Journal of Psychiatry and Neuroscience articles from November 2008

Journal of Psychiatry and Neuroscience archives from November 2008

What is the best treatment for bipolar depression?(Editorial)(Clinical report)
November 1, 2008... One of the challenges facing clinical psychiatry is how to treat bipolar depression effectively. (1) Surprisingly, its neurobiology and rational decisions about its treatment remain somewhat of a mystery. Recent findings have even called into...

The mediodorsal thalamic nucleus and schizophrenia.(Review Paper/Examen critique)(Clinical report)
November 1, 2008... The mediodorsal nucleus of the human thalamus is in a crucial position that allows it to establish connections with diverse cerebral structures, particularly the prefrontal cortex. The present review examines existing neurobiologic studies of...

[Serotonin.sub.2A] receptor binding potential in people with aggressive and violent behaviour.(Research Paper/Article de recherche)(Clinical report)
November 1, 2008... Objective: Indexes of brain [serotonin.sub.2A] ([5-HT.sub.2A]) density have never been investigated in a sample of humans with violent aggressive behaviour unbiased by medication use or current axis I psychiatric disorders. The objective of...

Hippocampus and amygdala morphology in adults with attention-deficit hyperactivity disorder.(Research Paper/Article de recherche)(Clinical report)
November 1, 2008... Objective: Attention-deficit hyperactivity disorder (ADHD) in adulthood is a serious health problem with a prevalence of up to 4%. Limbic structures have been implicated in the genesis of ADHD; it has been suggested that they mediate mood and...

Effects of mood stabilizers on DNA damage in an animal model of mania.(Research Paper/Article de recherche)(Clinical report)
November 1, 2008... Objective: Recent studies have suggested that oxidative stress and DNA damage may play a role in the pathophysiology of bipolar disorder (BD). We investigated the effects of the mood stabilizers lithium and valproate on amphetamine-induced DNA...

Alterations of white matter integrity in adults with major depressive disorder: a magnetic resonance imaging study.(Research Paper/Examen critique)(Clinical report)
November 1, 2008... Objective: The purpose of our study was to investigate alterations of white matter integrity in adults with major depressive disorder (MDD) using magnetic resonance imaging (MRI). Methods: We performed diffusion tensor imaging with a 3T MRI...

A comparison of affected and unaffected relatives of patients with bipolar disorder using proton magnetic resonance spectroscopy.(Research Paper/Article de recherche)(Clinical report)
November 1, 2008... Objective: Bipolar disorders have a strong genetic underpinning. Little is known about biological predispositions that convey vulnerability for the illness. We searched for biological vulnerability markers using proton magnetic resonance...

[Serotonin.sub.1B] heteroreceptor activation induces an antidepressant-like effect in mice with an alteration of the serotonergic system.(Research Paper/Article de recherche)(Clinical report)
November 1, 2008... Objective: We sought to demonstrate whether the specific activation of [serotonin.sub.1B] ([5-HT.sub.1B]) heteroreceptors by systemic or local administration of the selective [5-HT.sub.1B] receptor agonist anpirtoline could mediate...

Psychopharmacology for the clinician/Psychopharmacologie pratique.(Case study)
November 1, 2008... The information in this column is not intended as a definitive treatment strategy but as a suggested approach for clinicians treating patients with similar histories. Individual cases may vary and should be evaluated carefully before treatment...