Drug Discovery & Technology News articles from July 2000

Drug Discovery & Technology News archives from July 2000

MEETING REPORT "We Bought the Robots, Now Where Are the Drugs?".
July 1, 2000... A Report on High-Throughput Technologies: Summit and Exposition June 19-21 in Philadelphia, PA, sponsored by Cambridge Healthtech Institute The title, borrowed from Doug Livingston of Novartis Research Foundation (3115 Merryfield...

BASIC SCIENCE: Power Failure Leads to Osteoarthritis.
July 1, 2000... A team of scientists form the San Diego Veterans Affairs (VA) Medical Center and the University of California, San Diego (UCSD), in collaboration with MitoKor, Inc. (1194 Sorrento Valley Rd., San Diego, CA 92121; Tel: 858/793-7800, Fax:...

How E-Coli Grabs Intestinal Cells.
July 1, 2000... A team of molecular biologists and x-ray crystallographers at the University of British Columbia has produced the first detailed picture showing an E. coli bacterial adhesin attaching to its receptor on intestinal cells. The structure may...

SCREENING: Receptor Patented for Screening.
July 1, 2000... Synaptic Pharmaceutical Corp. (215 College Rd., Paramus, NJ 07652; Tel: 201/261-1331, Fax: 201/261-0623) has been awarded U.S. Patent 6,083,705 for the use of the alpha adrenergic 1D receptor to screen compounds that bind to it. The alpha...

Effect of Aneuploidy on Gene Expression.
July 1, 2000... In the July 3rd issue of Nature Genetics, researchers at Rosetta Inpharmatics, Inc. (12040 115th Ave. N.E., Kirkland, WA 98034; Tel: 425/820-8900, Fax: 425/821-5354; Website: www.rii.com) report findings illustrating the potential for gene...

Microsatellite Instability and Colon Cancer.
July 1, 2000... Exact Laboratories, Inc. (63 Great Rd., Maynard, MA 01754; Tel: 978/897-2800, Fax: 978/897-3841; Email: xactinfo@exactlabs.com, Website: www.exactlabs.com) will collaborate with Creighton University Professor Henry T. Lynch to study a...

Screening for Organ Donors.
July 1, 2000... Gen-Probe, Inc. (10210 Genetic Center Dr., San Diego, CA; Tel: 858/410-8000, Fax: 619/417-5001; Website: www.gen-probe.com) is beginning development of a single-nucleic-acid amplification (NAT) assay that will screen the blood of potential...

Sequenom Launches SNP Technology.
July 1, 2000... Sequenom, Inc. (11555 Sorrento Valley Rd . #C, San Diego, CA 92121-1331; Tel: 619/350-0345) has launched its 384 SpectroCHIP, which the company says increases throughput and reduces costs associated with the large-scale analysis of...

Screening Growth-Factor Receptors.
July 1, 2000... ImClone Systems, Inc. (180 Varick St., New York, NY 10014; Tel: 212/645-1405, Fax: 212/645-2054; Website: www.imclone.com) and Dako Corp. (6392 Via Real, Carpinteria, CA 93013; Tel: 805/566- 6655, Fax: 805/566-6688; Website: www.dakousa.com)...

INFORMATICS: Genome's Sequenced - Now What?
July 1, 2000... Craig Venter of Celera Genomics (45 W. Gude Dr., Rockville, MD 20850; Tel: 240/453 3000, Fax: 240/453 3900; Website: www.celera.com) and Francis Collins of the Human Genome Project announced last month that the monumental task of sequencing...

Rosetta Resolver Is Released.
July 1, 2000... Rosetta Inpharmatics, Inc. (12040 115th Ave. N.E., Kirkland, WA 98034; Tel: 425/820-8900, Fax: 425/821-5354; Website: www.rii.com) has begun the commercial launch of the Rosetta Resolver Expression Data Analysis System, a bioinformatics...

PROTEOMICS: Pulsatile Delivery of Proteins.
July 1, 2000... Ariad Pharmaceuticals, Inc. (26 Landsdowne St., Cambridge, MA 02139; Tel: 617/494-0400, Fax: 617/494-8144) has reported in a paper published in the June 20, 2000, issue of the Proceedings of the National Academy of Sciences, USA, on the...

DRUG TARGETS: Proto-Oncogene Is Identified.
July 1, 2000... A Johns Hopkins School of Medicine research team led by Linda Resar, an assistant professor in the division of pediatric hematology, has discovered a new family of genes that contributes to the process of malignancy, shedding new light on...

Metastasis Inhibitor Licensed.
July 1, 2000... AlphaOne Pharmaceuticals, Inc. (850 Marina Village Pkwy., Alameda, CA 94501-1034; Tel: 510/337-1250) has signed an agreement with the Dana-Farber Cancer Institute to commercialize the tumor suppressor gene for maspin, a family member of...

DRUG DELIVERY: Self-Assembling Nanocapsules.
July 1, 2000... By manipulating simple and nonspecific interactions, researchers from the University of Illinois (Champaign-Urbana) have discovered a way to make chemicals spontaneously self-assemble into ribbon- like tubules that resemble bacterial cell...

NEW COMPOUNDS: Imprinted Polymers Remove Toxins.
July 1, 2000... "Molecular imprinted" polymers (MIPs) were found to selectively bind to toxins linked to the onset of heart disease and several major cancers, raising hopes that these diseases might be prevented through the use of safe, nonabsorbable pills,...

Synergism in Anti-HIV Effects.(Brief Article)
July 1, 2000... Progenics Pharmaceuticals, Inc. (777 Old Saw Mill River Rd., Tarrytown, NY 10591; Tel: 914/789-2800, Fax: 914/789-2817) reported that the investigational drugs PRO 542 and T-20 demonstrated significantly enhanced anti-HIV activity when used...

INDUSTRY NEWS: June Weddings Abound.
July 1, 2000... Spring has sprung, the grass has riz, love's abloom in the biotech biz. M & A activity was plentiful in June. For instance: SignalGene (8475 Christophe-Colomb Ave., Suite 1000, Montreal, Quebec H2M 2N9, Canada; Tel: 514/850-2400, Fax:...

Riboproteomics Firm Established.
July 1, 2000... Scriptgen Pharmaceuticals (610 Lincoln St., Waltham, MA 02451- 2186; Tel: 781/768-3400, Fax: 781/768-0040), in collaboration with members of the European Molecular Biology Laboratory (EMBL), has recreated itself as Anadys Pharmaceuticals...

COLLABORATIONS: Aventis, Millennium Team Up.
July 1, 2000... Aventis Pharma, a division of Aventis S.A. (25 Quai Paul Doumer, 92408 Courvevoie Cedex, France; Tel: 610/454-3852) and Millennium Pharmaceuticals, Inc. (640 Memorial Dr., Cambridge, MA 02139; Tel: 617/679-7000, Fax: 617/374-9379; Website:...

Evolving Strategy in Post-Genomics Era.
July 1, 2000... Bristol-Myers Squibb Co. (345 Park Ave., New York, NY 10154; Tel: 212/546-4000, Fax: 212/546-4020) and 3-Dimensional Pharmaceuticals, Inc. (3DP, 665 Stockton Dr., Suite 104, Exton, PA 1043; Tel: 610/458-8959, Fax: 610/458-8258; Website:...

Fuzzy Wuzzy Wasn't Functional, Was He?(Brief Article)
July 1, 2000... GeneFormatics (58530 Oberlin Dr., Suite 200, San Diego, CA 92121- 3754; Tel: 858/450-3331, Fax: 858/450-1138) has entered into a contract with Schering-Plough Research Institute, a division of Schering-Plough Corp. (One Giralda Farms,...

Software Analyzes Affymetrix Arrays.(Brief Article)
July 1, 2000... Invitrogen Corp. (1600 Faraday Ave., Carlsbad, CA 92008; Tel: 760/603-7200, Fax: 760/603-7201) has signed an agreement with Affymetrix, Inc. (3380 Central Expy., Santa Clara, CA 95051; Tel: 408/731-5000, Fax: 408/481-0422; Website:...

RNA-Binding Drug Discovery Deal.(Brief Article)
July 1, 2000... Ibis Therapeutics (Website: www.ibisrna.com), a division of Isis Pharmaceuticals, Inc. (2292 Faraday Ave., Carlsbad, CA 92008; Tel: 760/931-9200, Fax: 760/931-9639) and Agouron Pharmaceuticals, Inc. (10350 N. Torrey Pines Rd., La Jolla, CA...