Journal of Psychiatry and Neuroscience articles from March 2006

Journal of Psychiatry and Neuroscience archives from March 2006

Fewer classes of drugs for more and more psychiatric disorders.(Editorial)
March 1, 2006... Psychopharmacology has a critical place in defining biological psychiatry. In fact, psychiatry may be unique among the fields of medicine in that many of the theories of the pathophysiology of major mental illnesses are based on the putative...

Antidepressant effects of exercise: evidence for an adult-neurogenesis hypothesis?(Review Paper/Examen critique)
March 1, 2006... It has been hypothesized that a decrease in the synthesis of new neurons in the adult hippocampus might be linked to major depressive disorder (MDD). This hypothesis arose after it was discovered that antidepressant medications increased the...

The "delayed onset" of antipsychotic action--an idea whose time has come and gone.(Review Paper/Examen critique)
March 1, 2006... 2004 Innovations in Neuropsychopharmacology Award Paper For years, it has been known that the "onset" of the antipsychotic response is "delayed," and this notion is expressed in many major textbooks, informs clinical decisions and has even...

Increased positive emotional memory after repetitive transcranial magnetic stimulation over the orbitofrontal cortex.(Research Paper/Article de recherche)
March 1, 2006... Objective: Several studies have demonstrated increased left orbitofrontal cortex (OFC) activity during negative and depressed mood. These mood states have also been associated with reduced memory for positive emotional stimuli. The aim of the...

Nuclear factor kappa B in the dorsal raphe of macaques: an anatomical link for steroids, cytokines and serotonin.(Research Paper/Article de recherche)
March 1, 2006... Objective: Nuclear factor kappa B (NF[kappa]B) is a transcription factor that activates gene expression in response to proinflammatory cytokines, and elevated cytokines are associated with depression, which has a serotonergic component. We...

Alexithymia and stress-induced brain activation in cocaine-dependent men and women.(Research Paper/Article de recherche)
March 1, 2006... Objective: Alexithymia means a reduced capacity to identify and describe one's own feelings. Both stress and an alexithymic response to stress can contribute to relapse into drug abuse, but to our knowledge the neural processing of an...

Efficacy of escitalopram in the treatment of major depressive disorder compared with conventional selective serotonin reuptake inhibitors and venlafaxine XR: a meta-analysis.(Research Paper/Article de recherche)
March 1, 2006... Objective: Escitalopram is the most selective of the selective serotonin reuptake inhibitor (SSRI) antidepressants. Previous studies have suggested that escitalopram is superior to citalopram in efficacy. We conducted a meta-analysis of studies...

The use of medroxyprogesterone acetate for the treatment of sexually inappropriate behaviour in patients with dementia.(Brief Report/Rapport sommaire)
March 1, 2006... Sexually inappropriate behaviour in a patient with dementia can be a problem for caregivers. Little research has been done concerning treatment for this behavioural disorder. The hormone medroxyprogesterone acetate (MPA) is a known, but...

Psychopharmacology for the Clinician/Psychopharmacologie pratique.
March 1, 2006... Treatment guidelines for mania The treatment of bipolar disorder is complex and should involve a multidimensional approach, including psychopharmacology, psychoeducation and psychotherapy. This discussion of the optimal treatment for mania...