Bioscience Technology articles from October 2003

Bioscience Technology archives from October 2003

Transfer membrane.
October 1, 2003... Rapid immunodetection method for Western blotting, developed using the Millipore Corporation Immobilon[TM]-P Transfer Membrane, eliminates the blocking step and minimizes the number and length of washes without compromising specificity or...

Antibody binding interaction measurement.
October 1, 2003... The 8500 Affinity Chip Analyzer identifies and characterizes antibody diagnostic and therapeutic candidates. As many as 400 antibody binding interactions can be detected and measured in less than two hours. Three primary applications are...

Multi-sample processing homogenizing.
October 1, 2003... PRO Scientific MULTI-GEN 7 7-mm homogenizer generators quickly attach to the homogenizer motor unit by means of a motor collar that also allows hands-free ejection of the used generator. This minimizes the chance of operator contamination when...

Rat, mouse brain matrices.(New Products)
October 1, 2003... Alto stainless steel and acrylic matrices make reproducible coronal and sagittal mouse and rat brain sections. Coronal matrices also have a mid-line cut for separating left and right hemispheres. CellPoint Scientific, Inc., Rockville, MD....

Mouse ICAM-1 kit.(New Products)
October 1, 2003... Quantikine ELISA is offered for mouse ICAM-1 (Intercellular Adhesion Molecule-1), an inducible transmembrane molecule that plays a role in cell migration, antigen presentation and leukocyte activation. Validated for serum, plasma, culture...

DNA polymerase.(New Products)
October 1, 2003... TaqPlus[R] Maxx[TM] DNA polymerase, a blend of cloned Taq and Pfu DNA polymerases mad ArchaeMaxx[TM] polymerase-enhancing factor, provides, with optimized buffer, high PCR product yields on targets to 10 kb. Stratagene, La Jolla, CA....

Apoptosis assays.(New Products)
October 1, 2003... Apoptosis Suite enables examination of three separate biological aspects of cell death in order to assess whether each cell is in the early- mid- or late-stages of apoptosis. The suite includes assays for membrane changes (Annexin V),...

Electronic Pipettes.(New Products)
October 1, 2003... SofTouch Electronic Pipettes provide a feather-touch button to initiate multiple liquid handling functions, including pipetting, reverse pipetting, multiple dispensing, sequenced dispensing, diluting, and mixing. Lever-action tip ejection...

Three-gas incubator.(New Products)
October 1, 2003... Heraeus[R] HERAcell[R] 150 trigas incubator is available with either stainless steel or fungicidal/bactericidal solid copper interior. ContraCon 90 C automatic decontamination routine covers the entire chamber interior and water reservoir,...

Genotyping System.(Editor's Choice)
October 1, 2003... GenomeLab[TM] SNPstream[R] Genotyping System, from Beckman Coulter, Inc., performs from 4,600 to over 800,000 genotypes per day. The automated, scalable, multiplexed system can process up to twelve SNPs in each well of an arrayed 384-well...

Electrochemical detector.(Editor's Choice)
October 1, 2003... The ESA CoulArray[R] electrochemical detector supports ADME-TOX screening and chemical assessment studies. Predicting a compound's tendency to undergo chemical oxidative degradation enhances efficiency and effectiveness in drug discovery and...

Automated C[O.sub.2] Incubator.(Editor's Choice)
October 1, 2003... Steri-Cult[R] R Automated C[O.sub.2] Incubator features a highspeed automated carousel and plate mover and class capacity for 196 plates. Stable, uniform chamber is suited for ADMF/Tox absorption assays such as Caco2, other cell-based assays,...

Gene-specific expression suppression.(Editor's Choice)
October 1, 2003... SureSilencing[TM] Kits contain a ready-to-use gene-specific siRNA population targeting one key regulator of a specific biological pathway. The populations are pre-tested and verified to decrease gene expression by at least 70 and as mirth as 90...

Lyse cells, extract proteins.(Editor's Choice)
October 1, 2003... EasyLyse[TM] Bacterial Protein Extraction Solution lyses bacterial cells for the isolation of proteins, especially recombinant gene products expressed in E. coil, without significant loss of enzymatic activity. It is formulated for ease of use...

New LC/MS.(New Products)
October 1, 2003... LCMS-2010A provides sensitive, high level throughput. A new drying gas system creates a fine spray for sensitive analyses of low to medium polarity compounds. Standard features include a metal capillary ESI probe for reduced adsorption and a...

Cell fractionation systems.(New Products)
October 1, 2003... Fraction-PREP[TM] systems provide formulations of buffers and reagents for preparation of highly enriched cellular fractions from mammalian cells. Prepared protein fractions are suitable for downstream assays, such as 2-D gel, Western blot,...

Electronic repeating pipette.(New Products)
October 1, 2003... HandyStep electronic repeating pipette is compatible with most standard syringe tips, and dispenses volumes from 1.0 ml-50 ml. Tip-recognition system identifies and displays the volume of BRAND PD-Tips[TM] upon insertion. Charging stand and...

DNA Ladders.(New Products)
October 1, 2003... SimplyLoad[TM] DNA Ladders come ready-to-load for gel electrophoresis fragment size determination. A range of sizes facilitate estimating fragment size for any moleculax biology application. Easily identifiable banding patterns speed...

miRNA Detection Kit.(New Products)
October 1, 2003... The mirVana[TM] miRNA Detection Kit simultaneously detects small RNAs, such as miRNA or siRNA and mRNA. The solution hybridization assay is based on a patented ribonuclease protection assay. miRNA and siRNA levels are monitored in a variety of...

Cell incubation chambers.(New Products)
October 1, 2003... Vacu-Cell[TM] cell incubation chambers hold coverslips or other surfaces by one side only. The coverslip or slide surface is held securely in place by the application of vacuum. Dual O-rings isolate the vacuum from the area of the coverslip...

Microarray data analysis software.(New Products)
October 1, 2003... Vector Xpression[TM] 3.0 provides statistical analyses of microarray and gene expression data, supported by a set of algorithms and accessible through a user interface. The program includes a recordable macro function that streamlines...

Robotic fluid dispensing.(New Products)
October 1, 2003... Encynova Model 2-4 system for robotic fluid dispensing applications is light enough to mount on lab robots, can be controlled via RS-485 communication, and is LabVIEW[TM] compatible. Travcy[TM] pumps are internally sealed, positive-displacement...

Tissue grinding beads.(New Products)
October 1, 2003... Beads used for homogenizing biological samples are available in various densities, including lower density glass and ceramic for processing easy-todisrupt tissues, as well as steel and tungsten carbide materials to handle difficult samples....

Handheld endotoxin detection system.(New Products)
October 1, 2003... Endosafe[R]-PTS is a portable test system based on the Limulus Amebocyte Lysate (LAL) assay. The LAL test is used to detect microbial contaminants in injectable drugs and medical devices. The PTS utilizes disposable cartridges loaded with...

Diode-laser systems.(Exhibit Highlights)
October 1, 2003... The new 56 ICS CleanBeam[TM] series of compact, doide-laser systems from Melles Griot provide output at 635, 640, 660, or 785 nm and beam quality previously avaiable only from a gas laser. Systems are avaialable with output power ranging from 7...

Digital stereotaxic instrument.(Exhibit Highlights)
October 1, 2003... Lab Standard[TM] digital stereotaxic features a zeroing function that allows setting a reference point for targeting specific coordinates on an animal's skull for injection, implantation, etc. Calculation of distance measurements via vernier...

Laboratory freezers.(Exhibit Highlights)
October 1, 2003... NuAire freezers are constructed of heavy-gauge cold-rolled steel. V-groove gasket provides a positive seal. CFC-free and HFC-free refrigerants are used with a mixture of azeotropic gases, making maintenance easy, allowing recharging practices...

Sample management system.(Exhibit Highlights)
October 1, 2003... The Micronic system from USA Scientific provides manual or automated sample identification, testing, storage, retrieval and transport. Tubes are available with a hexagonal or standard Data Matrix code, alphanumeric printing, or without...

Genotyping beads for Luminex[R] based-systems.(Exhibit Highlights)
October 1, 2003... FlexMAP[TM] beads from MiraiBio employ a universal tagging system, simplifying bead-based assays by eliminating the need to couple capture oligonucleotides to beads. Each of the 100 individual bead sets has a unique 24-base oligonucleotide...

Microdissection system.(Exhibit Highlights)
October 1, 2003... EasyBeam PALM microdissection system features a patented, non-contact laser beam that Selects, dissects and transports small cell areas and tissue in seconds, Built around the Zeiss Axiovert 40 inverted microscope, it is contamination-free and...

Plates for PCR.(Exhibit Highlights)
October 1, 2003... Eppendorf twin.tec PCR plate features a strong frame with then-walled wells. Polypropylene wells ensure minimal binding of DNA, RNA and enzymes and allow maximum recovery. Thin well walls facilitate hear transfer and a secure fit against a...

384-channel pipetting head.(Exhibit Highlights)
October 1, 2003... Tecan 384-channel pipetting head utilizes liquid displacement technology to provide accurate and reliable sample dispensing of volumes from 200 nl to 50 [mu]l. Lower compressibility of liquid compared to air allows the fluid-filled head to...

Small Animal Molecular Imager.(New Products)
October 1, 2003... Small Animal Molecular Imager (SAMI[TM]) uses time-domain optical imaging technology to visualize and quantify optical properties of tissue for multiple molecular imaging applications. The device enables in-vivo longitudinal characterization of...

Antibody development through genetic immunization.(New Products)
October 1, 2003... Custom monoclonal and polyclonal antibody development through genetic immunization involves direct immunization of the host animal with plasmid DNA encoding a protein of interest. The immunized host then produces the encoded protein and raises...

Sub-cellular imaging system.(New Products)
October 1, 2003... IN Cell Analyzer 1000 modular, subcellular image anlysis platform provides can be used in screening, lead profiling, target validation and assay development. Live cells can be observed in culture for responses to potential drug compounds to...

Sample concentrator.(New Products)
October 1, 2003... Discovery MK II high capacity, high throughput SpeedVac[R] system is offered for use with aggressive combinatorial chemistry solvents. It comes standard with sample temperature monitoring/control and complete automatic run programmability....

NFkB antibodies.(New Products)
October 1, 2003... NFkB is widely recognized as a critical mediator of immune and inflammatory responses. Other identified subunits include p52 (NFkB2), c-Rel, and RelB. The p65, cRel, and RelB subunits are responsible for transactivation. The p50 and p52...

SARS assay.(New Products)
October 1, 2003... Serologicals Corp. has announced that its research division, Chemicon International, Inc., will launch an OligoDetect[R] assay for fast and accurate detection of nucleic acids specific to SARS (Severe Acute Respiratory Syndrome). Detection of...

Tubing, accessories.(New Products)
October 1, 2003... The Upchurch Scientific[R] Div. of Scivex[TM] offers an expanding line of 1/32" OD tubing and fittings. Tubing includes PEEK[TM] PEEKsil[TM], Teflon[R] FEP, and 316 Stainless Steel. Direct connections with no sleeves needed is provided by 6-32...

Localization vectors.(Cloning Reagents)
October 1, 2003... BD Living Colors[TM)] subcellular localization vectors pHcRed1-Nuc and pHcRed1-Mito express the far-red fluorescent protein HcRed1 fused to a localization tag. Far-red shifted fluorescence easily distinguishes HcRed1 from other fluorescent...

Inducible BAC library kit.(Cloning Reagents)
October 1, 2003... CopyControl[TM] BAC Cloning Kits enable making libraries of stable, single-copy BAC clones that can be induced to high-copy number. A 1 ml culture of an induced clone yields microgram amounts of .BAC DNA for fingerprinting and sequencing. Each...

Gene assembly.(Cloning Reagents)
October 1, 2003... GENSA technology. Component DNA fragments are joined together by means of unique, non-palindromic termini of two, three or four bases, which are designed to ligate only with the correct, complementary sequences. Elimination of ambiguity means...

Cloning kits.(Cloning Reagents)
October 1, 2003... Lucigen's PCR-SMART Cloning Kits incorporate CloneSmart[TM] technology. PCR products containing "difficult-to-clone" sequences like AT- or GC-rich regions, toxic genes, nucleotide repeats, or strong promoters are often rearranged or lost...

Adenoviral vector for siRNA delivery.(Cloning Reagents)
October 1, 2003... The pSilencer[TM] adeno 1.0-CMV System combines adenoviral vectors with an siRNA expression system. The system provides efficient siRNA delivery to numerous cell types, including many primary and other difficult to transfect cells. A modified...

Cloning reagents.
October 1, 2003... USB Corporation reagents for various cloning applications include Tested User Friendly (TUF[TM]) enzymes. T4 DNA Ligase is available in both low and high concentrations, allowing flexibility in ligation reactions. Heat-labile Shrimp Alkaline...

Electroporation cuvettes.(Electroporation)
October 1, 2003... Electroporation cuvettes are offered in three color-coded gap sizes suitable for electroporation of bacteria, yeast or mammalian cells. The cuvettes fit most brands of electroporators and are individually wrapped and gamma irradiated for...

Yeast electroporation protocol.(Electroporation)
October 1, 2003... CelljecT Uno electroporator is a compact unit designed originally for bacterial applications. A new set of protocols for yeast applications expands its role. The protocols are supplied with the units, along with a free 40-page optimization...

Cordless electroporation instrument.(Electroporation)
October 1, 2003... Cloning Gun[TM] cordless, rechargeable, band-held electroporation instrument achieves transfection efficiencies exceeding 50% of viable cells with a variety of standard mammalian cell lines, and Transformation Efficiencies (TE's) of over...

Transfection of siRNA.(Electroporation)
October 1, 2003... ECM 830 Square Wave System features the BTX Power Platform, Fine Voltage Discrimination, Arc Quenching, Pulse Control, and monitoring capability. Products are offered for gene therapy, nuclear transfer, mammalian, plant, bacteria and yeast...

Electroporator.(Electroporation)
October 1, 2003... MicroPulser electroporator facilities safe, reproducible transformation of bacteria, yeast mad other microorganisms. The system offers one-button pulse delivery, attached cuvette chamber, and rapid charge-time speed sample handling. Preset,...

Electroporation system.(Electroporation)
October 1, 2003... Electroporator 2510 rapidly, and efficiently transforms bacteria and yeast. Optimized for specific experiments, the instrument is comfortable to operate. Applications include a variety of gram-positive and gram-negative bacteria as well as...

Multiple reagents for diagnosis of Epstein-Barr Virus/human herpesvirus.(Application Brief)
October 1, 2003... Epstein-Barr Virus (EBV) is a ubiquitous human herpesvirus with limited host range in other species; the virus primarily infects B-lymphocytes and nasopharyngeal pithelial cells. It is the causative agent of infectious mononucleosis (IM) cases...

Double-Density compound storage.(New Products)
October 1, 2003... TTP LabTech has announced the comPOUND[R] Double-Density (D2) sample store, holds two shorter microtubes (0.35 ml instead of the standard 1.0 ml) in each hole of comPOUND's carousels, doubling capacity to 200,000 tubes. Samples are sent to, and...

New oxidizing reagent.(New Products)
October 1, 2003... Resin-bound oxidizing reagent, MP-TsO-TEMPO, for alcohol oxidation, assists medicinal chemists in increasing the diversity of targeted drug compounds. MP-TsO-TEMPO substitutes cumbersome and loss-prone purification procedures with a simple...

Heated and refrigerated circulators.(New Products)
October 1, 2003... VWW[TM] and VWR Signature[TM] heated and refrigerated circulators facilitate intuitive programming and control. Redundant overtemperature and low liquid level detection is located on the control panel. Refrigerated models contain a purge port...

Animal bedding disposal station.(New Products)
October 1, 2003... PuriCare[TM] Bedding Disposal Station protects operators from airborne particulates. Room air is drawn into the front of the enclosure, preventing aerosols from escaping. Before leaving the enclosure and returning to the room through the top of...

High throughput whole blood DNA extraction.(New Products)
October 1, 2003... AutoGenprep 965, an automated 96 well format robotic system for DNA extraction, produces high yields of quality DNA at a very low cost per prep. The 965 was recently released with a protocols for whole blood and BAC/plasmid. Additional...

Automated benchtop DNA separation.(New Products)
October 1, 2003... MiniPrep bench-top lab, used with the new MagPrep(R) reagent kits, streamlines the DNA separation process, providing reproducible results at a fraction of the hands-on time of manual methods. Based on a magnetic separation technique, the system...

Plate sealing film.(New Products)
October 1, 2003... 96-Well Pattern Sealing Film is adhesive-free around the 96-wells, a feature that prevents the adhesive from adhering to plastic pipette tips or metal probes. The adhesive is solvent free. The sealing film is available in 2 rail or 5 rail thick...

Apoptosis detection kits.(New Products)
October 1, 2003... Magic Red[TM] substrate-based assays detect protease activity within whole living cells, and are based on a the cresyl violet leaving group that fluoresces once enzyme specific peptides are cleaved. FAM FLICA[TM] Apoptosis Detection Kits use a...

Deep Well Plate, Cap Mat.(New Products)
October 1, 2003... NUNC[TM] brand 384 DeepWell[TM] Plate and Well Cap Mat provide storage for DMSO and other strong chemicals and solvents. The plate, constructed of chemical-resistant polypropylene, features 240 ml wells with diamond-shaped conical well bottoms...

Extra-cellular matrix product line.(New Products)
October 1, 2003... The Cultrex extra-cellular matrix product line has been expanded. Product additions include BME in PBS, BME staining kit, Cell Recovery Solution, Poly-L-Lysine, Rat Tail Collagen, and Bovine Collagen I. Cultrex products are used for cell...

Human whole-genome array.(New Products)
October 1, 2003... Whole-genome human array is composed of almost 200,000 long oligo probes (60 mers), with an average coverage of 5 probes per gene. The chip designs are currently being used for gene expression analysis and comparative genomic hybridization...

Plate and tube shakers.(New Products)
October 1, 2003... Electromagnetic plate and tube shakers mix the contents of 96 or 384 well deep microplates as well as multiple racks of 1.5 to 3.0 mi tubes. Union Scientific Corp., Randallstown, MD. 410-496-0200; unionscientific.com * Write in 438 Or...

Hot plates, stirrers.(New Products)
October 1, 2003... Barnstead/Thermolyne brand Cimarec[R] hot plates and stirring hot plates offer digital technology and enhanced safety features. High wattage boils liquids quickly. Digital control technology ensures repeatable, accurate temperatures. Barnstead...

Active compound library.(New Products)
October 1, 2003... The Library of Pharmacologically-Active Compounds ([LOPAC.sup.1280[TM]]) is a collection of 1,280 characterized small ligands used for assay validation and orphan receptor characterization. This expanded version of LOPAC[TM] includes a range of...

Plasmid purification system.(New Products)
October 1, 2003... CosMCPrep[TM] SPRI[TM]-based, plasmid purification system isolates various high and low copy number templates. Plasmid DNA is selectively bound to paramagnetic microparticles, allowing easily automated filtration-free purification. CosMCPrep...

Infrared spectroscopy in drug discovery.(New Products)
October 1, 2003... Bruker Optics Inc. offers various infrared spectroscopy applications for supporting drug discovery, from the molecular to the cellular level, based on a new concept called "Infrared Fingerprinting". Since every molecule has a unique infrared...

Liquid handling workstation.(New Products)
October 1, 2003... Eppendorf epMotion 5070 liquid handling station automates pipetting, dispensing, and dispensing variants. Pipetting sequences that were previously carded out manually can be quickly transferred to me station. The mouse and keyboard of the...

Dark quencher.(New Products)
October 1, 2003... AbsoluteQuencher[TM] is used in combination With reporter fluorophores to create probes for real-time, quantitative PCR. Using absorption from 470 to 560 nm, it quenches fluorescent reporters such as FAM, TET, JOE, VIC, and HEX, providing low...

Hybrid mass spectrometer reduces time required to identify metabolites.(Tools & Techniques)
October 1, 2003... A hybrid mass spectrometer has reduced the time needed to analyze metabolites of drug compounds by two-thirds or more, according to researchers at the University of Geneva. Quantitative and qualitative analysis of metabolites becomes more...

Detection of West Nile virus RNA.(Tools & Techniques)
October 1, 2003... West Nile virus (1) is a flavivirus, which can infect humans, birds, horses and other mammals and is transmitted primarily by mosquitoes. The virus was recently introduced into the Eastern United States, with the first case reported in 1999,...

C18 columns.(New Products)
October 1, 2003... Prevail[TM] Select C18 HPLC columns analyze basic compounds at neutral to alkaline pH. C18 silica and bonding chemistry minimizes chromatography effects with basic and polar compounds. Alltech Associates, Inc., Deerfield, IL. 847-948-8600:...

Blended Agarose.(New Products)
October 1, 2003... Agarose Blenders[TM] are Agarose I[TM]/TBE and Agarose[TM]/TAE powder blends that provide improved background, clarity and resolution in electrophoresis. The TBE (or TAE) buffer is already mixed in with the agarose at a 1 X concentration....

Sequencing grade Aspartic-N.(New Products)
October 1, 2003... Purified Aspartic-N is modified to reduce autolysis, improve stability and simplify protein sequencing. Asp-N endoproteinase is consistent lot to lot and offers 24 hour stability for overnight protocols. Princeton Separations, Inc., Adelphia,...

Web services research tool.(New Products)
October 1, 2003... NCBI databases are growing to colossal sizes--GenBank, for example, contains 25 billion DNA sequences. As the frequency of searches escalates (20 million searches per month are conducted on PubMed alone), searches have become more complicated,...

Centrifuge for microarray slide drying.(New Products)
October 1, 2003... The slide spinner quickly dries two microarray slides, and easily removes wash buffer prior to slide scanning. The device includes the centrifuge and two removable cassettes that conveniently trap all liquid. The related product line for...

Growth factor antibodies.(New Products)
October 1, 2003... Biodesign International has recently added myostatin antibodies to its line of over 300 cytokine and growth factor products. Myostatin is a member of the transforming growth factor-beta (TGF-beta) family of secreted regulatory factors. Also...