Bioscience Technology articles from March 2005

Bioscience Technology archives from March 2005

Online reader service upgrades.(Editor's Note)
March 1, 2005... Our primary mission at BioScience Technology has always been to inform readers of the latest developments in instrumentation and biochemistry for use in biological research. An important piece of that information chain was the "Reader Service"...

PharmaDiscovery Conference to debut in May.
March 1, 2005... PharmaDiscovery Conference and Exhibition will have its initial meeting at the Washington Convention Center in Washington, DC from May 10 to 12, 2005. The conference program will be produced by Elsevier and Drug Discovery Today magazine and...

Tripos acquires Optive Research.
March 1, 2005... Tripos, Inc. (St. Louis, MO) has acquired privately held Optive Research, Inc., an Austin, Texas based company focused on chemoinformatics products for molecular discovery. Examples of new Optive products include Benchware, a suite of desktop...

Efficacy results of synthetic AFGP's.
March 1, 2005... The first series of results showing the efficacy of chemically synthesized AFGP (antifreeze glycoprotein) has shown efficient cell preservation viability on a delicate human cell line (kidney cells). At concentration levels from 10 times to 100...

Society for Biomolecular screening call for papers.
March 1, 2005... Drug Discovery: From Targets to Candidates, the 11th Annual Society for Biomolecular Screening conference and exhibition, will convene September 11-15, 2005 at the Geneva PalExpo in Geneva, Switzerland. Potential presenters should submit all...

ArtisOptimus licenses mouse models from Taconic.
March 1, 2005... ArtisOptimus, Inc. (Carlsbad, CA) and Taconic Farms, Inc. (Germantown, NY) have entered into multiple agreements to leverage their respective strengths in MEF production and patented mouse models to bring a collection of primary Mouse Embryonic...

Protein interaction analysis system.(March's Technology)
March 1, 2005... Biacore T100 protein interaction analysis system is offered for use in primary research and drug discovery. The instrument can analyze up to 384 samples per run, automatically, over a broad kinetic range. Software wizards facilitate assay...

Digital imaging system.(March's Technology)
March 1, 2005... KODAK Image Station 4000 digital imaging systems feature cooled CCD camera technology to provide fluorescent, luminescent, radiographic and chromogenic imaging. The 4 million pixel CCD and 10x optical zoom lens provide spatial resolution of up...

Western Blotting method.(March's Technology)
March 1, 2005... Double Blotting, a western blotting technique, uses proprietary Immobilon-P and [P.sup.SQ] transfer membranes, and overcomes non-specific binding of secondary anti bodies during immunoblotting. The procedure involves blotting proteins onto a...

Cell culture dishes.(March's Technology)
March 1, 2005... Vivadish, a rectangular cell culture plate with four parallel chambers, accommodates standard microscope slides. Simultaneous cell culture experiments can be performed in one plate: cells are grown directly on the inner surface or onto standard...

Microplate washer.(March's Technology)
March 1, 2005... ELx405 self-maintaining microplate washer uses Ultrasonic Advantage built-in ultrasonic cleaning to aid in routine maintenance, specifically to help prevent clogging in the manifold due to protein or salt crystal build-up. Instrument features...

Glassware washer.(March's Technology)
March 1, 2005... LANCER 910 LX glassware washer features an automatic door closing system, ergonomic loading height, on-board chemical storage with liquid level detection and HEPA filtered injector drying. Standard items include microprocessor controls, a small...

Automated yeast cell counting.(March's Technology)
March 1, 2005... NucleoCounter YC-100 automatically counts yeast cells in about 30 seconds. The system uses a fluorescence microscopy technique for accurately counting cell nuclei stained with propidium iodide. Combined with a CCD camera and integrated image...

Proteomics instruments unravel biomolecules.(Cover Story)
March 1, 2005... Life scientists haven't had time to rest on their laurels since the completion of the human genome project. According to Jeff Peterson, CEO of Target Discovery (Palo Alto, CA), the incomplete correlation between protein and gene expression led...

Multi-purpose image analyzer.(Image Analysis And Microscopy)
March 1, 2005... ChemiGeniusXE 3 multi-purpose image analysis system incorporates a computer-controlled darkroom with auto-lock sliding doors that houses a 3.2 million pixel resolution 16 bit CCD camera for separation of images with close bands or spots. The...

Scientific CCD Camera.(Image Analysis And Microscopy)
March 1, 2005... MacroFire monochrome camera incorporates a 4-megapixel CCD measuring 21.4 mm in diagonal with 2048 X 2048 pixels that are 7.4 X 7.4 microns square. with a 40,000 electron well depth. This is the optimal size for low-light photomicrography...

Digital camera.(Image Analysis And Microscopy)
March 1, 2005... AxioCam MRc5 color digital camera is equipped with a 5-megapixel CCD sensor. FireWire and flexibility in read-out modes. The camera offers true color images for applications in pathology, histology, cytology and biology. The 5 mega pixel....

Microscopy cameras.(Image Analysis And Microscopy)
March 1, 2005... Diagnostic instruments has announced three new camera models for microscopy. The SPOT Pursuit camera system is offered for fluorescent and analytic imaging needs, and features a 4 mega pixel CCD combined with regulated cooling at -10 C. New...

Z-focusing stage for scanning microscopy.(Image Analysis And Microscopy)
March 1, 2005... P-540 series microscopy nano-focusing Z-stages easily integrate into high-resolution microscopes and other probing instruments. They provide fast motion to 100 [micro]m in the Z-direction with sub-nanometer resolution in an ultra low-profile...

Fluorescence lifetime imaging microscopy system.(Image Analysis And Microscopy)
March 1, 2005... C9136 FLIM (Fluorescence Lifetime Imaging Microsopy) system is based on Hamamatsu's streak technology. Combined with a short-pulsed laser and a conventional inverse fluorescence microscope, the system offers rapid time-domain FLIM and FRET...

Structured light imaging system.(Image Analysis And Microscopy)
March 1, 2005... OptiGrid Structured-Light Imaging System affords 2D optical sectioning capabilities to the most recent generation of Nikon upright and inverted microscopes. For new Eclipse models (including the Eclipse /-series and inverted TE 2000-E/U/S...

Cooled monochrome CCD.(Image Analysis And Microscopy)
March 1, 2005... DP30 cooled monochrome CCD camera, offered for low-light microscope imaging applications, provides full-resolution live preview, vibration-free performance, and 12-bit low noise images. Developed for fluorescence microscopy applications, the...

Electron microscope film.(Image Analysis And Microscopy)
March 1, 2005... Reformulated Electron Microscope Film 4489 features T-GRAIN provides development uniformity across the entire film plane without modified processing agitation techniques. Users benefit from increased speed while maintaining a high...

Spectral imaging system.(Image Analysis And Microscopy)
March 1, 2005... DIGITAL ECLIPSE Clsi confocal laser fluorescence microscope simultaneously acquires fluorescence spectra over a 320 nm wavelength range at 10 nm spectral resolution, or over smaller ranges at 5 nm or 2.5 nm spectral resolution. Observed with a...

Shutter driver.(Image Analysis And Microscopy)
March 1, 2005... Sutter Instrument has announced the addition of a 35-mm shutter and Lambda SC controller to its SmartShutter product line. The unit incorporates a precise motor drive and stepper motor, and has only one moving part to minimize wear. It operates...

Gel documentation system.(Image Analysis And Microscopy)
March 1, 2005... GeneLine ImageSCI is a fully enclosed gel documentation system. Integral pc processor with installed acquisition and analysis software drives a 16-bit EDR performance CCD camera. The entire unit is light tight, ensuring that even small, faint...

CCD color camera.(Image Analysis And Microscopy)
March 1, 2005... ColorView IIIu light microscope CCD color cameras are 5 mega pixel units that provide a generous dynamic range, fast frame rates, partial readout and color binning. Standard C mount adapter makes installation easy for all standard microscopes....

Assay and cancer panel.(Array Technologies)
March 1, 2005... The DASL assay (Illumina, Inc.) generates reproducible gene expression pro files from formalin-fixed paraffin-embedded (FFPE) samples and other samples containing partially degraded RNAs. The assay enables the measurement of RNA abundance of...

Rat bioarray for ADME studies.(Array Technologies)
March 1, 2005... CodeLink ADME Rat 16-Assay bioarray features a multi-assay chamber that allows up to 16 samples to be processed in parallel on every slide. The gene expression profiling array is specifically for drug absorption distribution and metabolism...

Micro Spotting Devices.(Array Technologies)
March 1, 2005... Micro Spotting Devices 946. Stealth and ChipMaker are used in microarray manufacturing. A full line of stock and custom print heads are available to fit any robot. Spot sizes range from 50600 mm, depending on the tip size. Over 60 different...

Pre-spotted proteomics chip.(Array Technologies)
March 1, 2005... Prespotted AnchorChip, a second-generation disposable MALDI target for gel-based and LC-MALDI-based expression proteomics, eliminates cross-contamination from previous samples and calibration spot preparation and reduces sample preparation...

Plate arraying technology.(Array Technologies)
March 1, 2005... Arraying on the BioRobotics MicroGrid II and on the GeneMachines OmniGrid Accent enables the production of DNA and protein microarrays in 96- and 384-well plates and allows the printing of over 1000 features within an individual well in a...

Protein array analysis platform.(Array Technologies)
March 1, 2005... ProScanArray and ScanArray[G.sub.x] microarray scanners sup-port both proteomic and genomic array-based applications. ProScanArray series multi-application scanners utilize confocal technology to offer strong signal-to-noise ratio performance...

Antibody-based microarray.(Array Technologies)
March 1, 2005... Panorama Ab Microarray Cell Signaling Kit is the first in a line of antibody-based microarrays from Sigma-Aldrich. Antibody microarrays are valuable researching cancer and other diseases in which growth, invasion and transmission may result...

Phospho-RTK array kit.(Array Technologies)
March 1, 2005... Receptor Tyrosine Kinases are widely expressed transmembrane receptorsthat undergo phosphorylation events and participate in cell signaling processes. The Human phospho-RTK Array Kit screening tool simultaneously detects the tyrosine...

Microarray and software for comparative genomic hybridization studies in cancer research.(Array Technologies)
March 1, 2005... Human Genome CGH Microarray and CGH Analytics software (Agilent Technologies, Inc.) aids cancer biologists and cytogeneticists in the study of genomic alterations in cancer. Comparative genomic hybridization (CGH) is used to study the...

Human sequence microarray.(Array Technologies)
March 1, 2005... NimbleGen's ENCODE microarray contains more than 384,000 50-mer probes selected from 30 megabases of human sequence data specified by the ENCODE Project Consortium. These probes are tiled, or spaced apart, every 38 bases, thus creating a...

SNP genotyping arrays.(Array Technologies)
March 1, 2005... GeneChip Mapping 10K 2.0 Array and GeneChip Mapping 100K Array Set facilitate genotyping over 10,000 SNPs and provide an array set for genotyping over 100,000 SNPs. The Mapping 10K Array is used for linkage analysis and cancer genetics studies,...

Microarray scanner.(Array Technologies)
March 1, 2005... LS Reloaded automation-friendly microarray scanners support both customized array formats and microplates. High throughput and automatic gain control are accomplished using different laser and filter combinations in one scan. Dynamic range of...

Purify RNA from a single cell.(Array Technologies)
March 1, 2005... ArrayPure nano-scale RNA purification kit provides all reagents needed to purify RNA from one to ten thousand eukaryotic cells, as obtained with laser capture methods. The kit contains only aqueous solutions and requires no toxic organic...

Skin Pathology microarray.(Array Technologies)
March 1, 2005... PIQOR SkinPatho microarray is comprised of 1,132 genes associated with pathological expression changes in human skin. It is available as part of the Miltenyi Biotec Microarray Service. Within the scope of Memorec Biotec's skin research program...

Gene expression arrays.(Array Technologies)
March 1, 2005... Eppendorf DualChip microarray systems are offered for gene expression analysis and pathway identifications in toxicology, neuroscience, signal transduction and research on aging using human or rat models. Xmer technology-based probes contain...

Enzyme and competent cell quality ensure cloning integrity: PCR fidelity is largely determined by the intrinsic error rate of DNA polymerases under the reaction conditions employed. This error rate can be minimized, in part, by the presence of an integral 3'-5' exonuclease activity, also called proofreading.(Application Note)
March 1, 2005... Whether the goal of a biological investigation is to sequence an entire genome, learn all there is to know about one protein, or decipher the regulation of a particular pathway, the integrity of early DNA amplification and cloning can determine...

ADMETox Workstation.(Automation And Robotics)
March 1, 2005... The Biomek FX ADMETox Workstation, offered for in vitro drug permeability measurements, automates pION, Inc.'s Parallel Artificial Membrane Permeability Analysis (PAMPA) method for the determination of passive absorption of a drug candidate...

Liquid handling workstations.(Automation And Robotics)
March 1, 2005... Brinkmann Instruments, Inc. has introduced three new Eppendorf epMotion 5075 robotic liquid handling workstations. The units incorporate an optical sensor that monitors labware and liquid levels on a 12-place deck and the ability to...

Liquid handling workstation.(Automation And Robotics)
March 1, 2005... STARplus liquid handling workstations can be configured to meet user requirements, including the integration of readers, thermocyclers, centrifuges and other devices. The closed system contained in its own housing requires a minimum amount of...

DASi module.(Automation And Robotics)
March 1, 2005... The Dissolve/Absorb/Sample/injection (DASi) sample loading tool works with a range of purification instruments and consummables. The unit easily connects to any system with a female luer top fitting. The plunger functions without high wear...

Microplate stacker.(Automation And Robotics)
March 1, 2005... LeadStream ADME/Tox Solution platform consists of three integrated instrumentation modules and Orchestrator software, which collects and reports data in a unified database and optimizes the screening process across multiple assay types....

Automated antibody, protein purification, analysis.(Automation And Robotics)
March 1, 2005... Caliper Life Sciences, Inc. has integrated the PhyNexus Inc. PhyTip protein purification column into their Sciclone ALH 3000 liquid handling workstation. Detection follows using the Caliper LabChip 90 electrophoresis system. As many as 96...

Microplate stackers.(Automation And Robotics)
March 1, 2005... QuickStack conveyor and gripper-based microplate automation system can bring microplates to and from dispensers, plate readers and washers, and other instruments. SSI Robotics, 949-481-5874, ssirobotics.com For information specific to this...

Cell imaging, picking.(Automation And Robotics)
March 1, 2005... Mammalian cell imaging and picking instrument ClonePi[x.sup.FL] features fluorescent capabilities and the ability to pick antibody producing clones. Selection of cells is enabled using quantitative measurements based on the pharmacological...

DNA, RNA purification workstation.(Automation And Robotics)
March 1, 2005... BioRobot EZ1 automates purification of DNA and RNA from clinically relevant samples. From 1-6 samples can be processed in as little as 15 minutes. Ready-to-run protocols on pre-programmed EZ1 Cards simplify operation. Pre-filled reagent...

Linear motion table.(Automation And Robotics)
March 1, 2005... The 404LXR Linear Motor-Driven Table is offered for applications that require speed (3000 mm/sec) and precision (+ 0.5 micron repeatability), such as microarraying,. The unit accelerates up to 5g's, travels up to 1 meter. Parker Life Sciences,...

Microplate platform.(Automation And Robotics)
March 1, 2005... Evolution [P.sup.3] Modular Dispense Technology platform offers a series of dispense heads, including the Nano-Head, which dispenses volumes down to 50 nl. PerkinElmer Inc., 800-762-4000, www.perkinelmer.com For information specific to...

Robotic centrifuge.(Automation And Robotics)
March 1, 2005... Robotic version of Hettich's Rotanta 46RSC is a refrigerated unit with PC control and rotor positioning with maximum capacity of four 750 ml round bottom containers, sixteen microplates, or four deep-well plates. Offered for automatic sample...

Compound storage and retrieval.(Automation And Robotics)
March 1, 2005... MatriStore automated compound storage and retrieval system offers a compact, modular approach that accommodates expansion. Based on proprietary plate and tube technology and equipped with components from Yamaha Robotics, the system reliably...

MicroRNA Array Analysis Reveals Critical Biomarkers: hundreds of unique miRNAs are encoded in animal, plant, and fungal genomes and are expressed in a regulated manner. They affect early stage development, cell differentiation and cell death.(Application Note)
March 1, 2005... MicroRNAs (miRNAs) are small, siRNA-like molecules encoded in the genomes of plants and animals. They regulate gene expression by binding to and modulating the translation of specific mRNAs. The expression of miRNAs varies among tissues and...

Recombinant human Kallikrein 4 antibody.(New Technology)
March 1, 2005... Recombinant human Kallikrein 4 antibody is also known as Prostase and Enamel Matrix Serine Protease 1 (EMSPI). KLK4 is a recently characterized member of the Kallikrein family of serine proteases. Under normal conditions, KLK4 is specifically...

Triple quadrupole mass spec.(New Technology)
March 1, 2005... Highly-Selective Reaction Monitoring (HSRM) is incorporated in the TSQ Quantum family of triple quadrupole mass spectrometers. This analytical application helps further eliminate chemical noise, reduces generation of false positives, and allows...

Slide processing.(New Technology)
March 1, 2005... ThermoBrite programmable temperature controlled slide processing system automates the denaturation and hybridization steps in slide-based fluorescent in situ hybridization FISH assays. The unit accepts a range of sample types, is easy-to-use,...

Undercounter refrigerator.(New Technology)
March 1, 2005... MediCool Model SR-L6110W undercounter refrigerator features an upward angled, door-mounted microprocessor control with LED display. An integrated automatic alarm system provides audible and visual notification. Forced-air circulation offers...

Automated purification of viral nucleic acids.(New Technology)
March 1, 2005... BioRobot MDx DSP system provides walk-away purification of viral nucleic acids in clinical laboratories. The CE-marked system includes instrument, software, service, and protocols for use with the QIAamp DSP 96 Virus MDx Kit. IVD-D compliance...

Small rodent stereotaxic.(New Technology)
March 1, 2005... The Just For Mice stereotoxic instrument was developed for research being done with knockout and transgenic mice. It allows surgical procedures to be performed on two mice, neonatal rats or other small rodents at one time. Ear bar slots are...

Ultrasonic spectroscopy pressurizing system.(New Technology)
March 1, 2005... High-Resolution Ultrasonic Spectroscopy (HP-US) Pressurizing System features an internal compressor that delivers the desired pressure to each of two cells of spectrometers. The cells can be pressurized independently or simultaneously for...

Plasmid DNA isolation.(New Technology)
March 1, 2005... Gen-Elute Five-Minute Plasmid Miniprep Kit relies on two technologies. The first is a lysis chemistry that enables DNA purification directly from an overnight culture. Standard miniprep steps of pelleting cells and neutralizing and clearing the...

Homogenizer line.(New Technology)
March 1, 2005... Complete line of hand-held, post-mounted and programmable homogenizers offer the ability to homogenize various volumes (.03 ml to 40 L) at speeds of up to 30,000 rpm. Generator design insures micro-processing of volumes as low as .03 ml in...

Glassware.(New Technology)
March 1, 2005... H. S. Martin offers pre-engineered or custom designed systems tailored to the user's requirements. Standard products are offered in capacities from 10 to 200 L, with either spherical flasks or cylindrical reactors that are available jacketed or...

Contaminated Pipet disposal.(New Technology)
March 1, 2005... Terminal brand Pipet Keeper allows disposal of contaminated pipets, swabs and other items up to 15" long. Easy to use right and left handed, it has an interlocking top and reclosable flaps. It is disposable, made of paperboard with plastic...

Toll-like Receptor reagents.(New Technology)
March 1, 2005... New antibodies, inhibitors and enzymes have been added to this line of reagents for Toll-like Receptor (TLR) signaling and inflammation research. Other new products include antibodies to TLR2, TLR6, TLR7, Mal (TIRAP), and IRAK-4, and reagents...