Applied Genetics News articles from October 2000

Applied Genetics News archives from October 2000

BASIC SCIENCE: Transcription Factor Plays Role in Tumors.
October 1, 2000... In the October 5, 2000, issue of the journal Nature, two research teams show that a transcription factor called E2F-1 activates p53 and a related protein, p73. One of the teams was led by William G. Kaelin, and the other was led by Steven...

Mouse Model of Multiple Neoplasia.
October 1, 2000... In a late-breaking session of the annual meeting of the American Society for Human Genetics in Philadelphia, Judy Crabtree of the National Genome Research Institute introduced a new mouse model of the human genetic disease multiple endocrine...

GENOMICS: Late-Onset Parkinson's Disease Gene Found.
October 1, 2000... Researchers at Duke University Medical Center have demonstrated for the first time that alteration of a specific gene on chromosome segment 6q appears to contribute to both the common late-onset form of Parkinson's disease (PD) and the rarer,...

BRCA Mutations Enhance Risk.
October 1, 2000... The New York Breast Cancer Study has assessed the risk for developing breast or ovarian cancer in women carrying BRCA1 or BCA2 mutations. The numbers suggest that the risk of cancer is increasing, perhaps due to unknown environmental factors....

Susceptibility Gene for Type-2 Diabetes.
October 1, 2000... Howard Hughes Medical Institute (HHMI) researchers at the University of Chicago, led by Graeme Bell, have identified a new genetic culprit in type-2 diabetes. The multi-institution research reported their discoveries in articles published in...

Insulin, Obesity, Infertility Linked.
October 1, 2000... A protein that translates insulin signals during carbohydrate metabolism also plays an important role in female reproduction and in the regulation of appetite and obesity in mice. The link between energy metabolism and fertility may underlie an...

GENE THERAPY: Targeted Genetics Wins Patent.
October 1, 2000... Targeted Genetics Corp. (1100 Olive Way, Suite 100, Seattle, WA 98101; Tel: 206/623-7612, Fax: 206/223-0288) has received notification from the U.S. Patent and Trademark Office regarding the issuance of a patent relating to its synthetic gene...

Gene Therapy Chair at UCSD.
October 1, 2000... Collateral Therapeutics, Inc. (9360 Towne Centre Dr., San Diego, CA 92121; Tel: 619/824-6500, Fax: 619/824-6563) will support the establishment of a research chair at the University of California San Diego (UCSD) Cardiovascular Center to be...

ANTISENSE: Telomerase Compound Effective against Tumors.
October 1, 2000... A 2-5A antisense compound targeted toward telomerase that was developed by Gemini Technologies, Inc., a subsidiary of Atlantic Technology Ventures, Inc. (150 Broadway Ave., New York, NY 10038; Tel: 212/267-2503, Fax: 212/732-9453), has recently...

Here's How RNA Interference Works.
October 1, 2000... Using genetically altered strains of the roundworm C. elegans, scientists have revealed some of the genetic components responsible for a cellular process called RNA interference (RNAi) in which double-stranded RNA triggers the degradation of a...

CLONING: Bringing Back Endangered Species.
October 1, 2000... The first successful cloning of an endangered animal to late-stage fetal development has been reported. Advanced Cell Technology's (ACT, One Innovation Dr., Worcester, MA 01650; Tel: 508/756-1212, Fax: 508/756-0931; Website:...

Japanese Ban Human Cloning.
October 1, 2000... The Japanese cabinet has approved a bill banning the cloning of human beings, although scientific research on cloning will be allowed to continue. Specifically, the bill would make it illegal to introduce a cloned human embryo into the womb of...

ANTIBODIES: Plantibodies to Prevent STDs.
October 1, 2000... EPIcyte Pharmaceuticals, Inc. (5810 Nancy Ridge Dr. #150, San Diego, CA 92121-2384; Tel: 858/554-0281) has been awarded Phase I and Phase II Small Business Innovation Research (SBIR) grants, worth $2.3 million in total, from the National...

CAT Licenses Antibody Technology.
October 1, 2000... Cambridge Antibody Technology (CAT, The Science Park, Melbourne, England, Cambridgeshire SG8 6JJ, U.K.; Tel: 1763-363-223, Tel: 1763-263-413; Website: www.catplc.co.uk) has granted Wyeth-Ayerst Research (P.O. Box 8299, Philadelphia, PA; Tel:...

Preventing Pseudomonas- Induced Pneumonia.
October 1, 2000... A team of researchers investigating the therapeutic effects of antibodies to the PcrV protein (anti-PcrV) in a mouse model of Pseudomonas aeruginosa-induced pneumonia announced encouraging results yesterday at the 40th Interscience Conference...

Toleragen Prevents Thrombosis.
October 1, 2000... At the 9th International Symposium on Antiphospholipid Antibodies in Tours, France, La Jolla Pharmaceutical Co. (6455 Nance Ridge Dr., San Diego, CA 92121; Tel: 858/452-6600, Fax: 858/452-6893) researchers presented positive preclinical results...

CELL THERAPY: 3D Bioreactor Patent Issued.
October 1, 2000... Advanced Tissue Sciences, Inc. (ATS, 10933 N. Torrey Pines Rd., La Jolla, CA 92037-1005; Tel: 619/450-5730, Fax: 619/455-6455) has announced the issuance of U.S. Patent 6,121,042, entitled, "Apparatus and Method for Simulating In Vivo...

Altered CD4+ Cells Engraft into Marrow.
October 1, 2000... Enzo Biochem, Inc. (60 Executive Blvd., Farmingdale, NY 11735; Tel: 516/755-5500, Fax: 516/755-5569) has reported new data on the first individual treated in the Phase I clinical trial of HGTV-43. The company's HIV-1 gene medicine product shows...

Fetal Cells Engraft into the Mother.
October 1, 2000... At the annual meeting of the American Society for Human Genetics, Bharath Srivatsa of the New England Medical Center (Boston, MA) reported that fetal cells that cross the placental barrier incorporate into the mother and form tissues. Fetal...

Save Your Tumor Cells.
October 1, 2000... Don't just throw that old cancer away! AVAX Technologies, Inc. (4520 Main St., Suite 930, Kansas City, MO; Tel: 816/960-1333, Fax: 616/960-1334; Website: www.avax-tech.com) will store it for you. The company is launching a Tumor Cell Banking...

ENZYMES: Pharming Patents Alpha-Glucosidase.
October 1, 2000... Pharming Group N.V. (Niels Bohrweg 11-13, 2333 CA, Leiden, The Netherlands; Tel: +31 71 524 74 00, Fax: +31 71 521 65 07; Website: www.pharming.com) has announced the issuance of U.S. Patent 6,118,045, with claims covering both pharmaceutical...

Unclog Your Catheter with Alteplase.
October 1, 2000... Genentech, Inc. (1 DNA Way, South San Francisco, CA 94080; Tel: 650/225-1000, Fax: 650/225-8326; Website: www.gene.com) has submitted for review to the U.S. Food and Drug Administration (FDA) a Supplemental Biologic License Application (sBLA)...

HORMONES AND CYTOKINES Bonzo Gets a Mate.
October 1, 2000... A team of scientists at the University of California, San Francisco (USFC), and Compugen, Ltd. (72 Pinchas Rosen St., Tel Aviv, Israel; Tel: 3-765-8585, Fax: 3-765-8555; Email: info@cgen.com, Website: www.cgen.com) has discovered a new...

"Slippy" Heals What Ails You.
October 1, 2000... Scientists from the National Institute of Dental and Craniofacial Research (NIDCR, Bethesda, MD) have discovered that a protease inhibitor found in several bodily fluids has an additional function - it can promote the healing of abnormal skin...

AG-BIO: Bt Crops Do Not Endanger Monarchs.
October 1, 2000... The Environmental Protection Agency (EPA) has officially chimed in on the great monarch butterfly controversy, a "tempest in a teapot" that has brewed ever since an article appeared in Nature suggesting that Bt crops were bad for butterflies....

Of Cows and Men.
October 1, 2000... The most complete map to date comparing the genomes of humans and cattle has been developed by a team of investigators from The University of Illinois at Urbana-Champaign and Texas A&M University. This map will provide scientists with a more...

INDUSTRY NEWS: Global Biodiversity Information Facility.
October 1, 2000... An article published in the September 29 issue of Science details plans for the formation of a Global Biodiversity Information Facility (GBIF), the framework for facilitating the sharing of scientific information. GBIF will coordinate and make...

Neuroscience Firm Named Neurome.
October 1, 2000... Neurome, Inc. has been founded by neuroscientists Floyd Bloom and Warren G. Young of the Scripps Research Institute (10550 N. Torrey Pines Rd., La Jolla, CA; Tel: 858/784-1000), and by John Morrison of Mount Sinai School of Medicine (NY). The...

CALENDAR.
October 1, 2000... November 2-3, 2000, Nanobiotechnology, Life Extension and the Treatment of Congenital and Degenerative Disease, Glasgow, Scotland, U.K. Contact: Institute of Nanotechnology; Tel: 01786 447520. November 6-9, 2000, Chips to Hits,...