Life Sciences & Biotechnology Update articles from October 2000

Life Sciences & Biotechnology Update archives from October 2000

RESPONSES TO, AND CARDIOVASCULAR CONTROL OF, VASOCONSTRICTOR HORMONES DURING HYPOXIA.
October 1, 2000... These (Tripler Army Medical Center) studies address the role of certain factors on the ability to maintain blood pressure (BP), cardiac output (CO), and O2 delivery (O2del) during hemorrhage in the conscious goat. It studies the effects of:...

TRACHEOBRONCHIAL WOUND HEALING USING MINIMALLY-INVASIVE SURGICAL TECHNIQUES AND BIOLOGICAL GROWTH FACTORS-CIC3.
October 1, 2000... This (Albany Medical College) report concerns tracheobronchial injury, which is associated with significant morbidity and mortality. Morbidity occurs both early and late (i.e. airway stenosis). Current treatment options for post-traumatic...

HOSPITALIZATION RATES AND TRENDS FOR INPATIENT INJURIES.
October 1, 2000... This (Army Research Institute of Environmental Medicine) report analyzes injury hospitalizations relative to other diagnoses, and injury hospitalizations by external cause of injury. Hospitalization rates in the Army increased 8% between 1981...

GULF WAR ILLNESSES AND THE DOD: OPERATIONS OF THE OFFICE OF SPECIAL ASSISTANT TO THE DEPUTY SECRETARY OF DEFENSE FOR GULF WAR ILLNESSES.
October 1, 2000... This (Office of the Secretary of Defense) report covers the second year of operation of the Office of the Special Assistant to the Deputy Secretary of Defense for Gulf War Illnesses (OSAGWI). As noted in last year's report: When this office...

OXIDATIVE DAMAGE IN THE PATHOGENESIS OF PARKINSON'S DISEASE.
October 1, 2000... The aim of this (Massachusetts General Hospital) research is to determine whether there is a coherent body of evidence implicating oxidative damage in the pathogenesis of Parkinson's Disease and the MPTP model of Parkinsonism. Initial studies...

STAT PROTEINS IN BREAST CANCER CELLS MEDIATE CELL- GROWTH ARREST.
October 1, 2000... This (Yale University School of Medicine) work studies cell-growth arrest mediated by STAT proteins in breast cancer cells. Previous work had demonstrated that EGF activated STAT1 in some cell lines, causing cell-growth arrest and apoptosis....

THE ROLE OF TISSUE TRANSGLUTAMINASES IN BREAST CANCER.
October 1, 2000... Tumors require generation of new blood vessels to sustain their growth. Angiogenesis is the process through which tumors develop new blood vessels. This (Duke University) research investigates the role of tissue transglutaminase (TG) in...

MOLECULAR BASIS OF THE RESPONSE TO RADIATION.
October 1, 2000... This (Baylor College of Medicine) work involves the isolation of novel cDNAs encoding human homologs of yeast DNA damage response genes. Complementation of the yeast mutant rad9 have not yielded human cDNAs with significant homology. Thus,...

COMBATING METASTATIC BREAST CANCER WITH AN IMMUNOTHERAPEUTIC CELL-BASED VACCINE.
October 1, 2000... This (University of Maryland) report concerns an immunotherapeutic cell-based vaccine to combat metastatic breast cancer. No significant improvements for treatment of metastatic breast cancer have been developed in the last 20 years, and the...

NOVEL SPECIFIC AGENT FOR DETECTING HUMAN BREAST CANCER.
October 1, 2000... A non-invasive and accurate imaging technique is needed to further evaluate mammographically-suspicious lesions to reduce the number of cancer negative biopsies. This (Albany Medical College) work demonstrates that technetium-99m radiolabeled...

BREAST CANCER AMONG UNDER-SERVED MINORITY WOMEN: PRIMARY CARE AND REGULAR BREAST CANCER SCREENING.
October 1, 2000... This (Georgetown University) report examines features of the primary care structure and process that promotes regular breast cancer screening for under-served minority women. An existing data-base of 2600 multi-ethnic persons and their cancer...

INHIBITORS OF ONCOGENIC PHOSPHATES DERIVED THROUGH NOVEL COMBINATORIAL CHEMISTRY.
October 1, 2000... The overall goal of this (University of Pittsburgh) research is to identity and develop novel therapeutic agents for human breast cancer. A novel second generation small molecule library has been designed on a previous natural product...

MAPPING OF A BREAST CARCINOMA TUMOR-SUPPRESSOR GENE TO CHROMOSOME 11p15.
October 1, 2000... This (University of North Carolina) paper addresses mapping of a breast carcinoma tumor-suppressor gene to chromosome 11p15. The BRCAl gene is mutated in approximately 40% of the breast cancers seen in hereditary breast cancer. The function...

ELECTROCHEMICAL TREATMENT OF RAT BREAST CANCER WITH DIRECT CURRENT (DC).
October 1, 2000... This (City of Hope National Medical Center) report concerns electrochemical treatment of rat breast cancer using direct current (dc). Two hypotheses for using electrochemical treatment (EChT) for cancer therapy are studied: (1) both anodes...

NEU SIGNALING REGULATION IN BREAST CANCER.
October 1, 2000... This (Yale University) report concerns regulation of Neu signaling in breast cancer. Signaling by members of the epidermal growth factor receptor (EGFR) family plays an important role in breast development and breast cancer. Earlier work...

EVALUATION OF RACIAL DIFFERENCES IN PROSTATE CANCER TUMOR-SUPPRESSOR GENES.
October 1, 2000... This (University of California) report addresses racial differences in prostate cancer molecular biology. Prostate cancer is the most common cancer among African-American males. Recent reports suggest that not only is the incidence higher...

PTEN, A TUMOR SUPPRESSOR GENE FOR PROSTATE CANCER.
October 1, 2000... This (Baylor College of Medicine) report addresses a prostate cancer tumor suppressor gene. Inactivations of tumor suppressor genes are the most common genetic alterations in human cancers. The PTEN gene is a tumor suppressor gene recently...

PROSTATE CANCER: IDENTIFICATION OF NOVEL SECRETED MOLECULES.
October 1, 2000... This (Cedars-Sinai Medical Center) report concerns a newly developed approach to isolate new tumor markers of prostate cancer. In order to identify genes encoding secreted protein, the signal sequence trap technique is modified, using the SUC...

INSIGHT INTO THE MEANS BY WHICH CELL PROLIFERATION IS CONTROLLED BY CYCLIN-DEPENDENT KINASES.
October 1, 2000... The aim of this (Cold Springs Harbor Biological Laboratory) research is to gain further insights into the means by which cell proliferation is controlled by cyclin-dependent kinases. To this end, a screen is carried out for proteins that...

REDOX BALANCING IN RECOMBINANT STRAINS OF SACCHAROMYCES CEREVISIAE.
October 1, 2000... This (DOE) thesis deals with redox balancing in recombinant strains of Saccharomyces cerevisiae. In metabolically engineered Saccharomyces cerevisiae that express Pichia stipitis XYL1 and XYL2 genes, encoding xylose reductase (XR) and xylitol...

PC-BASED HEAD-SPINE MODEL.
October 1, 2000... This (Biodynamics Research Corp.) report addresses the computerized Head-Spine Model (HSM), which was originally developed for the Unix environment and is recoded for the personal computer. The recode includes code improvements and bug fixes,...

NEURAL RESPONSE TO THE PREVENTION, PROTECTION, AND REPAIR OF INJURY.
October 1, 2000... This (Louisiana State University School of Medicine) work on human neuromas -- uncovering cellular and molecular events in neuroma formation and developing models of human neuroma -- has proceeded with great productivity over the past year....

NEUROCHEMICAL PROTECTION OF THE BRAIN TO INJURY; NEURAL PLASTICITY AND REPAIR.
October 1, 2000... This (Louisiana State University School of Medicine) report concerns neurochemical protection of the brain to injury. The development of chronic epilepsy is a very serious complication of head injury, neurodegenerative diseases, brain tumors,...