Journal of Psychiatry and Neuroscience articles from January 2007

Journal of Psychiatry and Neuroscience archives from January 2007

Vulnerability for apoptosis in the limbic system after myocardial infarction in rats: a possible model for human postinfarct major depression.(Research Paper / Article de recherche)
January 1, 2007... Objective: Major depressive disorder occurs in 15%-30% of patients who have had a myocardial infarction (MI), but the neurobiological mechanisms involved are not well understood. Previously, we found early intracellular signalling changes in...

Effects of valproate on serotonin-induced intracellular calcium mobilization in human platelets.(Research Paper / Article de recherche)(Clinical report)
January 1, 2007... Objective: Valproate (VPA) is effectively used in the treatment of bipolar disorder, although the mechanism of action is unclear. In patients with bipolar disorder, 5-hydroxytryptamine (5-HT)-induced intraplatelet calcium (Ca) mobilization has...

Platelet serotonin levels support depression scores for women with postpartum depression.(Research Paper / Article de recherche)
January 1, 2007... Objective: It is very challenging to make an unbiased diagnosis of psychiatric illness. Platelets have long been proposed as easily obtainable, neurological models of serotonergic neurons. This study examined whether a new measurement for...

Cannabis and cognitive dysfunction: parallels with endophenotypes of schizophrenia?(psychiatric research)(Preamble also in French)(includes table)
January 1, 2007... Currently, there is a lot of interest in cannabis use as a risk factor for the development of schizophrenia. Cognitive dysfunction associated with long-term or heavy cannabis use is similar in many respects to the cognitive endophenotypes that...

Psychopharmacology for the clinician psychopharmacologie pratique.(psychiatric research)
January 1, 2007... The information in this column is not intended as a definitive treatment strategy but as a suggested approach for clinicians treating patients with similar histories. Individual cases may vary and should be evaluated carefully before treatment...

Of rats and schizophrenia.(Editorial)
January 1, 2007... Surprisingly (or not), I am sometimes greeted with skeptical grins from members of the audience at seminars when I explain that I use rats, mice and guinea pigs to attempt to understand the causes of schizophrenia. (Yeah, right, a schizophrenic...