Life Sciences & Biotechnology Update articles from September 2000

Life Sciences & Biotechnology Update archives from September 2000

HEALTH PORTRAIT IN THE U.S.: STATISTICAL TRENDS AND GUIDE TO RESOURCES.
September 1, 2000... This extensive (Bernan Associates) report provides current and historical information on a broad range of health issues, including: indicators of disease; correlates of behavior and health; trends in the provision of health care; and public...

OVERVIEWS OF THE BIOTECHNOLOGY AND MEDICAL TECHNOLOGY INDUSTRY IN OREGON AND WASHINGTON.
September 1, 2000... This industry overview from Canada (Consulate General) is intended as an informational resource for Canadian companies interested in identifying, pursuing, and concluding business development agreements in the biotechnology and medical...

MONITORING EMERGING INFECTIOUS DISEASES.
September 1, 2000... This (GAO) report to Congress addresses the monitoring of infectious diseases. Identifying diseases and their sources are critical for determining control and prevention efforts. Public health officials refer to this activity as surveillance...

CONFERENCE ON MICROBIAL PATHOGENESIS AND HOST RESPONSE.
September 1, 2000... Understanding microbial pathogenesis demands a detailed knowledge of the host response as well as the pathogen itself, and requires an interdisciplinary approach, integrating the fields of microbiology, eukaryotic cell biology, and immunology....

INVESTIGATION OF AN OUTBREAK OF RAPIDLY-GROWING MYCOBACTERIA (RGM) AMONG BONE-MARROW TRANSPLANT PATIENTS AT BROOKE ARMY MEDICAL CENTER.
September 1, 2000... This (Army Center for Health Promotion and Preventive Medicine) report details an epidemiologic consultation (EPICON) investigation to examine reports of an increased number of rapidly-growing mycobacteria (RGM) among bone marrow transplant...

REHABILITATION FOR CHILDREN AND ADOLESCENT TRAUMATIC BRAIN INJURIES.
September 1, 2000... This (Oregon Health Sciences University) report addresses a systematic review of the scientific literature, conducted to identify articles on child and adolescent traumatic brain injury (TBI) oriented around key research questions, and to...

MITOCHONDRIAL MECHANISMS OF NEURONAL INJURY.
September 1, 2000... This (University of Pittsburgh) project investigates intracellular signaling mechanisms associated with neuronal cell injury. In the acute form, neuronal cell injury results following stroke and head trauma, while in the chronic phenotype it...

EFFECTIVENESS OF LOW-BACK-PAIN TREATMENT STRATEGIES.
September 1, 2000... The goals of this (University of Washington) project are: (1) for patients with sciatica or spinal stenosis, to compare long-term functional and work-related outcomes of surgical and nonsurgical treatments; (2) to assess the impact of back...

CLINICAL DEVELOPMENT PROGRAMS FOR TREATMENT OF RHEUMATOID ARTHRITIS: DRUGS, DEVICES, AND BIOLOGICAL PRODUCTS.
September 1, 2000... This (FDA) guidance-document is designed to assist developers of drugs, biological products, and medical devices, intended for the treatment of rheumatoid arthritis (RA). The document discusses the types of label claims that can be considered...

EVALUATION OF PHARMACEUTICAL-CARE ASTHMA TREATMENT.
September 1, 2000... This (University of Washington) PEAK (Pharmaceutical Care Evaluation of Asthma in Kids) study is a community-based randomized controlled trial designed to assess the changes in disease control, functional status, and cost, associated with the...

PROGRESS AND PRIORITIES IN RENAL DISEASE RESEARCH.
September 1, 2000... This (National Institute of Diabetes and Digestive and Kidney Diseases) report addresses progress and priorities in renal disease research. Its partial contents includes: Renal Research: Status, Needs, and Priorities (Progressive Renal...

EFFECTIVE SUBSTANCE-ABUSE PROGRAMS FOR THE 21st CENTURY.
September 1, 2000... This (CDM Group Inc.) report addresses effective substance-abuse programs for the 21st century. Its partial contents includes: Introduction and Overview; Substance Abuse Prevention Programs Targeting High Risk Youth; The Evolution of...

A NEW CLASS OF SERINE AND CYSTEINE PROTEASE INHIBITORS HAVING CHEMOTHERAPEUTIC POTENTIAL.
September 1, 2000... This (Brown University) report concerns a new class of serine and cysteine protease inhibitors that have chemotherapeutic potential. Metastasis and angiogenesis in cancer are dependent on a variety of biologically active compounds, including...

PROSTATE CANCER: CONTROL OF CANCER CELL GROWTH AND SURVIVAL BY THE EXTRACELLULAR MATRIX.
September 1, 2000... This (Cornell University) document is a grant proposal to investigate whether adhesion of prostate cancer cells to extracellular matrices regulates cell growth and survival. It has been shown that attachment of LNCaP cells to a variety of...

PROSTATE CANCER: USING DIPHENYLUREAS FOR TREATMENT.
September 1, 2000... This (University of Kentucky Research Foundation) study investigates the use of diphenylureas for treating prostate cancer. The work is establishing procedures for determining the ability of the phosphonic acid diphenylureas to inhibit PC3...

IMPLICATIONS FOR CELL-CYCLE MANIPULATIONS IN BREAST CANCER.
September 1, 2000... This (Vanderbilt University Medical Center) report addresses the implications for cell-cycle manipulations in breast cancer. The role of DNA damage-intermediates and the network of signaling pathways by which cells activate p53 in the overall...

AFRICAN-AMERICAN WOMEN MULTIGENERATIONAL BREAST CANCER RISK FACTORS.
September 1, 2000... An increased rate of breast cancer is observed in African-American women under 50 years of age. Few epidemiologic studies of breast cancer focus explicitly on African-American women, and it is not established whether standard risk factors...

IN SITU BREAST CANCER GENETIC EPIDEMIOLOGY.
September 1, 2000... This (Yale University) five year project defines the risk factors associated with breast carcinoma in situ, through the mechanism of a case/control study. The study population consists of approximately 1100-1200 cases of female breast...

BREAST CANCER SCREENING BY PHYSICAL EXAMINATION.
September 1, 2000... This translation from France (International Agency for Research on Cancer) reports on breast cancer screening by physical examination, in the Philippines. A single screening round has been completed, involving examination of 150,000 women....

DEVELOPMENT OF BREAST CANCER: THE ROLE OF CHANGES IN EXPRESSION OF CYCLINS AND RETINOBLASTOMA PROTEIN.
September 1, 2000... This (University of Colorado) work studies the role of changes in the expression of cyclins and retinoblastoma protein in the development of breast cancer. The work demonstrates that essentially all breast cancer cell lines and tumor tissues...

MECHANISMS UNDERLYING THE IMMATURE MAMMARY GLAND'S VERY HIGH SUSCEPTIBILITY TO INITIATION OF CARCINOGENESIS.
September 1, 2000... The overall goal of this (Courter Products) project is to explore the toxic effects of physical and chemical carcinogens on the immature mammary gland, as compared to these effects on the young adult mammary gland, using a rat model. During...

GENE ACTIVATION BY ANTI-ESTROGENS USED IN BREAST CANCER THERAPY, VIA INTERACTION OF ESTROGEN RECEPTOR WITH AP-1.
September 1, 2000... This (University of California) report addresses gene activation by antiestrogens used in breast cancer therapy, via the interaction of estrogen receptor and AP-1. Estrogen receptor stimulates target genes that have AP-1 sites, with both...

THE ROLE OF CELL-TO-CELL ADHESION AND CALCIUM-DEPENDENT CELL ADHESION MOLECULES IN THE PROGRESSION OF BREAST CANCER.
September 1, 2000... The objective of this (Georgetown University) proposal is to elucidate the role of cell-cell adhesion, and calcium dependent cell adhesion molecules cadherins, in breast tumor progression. The work will test the hypothesis that, in addition...

HUMAN BREAST CANCER: MOLECULAR MECHANISMS OF THE SUPPRESSION OF METASTASIS.
September 1, 2000... The major cause of cancer deaths can be attributed to metastasis. This (Milton S. Hershey Medical Center) work has the goal to identify metastasis-controlling genes for human breast cancer. The research is based on findings that...

DETECTING DNA ADDUCTS IN HUMAN BREAST TISSUE.
September 1, 2000... Cancer of the breast and other tissues may be initiated or promoted by DNA adducts. Some of these adducts may be unknown at the present time, and differ from one individual to another, both qualitatively and quantitatively. This makes it...

OVERVIEW OF A RED BLOOD CELL STORAGE LABORATORY.
September 1, 2000... This (Bionetics Corp.) publication details staffed and maintained laboratories to support red blood cell preservation research. Three in vitro trials have been completed: the first trial evaluates an investigational system for processing...

GUIDANCE FOR INDUSTRY ON HUMAN SOMATIC CELL THERAPY AND GENE THERAPY.
September 1, 2000... This (FDA) guidance document updates and replaces the 1991 version with new information intended to provide manufacturers with current information regarding: (1) regulatory concerns for production, quality control testing, and administration,...