Life Sciences & Biotechnology Update articles from April 2000

Life Sciences & Biotechnology Update archives from April 2000

HEALTHY PEOPLE 2000: A REVIEW OF DRUG SAFETY PROGRESS.
April 1, 2000... This (FDA) video conference, on one 1/2 inch VHS video tape, contains discussions on how to improve the health of all Americans through prevention, drug safety procedures, goals, and medication reviews. It includes discussions on the best way...

NEWER PHARMACOTHERAPIES TO TREAT DEPRESSION.
April 1, 2000... This (University of Texas Health Science Center) report provides a comprehensive evaluation of the benefits and adverse effects of newer pharmacotherapies and herbal treatments for depressive disorders in adults and children. Depressive...

PHARMACOTHERAPY FOR ALCOHOL DEPENDENCY.
April 1, 2000... This (Research Triangle Institute) report addresses the pharmacotherapy of alcohol dependence, which is selected for review because of its timeliness, the severity and impact of the disease, and the need for careful evaluation of new...

RISK FACTORS FOR OSTEOPOROSIS: BONE TURNOVER, MENOPAUSE, AGING, AND ETHNICITY.
April 1, 2000... This (New England Research Institute) four-year study is a very cost-efficient and timely longitudinal study of bone turnover markers in mid-aged women as they experience the menopause transition. Building on the multisite Study of Women...

RISK FACTORS FOR OSTEOPOROSIS AND ORAL BONE LOSS IN POSTMENOPAUSAL WOMEN.
April 1, 2000... This (State University of New York) study is designed to: determine the relationship between skeletal and oral bone density; identify factors influencing bone loss; determine the relationship between osteoporosis and oral bone loss,...

PUBLIC-PRIVATE PARTNERSHIPS FOR CHILD CARE: COLLECTION OF FACT SHEETS.
April 1, 2000... This (Administration for Children and Families) publication contains a collection of fact sheets on public-private partnerships for child care. Its contents are as follows: What is a Public-Private Partnership; Child Care Loan Funds; Engaging...

GUIDE TO SUCCESSFUL PUBLIC/PRIVATE PARTNERSHIPS FOR CHILD CARE.
April 1, 2000... This (Administration for Children and Families) publication is a guide to successful public/private partnerships for child care. Its Table of Contents follows: Introduction; What is a Public/Private Partnership; Why Public/Private Child Care...

PROFILES OF PUBLIC/PRIVATE PARTNERSHIPS FOR CHILD CARE.
April 1, 2000... This (Administration for Children and Families) publication presents profiles of public/private partnerships for child care. A partial Table of Contents follows: 1199/Employer Child Care Fund; The Child Care Executive Partnership; Down East...

CASE STUDIES OF PUBLIC/PRIVATE PARTNERSHIPS FOR CHILD CARE.
April 1, 2000... This (Administration for Children and Families) publication presents case studies of public/private partnerships for child care. Its Table of Contents follows: Developing a Facilities Loan Fund in San Francisco; Creating An Early Education...

NEW METHOD FOR SURVEILLANCE OF OCCUPATIONAL CANCER.
April 1, 2000... This (Columbia University) report addresses a new method for occupational cancer surveillance. Biomarkers of response to exposure to occupational carcinogens may allow early detection of those individuals at risk for the development of...

CANCER OCCURRENCE BY COMMON DRINKING WATER SOURCE.
April 1, 2000... This (New York State Department of Health) report concerns a study of the occurrence of cancer by common drinking water source. In 1979, in conjunction with a statewide effort, the municipal wells of the public drinking water supplies in...

GENERIC METHOD TO PRODUCE PROTEIN-BASED INHIBITORS FOR THE PROTEINS INVOLVED IN CANCER METASTASIS.
April 1, 2000... This (University of North Carolina) program is developing a method to make protein-based inhibitors against protein targets (and as the test case, to a proteinase involved in metastasis, stromelysin). The approach uses phage display and a...

BREAST CANCER: EPIDERMAL GROWTH FACTOR-LIKE LIGANDS.
April 1, 2000... This (Burnham Institute) report addresses epidermal growth factor-like ligands in breast cancer. Cripto-1 (Cr-1) and Amphiregulin (Ar) are two EGF-like growth factors that occur at higher levels than normal in breast cancer cells and tissues....

A HUMAN MAMMARY CELL RESOURCE.
April 1, 2000... The (University of California) laboratory has generated a human mammary epithelial cell (HMEC) system for studies on normal and aberrant growth control mechanisms. To facilitate widespread use of HMEC, it has provided cells and cell culture...

APOPTOSIS OF BREAST CANCER CELLS: THE ROLE OF OXIDATIVE STRESS.
April 1, 2000... The long-term goal of this (University of Arizona) program is to use an understanding of apoptosis to improve the treatment of breast cancer. The project is aimed at testing the hypothesis that oxidative stress plays a critical role in the...

MEGAKARYOCYTOPOIESIS IN STEM CELL TRANSPLANTATION.
April 1, 2000... Mobilized peripheral blood progenitor cell transplant, used to reconstitute hematopoiesis following high-dose chemotherapy in breast cancer patients, is associated with a requisite period of profound thrombocytopenia. To prevent or reduce the...

BISPECIFIC ANTIBODIES THAT CAN REDIRECT T-CELL ACTIVITY AGAINST CANCER CELLS.
April 1, 2000... The purpose of this (University of Illinois) project is to: 1) construct novel bispecific antibodies that can redirect the activity of T-cells against a tumor; and 2) develop in vivo animal models that more closely resemble human cancer, for...

NOVEL MODEL SYSTEM FOR EXAMINING AGENTS USED IN BREAST CANCER THERAPY.
April 1, 2000... This (University of Maryland) report concerns work that: (1) isolated a multiprotein complex for DNA synthesis; (2) designated the DNA synthesome from human breast cancer (MDA MB-468) cells; and (3) biopsied human breast tumor tissue and...

ENVISIONING BIOLOGY IN THE YEAR 2010, AFTER THE GENOME.
April 1, 2000... This (Molecular Science Institute) report looks at biology in the year 2010, after the genome, as discussed at a workshop on the subject. The information will help the biological community think about, and prepare for, the changes in...

EFFECTS OF EXPOSURE TO NITROGEN DIOXIDE ON AIRWAY, BLOOD LEUKOCYTES, AND LYMPHOCYTE SUB-SETS.
April 1, 2000... Nitrogen dioxide is a free radical and oxidant gas present in both indoor and outdoor air. Inhalation of NO2 could cause airway inflammation and also decrease systemic immune function by changing the distribution of lymphocyte subsets, or...

POST-POLIO SYNDROME AS A MODEL FOR MUSCULO-TENDINOUS OVERUSE SYNDROMES.
April 1, 2000... Musculoskeletal injuries are common among military recruits: incidence rates of 20-90% have been reported. Of these, as many as 87% are due to overuse. This (Albert Einstein Medical Center) research has the objectives: (1) to predict an...

PROSTHETIC DEVICES MADE OF CARBON/CARBON FIBER- REINFORCED COMPOSITES.
April 1, 2000... This (Los Alamos National Laboratory) document is the final report of a one-year project to evaluate the use of carbon/carbon-fiber-reinforced composites for use in endoprosthetic devices. The application of these materials for the...

SEX AND GENDER PERSPECTIVES FOR RESEARCH ON WOMEN'S HEALTH.
April 1, 2000... This (NIH) report summarizes the second in a series of regional workshops and scientific meetings aimed at learning about the public's and scientific community's visions of the women's health research agenda for the 21st century. The public...

THE MOST COMMON U.S. COMMUNITY HOSPITAL DIAGNOSES AND PROCEDURES.
April 1, 2000... This (Agency for Health Care and Policy Research) report provides information on the most frequent diagnoses and procedures for hospital inpatients. The analysis is based on data for U.S. hospital inpatient stays (in 1996) using the...

HANDBOOK OF MEDICAL COUNTERMEASURES AGAINST THE BACTERIAL, VIRAL, AND TOXIC AGENTS USED IN BIOLOGICAL WARFARE AND TERRORISM.
April 1, 2000... Biological medical defense against biological warfare is an area of study for military health-care providers which does not apply readily to the day-to-day mission of caring for patients in peacetime. The possibility of biological agents...

UNDERSTANDING THE ALPHABET SOUP OF THE MANAGED CARE INTEGRATED DELIVERY SYSTEM.
April 1, 2000... This (Agency for Health Care Policy and Research) document presents the proceedings of a workshop on the managed care integrated delivery system (1998, Philadelphia, PA). The workshop was designed to help senior health officials understand...