Life Sciences & Biotechnology Update articles from March 1999

Life Sciences & Biotechnology Update archives from March 1999

ANTICANCER AGENTS BASED ON A NEW CLASS OF TRANSITION- STATE ANALOG INHIBITORS FOR SERINE AND CYSTEINE PROTEASES.
March 1, 1999... This (Brown University) report describes a new class of competitive inhibitors for serine and cysteine proteases. These compounds are potential anticancer agents that would act by inhibiting metastasis and angiogenesis. The first part of the...

ROLE OF Fe++ IN DUST-INDUCED CARCINOGENESIS.
March 1, 1999... This (New York University Medical Center) report deals with the role of Fe++ in dust-induced carcinogenesis. Increasing evidence demonstrates that an excess of lung cancer and stomach cancer has been observed in iron ore and steel factory...

THYROID FOLLICULAR CELL TUMORS.
March 1, 1999... This (EPA) report details a forum concerning the assessment of thyroid follicular cell tumors. It presents science policy guidance that describes the procedures the EPA will use in the evaluation of potential human cancer hazard and...

PSYCHOSOCIAL INTERVENTION IN WOMEN FOLLOWING BREAST CANCER DIAGNOSIS.
March 1, 1999... This (University of Rochester) report concerns the effects of psychosocial intervention in women following diagnosis of breast cancer. The American Cancer Society has estimated that 180,000 women in the U.S. are newly diagnosed with breast...

USING MICROVASCULATURE MAGNETIC RESONANCE IMAGING (MRI) FOR DIAGNOSING BREAST CANCER.
March 1, 1999... This report from Canada (John P. Roberts Research Institute) is directed toward developing new techniques for measuring tumor-blood flow in human breast lesions using MRI. The first section of the report addresses the underlying biological...

STUDY OF FATTY ACID SYNTHESIS INHIBITORS AS A MEANS TO TREAT BREAST CANCER.
March 1, 1999... This (Johns Hopkins University) report concerns the use of fatty acid synthesis inhibitors as a means to treat breast cancer in vivo. A nude mouse model of MDA-435 is validated, and the fatty acid synthesis inhibitor, C-75, is shown to...

EPIDEMIOLOGY OF BREAST CANCER IN WOMEN: CASE-CONTROLLED ANALYSIS OF BREAST CANCER RISK.
March 1, 1999... This (Fred Hutchinson Cancer Research Center) report presents a proposal for two years of postdoctoral training to support work on analyses involving the epidemiology of breast cancer in women. The analyses are being conducted using data from...

MICROSATELLITE ALTERATIONS AS MOLECULAR MARKERS IN THE PROGRESSION OF BREAST CANCER.
March 1, 1999... This (Johns Hopkins University) report addresses microsatellite alterations as molecular markers of breast cancer progression. Breast cancer detection and diagnosis has been limited by the lack of early and accurate markers of the disease....

EXPRESSION OF ESTROGEN RECEPTOR (ER) IN TWO TYPES OF NORMAL HUMAN BREAST EPITHELIAL CELLS AND THEIR TRANSFORMED CELL LINES.
March 1, 1999... This (Michigan State University) report details a study of the expression of estrogen receptor (ER) in two types of normal human breast epithelial cells (HBEC) and their SV4O transformed cell lines. The results show that Type I HBEC expresses...

DEVELOPMENT OF HIGH-RESOLUTION POSITRON EMISSION TOMOGRAPHY (PET) MAMMOGRAM MODULES.
March 1, 1999... This (Boston University) report focuses on the development of high-resolution PET mammogram modules. Because of the limitations of standard X-ray mammography for the early detection of breast cancer, in particular for women with...

ROLE OF PROTEASES IN BREAST CANCER PROGRESSION.
March 1, 1999... Metastasis is the major cause of death in breast cancer patients. Metastasis formation depends on the ability of the tumor cells to degrade extracellular matrices (ECM) using specialized proteinases, including matrix metalloproteinases (MMPs)...

INTERACTIONS BETWEEN P-GLYCOPROTEIN AND ANTICANCER DRUGS USED IN BREAST CANCER: A MOLECULAR STUDY.
March 1, 1999... This (University of Texas) study looks at interactions between P-glycoprotein and anticancer drugs. P-glycoprotein is a plasma membrane protein that functions as a drug transporter, and is responsible for multidrug resistance in some breast...

INTERNATIONAL CONFERENCE ON PATHOGENIC NEISSERIA.
March 1, 1999... This (University of Maryland) document reports on the 10th International Pathogenic Neisseria Conference (1996, Baltimore, MD). This major international conference was attended by 400 scientists and public health officials from more than 30...

PROTOCOL FOR THE DIABETES PREVENTION PROGRAM (DPP).
March 1, 1999... This (George Washington University) report presents and discusses the protocol for the Diabetes Prevention Program (DPP). It describes the background, design, and organization of the DPP. The protocol is maintained by the Coordinating Center...

BEHAVIORAL RESEARCH INVOLVING CARDIOVASCULAR, LUNG, AND BLOOD DISEASES.
March 1, 1999... This (National Heart, Lung, and Blood Institute) report reviews the current status and prospects for behavioral research into: disease risk; risk factor reduction; and the treatment of heart, vascular, lung, and blood diseases, and sleep...

PREVENTING ASTHMA IN ANIMAL HANDLERS.
March 1, 1999... This (NIOSH) report requests assistance in preventing asthma and allergies in animal handlers. Approximately 2 million workers have jobs that require constant contact with animals or animal products. About 33% of animal handlers have...

DEVELOPMENT OF REAL-TIME 3-D ULTRASONIC IMAGING SYSTEMS FOR PHYSIOLOGICAL MONITORING.
March 1, 1999... This (Battelle Pacific Northwest Laboratories) report documents the third year of a four-year project to develop a field prototype 3-D ultrasonic imaging system. It reports on the development of a third generation sequential B scan 3-D...

INSTANTANEOUS AXIS OF ROTATION FOR CONTINUOUS HUMAN KNEE MOTION.
March 1, 1999... This (Naval Postgraduate School) thesis, addresses the instantaneous axis of rotation of human knee motion. Previous studies of human knee motion are based on finite rotation data collected using large rotation steps varying from 5 to 30...

DETECTION AND CONFIRMATION OF DRUGS IN HORSE BODY FLUIDS: ANALYTICAL METHODOLOGY.
March 1, 1999... This (Canadian Pari-Mutuel Agency) report concerns detection of over 230 different equine drugs, based on analysis of post-administration blood and urine samples. For over 120 of these drugs, detailed studies have been performed to investigate...

STATISTICS ON CHILDREN'S HEALTH INSURANCE AND ACCESS TO CARE.
March 1, 1999... This (Agency for Health Care Policy and Research) report summarizes statistics on children's health from the Medical Expenditure Panel Survey. Information is presented on: health insurance; access to care; and health status. The data are...

EVALUATION OF ALTERNATIVE DEMOGRAPHIC, SURVEY, AND CLAIMS-BASED RISK-ADJUSTERS FOR MEDICARE CAPITATION PAYMENT.
March 1, 1999... This (Health Economic Research Inc.) study uses multiple years of the Medicare Current Beneficiary Survey to evaluate alternative demographic, survey, and claims-based risk adjusters for Medicare capitation payment. The survey health-status...

CONTINUING SURVEY OF FOOD INTAKES BY INDIVIDUALS AND THE DIET AND HEALTH KNOWLEDGE SURVEY.
March 1, 1999... This (Agricultural Research Service) publication is the official reference for information on the design and operation of the Continuing Survey of Food Intakes by Individuals (CSFII) and the Diet and Health Knowledge Survey (DHKS), 1994-96....

BETTER HEALTH CARE FOR ALL AMERICANS: FINAL REPORT TO THE PRESIDENT OF THE U.S.
March 1, 1999... This report to the president (by the President's Advisory Commission on Consumer Protection and Quality in the Health Care Industry) focuses on better health care for all Americans. Every day, millions of Americans receive high-quality health...

NEW INSIGHTS ON THE ECOLOGY OF FREE-LIVING HETEROTROPHIC NANOFLAGELLATES USING MOLECULAR- BIOLOGICAL APPROACHES.
March 1, 1999... Nanoplanktonic protists comprise a diverse assemblage of flagellate species. Current methods for identifying small protists do not readily permit identification and enumeration of nanoplanktonic flagellates in cultures or field samples. This...

STUDY OF THE ETIOLOGY OF PRETERM BIRTH.
March 1, 1999... Previous studies have found that both African-American and military women are at increased risk for preterm delivery. This (Mount Sinai School of Medicine) study assesses the influence of blood pressure responsivity on the risk of preterm...

COST-BENEFIT ANALYSIS OF TELEMEDICINE FOR SHIPBOARD USE.
March 1, 1999... This (Center for Naval Analysis) report concerns cost-benefit analysis for shipboard use of telemedicine (TM). TM is an umbrella term that covers various technologies used to transmit information for health services. TM uses electronic...

HEAT STRAIN AND COOLING OF EXERCISING PERSONNEL.
March 1, 1999... This (Naval Health Research Center) report addresses the heat strain and cooling of exercising personnel. Decreasing perfusate temperature (Tp) in a liquid cooling system (LCS) leads to a proportional increase in heat transfer (Q) when...

BIBLIOGRAPHY OF PUBLISHED WORKS REGARDING THE HEALTH OF VETERANS OF THE PERSIAN GULF WAR.
March 1, 1999... Persian Gulf War veteran research has captured national attention. Numerous federal and nonfederal researchers are currently conducting a wide array of investigations into reports of increased morbidity among Persian Gulf War veterans and...

MOLECULAR MECHANISMS OF THE BIOSYNTHESIS OF METAL- BINDING PCs.
March 1, 1999... This (University of California) research is directed toward three fundamental aspects of PCs: (1) metal- chelation by PCs; (2) sulfide complexes of PCs; and (3) biosynthesis of PCs. A thorough investigation is made of the metal-binding...

EFFECTS OF ENDURANCE AND RESISTANCE TRAINING ON THE CARDIOVASCULATURE RISK OF MILITARY-ELIGIBLE WOMEN.
March 1, 1999... This (University of Maryland) report concerns the effects of endurance and resistance training on the cardiovascular risk in military-eligible women. The overall hypothesis is that the decline in physical activity habits, and the resultant...