Life Sciences & Biotechnology Update articles from November 1999

Life Sciences & Biotechnology Update archives from November 1999

BIOINFORMATICS IN THE 21st CENTURY.
November 1, 1999... This (George Mason University) document summarizes a workshop (1998, Fairfax, VA) on bioinformatics for the 21st century. A panel of experts: discussed critical issues surrounding bioinformatics; identified problems and challenges; and...

HEALTH-POLICY REFORM INNOVATIONS FOR AMERICA.
November 1, 1999... This (M.E. Sharpe Inc.) text tracks the increasingly important role of the states in health policy reform and the experience that policy-innovating states have accumulated to date. (Order this LIFE SCIENCES & BIOTECHNOLOGY UPDATE reviewed...

RISK FACTORS FOR LOW BIRTH WEIGHT.
November 1, 1999... This (Air Force Institute of Technology) report defines maternal risk factors for the birth of a low birth weight (LBW) infant. Verran's (1997) theory-driven framework for outcome research is used to guide the selection of process and...

STRENGTHENING LOW-INCOME FAMILIES THROUGH PARENT- PEDIATRIC PARTNERSHIPS.
November 1, 1999... This (Hawaii Department of Health) project is a partnership between families and their medical practitioners, to develop a demonstration model for care coordination for environmentally at-risk infants and toddlers in low-income...

PHYSICAL MECHANISMS IN LASER THROMBOLYSIS.
November 1, 1999... This (Los Alamos National Laboratory) paper concerns the physical mechanisms of importance in laser thrombolysis. Bubble dynamics plays a key role in many medical procedures, including: laser thrombolysis (L-T); acoustic and laser lithotripsy;...

ADVANCED LIFE-SUPPORT EQUIPMENT R&D.
November 1, 1999... This (Krug Life Sciences) report provides summaries and accomplishments, including citations and abstracts for the publications documenting the results, of specific efforts undertaken to provide research and research support to on-going RDT&E...

EFFICACY AND TOLERABILITY OF PARENTERAL DRUG TREATMENTS FOR ACUTE MIGRAINE HEADACHE.
November 1, 1999... This (Duke University) work identifies and summarizes evidence from controlled trials on the efficacy and tolerability of parenteral drug treatments for acute migraine headache. A literature review is conducted to identify randomized...

EFFICACY AND TOLERABILITY OF SELF-ADMINISTERED DRUG TREATMENTS FOR MIGRAINE HEADACHE.
November 1, 1999... This (Duke University) work identifies and summarizes evidence from controlled trials on the efficacy and tolerability of self-administered drug treatment for acute migraine headache. A literature review is conducted to identify randomized...

CERVICAL SPINE INJURY CAUSED BY REPEATED EXPOSURE TO SUSTAINED ACCELERATION.
November 1, 1999... This (NATO Research and Technology Organization) report concerns cervical spinal injuries from exposures to sustained acceleration. It includes review and analysis of published articles and reports on current studies by several nations on...

SHOCK AND CYTOKINES.
November 1, 1999... This (Shock Society) publication presents summaries of symposia on shock (1998, San Antonio, Tx) and cytokines (1999, Jerusalem, Israel). Both symposia were very successful. The summaries describe the state of the art and the scientific...

REHABILITATING TRAUMATIC BRAIN INJURIES.
November 1, 1999... This (Oregon Health Sciences University) report examines the evidence pertaining to the effectiveness of rehabilitation methods at various phases in the course of recovery from traumatic brain injury (TBI) in adults. It addresses the...

STEM CELL THERAPY FOR INHERITED HEMATOPOIETIC DISORDERS.(Brief Article)
November 1, 1999... This translation from Italy (Istituto Superiore di Sanita) contains monographic articles and short reports on the most recent advances involving the cure of blood inherited diseases. It is not meant to be a comprehensive and definitive...

CANCER INCIDENCE AND SURVIVAL: GEOGRAPHIC AND RACIAL VARIATIONS.
November 1, 1999... This (Air Force Institute of Technology) thesis concerns geographic and racial variations in cancer incidence and survival. One of the stated purposes of descriptive epidemiology is to generate hypotheses for analytical epidemiologic studies....

REGULATION OF ESTROGEN RECEPTOR mRNA STABILITY IN HUMAN BREAST CANCER CELLS.
November 1, 1999... This (University of Illinois) paper addresses the regulation of estrogen receptor mRNA stability in human breast cancer cells. The growth and metastases of approximately 40% of human breast cancers are dependent on the 17...

HORMONAL CONTROL OF THE GROWTH OF BREAST CANCER CELLS.
November 1, 1999... This (Fox Chase Cancer Center) study addresses hormonal control of breast cancer cell growth. Although the cause of breast cancer has not yet been identified, there is much clinical and experimental evidence showing that full-term pregnancy...

THE ROLE OF ESTROGEN NUCLEAR-RECEPTOR COACTIVATORS IN THE PATHOGENESIS OF BREAST CANCER.(Brief Article)
November 1, 1999... This (University of California) project focuses on the role of nuclear-receptor coactivators in steroid- dependent regulation of cell growth in the pathogenesis of breast cancer. A novel nuclear-receptor coactivator of transcription, p300 and...

MODULATORS OF FGF IN BREAST CANCER.
November 1, 1999... The growth of new blood vessels, or angiogenesis, is an important part of breast cancer biology. It is found that a secreted binding protein for fibroblast growth factors (FGF-BP) is expressed in many breast cancer cell lines and primary...

EXPRESSION OF EPITHELIN/GRANULIN PRECURSOR IN HUMAN BREAST CARCINOMA.(Brief Article)
November 1, 1999... This (University of Maryland) report addresses the establishment of a solid foundation for the role of PCDGF in mammary epithelial cell biology, and the involvement of its autocrine expression in the progression of the tumorigenicity in human...

BREAST CANCER AND ESTROGEN BIOSYNTHESIS IN ADIPOSE TISSUE.
November 1, 1999... The long-term objective of this (University of Texas) program is to determine the cellular and molecular mechanisms responsible for increased aromatase expression in breast adipose fibroblasts proximal to malignant epithelial cells. The...

THE FUNCTION OF MAXIMAL MICROVESSEL DENSITY IN BREAST CANCER METASTASIS.
November 1, 1999... This (Georgetown University) work concerns the maximum microvessel density (MMVD) in primary tumors, which is a sensitive prognostic indicator for many solid tumors, including breast tumors. These data imply functional significance for the...

TREATMENT OUTCOME EFFECTS OF CONSERVATIVE SURGERY AND RADIATION THERAPY FOR PATIENTS HAVING AN INHERITED SUSCEPTIBILITY TO BREAST CANCER.
November 1, 1999... This (Dana-Farber Cancer Institute) paper addresses treatment outcome effects of conservative surgery and radiation therapy for patients having an inherited susceptibility to breast cancer. The recent ability to test for an inherited...

POSTDOCTORAL TRAINING IN THE BIOLOGY AND THERAPY OF BREAST CANCER.
November 1, 1999... Substantial improvements in the prevention, detection, and treatment of breast cancer require the addition of new laboratory-trained investigators. This (University of Pittsburgh) predoctoral training program is designed to attract new...

CHILDBEARING AND SURVIVAL AFTER BREAST CANCER.(Brief Article)
November 1, 1999... This (Fred Hutchinson Cancer Research Center) project obtains data from three population-based cancer registries in the Seattle, Detroit, and Los Angeles areas, to compare relative survival of women with and without births among those with...

REGULATION OF MICROTUBULE STABILITY IN BREAST CANCER.
November 1, 1999... This (University of Michigan) project explores novel strategies that target microtubules relevant to breast cancer. Prior studies have led to the cloning of a gene, designated Op18, which is expressed at high levels in breast cancer. Op18...

CYTOCHROMES AS A MAMMARY CANCER RISK FACTOR.
November 1, 1999... This (University of Wisconsin) report addresses cytochromes as a mammary cancer risk factor. The work has recently documented the expression of CYP1A1 and CYP1B1 (both of which are inducible by many environmental pollutants via the Ah...

A STOCHASTIC SIMULATION MODEL OF THE COST-EFFECTIVENESS OF PROMOTING BREAST CANCER SCREENING.(Brief Article)
November 1, 1999... This report, on the development of a stochastic simulation model of the cost-effectiveness of promoting breast cancer screening, extends previous work to include the simulation of populations of individuals from multiple birth cohorts....

ANALYSIS OF THE ADHESION OF STAPHYLOCOCCUS AUREUS TO TISSUE AND BONE.
November 1, 1999... This (University of Arkansas Medical Center) thesis concerns Staphylococcus aureus, which has the capacity to colonize essentially any tissue, including bone. The ability to colonize diverse tissues appears to involve bacterial surface...

THE EFFECTS OF MICROGRAVITY ON INSULIN AND GLUCAGON SECRETIONS.
November 1, 1999... This brief (Baylor College of Medicine) paper addresses the effects of microgravity on insulin and glucogen secretions. Long-duration space flight is associated with many physiological abnormalities in astronauts. In particular, altered...

ARE FREE RADICALS A FINAL COMMON PATHWAY TO BRAIN DAMAGE CAUSED BY CHEMICAL WARFARE AGENTS?
November 1, 1999... This (Kansas Mental Retardation Research Center) study investigates and tests the hypothesis that neurotoxins initiate a cascade of events that converge on the redox mechanisms common to brain injury. Neurotoxins (e.g., soman, kainic acid,...

DRUG ABUSE TRENDS.(Brief Article)
November 1, 1999... The (Office of National Drug Control Policy) report provides a snapshot of local drug abuse situations throughout the country. The focus is on trends in heroin, cocaine, marijuana, and methamphetamine, within a six-month period. It brings...

ASSESSMENT TOOLS TO EVALUATE TELEMEDICINE TECHNOLOGIES.(Brief Article)
November 1, 1999... This (Toigo Associates Inc.) report addresses the designs of a prototype assessment tool for evaluating technologies relevant to telemedicine. The assessment tool will be used to guide future investments, and to review and analyze current...

THE EFFECTS OF ALCOHOL ON THE ENDOCRINE SYSTEM.(Brief Article)
November 1, 1999... This (National Institute on Alcohol Abuse and Alcoholism) publication examines the endocrine system and the multiple effects that alcohol has on this complex system. The endocrine system involves the carefully choreographed communication of a...