Bioscience Technology articles from August 2004

Bioscience Technology archives from August 2004

Orange fluorescent protein.
August 1, 2004... CoralHue Kusabira Orange, a true orange fluorescent protein, is isolated from the stony coral Fungia concinna, and absorbs light maximally at 548 nm and emits orange light at 561 nm. Wild-type CoralHue KO matures rapidly to forma fluorescent...

Competent cells.
August 1, 2004... E. coli competent cells and SOC Medium are available for researchers who utilize transformation in the study of gene expression, cloning and other applications. GC5 and GC10 cells consistently show efficiencies of >[10.sup.9] and are resistant...

Electronic pipette.
August 1, 2004... Finnpipette Novus features a 2-level menu that includes 10 different pipetting options and is programmable for advanced functions, such as pipette and count, sequential stepper, and mix and dilute. Text-guided graphical user interface and clear...

Protein crystal imaging and analysis system.(Editor's Choice)
August 1, 2004... Designed to fit on the benchtop, the Minstrel I modular and expandable protein crystal imaging system offers tuned programmable lighting and an image processing method that configures to meet a range of performance requirements, from...

Custom peptide synthesis.(Editor's Choice)
August 1, 2004... PEPscreen peptide synthesis platform facilitates high throughput synthesis of custom peptide libraries (6-20 amino acids) comprising thousands of peptides at 70% purity. Higher purity development is also available. Peptides are synthesized in...

Polymer detection system.(Editor's Choice)
August 1, 2004... MACH 3 biotin-free polymer-based detection systems incorporate a small polymer that provides access to nuclear antigens, and sensitivity enhancing probes. The system reduces antibody budget while increasing antibody specificity. Polymer...

Stem cell starter panel.(Editor's Choice)
August 1, 2004... Human Embryonic Stem Cell Starter Panel is offered for in vitro expansion of human embryonic stem (ES) cells and contains recombinant human FGF basic, a growth factor used in human ES cell culture and a group of antibodies: anti-Oct-3/4,...

Liquid media for endothelial progenitor cells.(Editor's Choice)
August 1, 2004... EndoCult liquid medium is optimized for the growth of endothelial progenitor cells (EPCS) from human peripheral blood and bone marrow. The frequency of circulating EPCs may serve as a biological marker for vascular function and cardiovascular...

3-D Culture matrix for cancer research.(Editor's Choice)
August 1, 2004... 3-D Cell Culture is an innovative approach to modeling the morphological effects of early oncogenesis in three-dimensional microenvironments. Healthy cells undergoing differentiation exhibit a structured, polarized morphology that is critical...

UV/visible HPLC detector.(Bioanalytical Instruments Focus)
August 1, 2004... CE 4300 WaveQuest ultra-fast-scanning UV/visible HPLC detector can be used for both qualitative and quantitative analysis. The system provides detailed spectral scans of chromatograms, at a speed that allows the spectrum at any part of even a...

Automated MALDI plate spotter.(Bioanalytical Instruments Focus)
August 1, 2004... AccuSpot MALDI plate spotter automates LC micro-fractionation, spotting and preparation for MS analysis. Used intandem with any HPLC system for precise proteome analysis with greater sequence coverage, AccuSpot enables spotting in volumes of 10...

Micro HPLC adds fluorescence detection.(Bioanalytical Instruments Focus)
August 1, 2004... Nanostream, provider of high-throughput microfluidic analytical systems has announced the addition of fluorescence detection to its Veloce micro parallel liquid chromatography ([micro]PLC) system. Fluorescence detection increases system...

Integrated LC/MS system.(Bioanalytical Instruments Focus)
August 1, 2004... MDLC LTQ LC/MS system (Thermo Electron Corp.) provides experimental flexibility and precision for proteomics solutions. Co-developed with GE Healthcare (a combination of the former Amersham and GE Medical Systems), this instrument platform...

ESA systems expand mass spec molecular detection capability.(Bioanalytical Instruments Focus)
August 1, 2004... ESA Inc., has utilized its electrochemical (EC) systems in conjunction with a Mass Spectrometer (MS) to expand the number and types of molecules for analysis. The Coulochem, Coul Array or new Discov Array systems are easily integrated into...

Compact pipetting robot.(Bioanalytical Instruments Focus)
August 1, 2004... Freedom EVO 75 (Tecan) is a compact liquid handling system for medium throughput applications. The instrument supports fixed tips as well as disposable tips. It is controlled by the EVOware software, which provides flexibility and ease of use....

Luminometers for life science research.(Bioanalytical Instruments Focus)
August 1, 2004... Turner Biosystems has announced a program to grant luminometers to applicants working in the Life Sciences. TD-20/20 Tube Luminometer, Veritas Microplate Luminometer, GloRunner Microplate Luminometer, and the Reporter Microplate Luminometer...

Pipetting workstation.(Bioanalytical Instruments Focus)
August 1, 2004... Quadra3 workstation for cellular assays is designed with interchangeable pipet heads, two standard bi-directional cassette stackers, and two new Lidded Plate Stacker Cassettes that can handle lidded microplates. Behind the head there is a new...

Protein-protein interaction software.(Bioinformatics Focus)
August 1, 2004... Two software methods for studying protein-protein docking, ZDOCK, and RDOCK help researchers understand the action of therapeutically interesting proteins by predicting the manner in which two proteins interact at the atomic level. Most, if not...

Molecular database query converter and optimizer.(Bioinformatics Focus)
August 1, 2004... SMACK 1.0 converts substructure and reaction queries expressed in MDL file formats to Daylight's SMARTS strings. It automatically optimizes SMARTS queries for pattern-matching performance both in terms of average search times and maximum search...

Knowledge modeling system.(Bioinformatics Focus)
August 1, 2004... Genstruct's Molecular Epistemics platform enables the identification of mechanisms of action for small molecule drugs, mechanisms of drug resistance and potential biological markers to support decision making on clinical compounds. The platform...

ADME/Tox databases.(Bioinformatics Focus)
August 1, 2004... Thirteen databases have been introduced that contain measured ADME/Tox properties for a range of chemical compounds, covering seven endpoints including Blood Brain Barrier, Human Intestinal Absorption, log D, log P, Mutagenicity, Plasma-Protein...

Toolkit for IQ/OQ assistance.(Bioinformatics Focus)
August 1, 2004... Version 3.2 of the Validation Tool Kit includes two separate components, a software application and a full documentation package, that provide automated assistance and detailed guidance for both IQ and OQ. Together they reduce the time and...

Bioinformatics software bundle.(Bioinformatics Focus)
August 1, 2004... Vector Xpression and Vector PathBlazer software bundle enables researchers to discover biological insights through a cycle of discovery. For example, identifying differences in transcript levels of many genes between normal vs. cancer tissues...

Informatics platform.(Bioinformatics Focus)
August 1, 2004... Nonlinear Dynamics Progenesis Discovery Informatics platform supports the gel-based component of the company's proteomic service offering. The product automates high-throughput gel analysis, data mining, and support of lab-based research. The...

Data warehouse.(Bioinformatics Focus)
August 1, 2004... Netezza Performance Server (NPS) tera-scale data warehouse includes data types specific to bioinformatics applications and integrates sequence analysis using BLAST with an SQL relational database. The NPS system combines servers, storage, and...

Laboratory information management system.(Bioinformatics Focus)
August 1, 2004... SampleManager 2004 R2 offers optional new capabilities including integration of analytical instruments and advanced multi-dimensional study management supporting stability, clinical, DMPK, and bio-analytical applications. Web enhancements...

Genomic/proteomic sequence search.(Bioinformatics Focus)
August 1, 2004... GenomeQuestLive! genomic/proteomic sequence search service enables both functional and intellectual property (IP) sequence searchers with a secure, common interface to initiate scans and communicate results concerning biological function,...

Statistical modeling software.(Bioinformatics Focus)
August 1, 2004... S+ArrayAnalyzer 2.0 microarray analysis software provides statisticians, computational biologists and informaticians with workflows for data access, QC data diagnostics, robust data preparation, rigorous statistical modeling and annotated...

Expression Array System.(Bioinformatics Focus)
August 1, 2004... DecisionSite Data Visualization and Expression Array Systems provide highly sensitive gene expression capabilities together with thoroughly annotated transcript data sets. The solution is used to visually and statistically interrogate...

Picosecond pulsed laser diode source.(New Products)
August 1, 2004... NanoLED- 14 emits pulses with a duration of Miniaturized packaging and simple turnkey operation ensure functionality in applications presently using the blue argon-ion line. NanoLEDs are excitation sources for TCSPC-based...

RNA amplification and labeling system.(New Products)
August 1, 2004... The Ovation Biotin System, for RNA amplification and labeling, is used for Affymetrix GeneChip arrays. The system enables expression analysis with as little as 5 nanograms of RNA starting material. In one day, users can amplify RNA and achieve...

Microarray slides, accessories.(New Products)
August 1, 2004... Proprietary microarray slides are made with polymer or glass and are available with a number of different surface chemistries optimized for nucleic acid, protein, cell, and tissue applications. Polymer slides are offered in black to minimize...

Whole Chromosome Painting Probes.(New Products)
August 1, 2004... Whole Chromosome Painting Probes, available in Aquarius[R] liquid format, are directly labelled in either a red or a green fluorophore (Texas Red or FITC spectra). They can be mixed together to label a number of chromosomes in a single...

High-throughput protein crystallization platform.(Proteomics Reagents & Instruments Focus)
August 1, 2004... Odyssey high-throughput plate storage and retrieval system, use for protein crystallization, is equipped with an identification system and barcode tracking, enabling programmed access to each microwell plate, processing up to 60 plates per...

Gel filtration columns.(Proteomics Reagents & Instruments Focus)
August 1, 2004... Gel Filtration (Sephadex) SpinColumns come in a range of packings--G10, G25, G50, G100, P2, and P6--to clean up DNA, RNA, protein, peptides, and nucleotide preparation. Sampling sizes offered range from ultra-micro at 10 to 25 [micro]l, to...

DNA Purification Kit.(Proteomics Reagents & Instruments Focus)
August 1, 2004... BACMAX DNA Purification Kit reliably isolates high-quality BAC DNA, based on a modified alkaline-lysis procedure that typically yields 0.6 to 25 [micro]g of BAC DNA from 1.5- to 100-ml cultures of a single-copy BAC. Selective precipitation...

Liquid chromatography/mass spectrometry system.(Proteomics Reagents & Instruments Focus)
August 1, 2004... Instrumentation, software, columns, and method protocols are integrated in this complete system for identification of proteins and biomarkers. A manual of optimized method protocols is included for each step of the MS-based proteomics workflow,...

Image analysis system.(Proteomics Reagents & Instruments Focus)
August 1, 2004... [ChemiGenius.sup.2] image analysis system detects and analyzes the effects that potential therapeutic compounds have on human chemokines and cytokines in a 96-well protein array format. Following a typical sandwich ELISA, light is generated...

Rat Genome Oligo Set.(Proteomics Reagents & Instruments Focus)
August 1, 2004... Version 3.0 Array-Ready Oligo Set (AROS) for the Rat Genome contains 26,962 70mer probes representing 22,012 genes and 27,044 gene transcripts. Probe design is based on Ensembl, a public open-source database and genome browser, and allows...

C-Jun and ATF-2 cell-based ELISAs.(Proteomics Reagents & Instruments Focus)
August 1, 2004... FACE Kits for c-Jun and ATF-2 provide a method to study proteins activated by phosphorylation. Their cell-based format eliminates the need for extracts, gels, and radioactivity. FACE Kits come with everything needed to perform one 96-well assay...

Microcentrifuge tubes.(Proteomics Reagents & Instruments Focus)
August 1, 2004... Eppendorf LoBind microcentrifuge tubes are optimized for either proteomic or genomic (DNA/RNA) applications. Available in 0.5-, 1.5-, and 2.0-ml sizes, the tubes feature the Safe-Lock lid and contain no DNnase, RNase, human DNA, or PCR...

ELISA development screening sets.(Proteomics Reagents & Instruments Focus)
August 1, 2004... Human TNF[alpha], Human IFN[gamma], and Mouse MCP-1 Screening Sets for ELISA development contain the basic components, including coating antibody, detection antibody, five individual recombinant standards, Streptavidin-HRP one-step TMB...

Microarraying ceramic pins.(Proteomics Reagents & Instruments Focus)
August 1, 2004... NanoPins ceramic microarraying pins provide spot uniformity and efficient sample use, short printing run times, and eliminate pre-blotting with most print buffers. Capillary design reduces sample loss due to evaporation. Chemically-inert...

Western Blot Detection Kit.(Proteomics Reagents & Instruments Focus)
August 1, 2004... Visualizer Western Blot Detection Kit provides fast, sensitive detection of antigens, a long lasting signal, and low background. Utilizing the chemiluminescent HRP substrate luminol, this technique in a direct method for specifically...

Shaking rotator.(New Products)
August 1, 2004... Orbitron III shaking rotator offers variable speeds from 6 to 125 orbits per minute, a load range up to 20 lbs (9 kg), and an adjustable timer for up to 12 hours. Operating temperatures range from 4 to 55 C. This unit accepts various sized...

Signal transduction resource.(New Products)
August 1, 2004... PhosphoSite Bioinformatics Resource aids signal transduction research with literature and other information for in vivo phosphorylation sites in human and mouse proteins. Included on the protein page is parent protein information, isoelectric...

HPLC system.(New Products)
August 1, 2004... Express HPLC system combines a binary gradient pump with high-pressure mixing, autosampler, variable sample injection, UV detector, control software, and separation columns to deliver increased levels of separation resolution and speed. Sampe...

HPLC workstation software.(New Products)
August 1, 2004... LCsolution software simplifies instrument control of the Shimadzu Scientific Instruments LC-2010, PDA, and any LC-10/LC-VP series modules, and offers diverse data handling and integration with regulatory compliance requirements. Functions...

Mouse Models of Human Cancer Consortium.(New Products)
August 1, 2004... Funded by the National Cancer Institute, the Mouse Models of Human Cancer Consortium (MMHCC) supports the derivatization and validation of mouse models, as well as the generation of resources, information, and innovative approaches to the...

Cell cycle associated marker.(New Products)
August 1, 2004... Having applications in colorectal cancer the p[21.sub.waf-1] protein is a p53-regulated gene product that mediates cell cycle arrest. Levels of p21 are reduced or negligible in tumor cells that are lacking the p53 protein or contain a...

Fluorescence microscope system.(New Products)
August 1, 2004... TCS 4Pi fluorescence microscope system uses a phase- and wavefront-corrected double objective imaging system linked to a confocal scanner to enable a four- to seven-fold increased axial resolution over confocal and two-photon microscopy. Even...

Syringe Filters.(New Products)
August 1, 2004... GD/X Syringe Filters enable filtration of viscous samples to make sample preparation more efficient. Floating prefilter design contains four filtration layers for microfiber with a coarse top layer meshed with a finer layer, as well as greater...

High-pressure HPLC injectors.(New Products)
August 1, 2004... Cheminert C2XH series injectors are rated for use at up to 10,000 psi liquid and employ the patented feedback system used in the Extended Life Injectors (C2XL series). Injectors feature proprietary 1/16" fittings and are available with 0.010 or...

SNP genotyping capability.(New Products)
August 1, 2004... SNP genotyping data has been released, stemming from a study of human genomic samples using the proprietary high-density nanoliter through-hole array chip for PCR-based genomic assays. SNP genotyping is BioTrove's first commercial application...

Autosampler.(New Products)
August 1, 2004... Vortex autosampler consists of an integrated autosampling device and multi-stirrer, and increases efficiency, enhances precision, and promotes operator safety. The temperature-controlled, heated (up to 150 C) multi-stirrer assembly features a...

Nuclear Hormone Receptor cDNA clones.(New Products)
August 1, 2004... Nuclear Hormone Receptor (NHR) CloneSet[TM], a designated subset of 70 full-length nuclear hormone receptor cDNA clones, has been added to the TrueClone Collection product line. Nuclear hormone receptors are intracellular transcription factors...

Heating, refrigerating circulators.(New Products)
August 1, 2004... ME heating and refrigerating circulator series include a Pt100 external sensor connection that allows temperature direct measurement and control of an external system. VFD Comfort-Display shows the actual set point values. Warning and alarm...

Freeze Dryer Control System.(New Products)
August 1, 2004... Wizard 2.0 Freeze Dryer Control System provides full process automation with complete recipe management and critical process alarms. Available on the Advantage, Genesis, Ultra, and Benchmark freeze dryers, Wizard controls single or multiple...

Temperature-control water baths.(New Products)
August 1, 2004... Equipped with sensitive microprocessor-based PID controllers, these stationary and shaking water baths maintain temperatures from ambient +5 to 100 C with [+ or -] 5 C accuracy and [+ or -] 0.2 C uniformity. They come available with 2-, 5-,...

Thermal cycler.(New Products)
August 1, 2004... Tetrad 2 thermal cycler is a redesigned and updated version of the DNA Engine Tetrad cycler. The Tetrad 2 graphical interface with onboard touch pad allows input of protocols. Real-time monitoring of sample, block, and lid temperatures provides...

Cancer, diabetes, and inflammation targets.(New Products)
August 1, 2004... This kinase research solutions company is currently shipping 21 different core kinase enzymes for biomolecular screening in 24 hours at a new fixed price per milligram (mg). Cancer, diabetes, and inflammation targets are available in quantities...

FTIR spectrometers.(New Products)
August 1, 2004... FTIR-4000 and FTIR 6000 spectrometers, incorporated in the AccuTrac DSP mirror tracking system, provide reproducibility of interferometer mirror velocity and position resulting in a high signal-to-noise ratio. Quick Start System offers sample...

Conjugation chemistry.(New Products)
August 1, 2004... HydraLinK conjugation chemistry is selective, stable in solution, and not susceptible to non-specific binding. It satisfies the need for the preparation and expanded utility of combining crucial components in diverse areas including...

Eight-channel dispenser.(New Products)
August 1, 2004... High-speed, small-footprint, eight-channel fluid dispenser for 96- and 384-well plates features a height-adjustable dispense head to accommodate shallow- and deep-well plates and blocks. Disposable pre-sterilized tubing cartridges enable...

DNA polymerase.(New Products)
August 1, 2004... Restorase DNA polymerase combines Sigma-Aldrich's long and accurate enzyme with a small amount of a DNA repair additive. The optimized blend will initiate the repair and further amplification of damaged DNA templates greater than 800 bp. DNA...

Molecular delivery system.(New Products)
August 1, 2004... ECM 830 Square Wave Molecular Delivery electroporation system offers fine voltage discrimination, arc quenching, single dial control, pulse interval control, and full monitoring capability. The unit has a full two-year warranty. Applications...

Mutation/polymorphism scanning.(New Products)
August 1, 2004... The SURVEYOR line of bioconsumable kits complements and extends the capabilities of the Transgenomic Inc. WAVE System instrument platform, and offers platform-independent mutation/polymorphism scanning capability. The key component is an enzyme...

Electroporation Methods Optimization.(New Products)
August 1, 2004... Electroporation Methods Optimization Systems MOS 25 and MOS 96 boost productivity by optimizing conditions and increasing yields and viability. Key to the system are patented multi-well plates. The MOS 25 is a 5 x 5, 25 well plate and the MOS...

Expression Array System.(New Products)
August 1, 2004... Expression Array System (Applied Biosystems) combines gene detection capabilities with integration to proprietary complementary gene expression products, such as the company's TaqMan[R] Gene Expression Assays, TaqMan Low Density Array, Celera...

Electronic multichannel pipettors.(New Products)
August 1, 2004... eLINE[R] multichannel pipettors combine ergonomic design and electronic operation from aspiration to tip ejection. An electronic tip ejection system allows tip removal at the a touch of a button. Optiload tip loading mechanism allows tips to be...

Mass spec targets for small molecule analysis.(New Products)
August 1, 2004... Disposable QuickMass[TM] matrix-less laser desorption/ionization mass spectrometry targets identify low molecular weight compounds in MALDI (Matrix Assisted Laser Desorption Ionization) mass spectrometers. The targets increase selectivity and...

Ti:Sapphire laser.(New Products)
August 1, 2004... Chameleon-XR, the latest addition to the hands-free Ti:Sapphire product family, provides an extended 260-nm tuning range covering 720 to 980 nm. Like other members of the Chameleon family, Chameleon-XR produces femtosecond pulses with greater...

Sample clean-up.(New Products)
August 1, 2004... Cleanascite selectively removes lipids, cell debris, lipoproteins, and mucinous impurities from biological samples. The reagent is a non-ionic adsorbent suspension in saline, and it replaces protocols involving Freon or chloroform. It is...

Rapid gene deletion studies.(New Products)
August 1, 2004... Expression Arrest Zebrafish Morpholino Library is an antisense product that helps decipher the function of genes using model organisms. It provides access to hundreds of ready-to-use zebrafish morpholinos, and allows them to select specific...

Plasmid purification system.(New Products)
August 1, 2004... CosMCPrep[TM] is an SPRI[TM]-based plasmid purification system that isolates varous high- and low-copy number templates. Plasmid DNA is selectively bound to paramagnetic microparticles, allowing automated, filtration-free purification....

Portable Label Printer.(New Products)
August 1, 2004... LAB PAL Label Printer is a portable printer with labels that withstand extreme environments. Built-in date/time stamp provides exact documentation on the label. Serialization feature, preprogrammed vial sizes (0.6, 1.5, and 2 to 4 ml), and...

Metabolic Mouse Cage.(New Products)
August 1, 2004... NALGENE Mouse Metabolic Cage collects urine and feces from a single mouse. Features include a smaller chamber volume and collection tube design to minimize evaporation. Funnel and cone design with steeper angles separates the urine and feces...

Automated in situ hybridization.(New Products)
August 1, 2004... The Hybridizer ISH instrument (DakoCytomation) complements the Autostainer Plus and other staining systems, and allows for semi-automation of ISH by eliminating steps in the time-intensive manual procedure. In situ hybridization (ISH)...

Virus Purification Kits.(New Products)
August 1, 2004... Adeno-X Virus Purification Kits are chromatography-based systems for purification of adenovirus that provide a safe alternative to cesium chloride (CsCl) density gradient centrifugation. The kits include Benzonase for digestion of cellular...

Temperature control products.(New Products)
August 1, 2004... Polystat temperature control products provide coverage of temperatures ranging from -30 to 200 C, and are fitted with an independent over temperature protection device and bath-fluid level alarm. When activated, these units give both visual and...

Human tumor RNA.(New Products)
August 1, 2004... FirstChoice products each include 5 [micro]g of total RNA isolated from individual tumors and the normal adjacent tissue (NAT). Samples are derived from a single donor and have not been pooled with other RNA. Human RNAs have been prepared from...

Precision Current Source.(New Products)
August 1, 2004... The Midgard Precision Current Source features a high-compliance voltage of 1000 V for injections from very small or partially clogged pipette tips. Output current level can be regulated to [+ or -] 0.5%, from 0.0 to 200 MegOhms. In addition,...

Glass bottles.(New Products)
August 1, 2004... Glass bottle line consists of versatile, multi-use sampling and storage containers each made of Type III soda lime. Valumetric bottles are graduated in milliliters and ounces, for use as sample bottles or for dry powders, soil samples, and for...

Cell lysis and protein extraction.(New Products)
August 1, 2004... CellLytic Express cell lysis reagent is added directly to microbial culture media for non-denaturing protein extraction. It consists of a proprietary powder blend of detergent and enzymes optimized for in-culture bacterial cell lysis, yielding...