Bioscience Technology articles from August 2007

Bioscience Technology archives from August 2007

A New era for arrays.(Cover story)
August 1, 2007... M When it comes to gene expression, scientists invariably want more: they want to follow more genes, do more replicates, and study more organisms. And advances in microarray technology--more accurate probes, more probes on arrays, and better...

Snapshot.(Statistical table)(Brief article)
August 1, 2007... SNAPSHOT Funding For Signal Transduction Research Primary Sources % Respondents Government grant 58.1% Corporate funding 41.9% 25.8% Industrial-academic ...

Magic.(Editor's Note)
August 1, 2007... I typically write a more personal commentary in our December issue, using the end of the year holiday season as an excuse to deviate from the typical research and technology focus. But a couple of cancer research-related stories came out...

Multiplexing assay system.(August's Innovation)
August 1, 2007... FlexMAP 3D bead-based multiplexing assay system simultaneously measures up to 500 analytes in a single microplate well. This multiplexing ability enables broadening the types of' testing performed using bead-based multiplexing. The system...

Cell counting kits.(August's Innovation)
August 1, 2007... Bullseye Cell Counting Kits contain cell counting tubes that hold up to 1 ml of cell suspension, and can be centrifuged to pellet the cells into a graduated 5 ml Capillary at the bottom of the tube. The volume occupied by the cell pellet after...

Small RNA cloning system.(August's Innovation)
August 1, 2007... The miRCat system permits cloning of very rare small RNAs and takes into account the natural variability in structure and sequence between species. It is compatible with most existing standard laboratory protocols for processes such as RNA...

C[O.sub.2] incubator.(August's Innovation)
August 1, 2007... The C 150 C[O.sub.2] incubator features standard hot-air sterilization at 180 C. Units can stand alone or be stacked, and are easily accessible in either configuration. The incubator offers stable pH based on a drift-free FPI infrared...

C[O.sub.2] incubators.(August's Innovations)
August 1, 2007... These C[O.sub.2] incubators feature a fan-less design, which means there is no ductwork to disassemble and clean and no crevices or blades for mold to grow on. A shelving system without brackets or fittings can be removed or reinstalled in...

Automated gel electrophoresis.(August's Innovations)
August 1, 2007... The ScreenTape fully automated gel electrophoresis system comprises the TapeStation (that carries out liquid handling, electrophoresis and imaging), ScreenTape (a consumable that contains the pre-cast, pre-packaged gel and running buffer), and...

Single channel pipetting workstation.(August's Innovations)
August 1, 2007... StatPrep single channel robotic pipetting device accommodates almost any microplate, test tube, vial or reservoir. Offering a 315 mm x 446 mm footprint, the unit uses a pipetting mechanism (electromagnetic bellows) with no seals or parts to...

Real-time cell monitoring.(August's Innovations)
August 1, 2007... Tile ECIS 9600 monitors cell grown in arrays having a standard 96-well plate configuration and footprint. The consumable arrays, easily connect to the instrument, using a single lever to make electrical contact. The instrument can scan all 96...

Ambit Biosciences enhances Kinome profiling technology.(Research News)(Brief article)
August 1, 2007... Ambit Biosciences has enhanced its KinomeScan profiling technology, a high-throughput system for screening small molecule libraries against large numbers of human kinases. The company has added 36 new kinases to its screening panel, including...

Keynote speaker to cover green Lab Design at Fall Conference.(Research News)(Conference news)
August 1, 2007... Bill Odell, Director of Hellmuth, Obata + Kassabaum's Science & Technology Group, will deliver the keynote address at R&D magazine's fall Lab Design Conference. Sustainability in Lab Design: the Next Wave of Green will be among the highlights...

New lab for monitoring clinical trials.(Research News)
August 1, 2007... Beckman Coulter, Inc. (Fullerton, CA) has opened the Immune Tolerance Network (ITN) Flow Cytometry Core Laboratory at the company's Miami, Florida facility. The new lab will participate in the design of the flow cytometry assay plan and...

Assay development service.(Research News)(Brief article)
August 1, 2007... Nanostream, Inc., of Pasadena, California, has launched an organization to deliver assay development services for screening labs. Employing a separation-based approach to developing assays, the company has the capability to develop kinase...

HTRF symposium.(Research News)
August 1, 2007... Cisbio international, a developer of HTRF technology and services used in assay development and drug screening, will host its third "HTRF in Drug Discovery" symposium September 26-28 in Sonoma, California. Scientific experts will discuss the...

Liquid temperatures cause pipetting errors.(Research News)(Brief article)
August 1, 2007... Data taken at Yellowstone National Park during the ARTEL Extreme Pipetting Expedition show that pipettes deliver volumes that are inaccurate by up to 37 percent when handling fluids at temperatures different that of the pipette. Called thermal...

Spot fractions from LC/MALDI.(Drug Discovery Focus)
August 1, 2007... Integration of the Ekspot spotter/faction collector with the NanoLC MALDI Spotting System provides single-point, software-based control. The system enables the analysis of complex protein and peptide samples with MALDI MS. The spotter/ fraction...

UV/Vis/NIR spectrophotometers.(Drug Discovery Focus)
August 1, 2007... UV/Vis/NIR Spectrophotometers The V-600 Series UV/Vis/NIR spectrophotometer series consists of five. distinct models. The, V-630BIO consists of the V. -630 instrument, an intelligent Remote Module (iRM) de, dicated to biological and clinical...

Enzymatic assay system.(Drug Discovery Focus)
August 1, 2007... The LabChip EZ Reader II performs enzymatic assays on a variety of potentially druggable targets, including kinases, phosphatases, proteases, histone deacetylases (HDAC's) and phosphodiesterases (PDE's). The platform fits on a standard bench...

Image blots, small animals.(Drug Discovery Focus)
August 1, 2007... LAS-4000 luminescent image analyzer is suited for multi-spectral Western blotting and in vivo imaging of small animals with expanded fluorescent capabilities. The latest version of these CCD-based camera systems (FujiFilmLife Science, USA) adds...

Small animal optical imaging: seeing beyond the visible with infrared dyes.(Instruments & Systems)
August 1, 2007... Optical imaging offers the potential for non-invasive study of molecular targets inside the body of the living animal. This technology has been used to follow the progression of disease, the effects of drug candidates on target pathology, the...

Reader combines monochromator, filter technologies.(Product News)
August 1, 2007... Synergy 4 multi-detection microplate reader combines filter-based and quadruple monochromator-based fluorescence detection technology and offers fluorescence intensity, luminescence, fluorescence polarization, time-resolved fluorescence, and...

Microarray gene expression software.(Product News)
August 1, 2007... ArrayStar v2.0, a comprehensive gene expression analysis software product, permits microarray users to quickly determine gene expression levels, gene relationships and class discoveries. Its visualization capabilities, including heat maps and...

Automated electrophoresis.(Product News)
August 1, 2007... Experion electrophoresis system performs microfluidic separation, detection, and analysis of protein, DNA and RNA samples. Results are digitally stored. Bio-Rad Laboratories 800-424-6723, www.bio-rad.com [ILLUSTRATION OMITTED]

High throughput assay platform.(Product News)
August 1, 2007... SmaRTScreen is a compact, automated assay system that incorporates scheduling software and that can also be used for plate replication and small-scale cell culturing. A typical configuration features a storage device, a liquid or reagent...

Microplate washers.(Product News)
August 1, 2007... AquaMax series plate washers incorporate interchangeable 96and 384-well wash heads, which install in seconds. Comprehensive cleaning routines provide reliability and trouble-free operation at the touch of a button. A dispenser and washer are...

DNA analysis chip.(Product News)
August 1, 2007... HumanlM DNA Analysis BeadChip contains more than one-million single-nucleotide polymorphisms (SNPs). It targets an extensive catalog of known copy number variation (CNV) sites, and contains novel CNV content developed in collaboration with...

High-temperature GPC.(Product News)
August 1, 2007... Model 350 HTGPC high temperature (175 C) GPC features automated sample preparation and delivery, self-cleaning in-line sample filtration and a detector module that is easily removed for maintenance. Configuration with a Refractive Index...

Bladed HPC platform.(Product News)
August 1, 2007... Altix ICE 8200 bladed servers enable large scale-out environments while minimizing demands on data center space and power. Ultra-dense architecture provides power; a single rack can be powered by as many as 512 Intel Xeon processor cores and...

Measure protein size directly.(Product News)
August 1, 2007... In chromatography flow mode, the Zetasizer Nano permits the coupling of dynamic light scattering with size exclusion chromatography. This allows protein size to be measured directly rather than relying on column calibration or additional data...

Flow cytometry software.(Product News)
August 1, 2007... FACSDiva 6.0 (BD Biosciences, San Jose, CA) facilitates consistent data from flow cytometry systems used for basic and clinical research. The software includes Cytometer Setup and Tracking capability. This set of features characterizes and...

Triple laser microplate cytometer.(Product News)
August 1, 2007... Acumen eX3 microplate cytometer is equipped with up to three lasers offering a wavelength range of 405, 488 and 633 nm for excitation. This is similar to white light source instrumentation and significantly increases the variety of fluorescent...

LED light source.(Product News)
August 1, 2007... The Colibri Light Emitting Diode (LED) is a light source for fluorescence microscopy. The intensity of the LEDs can be set for any wavelength and exactly adapted to the specimen. Opto-electronic switching eliminates motion or vibration that...

Metabolite identification software.(Product News)
August 1, 2007... MetID Solutions software uses a statistics-based approach to component verification for metabolite identification. The package maximizes the information from data-dependent high mass accuracy MSn acquisitions and accelerates reporting. A...

Integrated cell culture observation device.(Product News)
August 1, 2007... BioStation CT cell culture observation and monitoring system allows the conduct of live cell imaging locally or by remote operation over a network. The system facilitates managing, observing and recording cell growth, morphology and protein...

RNA clean-up and concentration.(Molecular Biology Focus)
August 1, 2007... RNA Cleanup and Concentration Kit purifies up to 50 [micro]g of RNA isolated using various methods (including phenol/guanidine-based protocols) and from various upstream enzymatic reactions such as DNase treatment, labeling and in vitro...

DNA polymerase.(Molecular Biology Focus)
August 1, 2007... New iProof high-fidelity. DNA polymerase incorporates a nonspecific DNA-binding domain (Sso7d) that imparts a sliding grip on the minor groove of the template DNA. This lends physical stability to the polymerase-DNA complex, enhancing...

DNA purification and recovery.(Molecular Biology Focus)
August 1, 2007... Genfind v2 DNA purification system isolates and purifies genomic DNA from whole blood, serum and FTA cards (Whatman, Inc., Florham Park, NJ). Solid Phase Reversible Immobilization (SPRI) paramagnetic bead-based technology produces high recovery...

Rat-and-mouse double stain polymer detection kit.(Molecular Biology Focus)
August 1, 2007... This kit, for double stain procedures on rat tissues, utilizes a cocktail of alkaline phosphatase (AP) and horseradish peroxidase (HRP) polymer technology that increases staining sensitivity. The technology leads to a rapid 4-step double stain...

Human STR Primer Set.(Product News)
August 1, 2007... GenomeLab Human STR Primer Set, for Beckman Coulter CEQ Series and GenomeLab GeXP genetic analysis systems, is used to determine DNA purity. It is offered for applications using large numbers of DNA samples such as clinical trials, tissue...

Sequence specific DNA ligands.(Product News)
August 1, 2007... Resolve-It Kit, for applications such as differential display in which multiple DNA species of similar size need to be separated before subsequent excision and analysis, contains two ligands: AT-Yellow, a bisbenzimide-PEG conjugate which binds...

Extracellular matrix for tumor xenografts.(Product News)
August 1, 2007... Extracel-X hydrogel hyaluronan-based synthetic extracellular matrix for preparing tumor xenografts in mice is lactate dehydrogenase-elevating virus (LDEV) free. To reconstitute the hydrogel, simply dissolve the contents of three of the vials,...

D-Dimer assay.(Product News)
August 1, 2007... D-Dimer reagent, for use on Olympus America AU Series chemistry immuno-analyzers, acts as a negative predictor of diseases and conditions related to venous thromboembolism, including Deep Vein Thrombosis (DVT). Use of the assay assists in...

Recover nucleic acids from plant material.(Product News)
August 1, 2007... The Agencourt Chloropure system isolates both DNA and RNA from a variety of plant tissues. Solid Phase Reversible Immobilization paramagnetic bead-based technology makes the extraction kit amenable to automation. It is designed for use with...

Antibody quantification assays.(Product News)
August 1, 2007... Guava RapidQuant IgG Antibody Quantification Assays, for mouse and human antibodies, help users select optimal clones from hybridoma screens. Results from the assay are read on a plate-based benchtop flow cytometer, such as the Guava EasyCyte...

PCR reagent mix in bead.(Product News)
August 1, 2007... ReaX Mastermix PCR reagents are pre-aliquoted in a soluble bead and are available in plates or strips. The products facilitate consistent performance and reduce set-up time, and can be purchased as a customized mix of PCR reagents and...

PCR arrays.(Product News)
August 1, 2007... PCR Arrays, for analyzing the expression of a focused panel of genes, can be used to profile gene expression for a biological pathway or disease using almost any real-time PCR instrument. Over 100 RT2 Profiler PCR Arrays are available for...

Toll-like receptor wall chart.(Product News)
August 1, 2007... Wall chart illustrates Toll-like Receptor (TLR) signaling pathways, depicting key TLR ligands, their TIR domains, and associated adapter molecules along with the signaling responses that are induced. Toll-like receptors play an essential role...

Test detects 18 HPVs.(Product News)
August 1, 2007... Seeplex diagnostic test simultaneously detects 18 different Human Papillomaviruses (HPVs)--3 high-risk strains (16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, and 68) and five low-risk strains (6, 11, 42, 43 and 44). The test is performed with...

Division arrested cell lines.(Product News)
August 1, 2007... Suite of 60 division arrested cell lines screens a broad range of therapeutic targets. Division arrested cells do not require lengthy cell culture procedures to prepare live cells for screening assays. Division arrested cells may be plated and...

Biotin-free immunohistochemistry kits.(Product News)
August 1, 2007... PROMARK polymer detection kits for mouse and rat tissues offer biotin-free technology for immunohistochemistry (IHC), and provide sensitive staining and eliminates avidin-biotin blocking steps. A mouse-on-rat polymer kit has minimum...

Amino acid kit for protein production.(Product News)
August 1, 2007... MAD Amino Acid Kit for protein crystallographers offers a way to produce derivatized protein suitable for structure elucidation using multi-wavelength anomalous diffraction (MAD). The kit includes a pre-measured mix of all amino acids minus...

Small RNA analysis.(Product News)
August 1, 2007... Small RNA Kit analysis kit, for use on the 2100 Bioanalyzer microfluidics products (both Agilent Technologies), enables routine quantification and characterization of miRNA down to the picogram/microliter level, in any workflow. While...

Animal-free cell culture ingredients.(Product News)
August 1, 2007... Novozymes animal-free recombinant ingredients are offered for large mammalian cell culture. Recombinant growth factors, albumins and transferrin can be used individually or in combination. The product line includes: recombinant human...

Improving temperature uniformity at -86 C in a mechanically refrigerated ultra-low freezer by reducing compressor discharge temperatures and apportioning energy management between low and high stage cooling circuits.(Apparatus & Consumables)
August 1, 2007... Abstract The development of an application-specific refrigeration compressor for use in a mechanically refrigerated cascade system results in lower compressor discharge temperatures, more balanced workload between high and low stage...

Balance enclosures.(Sample Prep Focus)
August 1, 2007... These enclosures are designed for precision containment/operator protection when compounding and powder weighing. They exceed OSHA, ANSI and all relevant international standards for vented enclosures designed to handle potent compounds with...

Stainless steel microvials.(Sample Prep Focus)
August 1, 2007... Type 305 stainless steel microvial has a capacity of 1.5 ml and is sealed with an polyolefin flange-cap. Applications include PCR methods, cryological storage and cell disruption. It cannot not be breached by the high shaking energies of cell...

Compact evaporator.(Sample Prep Focus)
August 1, 2007... EZ-2 Series centrifugal benchtop evaporators are similar in size to a rotary evaporator, and are used in parallel synthesis, medicinal chemistry and general-purpose solvent removal applications in life science labs. SampleShield and Dri-Pure...

High-shear processor.(Sample Prep Focus)
August 1, 2007... The M-110EH-30 operates at up to 30,000 psi process pressure, and enables the production of nano-suspensions and nano-emulsions, as well as liposomal encapsulation and cell disruption. It is useful for producing small batches for clinical...

Low mass XY stage.(Product News)
August 1, 2007... Low Mass XY Stage MS-2000-LM Low Mass Stage (Applied Scientific Imaging, Eugene, OR) provides increased thermal response times with 3/4 the mass of the company's regular stage. The unit measures 200 x 200 x 26 mm, and has 100 x 100 mm of XY...

General purpose centrifuges.(Product News)
August 1, 2007... Sorvall Legend T and RT Plus centrifuges include a range of high-capacity rotors and adapters. The 3-1iter units utilize carbon fiber rotors to deliver superspeed centrifugation in a bench-top unit. The units accommodate: 14 x 50 ml conical...

Disposable cell culture.(Product News)
August 1, 2007... FibraStage cell culture system eliminates autoclaving, cleaning, learning curves, start-up, and cross-contamination issues. The high-yield system can produce mg quantities of proteins, virus or cell mass using just from one to four disposable...

X-Ray Scattering Protein Structure Determination.(Product News)
August 1, 2007... A new technique in protein structure determination is made possible with Small Angle X-Ray Scattering (SAXS) cells. Its application provides a tool which, when used in combination with other techniques, allows the elucidation and correlation of...

CRADA improves biofuel energy yield: cooperative research and development agreements (CRADAs) between private companies and government research labs allow partners to optimize their resources and share technical expertise in a protected environment.(GOVERNMENT SOURCEBOOK)
August 1, 2007... Researchers at Sandia National Laboratories, Albuquerque, N.M., and Monsanto Co., Creve Coeur, Mo., are engaged a three-year research collaboration that is expected to play a role in both organizations' interests in biology and bioenergy. ...

Another tool in the toolbox: private funding for technology maturation will help enable better commercialization of governmental scientific search.(GOVERNMENT SOURCEBOOK)
August 1, 2007... However compelling the technology, a gap often exists between government-funded research and its transfer to the marketplace. As a research project nears completion, federal dollars often dry up before an invention has progressed enough to spin...

A galaxy of spinoffs: through partnerships and spinoffs, NASA engineers advances in medicine, safety, and deep space observation.(GOVERNMENT SOURCEBOOK)
August 1, 2007... The great scope of ideas generated at NASA's network of research centers, test facilities, and spaceports have for years been the seed for germinating technologies. From freeze-dried foods to the latest spacesuit glove design, enabled concepts...

Advancing the frontiers in cancer research: technologies are being adapted to characterize cancer cells and provide new treatments.(GOVERNMENT SOURCEBOOK)(Disease/Disorder overview)
August 1, 2007... Cancer includes hundreds of diseases, each with a specific pattern of behavior and genetic makeup. No universal method can treat the many different types of cancer. Some cancers require surgery, while others are best treated with radiation,...

Protein profiling in cancer cells using protein lysate arrays.(Best Practices)
August 1, 2007... While the study of cells at the genomic level is quite complex, it gets even more complex at the protein level. At the posttranslational level, modifications such as phosphorylation, acetylation and others that come into play cause changes in...