Journal of Psychiatry and Neuroscience articles from September 2006

Journal of Psychiatry and Neuroscience archives from September 2006

Neurodegeneration and aldehyde load: from concept to therapeutics.(Editorial)
September 1, 2006... A vast amount of data has been generated over the last 30 years regarding neurodegenerative mechanisms. The basic question that has still not been answered is, how can selective cell populations degenerate? Specifically, N. basalis cholinergic...

The need for speed: an update on methamphetamine addiction.
September 1, 2006... The psychostimulant methamphetamine (MA) is a highly addictive drug that has surged in popularity over the last decadein North America. A burgeoning number of clandestine drug laboratories has led to dramatic increases in MA production, which...

Reduced hippocampal volume correlates with executive dysfunctioning in major depression.(Research Paper/Article de recherche)
September 1, 2006... Objective: Dysfunction of neuronal plasticity or remodelling seems to contribute to the pathopysiology of major depression and may cause the well-documented hippocampal changes in depression. We aimed to investigate whether reduced hippocampal...

Effects of lithium and valproate on amphetamine-induced oxidative stress generation in an animal model of mania.
September 1, 2006... Objective: Previous studies have suggested that oxidative stress may play a role in the pathophysiology of bipolar disorder (BD). Moreover, recent studies indicate that lithium and valproate exert neuroprotective effects against oxidative...

Fluoxetine-induced alterations in human platelet serotonin transporter expression: serotonin transporter polymorphism effects.
September 1, 2006... Objective: Long-term antidepressant drug exposure may regulate its target molecule--the serotonin transporter (SERT). This effect could be related to an individual's genotype for an SERT promoter polymorphism (human serotonin transporter coding...

Psychopharmacology of smoking cessation in patients with mental illness.
September 1, 2006... The information in this column is not intended as a definitive treatment strategy but as a suggested approach for clinicians treating patients with similar histories. Individual cases may vary and should be evaluated carefully before treatment...