Clinical and Investigative Medicine articles from June 2004

Clinical and Investigative Medicine archives from June 2004

The changing face of scientific misconduct.(EDITOR'S PAGE)(Editorial)
June 1, 2004... What has happened to scientific misconduct? In the 1980s and early 1990s, the medical literature and national newspapers seemed daily to report more ingenious and nefarious cases of fraud committed by medical researchers. Who could forget John...

Institute for Population and Public Health.(CIHR on Parade)
June 1, 2004... Specific scientific or technologic breakthroughs in medicine tend to garner far more attention than advances in public health, and many of the activities that allow for a healthier population are often hidden or taken for granted. The...

Antioxidant vitamins (A, C and E) and malondialdehyde levels in acute exacerbation and stable periods of patients with chronic obstructive pulmonary disease.(ORIGINAL RESEARCH)
June 1, 2004... Abstract Background: People with chronic obstructive pulmonary disease (COPD) undergo oxidative damage during exacerbations that continues in stable periods, gradually contributing to pathogenesis. Since serum concentrations of antioxidant...

A study of warning letters issued to clinical investigators by the United States Food and Drug Administration.(ORIGINAL RESEARCH)
June 1, 2004... Abstract Purpose: This study explores the ethical issues contained in warning letters issued to clinical researchers by the Food and Drug Administration (FDA) in the USA. Methods: The online FDA Warning Letter Index was reviewed for...

Spectrum of HNF1A and GCK mutations in Canadian families with maturity-onset diabetes of the young (MODY).(ORIGINAL RESEARCH)
June 1, 2004... Abstract Purpose: Maturity-onset diabetes of the young (MODY) is a subtype of type 2 diabetes characterized by autosomal-dominant inheritance and early onset. The pathophysiology of MODY is primarily defective insulin secretion resulting...

Radiotherapy wait times for patients with a diagnosis of invasive cancer, 1992-2000.(ORIGINAL RESEARCH)
June 1, 2004... Abstract Purpose: To study the wait times for cancer patients from the time of diagnosis to consultation with a radiation oncologist (T1), from consultation to radiotherapy (T2) and from diagnosis to radiotherapy (T3) in the context of...