Bioscience Technology articles from April 2005

Bioscience Technology archives from April 2005

PharmaDiscovery Conference debuts in D.C.(EDITOR'S Note)
April 1, 2005... The PharmaDiscovery Conference and Exhibition will convene for the first time at the Washington Convention Center in Washington, DC from May 10 to 12, 2005. "We are launching PharmaDiscovery specifically to give scientists a platform to discuss...

BSI Proteomics Corp to develop tools to aid CF drug discovery.(NEWS Brief)
April 1, 2005... BSI Proteomics Corp. has entered into an agreement with Cystic Fibrosis Foundation Therapeutics, Inc. (CFFT), the drug discovery and development affiliate of the Cystic Fibrosis Foundation, to apply its unique technology to develop new tools...

FDA works to speed the advent of personalized medicines.(NEWS Brief)
April 1, 2005... As part of an agency-wide initiative to speed development of new medical products through the science of pharmacogenomics, the Food and Drug Administration has issued a final guidance titled "Pharmacogenomic Data Submissions." ...

NIAID initiates experimental avian flu vaccine trial.(NEWS Brief)
April 1, 2005... Fast-track recruitment for a trial to investigate the safety of a vaccine against H5N1 avian influenza has been announced by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH). ...

Victorian research facility building world's largest parallel protein production facility.(NEWS Brief)
April 1, 2005... The world's largest parallel protein purification workstation is to be housed at Monash University, improving Australian scientists' abilities to study the molecular structure and function of proteins. Victorian Bioinformatics Consortium...

Monoclonal antibody purification media.(APRIL'S TECHNOLOGY)
April 1, 2005... MabSelect Xtra is a recombinant protein A-based chromatography medium that captures antibodies with efficiency and economy. It is engineered to provide high dynamic binding capacity, which translates directly into low cost of production,...

Chemical Inkjet Printer facilitates peptide mass fingerprinting and nano-Western blotting.(APRIL'S TECHNOLOGY)
April 1, 2005... ChIP 1000 Chemical Inkjet Printer (Shimadzu Biotech), a tool for proteomics analysis (peptide fingerprint mapping), protein macroarray analysis, and nano-Western analysis, was developed in partnership with Proteome Systems Ltd. The system...

NMR spectrometer series.(APRIL'S TECHNOLOGY)
April 1, 2005... Avance II NMR (Bruker BioSpin Corp.) Spectrometers incorporate second-generation (2G) digital receiver (DR) technology, which improves NMR detection fidelity. The 2G-DR technology will be beneficial for experiments in LC-NMR, MR imaging and...

Lifetime fluorescence protein analyzer.(APRIL'S TECHNOLOGY)
April 1, 2005... The Protein 280 ex lifetime spectrofluorometer measures three fluorescence lifetimes in just a few minutes. Time-Correlated Single-Photon Counting, a time-resolved fluorescence technique, is used to record reproducible lifetime data. Analytical...

Western assay system.(APRIL'S TECHNOLOGY)
April 1, 2005... Trevigen has introduced the E-3 Western assay system. The methodology utilizes free solution pulsed electrophoresis in specially formulated buffers to quickly move charged protein molecules in solution. The process establishes the rapid...

Amplification and labeling for microRNA microarrays.(APRIL'S TECHNOLOGY)
April 1, 2005... Array 900miRNA microarray labeling kits are offered for use with microRNA, siRNA and other small RNA molecules (tRNA, 5S rRNA, nuclease fragments, etc). 3DNA signal amplification technology produces validated results from 50-200 ng of microRNA...

Compact flow cytometry system.(APRIL'S TECHNOLOGY)
April 1, 2005... Cell Lab Quanta compact flow cytometry system combines Coulter volume measurement with two-color fluorescence capabilities for accurate, multi-parameter cell counting and sizing. Multiple excitation wavelengths, including UV, allow flexible...

Sequencing in the post-genomic age.(Cover Story)
April 1, 2005... Pronouncements of the "post-genomic age" notwithstanding, genome sequencing is as relevant today as before the Human Genome Project began seventeen years and $2.7 billion ago. If the promise of genomics is ever to be realized, then clearly the...

HPLC-chip/MS system.(PROTEOMICS)
April 1, 2005... The HPLC-chip/mass spectrometry system for protein identification integrates multiple functionalities on a single, microfluidics-based Protein ID HPLC-Chip. Smaller than a credit card, the chip integrates the sample enrichment and separation...

Proteomics mass spec.(PROTEOMICS)
April 1, 2005... The Proteomics(n) suite covers proteomics applications from top-down analysis to bottom-up sequencing and from high-throughput protein identification to automated protein quantification and biomarker discovery. A strategy for identifying and...

Label-free array platform.(PROTEOMICS)
April 1, 2005... The SPRimagerII detection system for life science and drug discovery research is a complete system for label-free analysis of proteins and other molecular arrays. Detection is achieved using Surface Plasmon Resonance (SPR), so molecular labels...

Liquid Chromatograph/Mass Spectrometer.(PROTEOMICS)
April 1, 2005... The LCMS-IT-TOF Liquid Chromatograph/Mass Spectrometer, a novel hybrid mass spectrometer for biomarker discovery, metabolite identification, and proteomics research, couples atmospheric pressure ionization with Ion-Trap (IT) and Time-of-Flight...

Phosphoprotein microarray.(PROTEOMICS)
April 1, 2005... Class slide microarray allows precise measurement of phosphorylation of EGFR, FAK, Src, Paxillin, Akt, JNK, p38 MAPK, HSP27, ATF2 and CREB. Using a technology similar to sandwich ELISA's, proprietary easy-to-use kits quantify 10 phosphoproteins...

MS analysis of formalin-fixed tissue.(PROTEOMICS)
April 1, 2005... MS Protein Prep Kit makes mass spectrometry analysis of formalin-fixed tissue possible. This simple protocol enables discovery and validation of protein biomarkers in the large numbers of archived tissue collections with well-documented...

Spectrometer for NMR applications.(PROTEOMICS)
April 1, 2005... Varian's NMR System incorporates a data acquisition control platform, is available at field strengths ranging from 300 to 900 MHz, and is used for applications such as protein structure, function and dynamics and small molecule structure...

Benchtop mass spectrometer.(PROTEOMICS)
April 1, 2005... Benchtop Mass Spectrometer microflex LT benchtop MALDI-TOF mass spectrometer (Bruker Daltonics) is offered for clinical proteomics and for routine analysis of peptides, proteins and other large molecules. The instrument incorporates a grid-less...

Yeast Two Hybrid System.(PROTEOMICS)
April 1, 2005... ACE1 Two Hybrid System for gene discovery and functional analysis is useful for efficiently identifying protein-protein interactions in vivo. It combines copper-inducible transcription factor ACE1 and the copper resistance-mediating CUP1 gene...

Protein fractionation column.(PROTEOMICS)
April 1, 2005... Macroporous reversed-phase C18 (mRP-C18) high-recovery protein fractionation and desalting LC column (Agilent Technologies) enables detection and identification of potential biomarkers in complex samples by providing sample recovery of greater...

Cloning vectors.(PROTEOMICS)
April 1, 2005... Cloning vectors for fluorescent proteins derived from Aequorea Victoria are available from Invitrogen. These clones will enable scientists to employ Emerald Green (EmGFP), the next-generation replacement for EGFP, as well as Cyan (CFP) and Blue...

Protein assays.(PROTEOMICS)
April 1, 2005... SPN and SPN-htp protein assays, suit able for use with as little as 0.5 [micro]g protein, resist interference from common laboratory agents. They can be used for rapid determination of protein samples in Laemmli or other SDS-PAGE loading...

2-D gel scanner.(PROTEOMICS)
April 1, 2005... ProteomeScan generates images of up to 12,800 X 12,800-dpi max output resolution, ensuring that small protein spots are detected. The device transfers images directly into Dymension, proprietary 2-D image analysis software that analyzes a...

Fluorescent protein vectors.(PROTEOMICS)
April 1, 2005... pIRES2-ZsGreenl or pZsGreen1-1 fluorescent protein vectors are offered for cellular assays. pIRES2-ZsGreenl contains an internal ribosome entry site that permits the cloned gene and the ZsGreen1-encoding region to be translated from a single...

Protein purification columns.(PROTEOMICS)
April 1, 2005... HisTrap FF crude (1 ml and 5 ml) pre-packed columns enable fast, reliable and simple one-step purification of histidine-tagged recombinant proteins directly from un-clarified cell lysates. The crude columns minimize the need for sample...

Gene expression array.(PROTEOMICS)
April 1, 2005... Eppendorf DualChip microarray systems are offered for gene expression analysis and pathway identifications in toxicology, neuroscience, signal transduction and research on aging using human or rat models. Xmer technology-based probes contain...

Gel electrophoresis kit.(PROTEOMICS)
April 1, 2005... The LP-NEXT GEL system analyzes large molecular weight proteins via horizontal agarose gel electrophoresis. Proteins from 14,000 Da up to 3,000,000 Da can be resolved on a single agarose gel. This is suitable for cytoskeletal and muscle...

Recombinant baculovirus production system.(PROTEOMICS)
April 1, 2005... A new technology for the production of recombinant baculoviruses, the flashBAC system removes the need to separate recombinant virus from parental virus by plaque purification or any other means. The technology removes the need to separate...

X-ray source for protein crystallography.(PROTEOMICS)
April 1, 2005... MICROSTA X-ray source finds application in proteincrys-tallography. Advances in anode design, electron and X-ray optics are incorporated to achieve high brightness and X-ray intensity, comparable to a typical second generation synchrotron...

MAbs for nuclear hormone receptor protein.(PROTEOMICS)
April 1, 2005... A complete selection of highly specific monoclonal antibodies to the nuclear hormone receptor protein family is available. Nuclear hormone receptors are targets for drug development as many are implicated in diabetes and other endocrine...

siRNA Transfection Reagent.(HIGH THROUGHPUT SCREENING)
April 1, 2005... HiPerFect Transfection Reagent is offered for the transfection of eukaryotic cells with siRNA and can be used with low siRNA concentrations. Transfection of the lowest effective siRNA concentration minimizes the likelihood of off-target...

Automated microplate storage.(HIGH THROUGHPUT SCREENING)
April 1, 2005... Cytomat 44 automated storage module provides stable microplate storage conditions and to compound integrity. Easy to access and set up, the module integrates with any automated assay system and accommodates all microplate configurations,...

Automated microwave reaction system.(HIGH THROUGHPUT SCREENING)
April 1, 2005... ExplorerPLS Automated Microwave Reaction Workstation is offered for speciation studies in analytical chemistry, as well as discovery or optimization of drug candidates in medicinal chemistry. A 24-sample deck with interchangeable racks...

384-well filter plates.(HIGH THROUGHPUT SCREENING)
April 1, 2005... Millipore 384-well [MuitiScreen.sub.HTS] filter plates are offered for high throughput bioassays. Available with glass fiber or phosphocellulose paper, the plates' automation compatibility increases throughput on a range of robots....

Phosphoprotein assays.(HIGH THROUGHPUT SCREENING)
April 1, 2005... Bio-Rad Laboratories, Inc. offers six bead-based phosphoprotein assays for its Bio-Plex suspension array system. Products include phospho-p70 $6 kinase, phospho-p90RSK, phospho-STAT2 and phospho-TrkA, total Akt, and total p90RSK. Single-plex...

Mass Spectrometer Workstation Software.(HIGH THROUGHPUT SCREENING)
April 1, 2005... Version 6.5 Mass Spectrometer (MS) Workstation Software (Varian, Inc.) includes CTC Autosampler control for liquid chromatography (LC). V6.5 provides ease-of-use enhancements for routine LC/MS analysis involving large numbers of samples, such...

Hybrid phosphoinositide analogs.(HIGH THROUGHPUT SCREENING)
April 1, 2005... Hy-PIPs hybrid phosphoinositide analogs, for use in lipid signaling research and drug discovery, behave like endogenous phosphoinositides and offer improved aqueous solubility. The analogs have potential for use in reporter-based, in vitro...

Assay kits for early ADME screening.(HIGH THROUGHPUT SCREENING)
April 1, 2005... Transil Membrane Affinity and Transil Human Serum Albumin (HSA) Binding assay kits (Molecular Devices) provide lead optimization and high-throughput screening labs with automation compatible, direct, biologically relevant products for increased...

ADMETox Workstation.(HIGH THROUGHPUT SCREENING)
April 1, 2005... Biomek FX ADMETox Workstation, for in vitro drug permeability measurements, is a validated system that automates the PAMPA (Parallel Artificial Membrane Permeability Analysis) method for the determination of passive absorption of a drug...

Histone Deacetylase Activity/Inhibitor Screening Assay.(HIGH THROUGHPUT SCREENING)
April 1, 2005... Histone Deacetylases (HDAC) catalyze the hydrolytic removal of acetyl groups from histone lysine residues, a process which is associated with chromatin condensation and transcriptional repression. This HDAC Activity/Inhibitor Screening Assay...

Liquid handling workstation.(HIGH THROUGHPUT SCREENING)
April 1, 2005... Eppendorf epMotion 5070 liquid handling workstation enables rapid, reproducible liquid handling through automated pipetting, dispensing, and dispensing variants. Pipetting sequences and protocols previously carried out manually can now be...

Microscope attachment for microplate cytometer.(HIGH THROUGHPUT SCREENING)
April 1, 2005... Locator is a software and microscope attachment from TTP LabTech for its Acumen Explorer microplate cytometers. With Locator, researchers can clarify early stage assay development data. Following scanning, wells are examined in detail on...

Screen GPCRs with flash luminescence reader.(HIGH THROUGHPUT SCREENING)
April 1, 2005... CyBi-Lumax flash HT flash luminescence reader, for functional screening of G-protein coupled receptors and calcium channels, features a new 16-channel dispenser that enables flash luminescence reading times of less than 60 seconds for 384-well...

Homogenous Kinase Activity Assays.(HIGH THROUGHPUT SCREENING)
April 1, 2005... QTL Lightspeed Kinase Activity Assays are homogeneous one-step "mix and measure" kits that require no washing steps, no radioactive compounds, no antibodies and no custom instrumentation. The technology combines sensitivity with speed for...

Syringe handling blocks.(LABWARE)
April 1, 2005... Syringe handling blocks are available for single, double or triple syringe capacity. These disposable, adhesive backed blocks accommodate unshielded syringes, providing a safe and simple solution for technicians. Procedure trays use these...

Biohazard Keeper.(LABWARE)
April 1, 2005... Terminal brand floor model Biohazard Keeper offers an easy and economical way to collect and dispose of laboratory waste. Constructed of corrugated cardboard, it comes with a 2 mil red plastic liner, providing both strength and leak-resistance....

Cell scraper.(LABWARE)
April 1, 2005... This 16-cm cell scraper features a 2-position blade that can be used to either scrape or lift cells. It is suited for T-25 flasks and 24-well plates. Compared to the 25-cm and 39-cm cell scraper, this smaller version features a soft flexible...

Non-treated tissue culture products.(LABWARE)
April 1, 2005... Non-treated tissue culture Multidishes and EasYFlasks from Nunc are offered for research on living cells where attachment is not needed. Applications include the growth of hybridoma cell lines and suspension cell cultures, or where the...

Borosilicate glass bottles.(LABWARE)
April 1, 2005... SIMAX brand borosilicate glass bottles are suitable for mixing, sampling and storage. A molded glass ridge indicates full capacity. Polypropylene screw cap has a drip-free pouring ring and permanent white graduations and marking areas. Clear,...

Micro-Slides.(LABWARE)
April 1, 2005... Micro-Slides ([micro]-Slides) allow cell culturing and high resolution microscopy on the same slide. The optical quality of the slides allows their utilization for cell-based assays in research and high throughput applications. The slides can...

Self-laminating labels.(LABWARE)
April 1, 2005... Self-laminating labels feature a clear wrap-around cover that protects the printed surface from extreme environments while keeping it legible. The materials offer a permanent bond to the sample and are suitable for in freezers, liquid nitrogen,...

Clear-bottomed microplates.(LABWARE)
April 1, 2005... The Krystal 2000 plate, for luminescence and fluorescence assays, incorporates clear, individual wells in an opaque matrix. This design eliminates well-to-well light cross-talk, enabling accurate, repeatable photometric readings. The plates are...

Polypropylene deep-well microplates.(LABWARE)
April 1, 2005... MASTER-BLOCK deep-well polypropylene microplates are available in 96-, 384-, and 1536well formats. Polypropylene is biologically inert, exhibits low binding characteristics and high temperature tolerance, and is chemically resistant, enabling...

Tubing sleeves.(LABWARE)
April 1, 2005... Upchurch Scientific brand 1/32" OD tubing sleeves facilitate connecting capillary tubing into ports intended for 1/32" OD tubing. Teflon FEP versions accommodate capillary ODs from 20 to 380 gm and will withstand up to 1,750 psi (121 bar),...

Molded rack holds 42 petri dishes.(LABWARE)
April 1, 2005... Scienceware Molded 100 mm Petri Dish Rack securely holds up to 42 Petri dishes with lids when carrying, incubating or processing samples on the benchtop. Up to 4 loaded racks can be stacked together and interlocked to prevent an accidental...

Pipette tips for Beckman Coulter systems.(LABWARE)
April 1, 2005... Narrow length P50 Tips for Beckman Coulters Biomek 3000, NX and FX and Multimek liquid handlers enable pipetting from the bottom of deep labware for maximum retrieval of valuable samples. The disposable non-conductive tips are suited for work...

Cell-based assays for screening G protein coupled receptors: measuring changes in the accumulation of second messengers such as camp mobilized by GPCR activation provides a highly sensitive assay technique for the measurement of ligand function.(APPLICATION Note)
April 1, 2005... G protein coupled receptors (GPCRs) are a major class of targets for drug discovery and frequently are targets within high throughput screening (HTS) laboratories. (1) Although GPCRs are a large, diverse and highly conserved class of...

Comprehensive Sartorius lab product catalog.(LITERATURE FOCUS)(Advertisement)
April 1, 2005... New Sartorius catalog offers a comprehensive overview of products including ultra-micro to basic balances and scales, pH meters, a water detection system and nationwide service. Application references, product descriptions and specifications...

Infectious disease antibodies.(LITERATURE FOCUS)(Advertisement)
April 1, 2005... ViroStat, Inc. is a primary manufacturer of infectious disease antibodies and recombinant anti-gens, including monoclonal and polyclonal antibodies to food-borne pathogens, respiratory viruses, STD agents, hepatitis viruses and Strep A among...

Laboratory chemicals.(LITERATURE FOCUS)(Advertisement)
April 1, 2005... Wako BioProducts has changed its name to Wako Laboratory Chemicals to incorporate all the reagents that we can supply. There are over 15,000 reagents in our new catalog! We are constantly adding new and unique items to our product lines to keep...

Spinning disk confocal microscope.(LITERATURE FOCUS)(Advertisement)
April 1, 2005... The Olympus DSU represents a breakthrough in spinning disk confocal technology. A spinning disk with an alternating slit pattern transfers more light than a Nipkow disk and allows use of a white light source. Image capture at 30 fps and beyond...

New-190 C Freezer.(LITERATURE FOCUS)(Advertisement)
April 1, 2005... CBS ISOTHERMAL liquid nitrogen vapor phase storage systems allow frozen sample storage at liquid nitrogen temperatures without liquid nitrogen contact. This innovative design provides storage temperatures in the -190 C range with absolutely no...

2005-06 Stratagene catalog.(LITERATURE FOCUS)(Advertisement)
April 1, 2005... The 2005-06 Stratagene catalog is now available. This 300-page catalog features more than 2,000 novel, reliable, and time-saving products (PCR, RTPCR, Quantitative PCR reagents and instrumentation, competent cells, vectors, microarray analysis,...

Personnel consultants.(LITERATURE FOCUS)(Advertisement)
April 1, 2005... FPC is a national network of executive search firms. The company has been providing human resource solutions since 1959. Advocates for both companies and candidates, FPC recruiters are committed to bringing together the right candidate with the...

Buffers, fluorescent compounds.(LITERATURE FOCUS)(Advertisement)
April 1, 2005... New catalog offers high purity biological buffers, reagent biochemicals, fluorescent compounds and enzyme substrates. Products include HEPES, MES, MES Na, Bis-Tris, Tris, Tris HCL, MOPS, MOPS Na, CAPSO Na, MOPSO, Tricine, ACES, DTT, Oxalacetic...

Microscopy, imaging software for IR, Raman.(NEW Technology)
April 1, 2005... OMNIC Atl[micro]s 7 software, for infrared and Raman microspectroscopy and imaging, integrates data acquisition, spectral processing, and image visualization in a single package. The software automates the collection of spatially-resolved...

Illumination systems for TIRF and high S/N fluorescence.(NEW Technology)
April 1, 2005... Nikon White Light Total Internal Reflection Fluorescence (TIRF) illuminator is a is multi-spectral product that allows all light wavelengths to be available with standard microscopy fluorescent filters for the selection of the excitation...

Nitric Oxide Assay kits.(NEW Technology)
April 1, 2005... Nitric Oxide and Total Nitric Oxide Assay kits provide quantitative determination of nitrite and nitrate in biological fluids (96 determination kit). The Nitric Oxide kit uses the enzyme Nitrate Reductase to convert nitrate to nitrite. Nitrite...

Dual dispenser and metering pump.(NEW Technology)
April 1, 2005... Ratio: Matic Series Dual Head Dispensers & Metering Pumps provide dual channel fluid control for a range of lab applications. The pumps consist of two FMI pump heads direct coupled to a single variable speed drive. Each pump head is...

HPLC analysis software for light scattering detector.(NEW Technology)
April 1, 2005... ASTRA V HPLC software, for use with Wyatt Technology's multi-angle light scattering detectors for absolute molecular weight determinations, can be used for on-line HPLC measurements and off-line batch measurements. Applications include: data...

HPLC column temperature controller.(NEW Technology)
April 1, 2005... Polaratherm Total Temperature Controller can heat HPLC column packings to elevated temperatures without causing column bleed or degradation. Column bleed is a problem as it leaches detectable compounds from the column packing materials causing...

Confocal microscopy system.(NEW Technology)
April 1, 2005... LSM 5 LIVE confocal microscope, for live cell imaging, combines scanning speed, image quality and sensitivity to facilitate real time observation of cellular motion and interaction. Up to 120 confocal images are collected per second at a...

Fluorescent resolution targets.(NEW Technology)
April 1, 2005... Fluorescent USAF 1951 Resolution Targets calibrate the optics of systems that use UV illumination, such as fluorescent microscopes and confocal microscopes. Targets are made of fused silica and reflective chrome. Positive and negative patterns...

Purify fosmid, cosmid, DNA.(NEW Technology)
April 1, 2005... FosmidMAX DNA Purification Kit provides reliable isolation of quality fosmid and cosmid DNA. The scalable protocol is based on a modified alkaline-lysis procedure that typically yields 0.6 to 25 [micro]g of fosmid DNA from 1.5 to 100 ml,...