Bioscience Technology articles from December 2006

Bioscience Technology archives from December 2006

Aiming at cancer.(ENABLING LIFE SCIENCE RESEARCH)(Cover story)
December 1, 2006... The rate of cancer incidence continues to remain stable while the death rate from cancer continues to decline, states the 2005 Cancer Trends Progress Report Update, published by the National Cancer Institute (NCI). This progress can be largely...

Snapshot.(Table)
December 1, 2006... Custom chemistry services used by readers of Bioscience Technology 7% ADME Screening 24.6% Antibody Conjugation 19.3% Antibody Development 19.3% Antibody Production 10.5% Compound Library Development 10.5%...

A present in the mail.(exchange of gifts)(Editorial)
December 1, 2006... In my mail this morning was a box. It was a made of plain cardboard, was from a pr firm, and it almost certainly contained a holiday present. You know, I was a little excited. It's a deeply ingrained response, with lots of resonance and...

Automated cell culture.(December's Innovations)
December 1, 2006... AutovaxID automated instrument employs a disposable, closed-system chamber incorporating a hollow-fiber cell-growth cartridge. This bioreactor replaces conventional stainless steel, glass, and plastic cell-growth chambers that require...

Dry blotting system.(December's Innovations)
December 1, 2006... The iBlot dry blotting system enables the transfer of proteins from gels to nitrocellulose membranes for Western blots in only six to seven minutes. Buffers are not required to achieve fast, reproducible protein transfer. Antibodies are...

Automated quantitative pathology system.(December's Innovations)
December 1, 2006... The PM-2000 platform with AQUA analysis quantitates protein expression within subcellular compartments in tissue sections automatically, with a high level of precision. The multi-tissue platform combines fluorescence-based image analysis with...

Confocal imaging accessory.(December's Innovations)
December 1, 2006... PhotoKinesis enables Fluorescence Recovery After Photobleaching (FRAP) and similar techniques on PerkinElmer UltraVIEW Live Cell Imaging systems. The accessory introduces "Track-It," on-demand, photoactivation and photoswitching that provides...

Human B cell isolation kits.(December's Innovations)
December 1, 2006... New products are offered for the negative selection of human B cells. Most of these deplete [CD43.sup.+] cells such as T cells, thymocytes and neutrophils, increasing the purity of B cells obtained from normal samples. However, B cells also...

Multizoom microscope.(December's Innovations)
December 1, 2006... The AZ100 Multizoom macro/micro microscope system features a wide field of view, long working distances, and high resolution. Observation techniques that are supported include EPI/DIA-DIC, DIA-BF and Oblique, EPI-FL, EPI-RL EPI/DIA-Simple POL....

Yeast RNA purification kit.(December's Innovations)
December 1, 2006... MasterPure Kit provides all of the reagents needed to purify RNA from various yeast cell types including: Candida, Saccharomyces, Schizosaccharomyces, and filamentous fungi, such as Aspergillus. The kit utilizes a rapid desalting process to...

CCD camera.(December's Innovations)
December 1, 2006... From bright, high dynamic range applications to single photon imaging over long integrations, ImagEM CCD provides images with excellent signal-to-noise ratios. New methods for driving this CCD offer modes for fast, low noise operation and...

Magnetic beads.(Cell Signaling Focus)
December 1, 2006... LCA magnetic beads are functionalized with concanavalin A, wheat germ agglutinin or boronic acid. A combination of optimized beads enables protein scientists to perform intelligent enrichment strategies for glycosylated peptides and proteins...

Ubiquitinylated protein kit.(Cell Signaling Focus)
December 1, 2006... The UbiQapture-Q Kit facilitates isolation of mono- and polyubiquitinylated proteins (independent of lysine residue chain linkage) from cell extracts, tissue lysates and in vitro assays through the use of a high-binding affinity matrix....

Fluorescent dyes.(Cell Signaling Focus)
December 1, 2006... Fluorescent dyes are available for the detection of live cells and key functional activities in a variety of cell-based assays. The fluorescent dyes, calcein acetoxymethylester (calcein AM) and DiIC12(3), can be used with Falcon FluoroBlok Cell...

Vectors for RNAi delivery.(Cell Signaling Focus)
December 1, 2006... AdenoSilence adenoviral shRNA expression vectors target the human druggable genome. The classes that are included in this initial release represent all the major protein classes amenable to small molecule intervention, including kinases, GPCRs,...

Melting curve-based analysis of adjacent SNPs: a single, fluorescent-dye labeled oligonucleotide was used to investigate different combinations of SNP alleles present in the TNF-[alpha] gene promoter.(Biochemicals & Kits)
December 1, 2006... Introduction Melting curve analysis (MCA) is a robust and well-established method to detect mutations or single nucleotide polymorphisms (SNPs) in amplicons generated by Real-Time PCRY. (1,2) Due to its high-end optical and thermal...

Protein expression medium.(Product News)
December 1, 2006... Serum-free, animal origin-free culture medium supports the adaptation, growth and expansion of transfected PER.C6 human embryonic retinoblast cells for large-scale, high-density suspension culture in shaker flasks, roller bottles, and...

48-kinase profiling panel.(Product News)
December 1, 2006... KinaseAdvisor screening panel (NovaScreen Biosciences Corp., Hanover, MD) is available for profiling a drug candidate's activity against a wide variety of kinases, which is crucial to understanding potential safety and efficacy issues. These...

Gold nanoparticles.(Product News)
December 1, 2006... Batch-to-batch variation in monodisperse gold nanopartides is less than 1% CV. In-batch variation is less than 3% CV. The particles are offered for surface enhanced Raman, resonance light scattering, and lateral flow applications. *...

Lentiviral shRNAmir library.(Product News)
December 1, 2006... Targeting the entire human genome with multiple shRNAmir constructs per gene, Expression ArrestT GIPZ lentiviral shRNAmir library consists of shRNAmir constructs pre-cloned into the GIPZ lentiviral vector, resulting in an RNAi trigger that...

Angiogenesis assay.(Product News)
December 1, 2006... Directed In Vivo Angiogenesis Assay (DIVAA) are used in evaluating the inhibition of angiogenesis in matrix metalloprotease-2-deficient mice and enhancement of angiogenesis associated with adrenomedullin and CD97. The kit was developed for...

mRNA production system.(Product News)
December 1, 2006... The mScript System provides researchers with a simple method for producing eukaryotic mRNAs. Incorporating an in vitro transcription system, capping enzymes, and RNA poly(A) tailing reagents, the kit contains everything needed to produce...

Neural Stem Cell Expansion Medium.(Product News)
December 1, 2006... Stemline Neural Stem Cell Expansion Medium offers a consistently high neural stem cell yield in a serum-free environment. In order to be regulatory friendly, the formulation was designed to be entirely animal component-free as well as complete...

Blue QPCR Master Mix.(Product News)
December 1, 2006... Absolute Blue QPCR Master Mix uses an inert blue dye, which does not effect the QPCR reaction, to enhance the contrast between reagent and plastic, making verification of master mix dispensing quick and easy. Whether dispensing manually or...

Pure blood microvascular endothelial cell systems.(Product News)
December 1, 2006... Clonetics Human Dermal Blood Microvascular Endothelial Cell Systems are pure, dermal-derived microvascular endothelial cells with guaranteed purity of 90% or more. Use of optimized media and supplements during enrichment ensures excellent...

In-Vivo molecular imaging.(Image Analysis Focus)
December 1, 2006... The KODAK In-Vivo Multispectral molecular imaging system provides multi-spectral fluorescence, luminescence, digital x-ray and radioisotopic imaging capabilities to provide non-invasire measurement of biological processes in small animals....

Laser scanning microscope.(Image Analysis Focus)
December 1, 2006... LSM 5 MP laser scanning microscope system is configured for multiphoton microscopy. Optical coatings ensure minimal power loss with direct-coupled femtosecond lasers. Filter technology guarantees suppression of exciting light with simultaneous...

Laser scanning confocal system.(Image Analysis Focus)
December 1, 2006... The Fluoview FV1000-EVA module adds computer control of excitation laser light at or beyond the critical angle for TIRF and evanescent wave excitation. Scientists doing TIRF illumination can opt to use any of the numerous laser wavelengths...

Controlled Light Exposure Microscopy.(Image Analysis Focus)
December 1, 2006... Using two-laser confocal imaging methods to optimize excitation and detector sensitivity range, the Controlled Light Exposure Microscopy (CLEM) unit reduces photo-bleaching effects and saturation of detector signal. When the unit senses the...

Automation reduces reaction volumes: moving lfrom a 50 [micro]l reaction volume to a 5 [micro]l reaction volume will require the use of 5-fold less reagents.(Instruments & Systems)
December 1, 2006... The benefits of automating biological assays include the elimination of problems introduced through human error, increased throughput and consistency, and decreased costs. Standard PCR and quantitative PCR are applications that have been...

Microdialysis perfusates analysis.(Product News)
December 1, 2006... Taro chromatographic methods for analysis of microdialysis perfusates enable neuroscience researchers to measure norepinephrine (NE), dopamine (DA) and serotonin (5HT) simultaneously with no interference, and measure dopamine and serotonin...

Gene expression sample preparation.(Product News)
December 1, 2006... Biomek 3000 GeXP software plug-in (Beckman Coulter, Inc., Fullerton, CA) provides sample preparation methods for the company's GenomeLab GeXP Genetic Analysis system on their Biomek 3000 Liquid Handling Workstation. The suite includes fully...

Protein identification, quantitation software.(Product News)
December 1, 2006... BioWorks 3.3 software enables automated quantitative analysis of iTRAQ-, SILAC- and ICAT-labeled samples, as well as label-free quantitation techniques. A probability-based scoring algorithm provides protein identification. A unified Search...

Software automates dose-response assays.(Product News)
December 1, 2006... Two software products, one to set up dose-response assays and the other to facilitate cherry-picking, enhance applications Labcyte Incorporated's (Sunnyvale, CA) Echo technology. Echo 550 and 555 liquid handlers use acoustic energy to transfer...

Fluorescence detector.(Product News)
December 1, 2006... Model XLC-3020FP fluorescence detector, for ultra high pressure liquid chromatography (UHPLC) applications, provides stability over a wide wavelength range (220-700 nm) for both excitation and emission measurements. Advanced optics, holographic...

Multi-detection microplate readers.(Product News)
December 1, 2006... Synergy 2 and Synergy HT plate readers provide fluorescence intensity, time-resolved fluorescence and UV-Vis absorbance detection, as well as luminescence and injection options. Synergy 2 also offers a fluorescence polarization mode. DLReady...

Scientific Workflow.(Product News)
December 1, 2006... Scientific Workflow Solution integrates dusters, supercomputers, data management tools and storage arrays. Desktop and server systems share a single pool of data. The platform incorporates: a common Linux operating system; platform-wide storage...

Protective apparel.(Product News)
December 1, 2006... Chemical Resistance Bundle safety products include KLEENGUARD G80 purple nitrile chemical resistant gloves, KLEENGUARD G80 neoprene/latex chemical resistant gloves and KLEENGUARD A70 chemical spray protection coveralls. Glove shape is based on...

Antioxidant measurement.(Product News)
December 1, 2006... The PHOIDCHEM system quantifies water soluble and lipid soluble antioxidants using photochemiluminescence, a combination of fast photochemical radical generation and sensitive luminometric detection. Superoxide anion free radicals are produced...

Peptide Separation.(Product News)
December 1, 2006... Peptide Separation Technology columns (Waters Corp. Milford, MA) are available in a 1.7 [micro]m-10 [micro]m particle size range, lengths from 50 to 250 mm and internal diameters of 75 [micro]m to 30 mm. Custom prepared columns are also...

Liquid Handling System Performance Verification.(Product News)
December 1, 2006... Liquid Handler Performance Verification supplies labs with third-party, documented assessment of the accuracy and precision of equipment. The service provides performance results traceable to national standards, ensuring repeatability between...

Acoustic detection of biomolecular interaction.(Product News)
December 1, 2006... RAPid 4 biomolecular interaction analysis system enables real-time label-free measurement and analysis of biomolecular interactions with accuracy, reproducibility and sensitivity. The flow-based system reduces the need to purify samples and...

IR, NIR Imaging Systems.(Product News)
December 1, 2006... Spotlight 400 FT-IR and 400N FT-NIR Imaging Systems provide fast data acquisition and sampling and spatial resolution flexibility. Linear Array Detector Technology addresses large sample sizes and increases captured IR spectral range. Multiple...

Liquid handling system.(Product News)
December 1, 2006... Zephyr scaleable liquid handling system increases productivity and walk-away time while fitting into space-constrained labs. MaestroT software'sintuitive interface guides researchers through set-up and initial use. Pre-configured preclinical,...

Motorized stage system.(Product News)
December 1, 2006... Model ES10 OptiScanII controller with USB provides smooth and quiet motion. The space saving design houses drives for a motorized stage, focus, two filter wheels and three shutters. * Prior Scientific, Inc. 800-877-2234 ...

Electronic handheld dispensers.(Pipettors Focus)
December 1, 2006... The Repeater stream and Xstream ergonomic, handheld dispensers offer speed and flexibility. The units dispense liquids with high vapor pressure and/or high viscosity, while also preventing cross-contamination. They feature a motorized piston,...

Electronic pipettor.(Pipettors Focus)
December 1, 2006... Electronic pipettor is ergonomically designed and certified with ISO 13485/17025/9001 accreditations. Microprocessor-controlled piston and patented braking mechanism ensure precision and accuracy, especially during repetitive dispensing...

Pipetting aid.(Pipettors Focus)
December 1, 2006... The increased motor power of the Finnpipette BioMate plus allows faster pipetting of volumes from 1-100 ml, with batteries that last up to eight hours under constant use. Comfort and grip are assured by a lightweight, ergonomic design that...

Pipetting aid.
December 1, 2006... Drummond Portable Pipet-Aid XL has a long, light-weight handle that lowers the arm-lift required to perform pipetting operations. This more comfortable arm position reduces shoulder and neck strain, particularly when working within a hood. An...

Pipette controller line.(Product News)
December 1, 2006... The accu-jet[R] pro has a sculpted grip that's comfortable in small and large hands, and offers sensitive control. Soft blow-out for cell culture applications is easy or secure. Volumetric dispensing to Class A tolerances is possible. The...

Isolation enclosures.(Product News)
December 1, 2006... EnviroMax Enclosures isolate lab automation equipment and robotic processes and maintain a safe working area. The units isolate liquid handling workstations, HPLC equipment sample weighing, high throughput screening, powers handling and other...

Vibration Control Workstation.(Product News)
December 1, 2006... MK26 Series Vibration Control Workstation, for ultra-low natural frequency applications and negative stiffness vibration isolators, is compact, passive and offers with vertical and horizontal isolation efficiencies. MK26 units can be configured...

Peristaltic dispensers.(Product News)
December 1, 2006... UltraSpense 2000 uniformly distributes live cells into 384-well microplates. Assay have been performed with CHO, Hek293 and Cos-7 cells. There are no edge effect or drip problems. Accuracy of seeding is improved results. Maerial is uniformly...

Disposable spinner flasks.(Product News)
December 1, 2006... Disposable spinner flask system comes ready-to-use with paddle and integrated magnet, eliminating the need for assembly or cleaning and reassembly. Molded from virgin polystyrene and gamma-irradiated, each spinner flask system is clean and...

Liquid handling package.(Product News)
December 1, 2006... Labpette DISCOVERY 4-Pack Plus liquid handling starter ki includes four pipettes to provide a volume range off 0.5 to 1000 [micro]l (0.5 to 10 [micro]l, 2.0 to 20 [micro]l, 20 to 200 [micro]l and 100 to 1000 [micro]l). The 4-Pack Plus also...

Water, water everywhere.(Best Practices)
December 1, 2006... Water was a problem for Leonard Tini. In his drug metabolism and pharmacokinetics laboratory at AstraZeneca (Wilmington, DE), Tini runs high-throughput studies--mostly cell-based assays. His group used half a dozen Tecan Inc. (Durham, NC)...