Bioscience Technology articles from July 2003

Bioscience Technology archives from July 2003

Automation-friendly gene-expression assays.
July 1, 2003... BioGridArray[TM] (BGA) uses a microplate platform, accepted gene-expression chemistries and protocols, and automated sample preparation to deliver high throughput. BGAs are made to specification, with 96 individual arrays of up to 1,024 unique...

Real-time 6D confocal microscope.
July 1, 2003... UltraVIEW[TM] RS six dimensional confocal microscope facilitates multidimensional confocal imaging of living and fixed samples in real time while preserving cell viability and fluorescence. The microscope uses the newly developed CSU21...

Benchtop, automated DNA extraction.
July 1, 2003... AutoGenprep 240, a fully automated, sell-contained robotic system for the isolation of DNA, is a benchtop instrument for low volume BAC and plasmid extractions. It will process up to 24 samples in approximately 3 hours at a very low cost per...

High density sample storage. (Editor's Choice).
July 1, 2003... The RTS Life Science Sample Store is now being supplied as a fully integrated package, with internal picking robotics, cold room and liquid handling stations. It is designed to eliminate internal dead space and provide very high density...

DNA agarose purification kit. (Editor's Choice).
July 1, 2003... UltraClean[TM] GelSpin[TM] DNA Purification Kit utilizes a silica spin filter method to purify DNA fragments from TAE or TBE agarose gels. The procedure, which takes five minutes, removes ethidium bromide, linkers, and labels. Kit format allows...

Human Cell Isolation. (Editor's Choice).
July 1, 2003... Human Cell Isolation Kits II products quickly and conveniently isolate untouched human pan T cells, CD[4.sup.+] T cells, CD[8.sup.+] T cells, monocytes, B cells, naive B cells and NK cells. Human Cell Isolation Kits II contain ready-to-use...

Thermostable DNA polymerase. (Editor's Choice).
July 1, 2003... GoTaq[TM] thermostable DNA polymerase Allows researchers to take reactions Directly from thermal cycler to agarose gel Electrophoresis. Green GoTaq Reaction Buffer has sufficient density to sink samples into the wells of agarose gel, so there...

Growth enhancement media supplement. (Editor's Choice).
July 1, 2003... EX-CYTE[R], from Serologicals, is a liquid concentrate of cholesterol, lipids, and fatty acid. This media supplement provides a cost-effective way to reduce or even replace the use of serum in cell culture when used in conjunction with...

Custom sIRNA oligonucleotide synthesis service. (Editor's Choice).
July 1, 2003... Thermo Electron Corporation is now offering a custom synthesis service for synthetic short interfering RNA molecules (siRNA). RNA interference (RNAi) has gained attention in drug discovery and development due to its ability to selectively...

Structured illumination in fluorescence microscopy: images have increased sharpness, contrast and resolution in the axial direction. (Tools & Techniques).
July 1, 2003... Resolution and contrast are extremely important in modern fluorescence microscopy, to allow the detection, for example, of the co-localization of structures in a cell or cluster of cells. With thicker samples in particular, such as tissue...

Sample preparation solutions for cellular protein fractionation. (BIO-RAD: Advertisement).
July 1, 2003... Introduction Two-dimensional (2-D) gel electrophoresis is a widely used, proven method for proteome analysis. The quality and value of the information obtained from a 2-D electrophoresis experiment is highly dependent upon the initial...

New Amicon[R] Ultra centrifugal filter devices combine high speed and high recovery for protein concentration and desalting.
July 1, 2003... Ultrafiltration centrifugal filter devices are effective tools for concentrating, desalting and purifying proteins. Traditionally, these devices have been able to provide either high recovery or fast spin times, but not both. This trade-off...

High-throughput data analysis technology. (Bioinformatics).
July 1, 2003... SARNavigator[TM], Tripos Incorporated's new discovery informatics technology, provides identification of promising chemical series in high volume/low quality screening data. Being previewed at the Drug Discovery Technology meeting, the product...

Array analysis software. (Bioinformatics).
July 1, 2003... Insightful Corporation's ArrayAnalyzer[TM], and adaptable microarray analysis module for the S-PLUS[R] data analysis software package, is the result of collaboration with the BioConductor Project, a team of academic researchers in the field of...

Molecular biology software. (Bioinformatics).
July 1, 2003... Stratagene and Iobion Informatics offer desktop software packages GeneSolve[TM], ProteinSolve[TM], PathwayAssist[TM] and Array Assist[TM] as a suite called IobionLab[TM]. GeneSolve and ProteinSolve are packages that allow researchers to import,...

Global proteomics server application. (Bioinformatics).
July 1, 2003... Waters[R] Corporation offers the ProteinLynx[TM] Global SERVER 2.0 suite on the IBM[R] eServer pSeries 630. The IBM eServer is equipped with IBM POWER4 microprocessors, a "server on a chip" containing two one-gigahertz processors and...

Gene expression analysis tool. (Bioinformatics).
July 1, 2003... Vector Xpression[TM], a new software tool for the analysis of microarray gene expression data, features a data import wizard. Data analysis capabilities include normalization, filtering, sorting, clustering, profiling, differential gene...

Human genomic DNA sequence web site. (Bioinformatics).
July 1, 2003... The website www.mutationdiscovery.com includes the genomic DNA sequences of over 8600 well-understood human genes with information on over 500,000 observed variations on these genes. Within this context, the site also includes PCR and DHPLC...

Data integration platform. (Bioinformatics).
July 1, 2003... DiscoveryCenter[TM] integration platform helps speed drag discovery by integrating cross-functional information from a variety of databases and applications. The platform combines the best features of proprietary SRS technology, for integrating...

Integrated ADME/Tox Informatics solution. (Bioinformatics).
July 1, 2003... The KnowItAll[R] ADME/Tox Edition is an integrated desktop informatics product for ADME/Tox evaluation that developed out of Bio-Rad's Laboratories' collaboration with ComGenex, Inc. and CompuDrug International, Inc. A fully integrated suite of...

Bioinformatics software. (Bioinformatics).
July 1, 2003... SilicoCyte[TM] is an integrated, microarray-independent, modular, end-to-end microarray analysis solution for gene expression analysis. A microarray analysis solution providing automated image analysis, comprehensive data annotation, data...

Ceramic microarray pins. (Microarray Fabrication).
July 1, 2003... Apogent Discoveries MicroSpot[TM] C ceramic pins make it easier to print quality microarrays. The ceramic pins are used with the MicroGrid[TM] arrayer to provide improved spot morphology, up to 5 times more spots per source visit, and require...

Tungsten microarray spotting pins. (Microarray Fabrication).
July 1, 2003... ACCELERATOR[TM] Brand microarray spotting pin products are made of Tungsten, and offer long life due to increased hardness corrosion resistance. Collars are color-coded to denote tip and slit size, and sequentially numbered for traceability...

Integrated microplate replication and reformatting. (Microarray Fabrication).
July 1, 2003... The CyBi[TM] -Replicator provides precise and reliable sample preparation. The system's hardware setup has been reworked to enable faster and parallel plate transport. Control software has been enhanced to enable parallel execution. Throughput...

Chemical Inkjet Printer for micro-scale proteomics. (Microarray Fabrication).
July 1, 2003... Chemical Inkjet Printer (ChIP) offers a new approach to Peptide Mass Fingerprinting (PMF) and Protein Macroarray Analysis. ChIP is a unique technology platform/for micro-scale on-membrane protein identification and characterization with...

Array Spotter. (Microarray Fabrication).
July 1, 2003... To achieve good spot uniformity within a slide and across multiple experiments, the Lucidea Array Spotter uses an integrated, 24-pen print head that is meticulously matched and factory tested to meet tight specifications. Pens are designed to...

Microarray Reagent Systems. (Microarray Fabrication).
July 1, 2003... Corning Incorporated, Life Sciences has introduced Pronto![TM] cDNA and Universal Microarray Reagent Systems for printing and hybridizing cDNA and long oligonucleotide arrays. The systems offer a complete microarray solution from printing...

Non-contact microarray production tool. (Microarray Fabrication).
July 1, 2003... The new Piezorray non-contact microarray production tool, based on PerkinElmer's PiezoTipnology[TM] has the ability to pipette into and aspirate out of a number of standard plate formats and dispense to a variety of non-porous and 3D...

Microarrayer. (Microarray Fabrication).
July 1, 2003... The new OmniGrid 300 ultra-high throughput microarrayer is designed to meet the needs of production facilities. The OmniGrid 300 microarrayer has the capacity for 308 slides and seventy-two 384-well plates with automated plate loading included....

Monosaccharide analysis column. (New Products).
July 1, 2003... CarboPac PA20 columns are packed with a 6 m m diameter resin. Smaller resin particles permit a shorter column configuration (3 x 150 mm), resulting in fast analysis times while maintaining peak resolution. The anion exchange chemistry has been...

Drug-target interaction screening technology. (New Products).
July 1, 2003... LeadCode[TM] drag-protein interaction technology increases the power and utility of the GPC Biotech AG Reverse Genomics[TM] technology platform, which had been primarily focused on analyzing the mechanism-of-action of compounds using gene...

Ultrapure water system. (New Products).
July 1, 2003... Milli-Q[R] Synthesis ultrapure water system provides water for critical biological applications, such as PCR and DNA sequencing, 2-D electrophoresis, blotting, mammalian cell culture, and MALDI-TOF MS. The system combines ultraviolet (UV)...

Ergonomic workstations. (New products).
July 1, 2003... Workstations adjust to make one work area ergonomically correct for several operators. Standard components such as tool hangers, AkroBins[R], swing arms, and linear beatings allow for quick setup changes. Aluminum extrusions can be used as a...

Sequencing Grade Water. (New Products).
July 1, 2003... A.C.E.[TM] Sequencing Grade Water is ideal for use in capillary electrophoresis. High purity, RNase and DNase free sterile water, for DNA sequencing, can be used for sample prep and is an alternative to formamide. AMRESCO, Inc., Solon, OH....

Low retention pipet tips. (New Products).
July 1, 2003... Low retention pipet tips are hydrophobic, allowing dyes, surfactants, solvents to be loaded, and viscous samples to be pipetted, with accuracy. The tips are available with the ART[R] self-sealing barrier, which are certified to be RNase-,...

Cooling, heating circulator. (New Products).
July 1, 2003... Huber Unistat 169W has a temperature range of--60 to 200 C and cools from 40 kW at -40 C. The units offer low fluid volumes and fast heating and cooling rates. CARON Products & Services, Marietta, OH. 740-373-6809; caronproducts.com *...

Electrocompetent E. coli. (New Products).
July 1, 2003... Phage T1-Resistant TransforMax[TM] EC 100[TM] -T1R Electrocompetent E. coli provide complete security against loss of valuable clones and libraries by accidental phage T1 contamination. For cloning applications including BAC and cDNA library...

MAPK detection. (New Products).
July 1, 2003... Cell-based ELISA Kits monitor protein phosphorylation, and enable modification-specific analysis directly within cells. Cells are grown, stimulated and assayed in a 96-well plate. Active Motif, Carlsbad, CA. 877-222-9543; activemotif.com *...

Whole genome amplification method. (New Products).
July 1, 2003... The GenomiPhi[TM] DNA Amplification Kit enables high-quality DNA to be prepared from limited biological material. A simple isothermal method allows microgram quantities of DNA to be produced overnight from nanogram amounts of starting material....

Affinity purified monoclonal antibodies. (New Products).
July 1, 2003... Anti-Oligodendrocyte Marker O1 and anti-Oligodendrocyte Marker O4 affinity purified monoclonal antibodies are now available. Oligodendrocytes are myelinating cells in the central nervous system (CNS) that form the myelin sheath of axons to...

Plate dispenser. (New Products).
July 1, 2003... BP96[TM] liquid handling system quickly and accurately dispenses solution into 96-well plates. Using a disposable syringe, the unit draws liquid from a reagent reservoir. As pressure is applied to the syringe plunger, solution is uniformly...

Antibody purification with affinity spin columns: kits include all the devices and premixed buffers necessary for prefiltration, purification concentration and desalting of mono and polyclonal antibodies from a variety of species. (Tools & Techniques).
July 1, 2003... Monoclonal and polyclonal antibodies serve as important reagents for capturing antigens of interest in a wide range of immunochemical procedures. Researchers commonly isolate antibodies from crude sources such as ascites, cell culture...

Fluorescence mapping: scanning the surface of samples in the x-y plane for fluorescence. (Tools & Techniques).
July 1, 2003... Introduction Fluorescence mapping, that is, scanning the surface in the x-y plane of a sample under a microscope for fluorescence, has been gaining interest in recent years, especially in biological research. (1) The technique lends itself...

Violet laser and lambda-blue objectives. (New Products).
July 1, 2003... The 405 nm violet diode laser enables fluorescence excitation of classical nuclear stains such as DAPI and Hoechst[R], and also covers CFP and GFP2, components of the FRET pairs CFP/YFP and GFP2/YFP. A series of lambda-blue objectives offer...

Mixer, temperature controller. (New Products).
July 1, 2003... Eppendor[R] Thermomixer[TM] R combines heating, cooling and mixing. Simultaneous mixing and incubation accelerate reaction processes. Unit temperature range extends from 13 C below room temperature up to 99 C. The ThermoStat Plus is a benchtop...

Fast polymer columns. (New Products).
July 1, 2003... Swift[TM] Monolithic Columns offer excellent resolution on both MPLC and HPLC equipment, for rapid separation of proteins, peptides, oligonucleotides, nucleic acids, and synthetic polymers. The columns are made by in-situ polymerization,...

Plasmid Mini Kit. (New Products).
July 1, 2003... The RapidPURE[TM] Plasmid Mini Kit provides the tools and reagents necessary for alkaline lysis and GENECLEAN[R]-based purification of plasmid DNA from E. coli. The Turbo filter can bind up to 20 m g of plasmid DNA with efficiency and...

Genetic analysis software. (New Products).
July 1, 2003... CEQ[TM] 8000 Software version 6.0 provides DNA sequence data analysis functions that automatically identify and trim off vector material, foreign sequences and poor quality bases. The quality values function helps identify and isolate the...

Digital camera. (New Products).
July 1, 2003... With a fully independent, stand-alone design, the DS-5M-L1, the first in Nikon Instruments' new Digital Sight series of high-resolution, stand-alone, network-ready color digital cameras, features a five-million-pixel CCD for the capture of...

Gene detection kit. (New Products).
July 1, 2003... HiLight[TM] Dual-Color Kits provide dual-color labeling and sensitive detection for a wide variety of arrays. The system uses Resonance Light Scattering (RLS) Technology[TM], which is based on the optical light-scattering properties of...

Drug Discovery Technology Conference highlights science, business, informatics. (New Products).
July 1, 2003... Last year, IBC Life Sciences' Drug DiscoveryTechnology[TM] attracted over 6000 attendees. The World Congress conference and exhibition focuses exclusively on how new technologies, scientific advances, business strategies and informatics...

Class II safety cabinets. (New Products).
July 1, 2003... Class II Heraeus[R] HERAsafe[R] KS safety cabinets feature a slanted front window and a rear-cabinet-wall eye-level display that allows parameter and operating functions to be conveniently monitored from a seated position. The information...

Assay method follows extravasion of endothelial cell layers by metastatic cells. (Application Brief).
July 1, 2003... The ECIS (electric cell-substrate impedance sensing) method of automatically monitoring cultured cell behavior has been demonstrated to follow extravasion of endothelial cell layers by metastatic cells. In this new ECIS assay, endothelial cells...

Intracellular nucleic acid localization. (New Products).
July 1, 2003... Label IT[R] siRNA Tracker[TM] intracellular nucleic acid localization kits from Mirus Corporation combine nucleic acid labeling and efficient transfection technologies for tracking siRNA delivery and silencing in mammalian cells. Each kit...

Chiral method development kits. (New Products).
July 1, 2003... New kits facilitate rapid method development of chiral separations. One protocol is offered for separating chiral pharmaceuticals, and a second is offered for enantiomeric a-amino acids, a-hydroxy acids, amines, alcohols and amino alcohols....

Closed-loop translation stage. (New Products).
July 1, 2003... Small closed-loop translation stage, with high-speed linear motor drive, provides 20 mm travel range, 0.1 m m resolution, 200 m/[sec.sup.2] (~20 g) acceleration, and 600 mm/sec velocity. The linear motor drive is based on a novel ultrasonic...

MS for proteomics research. (New Products).
July 1, 2003... The 4000 Q TRAP[TM] LC/MS/MS system provides ion trap sensitivity and triple quadrupole functionality in a range of applications. For proteomics researchers, the system can help with the rapid identification and measurement of...

High capacity ion trap mass spec. (New Products).
July 1, 2003... The esquire HCT (high capacity trap) ion trap mass spectrometer combines high ion storage capacity with proprietary UltraScan[TM] mode, for 26,000 Dalton/second analysis. Fast PeptideScan[TM] mode can differentiate double and triple charged...

Claudins, Claudin antibodies. (New Products).
July 1, 2003... Claudins 1, 2, 3, 4, and 5 are available for use in formalin-fixed, paraffin-embedded tissues. Recent studies implicate claudin 4 in pancreatic cancer, claudins 1, 2, 3 and 5 in colon cancer and claudin 3 in prostrate cancer. A range of Claudin...

Intelligent image database. (New Products).
July 1, 2003... IQbase[TM], from Media Cybernetics, is an intelligent database that concentrates on information derived from images, providing accessibility from the pixel level to the meta-data level. With IQbase, images and information can be viewed and...

Chemiluminescence imaging system. (New Products).
July 1, 2003... ChemiPro[TM] system for chemiluminescence imaging incorporates a back-illuminated CCD camera, ultrablack dark box, and software to provide a solution for applications that involve whole-plant or whole-animal imaging. Quantum efficiency of the...

Neurite Outgrowth quantification assay. (New Products).
July 1, 2003... Neurite Outgrowth Assay Kit, which uses microporous filter technology, is an efficient system for the quantitative determination of compounds that influence neurite formation and repulsion. With this system, it is possible to screen numerous...

Model for Alzheimer's disease. (New Products).
July 1, 2003... APP Microinjected Mouse Model, Tg2576, can be used to study human Alzheimer's Disease (AD) and various cellular mechanisms. The mice carry the trans-gene for the Swedish mutation (AP[P.sub.695]), and Alzheimer's associated isoform of the human...

Counting mammalian cells quickly and accurately.
July 1, 2003... Counting Mammalian Culturing mammalian cells successfully requires consistent, accurate measurements of cell growth and viability on a daily basis. A new, automated device, the NucleoCounter[TM], uses well-documented fluorescence microsocopy...

Proteomic services. (New Products).
July 1, 2003... Charles River Laboratories International, Inc. and Proteome Systems Ltd. (PSL) have announced the opening of a new contract laboratory dedicated to proteomic research services. In the 10,000-square-foot laboratory, services offered by Charles...

DNA contamination removal. (New Products).
July 1, 2003... TURBO DNase, an engineered version of wild-type DNase I, has markedly increased affinity for DNA. This is important for complete removal of DNA from a sample, since the concentration of the cleavable substrate is reduced as the DNase digestion...

Immunohistochemistry services. (New Products).
July 1, 2003... Ardais Corporation offers a broad array of immunohistochemistry (IHC) services. The firm provides research study design to meet specific client needs; research quality tissue; and the diverse Ardais BIGR[TM] Library. IHC Service, which...

Proteomic analysis kit. (New Products).
July 1, 2003... The FOCUS PhosphoRich Kit fractionates and enriches phosphorylated and unphosphorylated proteins. Spin column format and easy-to-use protocol provides enrichment of phosphoproteins from tissues and extracts. It is suitable for proteomic and...

Evaporative Light Scattering Detector. (New Products).
July 1, 2003... Modular Chromachem[R] Evaporative Light Scattering Detector (ELSD) for use with HPLC provides universal detection of non-volatile compounds. Features include a microprocessor, small footprint, RS232 interface, and a large graphic display. It is...

Mouse and Neonatal Rat Adapter. (New Products).
July 1, 2003... The Cunningham[TM] Mouse and Neonatal Rat Adapter attaches neatly to the proprietary 51600 series Lab Standard and other brands of stereotaxic instruments, creating a surgery table that is stable and easy to access. The instrument employs...

Low-volume UV microplate. (New Products).
July 1, 2003... The well height of the new half area 96 well UV microplate allows for a sample volume (175 L) directly corresponding to a 1-cm path length for calibration using UV absorbance, while offering a reduced reagent costs and sample requirements. Time...

Upright freezers. (New Products).
July 1, 2003... Forma[R] 8600 Series -86 C upright freezers are constructed and stress tested for application in biological product storage. Single and double door uprights are offered in sizes ranging from 13.0 to 28 cu/ft. The freezers combine engineering...

Coverslip holder for cuvette fluorescence. (New Products).
July 1, 2003... Models CCH-1 and CCH-2 coverslip holders hold an 11 by 22 mm coverslip with cultured cells attached at the proper position in a standard 12.5 mm cuvette for fluorescence measurements. Adequate space is provided at the base of the cuvette for a...

DNA, protein sequence analysis. (New Products).
July 1, 2003... Lasergene comprehensive DNA and protein sequence analysis software suite, for the Apple Computer Mac OS X, takes advantage of the system's UNIX-based operating system to provide a robust sequence analysis suite that is easy to use. The...

Digital Linear Stimulus Isolator. (New Products).
July 1, 2003... DLS100 Digital Linear Stimulus Isolator, offered for use with the DS8000 digital stimulator, connects to the stimulator via a flexible cable through which it receives power and stimulus signals in a digital format. Up to eight isolators can be...

MMP and TIMP antibodies. (New Products).
July 1, 2003... Matrix Metalloproteinase (MMP) and Tissue Inhibitor Metalloproteinase (TIMP) antibodies are offered. Rabbit antibodies are offered for MMP-1, 2, 3, 8, 9, 11-16, 19, 20, and 22-28. Antibodies are specific for the hinge region, propeptide domain,...

Roller culture apparatus. (New Products).
July 1, 2003... Compact roller culture system takes a minimum of incubator space, and accommodatestwo vessels. It expands to accommodate four or six vessels. Wheaton Science Products, Millville, NJ. 800-225-1437; wheatonsci.com * Write In 447 Or Reply...

Specimen Transport Bags. (New Products).
July 1, 2003... VonSeal[R] Specimen Transport Bags meet 20kPa IATA regulations for infectious substance air transports. The liquid tight bags feature a patented adhesive closure. A continuous seal makes them tamper evident. They are also approved for drug...

Gene silencing with PCR products: gene silencing in mammalian cells can be readily achieved by introducing or expressing small interfering RNA (siRNA) molecules targeting a gene of interest. (Tools & Techniques).
July 1, 2003... Gene silencing in mammalian cells can be readily achieved by introducing or expressing small interfering RNA (siRNA) molecules targeting a gene of interest. Many researchers prefer to express siRNA from a DNA construct rather than introducing...

Piston pump. (New Products).
July 1, 2003... Single-piston OEM pump Model 2-1 accurately meters fluids at flow rates up to 50 ml/min. Travcyl[TM] pumps are internally-sealed, positive -displacement and self-priming. Encynova, Broomfield, CO. 303-465-4800; encynova.com * Write In 449...

Benchtop tube chiller. (New Products).
July 1, 2003... Chillette insulated tube cooler has a screw cover filled with liquid refrigerant. When the cover is placed in its closed position, the refrigerant is only a few millimeters above the tops of the tubes. After being kept at -20 C overnight, the...

Microscope Slide Scanner. (New Products).
July 1, 2003... ScanScope Slide Scanner makes digitizing of entire slides practical, creating a virtual environment for automated inspection in pathology, cytology, hematology and related fields. Aperio Technologies, Vista, CA. 760-539-1101; scanscope.com ...

Pro-cathepsin B ELISA. (New Products).
July 1, 2003... Cathepsin B, a lysosomal protease thought to process proteins including pro- and active caspases, pro-renin, and secretory leucocyte protease inhibitor (SLPI), may be important in activation and inactivation of caspases, activation of renin,...

CCD camera. (New Products).
July 1, 2003... [CoolSNAP.sub.ES][TM] imaging system utilizes a 1392 x 1040-pixel CCD camera and low-noise electronics to deliver high-resolution, 12-bit images across the lull spectral band, even into the near infrared. Camera head, PCI card and RS Image[TM]...