Bioscience Technology articles from May 2007

Bioscience Technology archives from May 2007

Screening marches on.(ENABLING LIFE SCIENCE RESEARCH)
May 1, 2007... Every thing moves faster these days, or so hopes nearly everyone in pharma or biotech. Much of that increase in speed comes from high-throughput screening (HTS), which utilizes automation, robotics, and other technologies to run many compounds...

Ways in which signal transduction-related research is conducted.(SNAPSHOT)
May 1, 2007... Ways In Which Signal Transduction-Related Research Is Conducted In Vitro 75.3% In Cell Models 66.0% In Vivo 53.6% In Animal Models 48.5% In Silico 16.5% % Respondents Source: Current...

Will personalized medicine be universal?(Editorial)
May 1, 2007... Personalized medicine, while still in its infancy, is already having a positive impact on the diagnosis and treatment of disease. As the wave of genomic and proteomic knowledge broadens and rises, it carries with it the potential to bring ever...

Automated molecular imaging system for early disease detection.(May's Innovations)
May 1, 2007... The KODAK In-Vivo Imaging System FX Pro is designed for advanced multi-wavelength fluorescent, luminescent, radioisotopic and X-ray imaging in life science research and drug discovery applications. The instrument offers an automated lens,...

High-throughput colony-picking workcell.(May's Innovations)
May 1, 2007... RapidPick fully automated high-throughput colony-picking workcell (Hudson Control Group, Springfield, N J) allows researchers to automate the selection and growth of cells grown on a colony plate, and will retain a record and image of the...

Non-mutagenic DNA stain.(May's Innovations)
May 1, 2007... ENVISION non-mutagenic fluorescent DNA stain (Amresco, Inc., Solon, OH) is supplied in the firm's 6X loading buffer. The fluorescent reagent forms a complex with the sample DNA before electrophoresis. Bands are visible immediately with standard...

Flexible Thermal Cycler.(May's Innovations)
May 1, 2007... Veriti 96-Well Thermal Cycler features VeriFlex Blocks technology, which utilizes six separately controlled alloy blocks that allow users to set specific temperatures that will not encroach into neighboring zones. A touch screen interface...

Live cell incubation and monitoring.(May's Innovations)
May 1, 2007... BioStation IM is a compact cell incubation and monitoring system that allows users with minimal microscopy experience to conduct live cell imaging without a steep learning curve. Operation is intuitive from both the lab and from remote...

Multi-sheet data management workbook.(May's Innovations)
May 1, 2007... OriginLab Corp. (Northampton, MA) has announced the release of Origin 8 analysis and graphing software for Windows. A multi-sheet workbook facilitates organization and management of data, reports, graphs, and images. Reports can be created...

MALDI protein sample prep kit.(May's Innovations)
May 1, 2007... MALDI sample prep kit contains reagents for processing protein samples electroeluted for MALDI mass spectrometry for MALDI-TOF analysis. This kit can be used to process whole proteins for direct MALDI-MS analysis or for in-solution digestion of...

Ultrasound functional and molecular imaging.(May's Innovations)
May 1, 2007... Two contrast agents are offered for ultrasound functional and molecular imaging in preclinical animal models. Ultrasound imaging is non-invasive, performed in real time and in vivo. These products are biocompatible encapsulated microbubbles,...

Collaboration accelerates clinical whole blood sample expression profiling.(Research News)
May 1, 2007... Agencourt Bioscience, a Beverly, MA-based wholly-owned subsidiary of Beckman Coulter, Inc. (Fullerton, CA), has announced a collaboration with NuGEN Technologies, Inc. (San Carlos, CA) and Affymetrix Clinical Services Laboratory (ACSL) (Santa...

Brain networks strengthened by closing ion channels.(Research News)
May 1, 2007... Yale School of Medicine and University of Crete School of Medicine researchers report in Cell (April 20) the first evidence of a molecular mechanism that dynamically alters the strength of higher brain network connections. This discovery may...

Cancer gene signature data integrated with network analysis tools.(Research News)
May 1, 2007... Compendia Bioscience, Inc. (Ann Arbor, MI) a provider of cancer profiling data and analysis tools, and Ingenuity Systems (Redwood City, CA) a provider of software and databases for biological exploration, interpretation, and analysis, have...

Gene finding could lead to personalized breast cancer treatment.(Research News)
May 1, 2007... TriStar Technology Group (Rockville, MD) announced results of a genetic study that could have significant implications in treatment of breast cancer. The research, carried out using TriStar's high throughput tissue analysis platform and...

Protein research lab is focused on deadliest diseases.(Research News)
May 1, 2007... Waters Corp. (Milford, MA) and Northeastern University have opened the Waters Mass Spectrometry Laboratory within the Barnett Institute of Chemical and Biological Analysis at the university. The lab is dedicated to studying protein shapes and...

Syringe filter.(Filtration Focus)
May 1, 2007... This new syringe filter is just large enough that it will rest on top of a 50 ml tube and not slide into it. A large filter area makes filtering a little quicker without requiring as much pressure on hands and fingers. PES 0.22 [micro]m syringe...

Nylon syringe filters.(Filtration Focus)
May 1, 2007... New 33 mm Millex syringe filters with nylon membrane are offered for analytical sample preparation. The non-sterile filters are used for filtration of 10 to 100 ml volumes of aqueous and mild organic solutions prior to HPLC or other instrument...

Bioprocess filtration.(Filtration Focus)
May 1, 2007... A complete line of ULTA normal flow filters are offered for process efficiency from early phase product development through to full-bioprocess filtration production. The filters remove particulates and reduce bioburden (during pre-filtration or...

Conical culture media filters.(Filtration Focus)
May 1, 2007... NALGENE 50 mL Conical Filter Units incorporate a Pall Supor machV polyethersulfone (PES) membrane. Providing vacuum filtration of biological sample volumes ranging from 20 to 50 ml, the filters are attached to a 50 ml centrifuge tube for easy...

Helium and nitrogen purifiers.(Product News)
May 1, 2007... The HP2 helium purifier provides "point-of-use" purification of helium or other noble gases to sub-ppm levels. The NP2 (nitrogen purifier) purifies nitrogen to sub-ppm levels. The substrate in these purifiers is a non-evaporable gettering...

PCR workstations.(Product News)
May 1, 2007... AC600 Series PCR workstations, which come with the UVTect microprocessor controller, maintain a Class 100 work area during PCR preparation. The workstations have a built-in 254 nm ultraviolet light for irradiation and HEPA filtration, and both...

Surgical instruments.(Product News)
May 1, 2007... This line of surgical instruments features the Vannas microdissecting scissors. The tools are forged and finished from premium certified surgical-grade steel using the Dura Therm Forging process. Quality steel and fine stone polishing provide...

340 to 650 NM light source.(Product News)
May 1, 2007... PhotoFluor light source combines a metal halide lamp with a sputtered heat-blocking optic to deliver light across the 340 to 650 nm spectrum. With emphasis on power in the UV range, the unit allows bright imaging of DAPI, Hoechst and other...

Weigh boxes.(Product News)
May 1, 2007... XPert Weigh Boxes have inlet and outlet HEPA filters and provide a physical barrier to protect the operator from hazardous airborne particulates. Numerous accessories are available to accommodate specific applications. The boxes feature a...

General purpose lab refrigerator.(Product News)
May 1, 2007... Model 6CARE 6.1 cu/ft general purpose lab refrigerator offers electronic touchpad controls with LED temperature display. Audio and visual alarms alert for high and low temperature conditions, as well as door ajar and power failure events. The...

Mixers, shakers.(Product News)
May 1, 2007... Lab Plus Series of sample processing equipment includes the VSN-5 nutating mixer, the VSM-3 vortex mixer, the VSR-50 variable speed rocker, the VSOS-4 digital programmable ORBITAL Shaker, and HPS-7 hot plate stirrers (available with ceramic or...

Multiwell plates for ELISA assays.(Product News)
May 1, 2007... Fluoronunc and Luminunc LockWell modules are designed for enzyme-linked immunosorbent assay (ELISA) applications in immunology and in vitro diagnostics (IVD) that employ luminescence and fluorescence detection technologies. LockWell modules...

Coated PETG roller bottles.(Product News)
May 1, 2007... Ready-to-use InVitro roller bottles are pre-coated with Poly-D-Lysine (PDL) utilizing a proprietary process. PDL is a synthetic mimic of the extracellular matrix that has been shown to enhance cell attachment, growth and differentiation in...

Microplate handling system.(Product News)
May 1, 2007... R-Series BenchCel microplate handling system features enhanced positional accuracy, increased payload, reduced installation time and simpler user adjustments. A quick-swap robot module allows for fast exchange of one of the most critical and...

Fluorescence filters.(Product News)
May 1, 2007... Single-band fluorescence filter sets are optimized for popular quantum dot nanocrystals. Three of these sets are offered for multicolor imaging or quantitation with the highly utilized Qdot 525, 605, and 6Nanocrystals. A fourth filter set uses...

Microplates, sealers.(Product News)
May 1, 2007... Plate and accessory line includes 24-, 96-and 384-well Krystal-UV plates, which offer photometric performance down to 325 nm. The MiniSeal entry-level semi-automated thermal sealer was developed for laboratories sealing small to medium batches...

Ultrasonic cup horns.(Product News)
May 1, 2007... Cup horns produce high ultrasonic intensity without probe intrusion. These accessories can process biohazardous samples without cross-contamination or airborne pollution. Up to eight samples can be processed simultaneously. Water can be...

DNA extraction for medical mycology: early detection of invasive fungal infections is of the utmost importance for immunocompromised patients.(Apparatus & Consumables)
May 1, 2007... The early detection of invasive fungal infections (IFIs) is of the utmost importance for immunocompromised patients, such as individuals with HIV-AIDS, patients who have undergone a tissue or bone marrow transplant, and cancer patients...

MALDI Spotting capability for nanoflow LC.(Chromatography Focus)
May 1, 2007... Eksigent has announced the addition of a NanoLC MALDI Spotting System to its nanoflow chromatography product line. Featuring the new Ekspot spotter, the system complements the company's existing offerings for nanospray mass spectrometry...

Oligonucleotide Separation columns.(Chromatography Focus)
May 1, 2007... Oligonucleotide Separation Technology HPLC and UPLC columns are available for the purification and high-resolution LC or LC/MS analyses of synthetic DNA and RNA oligonucleotides. Both C18 offerings use Ethylene-Bridged Hybrid particles and...

Silica-based columns.(Chromatography Focus)
May 1, 2007... Fast LC columns (Dionex Corp.) have been added to the Acclaim bonded silica family. The columns are used with the Dionex UltiMate 3000 Intelligent LC series, and are available in 3 mm ID and 33 mm or 75 mm length, packed with a 3 [micro]m...

Micro-HPLC for proteomic analysis.(Chromatography Focus)
May 1, 2007... New 2D micro-HPLC system performs sensitive separation of complex peptide mixtures. The capillary-to-microflow system, co-developed by Shimadzu Scientific Instruments and the National Institutes of Health, separates complex peptide mixtures...

High-throughput Flow Cytometry.(Product News)
May 1, 2007... MPL (multi-platform loader) option for the Beckman Coulter Cell Lab Quanta SC Flow Cytometry System enables quick, accurate handling of a range of plate types or of a 24 ViCell sample cup holder. Enhancements to QuantaSC software enable easy...

Automated cell culture and assay system.(Product News)
May 1, 2007... The Cell Growth and Discovery (CGD) WorkCell is an enclosed, environmentally controlled, automated system for high capacity cell growth, supply and inline image analysis. Combining software and robotics, the system can simultaneously handle...

Single-sample cytometer.(Product News)
May 1, 2007... Equipped with a blue laser and 3-color detection, the Guava EasyCyte Mini (Guava Technologies, Hayward, CA) has all of the functionality of the company's EasyCyte 96-well platform in a single sample format, making the system accessible to...

Electrophoresis mini-gel system.(Product News)
May 1, 2007... The Mini-PROTEAN Tetra Cell 1-D electrophoresis mini-gel system is offered for both hand-cast and pre-cast gel users and features a clamping frame. Using two running modules, the system accommodates from one to four hand-cast or Ready Gel...

Microplate Washer.(Product News)
May 1, 2007... ELx50 Filter Microplate Washer (FMW) features a syringe drive fluid-delivery system with automated vacuum filtration for unattended processing of 96-well filter bottom plates. Filter microplates must be aspirated from below to maintain the...

Fluorescence, luminescence detection.(Product News)
May 1, 2007... PARADIGM modular detection platform features a selection of cartridges that can be interchanged in less than five minutes to meet various assay requirements. It is suggested for labs in which multiple users run a range of applications. The...

Chemiluminescent imaging of gene expression.(Product News)
May 1, 2007... The FireFly Imaging System is used with proprietary quantitative nuclease protection assay kits for direct measurement of gene expression on multiple targets simultaneously in a range of sample types including formalin fixed paraffin embedded...

Triple quadrupole MALDI mass spec.(Product News)
May 1, 2007... The FlashQuant mass spectrometry platform combines triple quadrupole mass spec with MALDI technology to provide fast drug compound screening. The platform is expected to enable scientists to generate data in a fraction of the time currently...

Post-translation modification analysis.(Product News)
May 1, 2007... Modiro--The PTM-Explorer automates the identification of post-translational modifications (PTMs) of proteins to provide comprehensive information while reducing analysis time. Modiro analyzes thousands of mass spectrometry profiles in parallel...

Thermal cyclers.(Product News)
May 1, 2007... This family of thermal cyclers has a variety of features centered on an updated user interface that makes it easy to program. Improved block technology offers improved heating and cooling rates for greater throughput. Products are available...

Screening data management.(Product News)
May 1, 2007... ActivityBase Xtended Edition (ActivityBase XE) vT.0 includes support for complex assay types (e.g. multiplexing and HCS). The release of this module offers screening scientists a single environment for data capture, visualization, verification,...

DNA methylation profiling: a four-probe design scheme is used to differentiate between methylated and unmethylated alleles of a target CpG site.(Instruments & Systems)
May 1, 2007... Introduction The study of epigenetic changes on a genomewide scale, termed epigenomics, is a rapidly growing field. With the advent of microarray technology, the elucidation of such changes can be monitored genome-wide, enabling the study...

HT Tube Formation Kit.(Cell Culture Focus)
May 1, 2007... CAS HT Tube Formation Kit facilitates detection of inducers and inhibitors of endothelial cell tube formation. The kit contains Cultrex Reduced Growth Factor (RGF) Basement Membrane Extract (BME), a soluble form of basement membrane purified...

Serum-Free media for human mammary epithelial cell culture.(Cell Culture Focus)
May 1, 2007... GIBCO HuMEC Serum-Free Medium is optimized for the culture of human mammary epithelial cells. It is formulated with known concentrations of proteins, growth factors and other supplements, and is consistent lot-to-lot. CDNA microarray studies...

Mycoplasma detection, elimination.(Cell Culture Focus)
May 1, 2007... LookOut Mycoplasma PCR Detection Kit (Sigma-Aldrich, St. Louis, MO) includes pre-coated reaction vials that reduce prep time. The kit is optimized for use with JumpStart Taq DNA Polymerase (Sigma-Aldrich), and enables cell culture supernatants...

Hepatocyte Isolation System.(Cell Culture Focus)
May 1, 2007... The Worthington Hepatocyte Isolation System provides a pre-optimized combination of enzymes that minimize lot-to-lot variation. Each lot is use-tested by isolating hepatocytes from adult rat to assure performance, reliability, and yield of...

PCR enzyme mix.(Product News)
May 1, 2007... TaqMan Gene Expression Master Mix and Genotyping Master Mix reagents are formulated for use in both routine and challenging real-time PCR applications. Used in quantitative real-time PCR protocols, the product helps researchers to detect low...

Kinase assay platform.(Product News)
May 1, 2007... HTRF KinEASE TK is a universal and sensitive assay for high throughput screening of Tyrosine (Tyr) kinases, major targets in drug discovery and, in particular, in oncology research. It combines a peptide substrate called $4 and a single,...

Amplify low abundance RNA.(Product News)
May 1, 2007... Optimized protocol for amplification of low abundance RNA by FISH combines Invitrogen IVGN TSA peroxidase enzyme-based amplification with Alexa Fluor dye tyramides. Used in conjunction with the FISH Tag RNA kits, the protocol enhances the...

High Throughput Superoxide Dismutase Assay.(Product News)
May 1, 2007... High Throughput Superoxide Dismutase (SOD) Assay kit measures SOD activity by the reduction of tetrazoleum salt to the diformazan counterpart in cell and tissue extracts. The assay is provided in a 96 well format suitable for high-throughput...

PH electrode solutions.(Product News)
May 1, 2007... The primary cause of pH measurement problems is a dirty ceramic diaphragm. In order to maintain the integrity of measurements, pH electrodes should be cleaned regularly. This selection of solutions includes electrode cleaners, buffers for pH...

Live cell assay system.(Product News)
May 1, 2007... CellReporter platform, for quantitative screening that produces qualified data for multiple-well, live cell assays, uses white light and multiplexed fluorescence. Multiple parameters are assessed in parallel, delivering immediate analysis and...

L-type calcium channel drug testing.(Product News)
May 1, 2007... Millipore Corp. has added the human L-type calcium channel, a voltage-gated channel involved in normal myocardial and vascular smooth muscle contractility, to its CardiacProfiler Service for compound liability testing. A link between hERG...

Western blotting standard.(Product News)
May 1, 2007... Precision Plus Protein WesternC standards offer 10 pre-stained protein bands that can also be detected through chemiluminescent Western blotting. The Immun-Star WesternC kit is a complementary chemiluminescent detection kit optimized for CCD...

Superparamagnetic beads.(Product News)
May 1, 2007... The surface of Dynabeads ClinExVwo CD3/CD28 superparamagnetic beads is with primary CD3 and costimulatory CD28 antibodies. Following a short ex vivo incubation with the patient's sample, the beads bind with T cells. The beads and bound T cells...

Complete kit for PCR product amplification.(Product News)
May 1, 2007... The Expand Long Range dNTPack is complete solution for the consistent amplification of PCR products of 5 to 25 kb from genomic DNA. This enhancement of the Expand Long Template PCR System combines optimized buffers, ultrapure PCR-grade...

Benchtop imaging, gene expression testing.(Product News)
May 1, 2007... The Firefly Imager, a sensitive, charged couple device (CCD) camera, can image multiple targets for an entire 96-well plate in about 15 minutes, allowing researchers to analyze samples directly at their workstation. The qSeries testing platform...

Live cell kinetic neurotransmitter transporter uptake assay kit.(Product News)
May 1, 2007... Molecular Devices' Neurotransmitter Transporter Uptake Assay Kit can be used in both kinetic and endpoint modes and is a simple, mix-and-read protocol performed in 96-or 384-well formatted plates. The assay utilizes a masking dye to extinguish...

MiRNA labeling and detection kit.(Product News)
May 1, 2007... miRtect-IT miRNA labeling and detection kit detects miRNA in as little as 50 ng or less of total RNA. The kit's linear detection range is 0.1-10 femtomoles, and mature miRNA can be measured without an amplification step. One labeling reaction...

Microarray system for expression profiling of human miRNAs.(Product News)
May 1, 2007... Agilent Technologies Inc. has introduced a microarray-based assay for microRNA (miRNA) expression profiling. The assay allows the use of very small amounts of sample (100 ng of total RNA), making it well-suited for miRNA expression profiling...

Gene expression kit.(Product News)
May 1, 2007... GenomeLab GeXP Rat MultitoxPlex Kit, for preclinical drug research screening, contains 25 genes involved in key toxicological pathways, including those for toxicity, stress, DNA damage and apoptosis. It also includes three reference genes and...

Cryopreservation Medium.(Product News)
May 1, 2007... Aedesta cryopreservation rnedium preserves tissue and cells without any cryoprotective additives, and prevents ice crystal formation without the use of DMSO. The medium has no animal serum or animal proteins. Harvard Apparatus Inc. ...

Disinfectant, virucide.(Product News)
May 1, 2007... SilverClene24 disinfectant and virucide, an EPA-registered disinfectant, has been proven effective against potentially dangerous bacteria viruses, and fungi. The is effective against a organisms including antibioticresistant bacteria, as well...

DNA Analysis microarray.(Product News)
May 1, 2007... BeadChip HumanCNV370-Duo DNA Analysis microarray targets regions of the genome that show copy number variation (CNV). Copy number variations can occur when a region within a chromosome or an entire chromosome is randomly amplified or deleted....

Peptide synthesis resins.(Product News)
May 1, 2007... Resins and supported reagents are offered for solid phase peptide and organic chemistry. ChemMatrix 100% PEG resin offers advantages in the synthesis of long or complex peptides. Activotec 44-1223-260008 www.activotec.com

Monoclonal antibody to proteinase inhibitor.(Product News)
May 1, 2007... A monoclonal antibody is available for the detection of human intracellular serpin, PI-9 (SERPINB9), which is present in cytotoxic and dendritic cells to protect against the pro-apoptotic protease, granzyme B. PI-9 may be unregulated by tumors...

Transfection reagents.(Product News)
May 1, 2007... Lipofectamine LTX delivers DNA into cells, the first critical step in characterizing gene function, and demonstrates transfection efficiency and high levels of protein expression with more than 90 percent viability for a wide range of cells,...

PCR Amplification Kit.(Product News)
May 1, 2007... MiniFiler PCR Amplification Kit generates genetic profiles from aged, compromised, or damaged DNA samples. The kit was developed in response to the growing backlog of samples recovered from crime scene investigations and other instances of DNA...

Experimental characterization of gene regulatory networks.(Biochemicals & Kits)
May 1, 2007... Introduction In the post-genome era, microarray expression analyses and ChiP-chip transcription factor binding assays have provided a more detailed understanding of genetic pathways. These technologies provide valuable observational data...

Microfluidics propels functional proteomics.(Best Practices)
May 1, 2007... Sebastian Maerkl joined the California Institute of Technology in 2001 to pursue his doctoral research in proteomics. He picked the eukaryotic transcription factors belonging to the basic-helix-loop-helix (bHLH) family for his initial studies....