Drug Discovery & Technology News articles from May 2000

Drug Discovery & Technology News archives from May 2000

RATIONAL DRUG DESIGN: COX-2 Co-Crystallized with Substrate.(Vanderbilt University and G.D. Searle research)(Brief Article)
May 1, 2000... A team of Vanderbilt University biochemists and G.D. Searle (5200 Old Orchard Rd., Skokie, IL 60077; Tel: 847/982-7000) researchers have determined, by x-ray crystallography, the three-dimensional structure of cyclooxygenase-2 (COX-2) when...

Structure of the Reovirus Core.
May 1, 2000... Using x-ray crystallography, a team led by Stephen C. Harrison, a Howard Hughes investigator at Children's Hospital in Boston (300 Longwood Ave., Boston, MA 02115-5737; Tel: 617/355-6874) and Harvard University, determined the three-...

ASSAYS: Cell-Based cAMP Assay Released.(LJL BioSystems, Inc.)(Brief Article)
May 1, 2000... LJL BioSystems, Inc. (404 Tasman Dr., Sunnyvale, CA 94089; Tel: 408/541-8787, Fax: 408/541-8786; Website: www.ljlbio.com) has initiated commercial shipments of its High Efficiency Fluorescence Polarization (HEFP), assay for cyclic AMP (cAMP)...

Quantum Dots for Biological Assays.(Brief Article)
May 1, 2000... Genentech, Inc. (1 DNA Way, South San Francisco, CA 94080; Tel: 650/225-1000, Fax: 650/225-8326; Website: www.gene.com) has agreed to evaluate Quantum Dot Corp's. (QDC, 4030 Fabian Way, Palo Alto, CA 94303; Tel: 650/812-7390, Fax:...

Gene Sequencing Yields New Products.(Human Genome U95 Set from Affymetrix)(Brief Article)(Product Announcement)(Statistical Data Included)
May 1, 2000... As a result of progress in the Human Genome Project, Affymetrix (3380 Central Expy., Santa Clara, CA 95051; Tel: 408/731-5000, Fax: 408/481-0422; Website: www.affymetrix.com) has launched a new human gene expression analysis product line:...

Nanobots Examine DNA for Mismatches.(IBM Zurich Research Laboratory , University of Basel)(Brief Article)
May 1, 2000... Scientists from IBM Zurich Research Laboratory (Saumerstrasse 4, Postfach 8803, Ruschlikon, Switzerland; Tel: +41-1-724-8111; Website: www.zurich.ibm.com) and the University of Basel (Website: www.monet.physik.unibas.ch/nose/kbiosensor) have...

SCREENING: Invader is 99.5% Accurate for Factor V.(Brief Article)
May 1, 2000... Results from a multi-center study of Third Wave Technologies'(502 Rosa Rd., Madison, WI 5371-1256; Tel: 608/273-8933; Website: www.twt.com) Invader operating system for DNA analysis were published in the May 2000 issue of the Journal of...

High Throughput Screening Patents.(Brief Article)
May 1, 2000... Nanogen, Inc. (10398 Pacific Center Ct., San Diego, CA 92121; Tel: 619/546-7700, Fax: 619/546-7718) has been awarded two additional U.S. patents relating to its electronic microarray technology. U.S. Patent 6,048,690, entitled "Methods For...

Using Biomolecules to Form Electronic Circuits.(Brief Article)
May 1, 2000... Clinical Micro Sensors, Inc. (CMS, 101 Waverly Dr., Pasadena, CA; Tel: 626/584- 5900; Website: www.microsensor.com) has been awarded two U.S patents, strengthening the company's proprietary position in bioelectronic technologies. The two...

High-Throughput Microscopy Licensed.(Brief Article)
May 1, 2000... Pharmacopeia, Inc. has signed an agreement with PE Biosystems Group, a PE Corp. business, and Becton, Dickinson and Company (1 Becton Dr., Franklin Lakes, NJ 07417-1880; Tel: 201/847-6800, Fax: 201/847-6845; Website: bd.com) through its BD...

3-D Cultured Heart Licensed.(MediGene AG)(Brief Article)
May 1, 2000... MediGene AG (Lochhamer Str. 11, Munchen (Munich) 821, Germany; Tel: 089/89500033) has in-licensed an "in vitro heart," a 3-D matrix technology used to validate a gene's biological role and perform drug screening in a lifelike surrounding....

PROTEOMICS: Traffic Regulation and Export Controls.(Brief Article)
May 1, 2000... Ciblex Corp. (11025 Roselle St., San Diego, CA 92121; Tel: 619/546-7848, Fax: 619/546-7596; Website: www.ciblex.com) has been issued two patents, U.S. Patent 6,028,058 and U.S. Patent 5,891,855, related to the company's core focus on protein...

INFORMATICS: Incyte to Sequence NIH Gene Collection.(Brief Article)
May 1, 2000... Incyte Genomics, Inc. (3174 Porter Dr., Palo Alto, CA 94304; Tel: 650/855-0555, Fax: 650/855-0572; Website: www.incyte.com) has signed a contract with the National Institutes of Health (NIH) to sequence DNA for the Mammalian Gene Collection...

Chemical and Material Informatics Tools.(Brief Article)
May 1, 2000... Molecular Simulations, Inc. (MSI), a wholly-owned subsidiary of Pharmacopeia, Inc. (CN 5350, Princeton, NJ; Tel: 609/452-3600; Fax: 609/452-2434) and hte GmbH (Heidelberg, Germany) have entered into a collaborative relationship. The...

Consortium Releases 60,000 More SNPs.(Brief Article)
May 1, 2000... The SNP Consortium, Ltd., a collaborative effort to create a genome-wide map of genetic markers called single nucleotide polymorphisms (SNPs), has recently released into the public domain approximately 60,000 newly identified SNPs, bringing...

Vanderbilt Accesses Celera's Databases.(Brief Article)
May 1, 2000... Vanderbilt University has become the first academic institution to partner with Celera Genomics (761 Main Ave., Norwalk, CT 06859; Tel: 203/762-1000, Fax: 203/762-6000) for access to the company's vast library of genomic data. Can Harvard...

DIAGNOSTICS: Armored RNA for In Vitro Diagnostics.(Brief Article)
May 1, 2000... Ambion, Inc. (2130 Woodward St., Ste. 200, Austin, TX 78744-1832; Tel: 512/445- 6979, Fax: 512/651-0194) has granted Abbott Laboratories (100 Abbott Park Rd., Abbott Park, IL 60064; Tel: 847/937-6100, Fax: 847/937-1511; Website:...

DRUG TARGETS: Telomerase Region Is Cancer Therapy Target.(Brief Article)
May 1, 2000... University of California at San Francisco (UCSF) researchers have discovered a region in the telomerase enzyme that they say could prove to be a target for killing cancer. Telomeres maintain the stability of chromosomes in numerous ways...

DRUG DELIVERY: Generating Fine, Particulate Protein.(Brief Article)
May 1, 2000... Aphios Corp. (3-E Gill St., Woburn, MA 01801; Tel: 781/932-6933, Fax: 781/932- 6865; Email: aphios@aol.com, Website: www.aphios.com) has been granted U.S. Patent 6,051,694, entitled "Method for Size Reduction of Proteins," which is available...

Special Delivery to the Cytoplasm.(Brief Article)
May 1, 2000... AVI BioPharma, Inc. (One S.W. Columbia St., Suite 1105, Portland, OR 97258; Tel: 503/227-0554, Fax: 503/227-0751; Website: www.avibio.com) has been granted U.S. Patent 6,030,941 for Cytoporter, its drug delivery system. Cytoporter transports...

Iontophoresis Delivers Drugs to the Eye.(Brief Article)
May 1, 2000... Iomed, Inc. (3385 W. 1820 S., Salt Lake City, UT 84104; Tel: 801/975-1191, Fax: 801/972-9072; Website: www.iomed.com) has successfully completed proof-of- principle studies involving trans-scleral iontophoretic delivery of an antibiotic to...

INDUSTRY NEWS: Finnish Diabetes Initiative Launched.(Brief Article)
May 1, 2000... The Juvenile Diabetes Foundation (JDF) has launched The Targeted Program on Type 1 Diabetes, a Finnish initiative that will fund innovative, multi-disciplinary research towards a cure for diabetes and its complications. The Academy of...

Sell Your Stock on the Internet.(Brief Article)
May 1, 2000... Ixion Biotechnology (13709 Progress Blvd., Box 13, Suite N-111, Alachua, FL 32615; Tel: 904/418-1428, Fax: 904/418-1583; Email: info@ixion-biotech.com, Website: www.ixion-biotech.com) has successfully sold out its Internet registered...

Online Clinical Trial Matching.(Brief Article)(Statistical Data Included)
May 1, 2000... LifeMetrix, Inc., (1430 Spring Hill Rd., McLean, VA 22102; Tel: 800/482-2280, Fax: 703/506-0623) has announced the availability of its latest product, TrialMatch, an online tool that connects people who have specific chronic diseases with...

NEW COMPOUNDS: Catalytic Scavengers Combat Stroke.(Brief Article)
May 1, 2000... Eukarion, Inc. (6F Alfred Circle, Bedford, MA 01730; Tel: 781/275-0424, Fax: 781/275-0752; Website: www.eukarion.com) has been awarded a Phase II Small Business Innovative Research (SBIR) grant from the National Institute of General Medical...

Countering Excess Dopamine Levels.(Brief Article)
May 1, 2000... Researchers at University of California at Irvine's College of Medicine, led by Daniele Piomellia, professor of pharmacology, have developed a compound that could form the basis of a new class of drugs to treat a number of psychiatric...

Ginkgo May Protect Against Stroke.(Brief Article)
May 1, 2000... Ginkgo extract, a dietary supplement believed by many consumers to improve memory, reduces the extent of brain damage caused by stroke induced in mice. Ginkgo could thus play a future role in protecting humans by limiting stroke damage,...

Carbohydrate Inhibits Angiogenesis.(Progen Industries, Ltd. research)(Brief Article)
May 1, 2000... Progen Industries, Ltd. (2806 Ipswich Rd., Darra, Queensland 4076, Australia; Tel: 7-3375-1888, Fax: 7-3375-9318; Website: www.progen.com.au) announced an update to its research on carbohydrate-based angiogenesis inhibitors at the 91st...

Neutrophil Elastase Inhibitor Developed.(Sivelestat)(Brief Article)
May 1, 2000... Eli Lilly and Company (Lilly Corporate Ctr., Indianapolis, IN 46285; Tel: 317/276-2000, Fax: 317/277-3354; Website: www.lilly.com) has signed a letter of intent with Ono Pharmaceutical Co., Ltd. (Osaka, Japan) on the development,...

Fatty Acids Carry Chemotherapeutics.(Protarga contract for anticancer drug development)(Brief Article)
May 1, 2000... Protarga, Inc. (1100 E. Hector St., Suite 450, Conshohocken, PA 19428) has entered into a Cooperative Research and Development Agreement (CRADA) with the U.S. National Cancer Institute (NCI) to accelerate the development of novel anti-cancer...

COLLABORATIONS: Consortium Takes on Leishmaniasis.(Brief Article)
May 1, 2000... Immtech Intl., Inc. (1 N. End Ave., Suite 1111, New York, NY; Tel: 212/791-2911, Fax: 212/791-2917) is establishing a research consortium focused on developing new treatments for leishmaniasis, a parasite-transmitted disease that affects...

CALENDAR.(Brief Article)
May 1, 2000... June 12-13, 2000, Anti-Cancer Drug Discovery and Development Conference, Princeton, NJ. Contact: Strategic Research Institute; Tel: 212/967-0095, ext. 251; Email: jliong@srinstitute.com. June 26-28, 2000, Pharma R&D Directions 2000,...

Osteoporosis Test Measures Phosphatase.(Beckman Coulter Inc.)(Brief Article)(Product Announcement)
May 1, 2000... Beckman Coulter's (4300 Harbor Blvd., Fullerton, CA; Tel: 714/871-4848, Fax: 714/773-8283, Website: www.beckmancoulter.com) Access Ostase blood test is the first automated, serum-based assay to receive clearance from the U.S. Food and Drug...