Bioscience Technology articles from February 2006

Bioscience Technology archives from February 2006

A transformative technology.(Editorial)
February 1, 2006... The microarray has come a very long way in a very short time. The first commercial arrays were offered for sale in the early 1990's (by Affymetrix). These early arrays offered libraries of short peptides affixed to glass slides. Today arrays...

Enzo Biochem patent covers process for producing therapeutic proteins or RNAs in living cells.
February 1, 2006... Enzo Biochem, Inc. (Farmingdale, NY) has been issued a patent covering processes for producing large quantities of therapeutic proteins or RNAs within living target cells. The invention relies upon signals and regulatory elements that do...

Harvard Medical School and Lumera collaborate on protein biochip.
February 1, 2006... Lumera Corporation (Bothell, WA) has entered into an agreement with Harvard Medical School (HMS) and the Harvard Institute of Proteomics to develop a silicon chip substrate that combines Lumera's NanoCapture technology with HMS's nucleic acid...

Illumina offering HapMap chip.(Sentrix HumanHap300 Genotyping BeadChip)(Brief Article)
February 1, 2006... Illumina, Inc. (San Diego, CA) has begun commercial shipment of the Sentrix HumanHap300 Genotyping BeadChip. Using the company's Infinium assay method, each chip analyzes over 317,000 SNP loci per sample. Content is derived principally from...

Laboratory Design Conference Scheduled for April.
February 1, 2006... The Spring 2006 Laboratory Design Conference will convence April 3-5 at the Grand Hyatt Buckhead in Atlanta, Georgia. Sponsored by R&D Magazine, the conference offers a range of sessions and tours of local laboratories. The conference...

Arrayer prints to slides, membranes, plates.(FEBRUARY'S TECHNOLOGY)
February 1, 2006... BioOdyssey Calligrapher miniarrayer is a benchtop instrument that prints nucleic acids, proteins and carbohydrates via software and a laser-etched platen. An eight-pin print head prints from a single source plate onto up to 16 slides, 2...

In Vitro Molecular Imaging.(FEBRUARY'S TECHNOLOGY)
February 1, 2006... Gel Logic 2200 Digital Imaging System features a cooled CCD camera and an integrated illumination cabinet to permit detection of fluorescent, chemiluminescent, and chromogenic assays. A 2.2 million-pixel sensor, an f 1.2 lens, and a 6X optical...

Purify Cellular DNA.(FEBRUARY'S TECHNOLOGY)
February 1, 2006... The versaGene DNA Cell Purification Kit uses novel chemistry and column design to purify DNA that is virtually devoid of RNA and protein contamination. The product is scalable, and allows purification of double-stranded DNA from as few as 1,000...

Portable pipettor.(FEBRUARY'S TECHNOLOGY)
February 1, 2006... The Drummond Portable Pipet-Aid XL has a long lightweight handle that lowers the arm lift required to perform pipetting operations. This more comfortable arm position reduces shoulder and neck strain, particularly when working under a hood. An...

Mini gel electrophoresis.(FEBRUARY'S TECHNOLOGY)
February 1, 2006... The Gel XL Ultra V-2 mini gel electrophoresis system includes an intelligent power supply, migration tank and gel casting sets. The unit and direct-connect power supply take up less than 1/2 sq/ft of bench space. The migration tank plugs...

Feed-thrus for implantable neurostimulation devices.(FEBRUARY'S TECHNOLOGY)
February 1, 2006... Custom-designed, hermetic ceramic feed-thrus for implantable neurostimulation devices are made of 100% biocompatible, corrosion-resistant materials. Transmitting voltages from the device's power supply to a single or dual channel lead delivery...

XY nanopositioning stages.(FEBRUARY'S TECHNOLOGY)
February 1, 2006... P-542 XY nanopositioning stage offers a frictionless, flexure-guided design that provides a large travei range of 200 x 200 [micro]m. High-performance piezo-drives allow fast multi-axis motion with response times in the millisecond range....

Microarrays: mainstays of biological research.(Cover Story)
February 1, 2006... Within a few years of their introduction, microarrays have become a mainstay of biological research. The first commercial microarrays, produced by Affymax in 1991, featured combinatorial libraries of short peptides affixed to a glass substrate....

Bioreactors.(CELL CULTURE)
February 1, 2006... BioFlo Pro pilot and production-scale bioreactors are offered in 75-, 150-, and 300-liter capacities. Modular design makes it easy to upgrade system features. A compact frame minimizes space requirements and open piping provides easy access...

Cell culture dishes.(CELL CULTURE)
February 1, 2006... SUREGrip cell culture dishes are comfortable and safe to handle, even when stacked. Available sizes measure 100-mm x 20-mm, 60-mm x 15-mm and 35-mm x 10-mm. Raised ring around the circumference of the dish provides a secure grip for both the...

Pre-filled media bags.(CELL CULTURE)
February 1, 2006... GIBCO media bags have universal tubing connections for easy integration into automated cell maintenance systems. The bags are pre-filled with media in a variety of formulations and sizes and are stocked by the manufacturer. Specially formulated...

Automated cell culture system.(CELL CULTURE)
February 1, 2006... Automated CompacT SelecT cell culture system (The Automation Partnership) manages the process of preparing, culturing and harvesting cells in T-flasks and delivering them into assay-ready plates. Slightly larger than a Class II safety cabinet,...

Recombinant protein expression without IPTG.(CELL CULTURE)
February 1, 2006... Overnight Express auto-induction systems allow users to regulate protein expression in E. coli without monitoring the culture or adding IPTG. Auto-induction media use differentially metabolized components to promote high-density cell growth and...

Cell binding dishes, plates.(CELL CULTURE)
February 1, 2006... The NUNC low cell binding (LCB) surface prevents cell attachment in plates and dishes by presenting a phosphorylcholine moiety to cells, mimicking the surface of a cell membrane. The surface is non-animal-derived, biologically inert,...

Pre-coated screening plates.(CELL CULTURE)
February 1, 2006... BioCoat Collagen I and Poly-D-Lysine (PDL) 96- and 384-well microplates are offered for cell-based fluorescence, luminescence, colorimetric, and radiometric assays and contribute to the reliability of high-throughput transfection analyses....

Tissue culture inserts for multi-well plates.(CELL CULTURE)
February 1, 2006... ThinCert tissue culture inserts provide permeable support for co-cultivation, cell migration and transport process applications. The inserts feature PET membranes with defined, uniform pore sizes that provide cell adhesion and assure exchange...

96-Well BME cell invasion assay.(CELL CULTURE)
February 1, 2006... The Cultrex 96-Well BME cell invasion assay offers a flexible, standardized, high-throughput format for quantifying the degree to which invasive cells penetrate a barrier consisting of basement membrane components in vitro in response to...

Protein expression system.(CELL CULTURE)
February 1, 2006... The Bacillus megaterium expression system allows efficient protein expression without any proteolytic degradation (akaline proteases are lacking in B. megaterium). Moreover, no endotoxins are found in the cell wall. A versatile polylinker...

Recombinant human lactoferrin.(CELL CULTURE)
February 1, 2006... Lacromin recombinant human lactoferrin A recombinant protein is available through a collaboration between SeraCare Life Sciences and Ventria Bioscience. Lacromin, used in applications where transferrin and FBS might be used, is derived from...

Cell culture plates.(CELL CULTURE)
February 1, 2006... Supporting suspension and adherent cell growth and differentiation, both 24-well plate and single-well inserts for cell culture assays incorporate track-etched thin film membranes for reliable monolayer formation, microscopically transparent...

Visualization and analysis of confocal microscopy datasets: Combining analytical and visualization components enable a researcher to create and catalog a variety of different "views" of observed data, each created by a separate automated analysis.(APPLICATION Note)
February 1, 2006... Silicon Graphics, Inc. (SGI) collaborated with the National Cancer Institute's Advanced Biomedical Computing Center (NCI ABCC) to develop tools to accelerate microscopy workflows through visualization, analysis, and collaboration. The solution...

HPLC offers multiple configurations.(SHOW Preview)
February 1, 2006... Booth 2761 The Agilent 1200 provides comprehensive HPLC capabilities: With more than 60 instrument modules, it can be configured for standard, nanoflow, capillary, narrow, prep-scale and chip, and is reverse-compatible with the Agilent 1100...

Benchtop evaporator.(SHOW Preview)
February 1, 2006... Booth 4554 EZ-2 personal evaporator allows users to see solvents as they collect in the trap: Emptying the collection vessel is simple, requiring no defrosting. Running the unit is simple: load samples, select maximum safe temperature and...

LC/MS/MS system.(SHOW Preview)
February 1, 2006... Booth 2433 The QSTAR Elite LC/MS/MS quadrupole time-of-flight mass spectrometer is offered for proteomics and metabolomics researchers discovering protein and small molecule biomarkers from complex biological samples. Analyst QS 2.0 software...

Undercounter refrigerator.(SHOW Preview)
February 1, 2006... Booth 4453 The 6CRD undercounter drawer refrigerator is Commercial UL Listed for laboratory use. The unit's configuration allows for easy use even from a seated position. Two deep, full-extension drawers store nearly all types of containers and...

Multi-mode reader.(SHOW Preview)
February 1, 2006... Booth 3733 Vanoskan spectral scanning multi-mode reader offers Time-Resolved Fluorescence (TRF) measurement for cellular assays, technology that minimizes interference of background fluorescence. TRF labels are used in multi-label assays...

Capillary luer adapter.
February 1, 2006... Booth 3045 Luer-to-Micro-Tight adapter added to Upchurch Scientific's micro- and nanoscale connector line introduces no dead volume to the flow path and is suited for infusing sample into lab-on-a-chip devices. The adapter can be used to...

Diluter/Dispenser.(SHOW Preview)
February 1, 2006... Booth 4868 Cheminert M Series Diluter/Dispensers features a set-up Wizard that eliminates all the math calculations and external charts associated with diluting and dispensing applications. Just enter the dilution ratio and the final volume,...

XY-Nanopositioning stages.
February 1, 2006... Booth 2019 P-714 high-speed XY-nanopositioning and scanning stages are piezo-driven. A resonant frequency of 2.2 kHz provides sub-millisecond response. Integrated high-resolution position sensors and piezoelectric drives provide sub-nanometer...

Electrochemical detector with single cell redox.(SHOW Preview)
February 1, 2006... Booth 6269 Coulochem III combines coulometric and amperometric detection in a flexible system that offers redox capability in a single cell. Compatible with all HPLC columns and offering a choice of operating modes, the device quantifies...

Preparative Chromatography System.(SHOW Preview)
February 1, 2006... Booth 2644 Buchi Sepacore Preparative Chromatography System, for solvent separation/purification, features a modular pumping system with pulse-free pistons, flow tares up to 250 ml/min, maximum pump pressures up to 50 bar or 725 psi, and a...

Cation exchange media.(SHOW Preview)
February 1, 2006... Booth 2405 Capto MMC chromatography media is offered for large scale biopharmaceutical manufacturing. The multimodal cation exchanger is used in the early stages of downstream purification. Adsorption to Capto MMC is salt tolerant, enabling the...

Wall storage module.(SHOW Preview)
February 1, 2006... Booth 3545 SmartWall Plus allows wall storage to be customized with a variety of open and closed options. Room layout is accomplished with wall tracks to which are attached storage options utilizing shelves, accessory grids and Starsys wall...

Single, multichannel pipettes.(SHOW Preview)
February 1, 2006... Booth 659 Labpette Discovery Pipettes allow volume to be set using either thumbwheel or pushbutton. Pushbutton design prevents accidental change. Ergonomic design and reduced plunger forces make the pipettes comfortable to hold and lower the...

Macromolecular characterization.(SHOW Preview)
February 1, 2006... Booth 1944 DAWN HELEOS Multi-Angle Light Scattering (MALS) Detector will be featured at this booth. The on-line instrument incorporates both MALS and QELS (Quasi-Elastic Light Scattering) into a single unit. Also being exhibited, the automated...

High throughput homogenizing.(AUTOMATION/ROBOTICS)
February 1, 2006... Programmable Omni Prep homogenizer processes up to 250 samples per hour. Operation with disposable Omni Tip probes eliminates cross contamination and cleaning. Brushless motor technology is utilized for quiet operation and long motor life....

Automated liquid handling.(AUTOMATION/ROBOTICS)
February 1, 2006... Workstation JANUS Automated Workstation offers three new platforms. The JANUS MDT is a 96 or 384-channel system providing Modular Dispense Technology (MDT). Interchangeable dispense heads include the NanoHead, which enables assay...

Microarray Workstation.(AUTOMATION/ROBOTICS)
February 1, 2006... The BriteSpot Workstation reduces the human, physical, and environmental variables that negatively affect microarray data. Three systems work together to process microarrays in an ozone-safe environment: the Hybex Microarray Incubation System,...

Flash-luminescence screening platform.(AUTOMATION/ROBOTICS)
February 1, 2006... CyBi-Cellight flash luminescence screening system integrates the CyBi-Lumax flash reader, the CyBi-Well vario pipettor with stackers, plate handling, optional incubators and CyBi-Drop non-contact dispensers. The workstation covers the complete...

Liquid handling system.(AUTOMATION/ROBOTICS)
February 1, 2006... The Sciclone i1000 liquid handling system incorporates 96 individually programmable channels, giving the instrument the ability to aspirate/ dispense different volumes on each tip. A microprocessor-microflowmeter assembly in each channel...

Cytochrome P4500 assay.(AUTOMATION/ROBOTICS)
February 1, 2006... Promega P450-Glo assay kits are fully automated on the Protedyne BioCube System SX1400, allowing high throughput screening of cytochrome P450 activity. Cytochrome P450 enzymes play a pivotal role in the metabolism of drug compounds. Detecting...

Robot handles plates, tip racks.(AUTOMATION/ROBOTICS)
February 1, 2006... PlateCrane EX cylindrical robot arm is optimized for handling labware, including microplates, reservoirs and disposable tip racks in the SBS footprint. The E Series arm features state-of-the-art controls and a rugged design. AutoTeach function...

Robot arm increases workstation throughput.(AUTOMATION/ROBOTICS)
February 1, 2006... Beckman Coulter is integrating Motoman industrial robot arms with their automated liquid handling systems, providing drug discovery/ screening and sample prep users with an option for ultra-high throughput. The robot will join Beckman Coulter's...

Acoustic ejection dispenser.(AUTOMATION/ROBOTICS)
February 1, 2006... Echo 555 liquid handler employs acoustic droplet ejection technology for touch-less transfer of liquids, and can dispense up to 600,000 different compounds in 24 hours. Direct plate-to-plate transfers are performed on droplets down to 2.5 nl....

Real-Time PCR System.(AUTOMATION/ROBOTICS)
February 1, 2006... The 7500 Fast RealTime PCR System reduces PCR run times to * Applied Biosystems 800-327-3002 www.appliedbiosystems.com [ILLUSTRATION OMITTED]

Polypropylene microplates.(AUTOMATION/ROBOTICS)
February 1, 2006... These microplates meet SBS recommendations for compatibility with automated equipment and are certified RNase- and DNase-free and non-pyrogenic. Standard volume plates with flat, round and conical well bottoms offer maximum volumes of over 300...

High-content screening.(AUTOMATION/ROBOTICS)
February 1, 2006... HCS WorkCell high-content screening (HCS) system combines instrumentation and software to enable complete sample preparation and scheduled analysis for applications in stem cell research, cell health and RNAi. The system allows for easy...

Lab automation system.(AUTOMATION/ROBOTICS)
February 1, 2006... FLASH lab automation system utilizes flexible robotics controlled by a combination of motion control and lab process software. Control software interfaces with LIMS, database and network systems and merges information with internal system...

High throughput electroporation.(AUTOMATION/ROBOTICS)
February 1, 2006... This Electroporation System delivers siRNA and DNA expression vectors into mammalian cells. The system provides a 96-well electroporation plate and a plate handler that can be used to design electroporation experiments. User-friendly interface...

Molecular diagnostics instrument, chips.(NanoChip 400 )(Brief Article)
February 1, 2006... Nanogen's NanoChip 400 molecular diagnostic testing and development platform is designed for both research and clinical reference laboratories. The NanoChip 400 cartridge provides multi-ample and multi-analyte reporting capabilities when...

GPC/SEC software.(NEW Technology)
February 1, 2006... OmniSEC 4.1 GPC/SEC integrated software package, for multiple detection analysis, can calculate the molecular weight of a protein sample without knowing dn/dc or concentration. Other features include variable dn/dc and a report designer. The...

Biological pathway software.(NEW Technology)
February 1, 2006... PathwayArchitect systems biology-focused pathway analysis software offers a biology-focused workflow and a database of more than one million biological interactions. The package features a new method of exploring biological interactions, the...

Interactive signal transduction pathway maps.(NEW Technology)
February 1, 2006... A sponsor of Science magazine's Signal Transduction Knowledge Environment (STKE), Active Motif hosts over 20 of STKE's interactive connections maps for cell signaling on its Web site. Users simply click on a molecule of interest in a given map...

CDNA Synthesis Kit for qPCR.(Quantitative Polymerase Chain Reaction)(Brief Article)
February 1, 2006... MessageBOOSTER cDNA Synthesis Kit for qPCR improves qRT-PCR sensitivity of low-abundance transcripts from as little as one cell. A reaction amplifies the Poly(A) RNA in total RNA from 1 to 50 cells and then converts the amplified RNA to cDNA...

Fluorescent homogeneous Kinase Assays.(NEW Technology)
February 1, 2006... TruLight Kinase Assays are homogeneous and do not require antibodies or radioactivity. Superquenching fluorescence yields high Z'-values at low enzyme conversion, using less enzyme without compromising data integrity. Users may choose from 11...

Mouse TNF alpha antibodies.(NEW Technology)
February 1, 2006... Mouse TNF alpha antibodies, available unlabeled and biotin-labeled, are validated for ELISA development and Western blot. TNF alpha antibodies for bovine, equine, human, porcine and rat are also available. * Pierce Biotechnology ...

Ozone-Safe workspace for microarrays.(NEW Technology)
February 1, 2006... NoZone workspace system is a sealed acrylic enclosure with ozone filtration and monitoring equipment that maintains low ozone levels when working with microarrays. Sufficient interior space is provided for the Hybex microarray incubator and the...

Modular worktables.(NEW Technology)
February 1, 2006... MetroMax worktables resist corrosion and are built of polymers that include Microban antimicrobial protection. Black and gray work surfaces are offered in steel and TRESPA phenolic resin. Accessories and caster options permit users to customize...

Lentiviral shRNAmir library.(NEW Technology)
February 1, 2006... Open Biosystems' lentiviral microRNA-adapted short hairpin RNA (shRNAmir) library enables investigators to inhibit expression of specific genes within the human genome, providing access to information on gene function in normal and disease...

Standard, custom SNP panels.(Single-Nucleotide Polymorphism )(Brief Article)
February 1, 2006... Selection of SNP panels for targeted genotyping applications includes custom panels spanning 1500 to 20,000 SNPs per assay, as well as seven standard SNP panels for whole-genome coding SNP analysis, disease-related studies and common animal...

High throughput screening analysis software.(NEW Technology)
February 1, 2006... Screener 4.0 open, scalable screening analysis software offers a public application programming interface and procedures for analyzing data. The software handles high content screening data and consolidates its strengths in compound potency...

Confocal laser fluorescence microscope.(NEW Technology)
February 1, 2006... Digital Eclipse Clsi confocal laser fluorescence microscope system acquires fluorescence spectra over a 320 nm range in wavelengths at 10, 5 or 2.5 nm spectral resolution. FRAP and FRET macros facilitate fast fluorescence recovery after...

Electronic lab notebook.(NEW Technology)
February 1, 2006... MDL Notebook provides a hub for total workflow integration. Users can store protocols, share hypotheses, and legally document discoveries. Workflows are streamlined, repetitive tasks are automated, and scientists can create reports. Users can...