Drug Discovery & Technology News articles from January 2000

Drug Discovery & Technology News archives from January 2000

BASIC SCIENCE: How Does Aging Affect the Brain?(dopamine loss)(Brief Article)
January 1, 2000... Researchers from the U.S. Department of Energy's Brookhaven National Laboratory, the State University of New York at Stony Brook, and the University of Pennsylvania School of Medicine have found chemical changes in the brain that may...

New Angiogenesis Mode Discovered.(research at Beth Israel Deaconess Medical Center (Boston), Angiogenesis Research Center)(Brief Article)
January 1, 2000... Cardiologist Michael Simons, director of the Angiogenesis Research Center at Beth Israel Deaconess Medical Center (330 Brookline Ave. #B, Boston, MA 02215- 5400), and his colleagues have found that a naturally occurring antibacterial peptide...

How HIV Affects Cellular Genes.(University of Washington research)(Brief Article)
January 1, 2000... Genes involved in T-cell signaling, protein trafficking, and transcriptional regulation were among the genes that displayed functional changes within three days of exposure to the HIV virus, according to a University of Washington study...

Prolonged Analgesia in Engineered Mice.(Duke University research)(Brief Article)
January 1, 2000... Knocking out a gene that muffles the painkilling signal of morphine yields animals that can tolerate pain for longer periods of time, even while receiving lower doses of the drug, reports a pair of Howard Hughes investigators, Robert J....

RATIONAL DRUG DESIGN High-Throughput Crystallography.(Structural GenomiX receives venture capital)(Brief Article)
January 1, 2000... Structural Genomix (10505 Roselle St., San Diego, CA 92121; Tel: 858/558-4850, Fax: 858/558-4859; Email: info@stromix.com, Website: stromix.com) has received $7.5 million in initial venture capital financing to support its aim of providing...

How Polioviruses Attach to Cells.(viral research at Purdue University and the State University fo New York (Stony Brook))(Brief Article)
January 1, 2000... Using high-resolution cryo-electron microscopy and three-dimensional image reconstruction techniques, scientists from Purdue University (West Lafayette, IN) and State University of New York (Stony Brook) were able to obtain the first...

ASSAYS: There's Profit in Promiscuity.(Aurora Biosciences Corp.'s patent for promiscuous G-proteins)(Brief Article)
January 1, 2000... Aurora Biosciences Corp. (11010 Torreyana Rd., San Diego, CA 92121; Tel: 619/404-6600, Fax: 619/404-6714; Website: aurorabio.com) has announced the issuance of U.S. Patent 6,004,808, entitled "Promiscuous G-Protein Compositions and Their...

Caliper Wins Microfluidics Patents.(Caliper Technologies Corp.)(Brief Article)
January 1, 2000... Caliper Technologies Corp. (1275 California Ave., Palo Alto, CA 94304; Tel: 650/842-1960, Fax: 650/842-1970) has announced that two broad U.S. patents covering fundamental microfluidic chip technology have been issued to the Department of...

Combimatrix Patents Nanode Sensors.(Department of Defense Contract awarded to CombiMatrix Corp.)(Brief Article)
January 1, 2000... CombiMatrix Corp., a majority-owned affiliate of Acacia Research Corp. (55 S. Lake Ave., #650, Pasadena, CA, 91101-2676; Tel: 626/396-8300; Website: acaciaresearch.com) has been awarded a $730,000 Phase II SBIR grant from the Department of...

SNP Genotyping Assays to be Developed.(single nucleotide polymorphism research by Orchid Biocomputer, Inc. and Affymetrix, Inc.)(Brief Article)
January 1, 2000... Affymetrix, Inc. (3380 Central Expwy., Santa Clara, CA 95051; Tel: 408/731-5000, Fax: 408/481-0422; Website: affymetrix.com) and Orchid Biocomputer, Inc. (Princeton, NJ 08540; Tel: 609/750-2200; Website: snps.com) have entered into an...

SCREENING: Agilent to Enter Micro-Array Market.(Agilent Technologies Inc.)(Brief Article)
January 1, 2000... Agilent Technologies, Inc. (3000 Hanover St., Palo Alto, CA 94304; Tel: 650/857- 1501, Fax: 650/857-7299; Website: agilent.com), newly spun-off from Hewlett- Packard, plans to expand its presence in the life science market through the...

Biochips to Reach $950M by 2005.(Brief Article)
January 1, 2000... The worldwide biochip market, consisting of DNA chips, lab chips, and protein chips, will reach $950 million in sales by 2005, according to a new study from BioInsights (Tel: 650/701-0280; Email: marketing@biotechinsights.com) called...

Enzo Gets Biochip Patents.(Enzo Biochem Inc.)(Brief Article)
January 1, 2000... Enzo Biochem, Inc. (60 Executive Blvd., Farmingdale, NY 11735; Tel: 516/755- 5500, Fax: 516/755-5569) has received two United States patents covering areas applicable to genomic analysis and DNA diagnostics. Patent 5,998,135 covers...

Gene Display Slides Available.(Display Systems Biotech)(Brief Article)
January 1, 2000... Display Systems Biotech (1260 Liberty Way, Suite B, Vista, CA; Tel: 760/599- 0598, 800/697-1111, Fax: 760/599-9930; Email: info@displaysystems.com, Website: displaysystems.com) has announced the debut of its first discoveryARRAY Gene Display...

Third Wave High Throughput.(Third Wave Technologies)(Brief Article)
January 1, 2000... Third Wave Technologies' (502 Rosa Rd., Madison, WI 5371-1256; Tel: 608/273- 8933) Invader DNA/RNA analysis technology has now been integrated with Beckman Coulter's SAGIAN high-throughput automation platform to create an automated...

INFORMATICS: Celera Sequenced 90% of Human Genome.(Celera Genomics group)(Brief Article)
January 1, 2000... Celera Genomics (761 Main Ave., Norwalk, CT 06859; Tel: 203/762-1000, Fax: 203/762-6000) a PE Corp. business, announced that it now has DNA sequences in the Celera database that cover 90% of the human genome. Based on statistical analyses,...

Hyseq Adds 5,000 Genes.(Brief Article)
January 1, 2000... Hyseq, Inc. (670 Almanor Ave., Sunnyvale, CA 94086; Tel: 408/524-8100; Website: hyseq.com) has added more than 5,000 completely sequenced proprietary genes to its HyProfile Portfolio. The company intends to pursue commercialization of select...

Free Genome Analytical Tools.(eBioinformatics Inc.)(Brief Article)
January 1, 2000... eBioinformatics Inc., (P.O. Box 5430, Pleasanton, CA 94566-5503; Tel: 877/324- 6463, Fax: 603/994-1792; Website: eBioinformatics.com) is providing genome data, private data curation, and a popular set of genome analysis methods - free to...

DRUG TARGETS: Calcium and Glutamate Receptors Patented.(NPS Pharmaceuticals Inc.)(Brief Article)
January 1, 2000... NPS Pharmaceuticals, Inc. (420 Chipeta Way, Salt Lake City, UT 84108; Tel: 801/583-4939, Fax: 801/583-4961) has announced the issuance and notices of allowance of 14 U.S. patents. Together, this group of patents defines a cohesive and large...

Receptor Regulates Blood/Brain Barrier.(Brief Article)
January 1, 2000... Researchers at the University of Maryland School of Medicine (Baltimore, MD) have identified a receptor in the human brain that regulates the interface between the bloodstream and the brain, which is known as the blood-brain barrier. The...

COLLABORATIONS: PE, Symyx Make Analysis Polymers.(PE Biosystems, Symyx Technologies Inc.)(Brief Article)
January 1, 2000... PE Biosystems (335 Menhaden Ct., Foster City, CA 94404-1932; Tel: 650/571-6603) a PE Corp. business, and Symyx Technologies, Inc., (3100 Central Expwy., Santa Clara, CA 95051; Tel: 408/764-2000, Fax: 408/748-0745) have initiated a strategic...

Invading the 22nd Chromosome.(Third Wave Technologies)(Brief Article)
January 1, 2000... Third Wave Technologies Third Wave Technologies (502 Rosa Rd., Madison, WI, 5371-1256; Tel: 608/273-8933; Website: twt.com) and the Sanger Centre have entered into a collaboration agreement to use Third Wave's proprietary Invader technology...

NEW COMPOUNDS: Kinase Inhibitor Fights Gehrig's Disease.(Hughes Institute)(Brief Article)
January 1, 2000... Scientists at the Hughes Institute in St. Paul, Minnesota (2665 Long Lake Rd., Roseville, MN 53113; Tel: 651/697-9228; Website: hughesinstitute.org) report the effectiveness of a specific inhibitor of a cellular protein known as Janus Kinase...

Pfizer to Develop Osteoporosis Drug.(lasofoxifene)(Brief Article)
January 1, 2000... Pfizer Inc. (235 E. 42nd St., New York, NY 10017; Tel: 212/573-2323, Fax: 212/573-7851) has narrowed its focus to one of two compounds it was developing following conclusion of its collaboration with Ligand Pharmaceuticals, Inc. (10275...

Warner-Lambert Buys Rights to Panic Drug.(pagoclone)(Brief Article)
January 1, 2000... Interneuron Pharmaceuticals, Inc. (One Ledgemont Ctr., 99 Hayden Ave., Lexington, MA, 02421; Tel: 781/861-8444, Fax: 781/861-3830) has entered into a definitive agreement with Warner-Lambert Co. (201 Tabor Rd., Morris Plains, NJ; Tel:...

INDUSTRY NEWS: Pharmacia, Upjohn to Merge with Monsanto.(Brief Article)
January 1, 2000... Monsanto Co. (800 N. Lindbergh Blvd., St. Louis, MO 63167; Tel: 314/694-1000, Fax: 314/694-7625; Website: monsanto.com) and Pharmacia & Upjohn (95 Corporate Dr., Bridgewater, NJ 08807; Tel: 908/768-5501, Fax: 908/306-4433) have agreed to...

Orchid Acquires GeneScreen.(Orchid Biocomputer Inc.)(Brief Article)
January 1, 2000... Orchid Biocomputer, Inc. (Princeton, NJ 08540; Tel: 609/750-2200; Website: snps.com) has acquired Dallas-based GeneScreen, Inc., a company that provides genetic diversity analysis services. GeneScreen performs more than 1.5 million analyses...

Competition Accelerates Pharmaceutical Research.(Brief Article)
January 1, 2000... Increasing competition within the pharmaceutical industry, along with more intense public scrutiny during this year's U.S. presidential campaign, will force drug and biotechnology companies to increase the pace of drug development, according...

CALENDAR.(pharmaceutical research calendar)(Brief Article)
January 1, 2000... January 26-30, 2000, Transcription Factor Pathogenesis of Cancer at the Millennium, Dana Point, CA. Contact: American Association for Cancer Research; Tel: 215/440-9300, Fax: 215/351-9165. February 7-8, 2000, Proteomics, London, U.K....