Clinical and Investigative Medicine articles from February 2004

Clinical and Investigative Medicine archives from February 2004

Parenteral vitamin [B.sub.12] therapy of hyperhomocysteinemia in end-stage renal disease.(Original Research)
February 1, 2004... Abstract Background: End-stage renal disease (ESRD) is associated with moderately severe hyperhomocysteinemia that is incompletely normalized by oral folic acid therapy and vitamin [B.sub.12]. Method: We administered 1 mg...

Genetic medicine: ethical and practical issues of application of the new technology.(CSCI/RCPSC Symposium)
February 1, 2004... At present, the most promising clinical application of human genetic research is diagnostic and susceptibility testing. Such assays are already available for more than 300 diseases, but introducing these tests to practice is often problematic....

New genetic technologies: clinical application and ethical issues in familial ovarian cancer.(CSCI/RCPSC Symposium)
February 1, 2004... Epithelial ovarian cancer remains the most common cause of death from tumours of the pelvis and ranks fifth among causes of death from cancer overall. Among the risk factors for this cancer, the strongest is a positive family history. Although...

BRCA testing: ethics lessons for the new genetics.(CSCI/RCPSC Symposium)
February 1, 2004... So far, the principal fruit of the Human Genome Project has been its ability to develop tests for genetic susceptibility to particular diseases (the "new genetics" of my title). The test to identify mutations at BRCA1 or BRCA2 that are...

Caveat emptor: direct-to-consumer supply and advertising of genetic testing.(CSCI/RCPSC Symposium)
February 1, 2004... Most Canadians who wish to access genetic diagnostic and susceptibility tests do so through the publicly funded health care system. (1) However, some genetic tests are not covered under that system, and individuals may seek to purchase them...

Innovative strategic Canadian research training from TomorrOw's Research Cardiovascular Health Care Professionals (TORCH).
February 1, 2004... Abstract Cardiovascular research training is experiential, and "skills" are traditionally acquired through a master-apprentice paradigm. The complexity of contemporary clinical research requires a new model for research training....

Cerebrotendinous xanthomatosis: clinical course, genotypes and metabolic backgrounds.
February 1, 2004... Abstract Cerebrotendinous xanthomatosis (CTX) is a rare autosomal recessive metabolic disease. It has been reported in more than 200 people worldwide. This review covers the epidemiologic, biochemical and molecular characteristics of the...

Genes, race and drugs.(Editor's Page)(Editorial)
February 1, 2004... Several years ago in Vancouver it was widely held that the rapidly growing population of immigrants from Hong Kong was "sensitive to drugs." This was thought to be because of their naive exposure to western medicine. For drugs used in...

Is there any hope for AIDS?(CSCI Distinguished Scientist Lecture)
February 1, 2004... Abstract Infection by HIV-1 is characterized by genetic diversity wherein distinct viral subtypes (clades A, B, C, D, E, F, G, K and O) are expanding in different geographic regions. With respect to HIV-1 sensitivity to antiretroviral...

Institute of Health Services and Policy Research.(CIHR on Parade)
February 1, 2004... Unlike other Canadian Institutes of Health Research (CIHR), the primary focus of the Institute of Health Services and Policy Research (IHSPR) is not basic medical science, a specific clinical area or even a specific population. Instead, this...