; mouse IFNg and MCP-1; porcine TNFa; and primate IL-lb and TNFa, with more released each month....

Plate-sealing films with color-coded end tabs.(NEW Technology)(Brief Article)
October 1, 2005... SealPlate ColorTab Adhesive Films are made of 50 mm thick clear polyester. They minimize evaporation, prevent spillage and contamination between wells, and provide a secure seal for ELISA, EIA, and assays. These films include a color dot and...

HPLC columns.(NEW Technology)(Brief Article)
October 1, 2005... Monolithic silica Onyx HPLC columns offer decreased column backpressure, which enables high throughput and separation efficiencies by column coupling. Column life is increased, even with biological samples. The portfolio includes various silica...

Bottletop dispenser.(NEW Technology)
October 1, 2005... Dispensette III bottletop dispenser can be used with bases, saline solutions, polar solvents and most acids, and can be autoclaved. Safety system permits recirculation to minimize waste. BrandTech Scientific, Inc., 888 522-2726,...

Applying ergonomics for injury free pipetting: Ovation BioNatural pipettes overcome ailments associated with older axial devices.(AN ADVERTISING SUPPLEMENT)(Advertisement)
October 1, 2005... Numerous liquid handling procedures rely on the ubiquitous pipette, and pipetting has long been an indispensable laboratory skill. The awkwardness, repetitiveness, stress and tedium inherent in traditional pipetting, however, are all harbingers...