Bioscience Technology articles from February 2005

Bioscience Technology archives from February 2005

Online conference--biomarkers, expression profiling, RNAi.(Editor's Note)
February 1, 2005... BioDiscovery Expo will convene February 15 and 16 at www.biodiscoveryexpo.com. (Archived viewing is offered for 6 months.) The following partial list of topics and speakers should be encouragement enough to spend time at this event. ...

Cytovance Biologics launches process development services for biopharmaceuticals.
February 1, 2005... Cytovance Biologics Inc., makes available process development services to biotechnology companies preparing to progress products into clinical development. Services include cell culture process development, purification process development,...

$10,000 prize for siRNA versus Morpholino comparison.
February 1, 2005... The recently-completed Human Genome Project uncovered many thousands of new genes. To understand the functions of those new genes researchers are increasingly turning to tools designed to specifically knock down the activity of any selected...

PerkinElmer launches expanded availability of radionucleotides.
February 1, 2005... PerkinElmer, Inc. will manufacture its NEN [sup.32]p and [sup.33]p radionucleotides twice as often. Fresh lots of [sup.32]p radionucleotides willbe available twice a week on Mondays and Thursdays, and fresh lots of [sup.33]p radionucleotides...

Scientists vs. the public: the cloning controversy.
February 1, 2005... The majority of the 2,400+ life scientists who participated in a study on cloning conducted by The Science Advisory Board (Arlington, VA) strongly believe that human therapeutic cloning research should proceed primarily so as not to delay or...

Scientists develop split green for tagging protein.
February 1, 2005... University of California scientists at Los Alamos National Laboratory have developed a protein tagging and detection system based on a process for "splitting" a green fluorescent protein. Unlike current detection methods, the method works both...

Mass spectrometer.(February's Technology)
February 1, 2005... From a family of triple quadrupole analyzers, the API 5000 LC/MS/MS System features a sensitive and accurate mass spectrometer for small molecule quantification, which is essential for Drug Metabolism And Pharmacokinetics (DMPK) and Absorption,...

Kinase assay, substrate products.(February's Technology)
February 1, 2005... Kinome Hunter is a homogeneous, non-radioactive platform that allows rapid assay development without the need of an associated antibody. Substrate Hunter is a panel of 45 dye labeled peptides as potential substrates for the AGC, CAMK, CMGC, CK...

Compound storage, screening system.(February's Technology)
February 1, 2005... RTS Group Life Science's Symphony combined store and ultra-high throughput screening system is capable of generating 1,000,000 data points per day, and of 48 hours of unattended operation. Symphony provides storage for over 1,000 compound...

Protein crystallization screening.(February's Technology)
February 1, 2005... Zetasizer Nano S combined static and dynamic light scattering instrument is optimized for the characterization of proteins in solution prior to crystallization. The compact system rapidly delivers accurate and extensive information that can...

Multi-purpose bioreactor.(February's Technology)
February 1, 2005... The Automatic Perfused HFB (Hydrodynamic Focusing Bioreactor) System is a multi-purpose bioreactor that provides automatic control of major process parameters. The system is equipped with controls for pH, D.O., rotation, perfusion and...

Purify RNA from a single cell.(February's Technology)
February 1, 2005... ArrayPure nano-scale RNA purification kit provides all reagents needed to purify RNA from one to ten thousand eukaryotic cells, as obtained with laser capture methods. The kit contains only aqueous solutions and requires no toxic organic...

Infrared imaging for automated protein research.(February's Technology)
February 1, 2005... Aerius Automated Infrared Imaging System from LI-COR Biosciences is designed for protein discovery using infrared plate-based assays. The system builds on the company's Odyssey two-channel infrared detection system and adds a reader capable of...

Cell-based assays: analysis in context.(Cover Story)
February 1, 2005... Context is everything in biology. "The old days of saying that a protein does such-and-such are over," notes Ian Ley, Director of Cellular Analysis at Beckman Coulter (Fullerton, CA). "Now everything is understood to be interconnected, and...

Mouse whole genome bioarray.(Genomics Instruments And Reagents)
February 1, 2005... A mouse whole genome bioarray has been added to the GE Healtcare CodeLink microarray platform. For researchers using the mouse as a model system for human disease study, this product offers the entire mouse genome on a single array for...

Automated bacterial protein expression system.(Genomics Instruments And Reagents)
February 1, 2005... The Q[P.sup.Expression] system integrates proprietary autornated colony picking with liquid handling. The system supports the multi-day workflow of plasmid transformations, bacterial streaking, colony imaging, picking, tracking and management....

Phospho-RTK array kit.(Genomics Instruments And Reagents)
February 1, 2005... Receptor Tyrosine Kinases (RTKs) are widely expressed transmembrane receptors that undergo phosphorylation events and participate in cell signaling processes. The Human phospho-RTK Array Kit is a screening tool designed to simultaneously detect...

Protein array analysis platform.(Genomics Instruments And Reagents)
February 1, 2005... ProScanArray and ScanArray [G.sub.x] microarray scanners support both proteomic and genomic array-based applications. The ProScanArray series of multi-application microarray scanners utilize proven confocal technology that collects more signals...

Dual expression vector system.(Genomics Reagents & Instruments)
February 1, 2005... New pPICHOLI shuttle vector system has been constructed for efficient protein expression both in E. coli and Pichia pastoris, making subcloning experiments superfluous. The expression of many (mainly eukaryotic) genes, often results in the...

Mouse and rat brain tissue microarrays.(Genomics Reagents & Instruments)
February 1, 2005... MaxArray mouse and rat brain tissue microarrays contain 64 mouse or rat brain tissue samples arrayed on Superfrost Plus microscope slides. Each slide contains 4 cores from each of 4 distinct types of brain tissue from 4 mice or rats, for a...

Microarray and software for comparative genomic hybridization studies in cancer research.(Genomics Reagents & Instruments)
February 1, 2005... Human Genome CGH Microarray and CGH Analytics software (Agilent Technologies, Inc.) aids cancer biologists and cytogeneticists in the study of genomic alterations in cancer. Comparative genomic hybridization (CGH) is used to study the...

Clone toxic genes.(Genomics Reagents & Instruments)
February 1, 2005... The CopyCutter EPI400 Competent E.coli allows users to clone potentially toxic genes and unstable DNA sequences by lowering the copy number of ColE1 and pMB1-based vectors, including pUC and pET vectors. To facilitate plasmid DNA purification,...

Dyes for multiplex PCR.(Genomics Reagents & Instruments)
February 1, 2005... CAL Fluor and Quasar Dyes, two series of dyes for multiplex real-time, quantitative PCR (rt, Q-PCR), have emission maxima ranging from 522 nm to 670 nm. The dyes are offered as alternatives for seven fluorophores commonly used on real-time...

Purify mRNA from cells, tissue, or total RNA.(Genomics Reagents & Instruments)
February 1, 2005... New mTRAP mRNA Purification Kits incorporate a peptide nucleic acid (PNA) molecular probe that has high binding affinity for mRNA. As a result, mRNA isolation can be performed in buffers with low salt concentrations, eliminating secondary...

Gene expression arrays.(Genomics Reagents & Instruments)
February 1, 2005... Eppendorf DualChip microarray systems are offered for gene expression analysis and pathway identifications in toxicology, neuroscience, signal transduction and research on aging using human or rat models. Xmer technology-based probes contain...

Buccal cell genomic DNA purification kit.(Genomics Reagents & Instruments)
February 1, 2005... Isopure is based on Solid Phase Reversible Immobilization (SPRI) technology and expands Agencourt's line of magnetic bead-based kits to include isolation of genomic DNA. The reagent purifies genomic DNA from buccal cells collected either by...

Sequence information broadcast network.(Genomics Reagents & Instruments)
February 1, 2005... GenomeCast, a genomic broadcast network addressing the labor-intensive problem for bio-IT staff of keeping the vastly-growing biological and patent sequence references current for in-house bio-sequence investigation, broadcasts sequence content...

Cold Shock vectors.(Genomics Reagents & Instruments)
February 1, 2005... pCold Vectors, four vectors that utilize the Cold Shock Protein A (cspA) promoter for expression of pure, high yield recombinant protein in E. coli. These vectors selectively induce target protein synthesis at low temperatures (15 C) where the...

SNP browsing, selection Software.(Bioinformatics)
February 1, 2005... Applied Biosystems has released a new version of its freely available SNPbrowser Software tool, which includes data on 20 million genotypes obtained from 160,000 SNPs typed on 180 individuals across four populations. The software, available at...

Target identification program.(Bioinformatics)
February 1, 2005... LION Target Engine 1.1 enables scientists of different expertise levels in target identification and validation to access all available life science data through a simplified Web interface. Scientists can also annotate and share biological...

Programs generate charge states and charges.(Bioinformatics)
February 1, 2005... QUAC PAC 1.1 is a suite of programs that generates high-quality charge states and charges for both small molecules and proteins. OpenEye's fundamental philosophy is that the chemistry of molecular interactions is a matter of shape and...

Scientific computational software.(Bioinformatics)
February 1, 2005... TurboBench 2.0 updates application software for computational workflows common in drug discovery. V 2.0 enables users to exploit computing power available on heterogeneous mixtures of multiprocessor servers, clusters, networked desktops, and...

Genetic sequence database.(Bioinformatics)
February 1, 2005... GenomeQuest GeneRef MAX contains more than 266,000 unique transcripts from six major public data sources and is cross-referenced with leading microarray probe sets and more than 9.6 million genetic sequences found in the patent literature....

Information management for bio data.(Bioinformatics)
February 1, 2005... MDL Isentris information management and integration platform is an only n-tier informatics architecture supporting enterprise-wide process, data, application building and application integration for the life sciences. Isentris streamlines the...

Genotyping, AFLP analysis software.(Bioinformatics)
February 1, 2005... GeneMarker has multiple applications in amplified fragment-length polymorphism (AFLP), fragment, STOR and microsatellite analysis. The program features automated stutter peak and saturation correction. Enhanced sensitivity and accuracy is...

Workstation.(Liquid Handling)
February 1, 2005... The Biomek Assay Workstation configured with either the Biomek FX or NX liquid handlers. provides multiple pipetting options for varying capacity throughput and lab space requirements. The system integrates the proprietary DTX Series multimode...

Sample mixer.(Liquid Handling)
February 1, 2005... Mini LabRoller Rotator allows mixing sample tubes at various levels of agitation. Three rotisseries are available to accommodate plates, various tube sizes such as 1.5/2.0 ml micro tubes, common test tubes, and standard 15 ml and 50 ml conical...

Liquid handling workstation.(Liquid Handling)
February 1, 2005... Eppendorf epMotion 5075 liquid-handling workstations incorporate an optical sensor that monitors labware and liquid levels on the 12-place deck. Stations can automatically change pipetting heads and move labware. Base Model LH can be upgraded...

Electronic, ergonomic pipette.(Liquid Handling)
February 1, 2005... Multi-channel model Ovation BioNatural Pipette offers ergonomic benefits for protocols and applications in multiple-well plates. Eight-channel Ovation pipettes share their design with single-channel models, and include a number of electronic...

Pipette controller.(Liquid Handling)
February 1, 2005... SoftAide Pipette Controller serial pipetting is light-weight and fatigue-free for precise measuring and dispensing from 0.1 ml to 200 ml. The controller has an easy-to-read LED display for mode and speed selection. NiMH batteries provide...

Acoustic-based plate and tube filling.(Liquid Handling)
February 1, 2005... Echo 380 auditor determines the fill volume of multi-well plates or sample tubes. Users can even interrogate lidded or sealed containers. The Echo 380 auditor will join the Echo 550 compound reformatter as the second acoustic based instrument...

Printed Wash Bottles.(Liquid Handling)
February 1, 2005... Printed Wash Bottles dispense an accurate fine controlled stream of liquid. Made of LDPE, the bottles are flexible and easy to squeeze. Hazard symbols and contents are printed in German, French and English in abrasion resistant ink. Variety...

Pipetter.(Liquid Handling)
February 1, 2005... PIPETBOY comfort royal transparent blue pipetter has been designed to fit perfectly into even small hands. Weighing 190 grams and powered by 2 NiMH rechargeable batteries, the pipetter can be used continuously all day and still remain...

Programmable pipettor.(Liquid Handling)
February 1, 2005... Programmable Pipet-Aid Elite 400 hand-held pipettors features programming functions that enable quick volume setting based on pipet size. The unit can accommodate pipet sizes from 1 to 50 ml and will reproducibly dispense volumes as small as...

Threaded compression fittings.(Liquid Handling)
February 1, 2005... Ultra-miniature M3 threaded compression fittings are offered for applications where space, leak-tightness and light weight are required. Applications include instruments, chromatography, gas delivery systems and other lab equipment. The...

New MicroTees, Crosses, adapters.(Liquid Handling)
February 1, 2005... Scivex has expanded its line of Upchurch Scientific brand MicroTees, MicroCrosses and MicroTight adapters, which provide direct connection of 1/32" and 360 [micro]m OD tubing without using sleeves. Made of chemical-resistant PEEK polymer, the...

Valveless dispensers and metering pumps.(Liquid Handling)
February 1, 2005... Model SMTRH dispensing pump utilizes Fluid Metering's CeramPump valveless piston pumping principle and has a fluid path of zirconium and ceramic. The pump is driven by a stepper motor and delivers from 500 nl to 5 [micro]1 per dispense. Piston...

Dispensing pump.(Liquid Handling)
February 1, 2005... The 520Di-dispensing pump features spring loaded stainless-steel rollers and a larger swept volume pump head, to combine gentle handling of fluids with capacity suited for vial or bottle filling of vaccines, biological reagents and diagnostics....

Syringe pumps.(Liquid Handling)
February 1, 2005... Syringe pumps provide accurate metering of liquids at constant output pressure and constant output flow irrespective of the viscosity of the fluid. Consistent and pulse-less flow is delivered at discharge pressures from atmospheric up to...

Adjustable volume pipettors.(Liquid Handling)
February 1, 2005... New mLINE pipettors reduce muscle stress, and work with TipOne and other universal tips. Eight and 12-channel pipettors are available in addition to single-channel instruments. All pipettors have a spring-assisted Optiload System that regulates...

Nanoliter pipettor.(Liquid Handling)
February 1, 2005... TWo new exchangeable modules for nanoliter parallel pipetting extend the range of applications of the CyBi-Well vario pipetting platform. These pipetting modules, equipped with 96 or 384 tips, operate in the 100 to 2500 nanoliter volume range....

Pipet tips.(Liquid Handling)
February 1, 2005... Pipet tips are molded from medical grade, virgin polypropylene, certified to be free of DNase, RNase and endotoxins, and can be autoclaved at 122 C for 15 minutes at 15 psi. General purpose tips fit 1-200 [micro]1 or 200-1,000 [micro]1 single-...

High throughput nanoliter pipetting.(Liquid Handling)
February 1, 2005... TTP LabTech's high throughput option for its mosquitonanoliter liquid handling system provides enhanced capacity for compound dissolution applications such as compound-to-assay plate creation using a single step dilution. The mosquito can...

Pre-plumbed fluidic module.(Liquid Handling)
February 1, 2005... LabKit is an integrated fluidic module ideal for liquid handling applications. Available in eight standard configurations, the pre-plumbed kit incorporates high resolution LPV variable volume pumps (250 or 750 [micro]1) and miniature precision...

Molded silicone stoppers, seals.(Liquid Handling)
February 1, 2005... Molded silicone component line consist of stoppers and sealing systems for carboys and vessels, bottles and storage containers. Components are made from Class VI platinum-cured silicone elastomer and are manufactured in-house in a controlled...

Interleukin-19 monoclonal.(Immunological Reagents & Kits)
February 1, 2005... Purified monoclonal antibody raised against human Interleukin-19 is available from R&D Systems. IL-19 is a novel member of the multifunctional IL-10 family. It is secreted as a monomer that contains a unique bundle of seven amphipathic helices....

Human IL-2 and Bovine TNF alpha Screening Sets.(Immunological Reagents & Kits)
February 1, 2005... Human IL-2 and Bovine TNF alpha Screening Sets are offered for development of 5 colorimetric ELISA plates each Additional Screening Sets are available for human IFN[gamma] IL-1[beta] IL-6, IL-8 and TNF[alpha]; bovine IFN[gamma]; mouse...

Ghrelin (human acylated) EIA kit.(Immunological Reagents & Kits)
February 1, 2005... Ghrelin is a 28 amino acid peptide synthesized in the stomach that acts to stimulate food intake and help maintain energy homeostasis. Post-translational modification by n-octanoylation at serine 3 is essential for biological activity. Based on...

Antibodies for signaling research.(Immunological Reagents & Kits)
February 1, 2005... Signaling research line includes antibodies for the Akt pathway, cell cycle and Checkpoint control, cytokines, DNA damage, the NfkB pathway and for ubiquitin. Secondary antibodies are conjugated to IRDye800, alkaline phosphatase, Cy dyes,...

cGMP Assay development kit.(Immunological Reagents & Kits)
February 1, 2005... HTRF-based cGMP (Cyclic GMP) Assay kit, a homogenous assay, was developed to measure cGMP, an important cell signaling molecule, and more specifically to monitor both soluble (sGC) and particulate (pGC) Guanylyl Cyclases activity. cGMP is a...

Human Smac/DIABLO EIA kit.(Immunological Reagents & Kits)
February 1, 2005... Assay Designs has introduced an immunoassay for the quantitative determination of human Smac/DIABLO in cell lysates. The colorimetric, 96 well-plate format measures Smac/DIABLO concentration with a range of 31.25 to 1000 pg/ml. The three-hour...

Cell toxicity, proliferation assay.(Immunological Reagents & Kits)
February 1, 2005... CytoScan[TM]-LDH measures cytosolic enzyme lactate dehydrogenase (LDH) release as cells die. Released LDH is measured with a color producing diaphorase linked tetrazolium salt reaction. The amount of color produced is proportional to the number...

Cell Cycle Assay.(Immunological Reagents & Kits)
February 1, 2005... Cell Cycle Assay (Guava Technologies, Inc.) incorporates staining reagents pre-combined in a single optimized format, eliminating reagent preparation following cell fixation. Protocols are offered for use with either individual tubes or 96-well...

Recombinant antibody for detection of Cyclophilin A, a component of protein folding.(Immunological Reagents & Kits)
February 1, 2005... In vitro-derived, recombinant antibody is targeted against human Cyclophilin A, which is indicated to play an important role in the mechanism of protein folding. Recently a number of diseases have been linked to protein folding problems....

Cell culture plate insert.(Immunological Reagents & Kits)
February 1, 2005... BD Falcon 96-Multiwell Insert System is a cell culture insert platform suitable for both manual and robotic screening of compounds in cell-based assays. The system has been tested for its ability to produce a differentiated monolayer of Caco-2,...

Kinase and protease assays.(Immunological Reagents & Kits)
February 1, 2005... Lightspeed kinase assays, quenching fluorescence-based assays for drug discovery, are offered for PKCa (diabetes and leukemia), Akt-1 (cancer), Src (cancer) and p38a (leukemia and lymphoma). The universal platform for the detection of kinase...

Polyclonal antibody against Human Parkin.(Immunological Reagents & Kits)
February 1, 2005... Parkinson's Disease (PD) is a movement disorder resulting from degeneration of dopaminergic neurons in the substantia nigra pars compacta. The gene encoding human parkin has been linked to an autosomal recessive form of PD. Polyclonal antibody...

Avian IgY antibody conjugates for proteomics sample processing.(Immunological Reagents & Kits)
February 1, 2005... Charles River Proteomic Services Inc. (Worcester, MA) and GenWay Biotech Inc. (San Diego, CA) have collaborated to produce avian IgY polyclonal antibodies that function as a fractionation step prior to protein separation. The antibodies are...

Direct identification and isolation of murine plasmacytoid dendritic cells.(Immunological Reagents & Kits)
February 1, 2005... Anti-mPDCA-1 antibodies provide specific detection and isolation of murine plasmacytoid dendritic cells (mPDCs). The antibodies detect specifically an antigen (mPDCA-1) exclusively expressed on mPDCs in different tissues and allow direct...

Mouse Ig blocking reagent.(Immunological Reagents & Kits)
February 1, 2005... Three M.O.M. (Mouse-on-Mouse) kits are offered for the localization of mouse primary antibodies on mouse tissue sections. The kits allow mouse primary antibodies to be stained while avoiding interfering background due to the detection reagents...

Cardiac antibodies, antigens.(Immunological Reagents & Kits)
February 1, 2005... Cardiac related antibody and antigen line offers numerous monoclonals specific to the human cardiac isoform of Troponin I (cTnI). BIODESIGN International, 888-530-0140, www.biodesign.com For information specific to this item enter InfoLINK...

Immunohistochemical staining of mouse tissue.(Immunological Reagents & Kits)
February 1, 2005... Expanded line of iso-IHC Core kits come with the components required for performing iso-IHC, except the substrate-chromogen system, which the user can select from the Core Kit Accessories. BioGenex Laboratories Inc, 800-421-4149,...

Caspase 8 & 9 assays.(Immunological Reagents & Kits)
February 1, 2005... Caspase-Glo 8 and Caspase-Glo 9 assays offer apoptosis detection. The homogeneous assay protocol for Caspase 8 & 9 provides results in 20 minutes. Sensitivity is orders of magnitude greater than fluorescent methods, and the assays enable...

Immunodepletion of high-abundant proteins from rat serum.(Application Note)
February 1, 2005... The Multiple Affinity Removal System depletes albumin, IgG, and transferrin from mouse serum/plasma samples. The system is comprised of an immunoaffinity column packed with affinity purified polyclonal antibodies and proprietary buffers used to...

Stem Cell Antibody Panels.(New Technology)
February 1, 2005... R&D Systems has added two new Stem Cell Antibody Panels to its line of stem cell products. Human Embryonic Stem Cell Marker Antibody Panel contains the antibodies anti-alkaline phosphatase; anti-Nanog; anti-Oct-3/4; anti-SSEA-1; and...

Live cell imaging confocal.(New Technology)
February 1, 2005... LSM 5 LIVE confocal microscope, for studies on living specimens can collect up to 120 confocal images/second at a resolution of 512 X 512 pixels. With nearly 100% excitation efficiency and efficient emission yield, the AchroGate beam splitter...

Automated embryonic stem cell culture system.(Application Note)
February 1, 2005... It was our aim to develop a system for the automated culture of primary cells, cell lines and embryonic stem cells that would provide high-quality cells in large numbers. Requirements were the automation of cell plating, media change, growth...

IX81 motorized inverted microscope.(Literature Focus)(Advertisement)
February 1, 2005... The IX81 advanced motorized inverted microscope from Olympus features a modular frame and two-tiered, V-shaped optical design to provide 9 access ports for input or output devices. Four ports offer simultaneous access to a primary image....

Autoimmune kit.(Literature Focus)(Advertisement)
February 1, 2005... Prlmiah Autoimmune Kit is an RNA expression microarray, which empowers classification of subjects for linkage, association and other genetic or clinical studies of specific autoimmune diseases. Prlmiah allows users to quickly and accurately...

Sarstedt laboratory product catalog.(Literature Focus)(Advertisement)
February 1, 2005... The Sarstedt organization is recognized as a world-class manufacturer and distributor of laboratory consumables, specimen collection products, medical devices and instrumentation. Our product range includes innovative blood collection systems,...

Real-time, Q-PCR multiplexing.(Literature Focus)(Advertisement)
February 1, 2005... Two new series of performance-optimized dyes for multiplex real-time, are available: the Q-PCR--the CAL Fluor(r) and Quasar(r) Dyes. These dyes are high performing, low-cost alternatives for many commonly used fluorophores, and are compatible...

mLINE multichannel pipettors.(Literature Focus)(Advertisement)
February 1, 2005... These new multichannels pipettors are designed using lightweight materials and incorporate the "Optiload" tip-sealing feature which perfectly seals and allows for the lowest ejection forces. These multichannel pipettors are fully autoclavable...

Vapor pressure osmometer.(Literature Focus)(Advertisement)
February 1, 2005... The Vapro vapor pressure osmometer covered in this brochure provides fast, simple determination of osmolality. Multiple functions are selected from its simple, logical menu. Wescor, Inc., 800-453-2725, www.wescor.com For information...

Reagents.(Literature Focus)(Advertisement)
February 1, 2005... Oxford Biomedical Research supplies research laboratories around the world with high quality reagents in the areas of Oxidative Stress, Eicosanoid Metabolism, Xenobiotic Metabolism, Vascular Biology and Signal Transduction. The 2005 catalog...