Journal of Psychiatry and Neuroscience articles from September 2007

Journal of Psychiatry and Neuroscience archives from September 2007

Amine oxidases and their inhibitors: what can they tell us about neuroprotection and the development of drugs for neuropsychiatric disorders?(Editorial
September 1, 2007... Although monoamine oxidase (MAO) inhibitors are not used as extensively as other antidepressants, they continue to have an important place in the armamentarium of drugs used to treat psychiatric and neurological disorders. Interest in MAO...

Dysfunction in early auditory processing in major depressive disorder revealed by combined MEG and EEG.(Research Paper / Article de recherche)(magnetoencephalography, electroencephalography )
September 1, 2007... Background: Patients with major depressive disorder (MDD) show impairments in cognitive functions. However, neural mechanisms underlying these disturbances are poorly understood. We investigated whether MDD affects neural mechanisms of...

Haloperidol induces the nuclear translocation of phosphatidylinositol 3'-kinase to disrupt Akt phosphorylation in PC12 cells.(Research Paper
September 1, 2007... Objective: The antipsychotic drug haloperidol (HAL) has been linked to apoptosis and to inhibition of prosurvival Akt signalling in pheochromocytoma (PC12) and neuronal cell cultures. However, the mechanism involved is unclear. Methods: We used...

Changes in serum lipids, independent of weight, are associated with changes in symptoms during long-term clozapine treatment.(Research Paper / Article de recherche)
September 1, 2007... Objective: Investigators have reported that weight gain attributed to clozapine is associated with its clinical response. However, weight gain is a nonspecific physiological variable that, in itself, does not explain the mechanism underlying...

Auditory processing in schizophrenia during the middle latency period (10-50 ms): high-density electrical mapping and source analysis reveal subcortical antecedents to early cortical deficits.(Research Paper
September 1, 2007... Introduction: Auditory sensory processing dysfunction is a core component of schizophrenia, with deficits occurring at 50 ms post-stimulus firmly established in the literature. Given that the initial afference of primary auditory cortex occurs...

The 5HTTLPR polymorphism, prior maltreatment and dramatic--erratic personality manifestations in women with bulimic syndromes.(Research Paper / Article de recherche)(serotonin transporter promoter)
September 1, 2007... Background: Low-function alleles of the serotonin transporter promoter polymorphism (5HTTLPR) have been linked to various psychopathological entities, especially in individuals exposed to prior stressors. In women with bulimic syndromes, we...

Fatty acid composition in postmortem brains of people who completed suicide.(Research Paper / Article de recherche)
September 1, 2007... Objective: Cholesterol levels have been reported to be lower in suicidal patients, and alterations in blood levels of polyunsaturated fatty acids have been found in people with depression. Given that the evidence for the link between lipid...

Pharmacological treatment of post-stroke pathological laughing and crying.(Psychopharmacology for the Clinician / Psychopharmacologie pratique)
September 1, 2007... A 60-year-old man with left-sided limb weakness after a stroke was referred for assessment and treatment of depression. The patient reported that, after his stroke 2 weeks ago, he has been crying "for no reason" several times a day. He...