Bioscience Technology articles from March 2006

Bioscience Technology archives from March 2006

What reader's want.(survey on bioscience technology)(Editorial)
March 1, 2006... Bioscience Technology recently completed its annual survey of readers. The results told us a lot about who our readers are, the places they work, the kinds of methods and technologies being adopted, and interaction with various sources of...

Microwave synthesis workstation.(MARCH'S TECHNOLOGY)
March 1, 2006... SWAVE microwave synthesis system combines the Biotage Initiator Microwave Synthesis Module and the Chemspeed automated workstation. Reagents are added under inert atmosphere for handling of sensitive chemicals. Overhead solid weighing and...

Dual access laminar flow cabinet.(MARCH'S TECHNOLOGY)
March 1, 2006... PuriCare Dual Access Laminar Flow Cabinet is designed for permanent installation in the wall opening between vivarium "clean" and "dirty" rooms that is exposed to dust and other particles. It provides Class 100 clean air in the work area....

LC/MS/MS System.(MARCH'S TECHNOLOGY)
March 1, 2006... QSTAR Elite LC/MS/MS System (Applied Biosystems), a quadrupole time-of-flight mass spectrometer, is offered for the discovery of protein and small molecule biomarkers from complex biological samples. Analyst QS 2.0 software provides stability...

Protein screening system.(MARCH'S TECHNOLOGY)
March 1, 2006... Flexchip screening system utilizes an array format that allows hundreds of protein interactions to be monitored simultaneously, in real time and without the use of labels. Interactions of interest may be selected for downstream...

Protein crystallization products.(MARCH'S TECHNOLOGY)
March 1, 2006... Analysis of a protein's three-dimensional structure is essential to understand its function. Until now, identifying the chemical conditions that lead to highly-diffracting protein crystals has been a time-consuming process. QIAGEN offers...

Linear cloning system.(MARCH'S TECHNOLOGY)
March 1, 2006... BigEasy Linear Cloning System, for cloning DNAs up to 50kb, features a vector derived from a linear bacteriophage genome. The pJAZZ-KA vector remains linear in the host cell, avoiding the problems of insert instability that occur when circular...

Disposable bioreactors.(MARCH'S TECHNOLOGY)
March 1, 2006... The NUNC Cell Factory a flexible, safe and low-investment bioproduction product, easily scales-up and offers a low contamination risk. Bioproduction products and accessories include NUNC standard and Actively Gassed Cell Factories, as well as...

Tangential flow filtration system.(MARCH'S TECHNOLOGY)
March 1, 2006... Minimate tangential flow filtration (TFF) system concentrates samples from 1 L to 5 ml. Subsequent desalting or buffer exchange steps can be run on the same system with minimal user intervention. The device works with the disposable Minimate...

More than a messenger: the evolution of RNA.(Cover story)
March 1, 2006... During the last ten years RNA has revealed itself as much more than a simple messenger, or intermediary between DNA and protein. RNA can act as a catalyst, binding site for small molecules, regulator of gene expression, structural component of...

Transfer membrane improves fluorescent detection of proteins.(APPLICATION Note)
March 1, 2006... Fluorescent detection methods enable the simultaneous detection of two or more proteins on the same blot, known as multiplexing. Multiplexing enables a variety of analyses, including differential protein expression and post-translational...

Fluorescence filters.(MICROSCOPY/IMAGING)
March 1, 2006... BrightLine optical filters are specifically tailored for fluorescence instruments including Molecular Devices GenePix microarray scanners, the Becton Dickinson CARV II confocal imager, and the Yokogawa CSU 10 and CSU 22 confocal scanners....

High-speed confocal imager.(MICROSCOPY/IMAGING)
March 1, 2006... [ImageXpress.sup.ULTRA] laser-scanning, confocal imager (Molecular Devices, Sunnyvale, CA) utilizes up to four configurable solid-state lasers and is available with a robotic plate handling option for automated, high throughput image-based...

Laser TIRF Imaging System.(MICROSCOPY/IMAGING)
March 1, 2006... Laser TIRF (Total Internal Reflection Fluorescence) Imaging System facilitates the examination of dynamic processes near the membrane of living cells or on the cover slip of cell-free systems. The observation of the dynamic behavior of proteins...

Stages add intelligent control.(MICROSCOPY/IMAGING)
March 1, 2006... Prior ProScan II series motorized stages have added Intelligent Scanning Technology (IST) to all model H101A, H107 and H117, 4" X 3" scanning stages. In conjunction with extensive testing, IST allows each stage to be pre-programmed with a...

Raman, FTIR microscopes.(MICROSCOPY/IMAGING)
March 1, 2006... Raman and FTIR microscope systems LabRAM [IR.sup.2] and LabRAM ARAMIS [IR.sup.2] provide a range of micro-analysis facilities. A complete 2D chemical image can be derived from Raman and FTIR spectral information. Temperature and humidity cells...

Electron multiplier CCD.(MICROSCOPY/IMAGING)
March 1, 2006... C9100 camera features high gain and a hermetic vacuum chamber evacuated to [10.sup.-8] Torr. Using on-chip electron gain multiplication and deep cooling, the signal level can be greatly increased relative to camera noise, providing a relative...

Mass spec tissue imaging.(MICROSCOPY/IMAGING)
March 1, 2006... Mass spectrometry tissue imaging service, based on proprietary processes and exclusive technology licenses from Vanderbilt University and the University of Texas, provides insight into protein expression, disease progression and drug...

Live cell confocal imaging.(MICROSCOPY/IMAGING)(Brief article)
March 1, 2006... LiveScan swept field confocal microscope features a pinhole scan mode that provides high Z-axis resolution with data acquisition at rates up to 30 frames/sec, and a slit scan mode for acquisition frequencies up to 1200 frames/sec. Events in...

EMCCD camera.(MICROSCOPY/IMAGING)(Brief article)
March 1, 2006... SPOT Boost EMCCD cameras utilize electron multiplication technology for use in low to extremely low-light, live cell microscopy applications. Temperature compensated linear electron multiplication gain of up to 1000x offers the capability to...

6-axis piezo stage.(MICROSCOPY/IMAGING)(Brief article)
March 1, 2006... New 6-axis piezo nanopositioning and scanning system P-587.6CD provides active trajectory error compensation, millisecong responsiveness, nanometer resolution, and travel ranges from 800 [micro]m/10,000 [micro]rad. AutoCalibration speeds setup...

Macroscopic fluorescence system.(MICROSCOPY/IMAGING)
March 1, 2006... The Leica MacroFluo system combines the long working distance and large field of view of a stereomicroscope with the vertical optical path of a classical light microscope. This allows imaging very large fields and increases the accuracy of...

Attenuated Total Reflectance microscope objective.(MICROSCOPY/IMAGING)(Brief article)
March 1, 2006... Slide-On Attenuated Total Reflectance (ATR) microscope objective collects data from samples between obstacles because of its conical crystal shape. The objective performs micro-ATR analysis of inclusions, surfaces and samples inside depressions...

Live cell imaging software.(MICROSCOPY/IMAGING)
March 1, 2006... InVivo Analyzer Suite 3.0 combines three scientific software applications into a complete live cell imaging solution. This updated version takes advantage of the acquisition tools of InVivo, the analytical capabilities of Image-Pro Analyzer and...

Particle image analysis.(MICROSCOPY/IMAGING)
March 1, 2006... Morphologi G2 particle image analyzer measures particle size using circle equivalent diameter, and employs a variety of parameters for particle shape analysis. This enables the determination and quantification of even small differences between...

Yellow DPSS laser.(MICROSCOPY/IMAGING)
March 1, 2006... 85 YCA-series diode-pumped solid-state (DPSS) lasers have output power of 25 mW at 561 nm, which can be used to compensate for fiber-coupling losses or optical throughput inefficiencies associated with scanning and imaging devices. The...

TIRF objective.(MICROSCOPY/IMAGING)(total internal reflectance fluorescence)(Brief article)
March 1, 2006... Olympus 150x, 1.45 NA oil objective, for total internal reflectance fluorescence (TIRF) research microscopy over the ultraviolet (UV) to infrared (IR) spectrum, are high-NA U Apochromat products that enable TIRF observation using a standard...

Extended range nano focus control system.(MICROSCOPY/IMAGING)(Brief article)
March 1, 2006... New system for extended range nano focus control for microscopes features a 3 nm resolution piezo Z-stage integrated with a precise stepper motor focus drive. The combined functions enable high speed nano focus control over the full focus...

CCD camera.(MICROSCOPY/IMAGING)
March 1, 2006... Cooled digital 12bit CCD camera system sensicam qe offers thermo-electrical cooling of the image sensor (down to -12 C), low noise (4e-rms) and quantum efficiency, all of which combine to achieve high spectral sensitivity in general and...

Array analysis system.(ARRAY TECHNOLOGIES)(Brief article)
March 1, 2006... Illumina's BeadStation 500 supports a range of array-based genotyping and gene expression incorporating multiplexed assay capability, multi-sample microarrays, a submicron-resolution scanner, and SNP scoring software. The system can perform...

Human Cytokine Antibody array.(ARRAY TECHNOLOGIES)
March 1, 2006... Multiplex Human Cytokine Antibody (Ab) array provides a simple, focused way to streamline the study of immune system regulation and disease. It allows simultaneous quantitative measurement of 16 human cytokines from each sample of serum or...

Human tiling arrays.(ARRAY TECHNOLOGIES)(Brief article)
March 1, 2006... GeneChipTiling Arrays, for the discovery of novel RNA transcripts or mapping sites of protein/DNA interaction in chromatin immunoprecipitation experiments, feature 25-met oligonucleotides for hybridization specificity. Tiling arrays offer a...

Micro RNA profiling arrays.(Locked Nucleic Acid technology)(Ribonucleic Acid)(Brief article)
March 1, 2006... miRCURY Arrays use Tm-normalized capture probes that incorporate Locked Nucleic Acid (LNA) technology to provide affinity and mismatch discrimination for short microRNA targets. miRCURY Arrays work on less than 2 [micro]g total RNA (no need for...

Isolate protein-based biomarkers.(IMMUNOLOGICALS)
March 1, 2006... Beckman Coulter, Inc. has added IgY-R7 rodent and single-component chemistries to its ProteomeLab Partitioning Systems. The new IgY-R7 rodent chemistry selectively partitions seven highly abundant proteins--up to 70 percent of the protein...

Anti-CCP ELISA.(IMMUNOLOGICALS)(Anti-Cyclic Citrullinated Peptide )(Brief article)
March 1, 2006... Anti-Cyclic Citrullinated Peptide (CCP) ELISA, for detection of IgG class autoantibodies against CCP in human serum or plasma, comes with 12 x 8 well strips, calibrators, controls, wash buffer, diluent, conjugate and stop solution. The kit has...

Human Bax EIA kit.(IMMUNOLOGICALS)
March 1, 2006... Colorimetric, 96-well plate immunoassay measures human Bax concentration in cell lysates with a range of 62.5-2,000 pg/ml in just three hours. The assay is non-radioactive, stable and sensitive to 10.1 pg/ml. Each kit comes complete with...

Equine TNF-alpha screening set.(IMMUNOLOGICALS)
March 1, 2006... Equine TNF-alpha screening sets develop 5 colorimetric ELISA plates each. Additional sets are available for other species and analytes. Screening sets contain the basic components and protocol to develop 5 sandwich ELISAs for cytokine...

Tumor necrosis factor converting enzyme ELISA.(IMMUNOLOGICALS)
March 1, 2006... Human TACE/ADAM17 Quantikine ELISA kit is available. Tumor necrosis factor [alpha] converting enzyme (TACE) is a metalloprotease initially identified by its ability to cleave the membrane-anchored, 26 kDa form of TNF-[alpha] and release the...

Kinase assays.(IMMUNOLOGICALS)(Brief article)
March 1, 2006... Omnia Kinase Assay utilizes a fluorescence peptide substrate-based technology for homogenous detection of enzymatic activity. Results are measured under optimal kinetics, physiological (mM) ATE and in real-time without radioactive tracers or...

Transcription Factor Assay.(IMMUNOLOGICALS)
March 1, 2006... PPAR Transcription Factor Assay provides a non-radioactive method for detecting specific transcription factor DNA binding activity in nuclear extracts. A specific double-stranded DNA (dsDNA) sequence containing the peroxisome proliferator...

Online Assay Library.(IMMUNOLOGICALS)
March 1, 2006... The Sigma-Aldrich Corp. Assay Library features over 600 detailed procedures for measuring enzyme activity and related metabolites. It is available on the company's Enzyme Explorer, which also features in-depth resources on protein research,...

In vitro monoclonal antibody production.(IMMUNOLOGICALS)
March 1, 2006... In vitro manufacturing service will provide 10 mg, or 200 grams, of antibody, cell factor, or any secreted cell product. The facility uses hollow fiber bioreactor technology, which results in concentrated batches of high MW products, while...

Kinase assay panel.(IMMUNOLOGICALS)
March 1, 2006... KinaseAdvisor kinase assay detects even weak kinase activity when paired against potential therapeutic compounds. The assay uses Caliper Life Science's LabChip technology, which allows screening to be completed using a tenth of amount of...

Mouse interferon beta ELISA.(IMMUNOLOGICALS)
March 1, 2006... Mouse IFN alpha ELISA kit detects mouse interferon beta in cell culture and serum using a sandwich immunoassay, and makes possible differentiation of mouse IFN alpha and beta levels. The assay is specific to Mouse IFN beta and will not...

Detect oxidative stress damage.(IMMUNOLOGICALS)
March 1, 2006... Trevigen's anti-8-oxo-dG detects and quantitates 8-hydroxyguanine in DNA, cell and tissue samples, and can be used in immunocytochemisty, ELISA, immunoprecipitation and immunohistochemistry. The antibody, raised against 8-hydroxyguanine coupled...

Peptide database predicts immunogenicity.(IMMUNOLOGICALS)
March 1, 2006... ImmunoFilter predicts immunogenicity of therapeutic proteins and monoclonal antibodies early in the drug discovery pathway. Immunogenicity can decrease efficacy and potency and has been difficult to predict. The product examines a protein...

Pipettors offer gel mode.(NEW Technology)
March 1, 2006... Transferpette electronic pipettors include a "gel" mode that simplifies loading of electrophoresis gels. Pipettes dispense slowly into gels and measure liquid volume as it is dispensed, so the user knows exactly how much has been loaded. The...

Dynamic batching to optimize lab resources.(NEW Technology)
March 1, 2006... TERANODE XDA 2.8 informatics model-driven platform transforms experiment designs into automation without the need for programming. Workflow feature tracks individual compounds or samples and associated data across dynamic plate structures...

Biotech spelling dictionary.(NEW Technology)
March 1, 2006... The Biotech spelling dictionary can be added to the dictionary of a favorite software program and will provide correct spelling choices for incorrectly spelled bioscience words. The dictionary also allows users to look up unsure spellings of...

Syringe filters.(NEW Technology)
March 1, 2006... Millex 33 mm sample preparation syringe filters feature Express PLUS polyethersulfone (PES) membrane. Used for general particulate filtration prior to liquid chromatography (HPLC) or other instrument analysis, the filters remove fine particles...

Flow cytometer.(NEW Technology)
March 1, 2006... Cell Lab Quanta SC, from Beckman Coulter's family of flow cytometers for drug discovery and basic clinical research, combines side light scatter detection and a third fluorescent channel with Coulter volume measurement to deliver...

DNA polymerase IV.(NEW Technology)
March 1, 2006... The Dpo4 enzyme is a thermophilic Y-family DNA polymerase that performs trans-lesion synthesis. It also allows for coupling to PCR for amplification of damaged DNA. The enzyme is purified from E. coli containing a recombinant plasmid harboring...

Chemiluminescent blotting kits.(NEW Technology)
March 1, 2006... Chemiluminescent Western blotting kits detect either rabbit or mouse antibodies complexed with antigen immobilized on PVDF or nitrocellulose membranes. The purified secondary antibody conjugates and matching reagents provide sensitivity,...

Searchable inhibitor database.(NEW Technology)
March 1, 2006... Online Substructure Searchable Inhibitor Database Files (EMD Biosciences-Calbiochem) consists of a chemical structure data file (.sdf) and ChemFinder-compatible file currently with more than 650 records based on the Calbiochem collection of...

Ergonomic pipet tips.(NEW Technology)
March 1, 2006... Ergonomic tips reduce the force used to eject tips from the shafts of Gilson, FinnPipette Digital, and FinnPipette Focus pipettors. A bi-fabricated wall creates a strong seal around the pipettor shaft as a result of a small, non-variable...

Temperature microprobes.(NEW Technology)
March 1, 2006... This 0.23 mm Teflon-coated probe facilitates taking temperatures in blood vessels, spectrometer cuvettes or rectally with neonatal mice. The flexible probe can be autoclaved. Its small mass allows for fast reading times with time constants as...

Plastic serological pipettes.(NEW Technology)
March 1, 2006... Shorty plastic serological pipettes are available in 5 ml and 10 ml sizes. They are 4-1/2" shorter than standard products. Both pipettes have additional and reverse graduations and full colored mouthpieces (blue on the 5 ml; orange on the 10...

Microcentrifuges.(working with biohazardous samples)(Brief article)
March 1, 2006... Seward Clearspin 10K and 12K microcentrifuges provide safety and convenience when working with biohazardous samples. Low-cost, easily replaceable rotors and disposable tube carriers feature certified hermetic sealing in a clear, chemical-and...

Refrigerating/heating circulators.(temperature control)(Brief article)
March 1, 2006... Low-temperature circulators provide temperature control. 9700 Series Refrigerating/Heating Circulators offer a -45 to 200 C temperature range, a 13-L reservoir, and a choice of three controllers. Standard features include integrated simplex or...

Vortex mixers.(NEW Technology)
March 1, 2006... Two versions of the LW Scientific Turbo Mixer are now available. For quick and complete mixing of samples, cup and platform models come with variable speed control up to 3000 rpm and can be activated to vibrate continuously or by pressure to...

Stroke rate controller.(NEW Technology)
March 1, 2006... V300 stroke rate controller for FMI V-Series variable speed metering pumps features front panel membrane switches for convenient manual setting of pump stroke rates adjustable in 0.1% increments. Stroke rate can also be controlled...

Stainer labeling.(NEW Technology)
March 1, 2006... Dual Tech labels are non-heat sensitive and can be read in conventional barcode-based Autopap systems similar to Tripath's Neopath system, as well as OCR liquid-based imagers like CYTYC's Thin Prep system. They are available in sets of two...

LIMS enables enterprise-wide access.(NEW Technology)
March 1, 2006... Sapphire R4.4 offers new scheduling and analytical quality control functionalities and a new archiving module. The software enables enterprise-wide access and visibility. As a benefit to current maintenance and support users, free virtual...

Temperature controller.(chemical reactors)(Brief article)
March 1, 2006... FS18-HE temperature controller provides rapid control of the temperature of external systems, such as chemical reactors, having volumes up to 5 liters. It is designed with a bath volume only a fraction of normal baths, and therefore can change...

Mobile workbench.(chemical-resistant surfaces)(Brief article)
March 1, 2006... Starsys Mobile Workcenter modular furniture system enables flexible lab configuration. An aluminum and steel-framed substructure has an outer skin of advanced polymers. Easily-cleaned, chemical-resistant surfaces will not chip, peel, dent or...

PCR reagents.(NEW Technology)
March 1, 2006... Power SYBR Green PCR Master Mix is a line of reagents for real-time PCR gene expression applications. The kit provides sensitivity for gene expression analysis, gene detection and quantitation. The reagents offer sensitivity comparable to...

Pathways analysis.(NEW Technology)
March 1, 2006... Latest release of Ingenuity Pathways Analysis will be integrated into the Genizon Target Express platform. The software facilitates modeling, analysis and understanding of complex biological systems. Large knowledge base, a curated database,...

Competent E. coli cells.(NEW Technology)
March 1, 2006... E-Shot DH10B T1R Electrocomp cells are competent E. coli pre-aliquotted in single-use, 0.1 cm universal-fit cuvettes ready for electroporation. Few pipetting steps are required, and freeze-thaw cycles can be eliminated. The cells feature...

Miniature check valve.(NEW Technology)
March 1, 2006... Series 120 ultra-miniature, magnetically latched solenoid valve offers weighs just 300 mg and requires only a momentary 1 ms pulse to switch the state (+ 5 VDC to open, -5 VDC to close) and is suited for compact, battery-powered pneumatic...

Electroporation mediated in vivo gene delivery.(NEW Technology)
March 1, 2006... The ECM 830 square wave electroporation system and specialty electrodes are offered for mammalian cell and in vitro electroporation. Experimental cancer research now incorporates a direct injection of plasmid DNA into a tumor lesion, followed...

LysoPLD substrate.(Lysophospholipase D)(Brief article)
March 1, 2006... Lysophospholipase D (lysoPLD) activity assays can be developed using FS-3, a fluorogenic lysoPLD substrate. The substrate is a doubly labeled analog wherein the fluorophore is quenched through intramolecular energy transfer. Cleavage of...

Circular ssDNA for rolling circle applications.(NEW Technology)
March 1, 2006... CircLigase ssDNA Ligase catalyzes the circularization of single-stranded DNA (ssDNA) without need for oligo "bridges" or "splints" Virtually no linear or circular concatamers are produced. Circular ssDNA is prepared for rolling circle...

Depth filter cartridge.(NEW Technology)
March 1, 2006... DeltaMax depth filter cartridge is an absolute-rated all-polypropylene filter available with removal ratings of 0.5, 1, 3, 5, 10, 20, 40 and 70 [micro]m. Cartridges are available in lengths from 25 to 100 cm. [ILLUSTRATION OMITTED] *...

Monoclonal antibody purification.(NEW Technology)
March 1, 2006... HiTrap MabSelect SuRe, for use in small-scale monoclonal and polyclonal antibody purification, allows the cleaning and re-use of columns prepacked with MabSelect SuRe, an affinity chromatography medium resistant to cleaning agents such as 0.5 M...

Pipettor calibration service.(NEW Technology)
March 1, 2006... Pipettor calibration service program features lightweight, space-saving packaging. The compact inflatable pouch and brightly colored, water-resistant envelope come pre-labeled and include simple documentation, shipping and decontamination...

Human validated kinase SiRNA set.(NEW Technology)
March 1, 2006... SiRNAs in the Human Validated Kinase siRNA Set V1.0 have been verified by stringent real-time RT-PCR analysis to provide at least 70% target gene knockdown. RNAi screening with the set eliminates the possibility of false-negative results and...

Fractionator System.(NEW Technology)
March 1, 2006... The flashPAGE Fractionator System purifies small nucleic acids, such as siRNAs and microRNAs in approximately 12 minutes. The system uses an electrical current to drive nucleic acids through a proprietary denaturing gel matrix and buffer...

Electrophoresis kit for high MW DNA.(NEW Technology)
March 1, 2006... GelAmp Electrophoresis Kit resolves high molecular weight DNA. The kit contains high strength agarose, running buffer and a polymer additive that allows resolution and separation of high molecular weight plasmid preparation, BAC, YAC, cosmid...

Researchers assemble second non-human primate genome.
March 1, 2006... A multi-center team has deposited the draft genome sequence of the rhesus macaque monkey into free public databases for use by the worldwide research community, the National Human Genome Research Institute (NHGRI), one of the National...

MIT researcher explains how rats think.(Massachusetts Institute of Technology)(Brief article)
March 1, 2006... After running a maze, rats mentally replay their actions--but backward, like a film played in reverse, a researcher at the Picower Institute for Learning and Memory at MIT reports Feb. 12 in the advance online edition of Nature. His latest...

Comprehensive database of knockout mouse lines.
March 1, 2006... Taconic Farms, Inc. (Hudson, NY) has made its inventory of more than 1,000 knockout mouse lines accessible through a searchable database. This database enables researchers to review the portfolio of knockout mouse lines and select lines for...

Depression model leaves mice with molecular scar.
March 1, 2006... In addition to triggering a depression- like social withdrawal syndrome, repeated defeat by dominant animals leaves a mouse with an enduring molecular scar in its brain that could help to explain why depression is so difficult to cure, suggest...

Computational diagnostic methods for viral pathogens.
March 1, 2006... Virginia Bioinformatics Institute (VBI) at Virginia Tech and Orion Integrated Biosciences Inc. (OIB) have entered an agreement to facilitate the development of new diagnostic methods for key viral pathogens. Under the terms of the agreement,...