Generations articles from September 2000

Generations archives from September 2000

Oxidative Stress in Friedreich's Ataxia: Mechanisms and Potential Therapy.
September 22, 2000... The following is an update on research funded by NAF in 1999. Friedreich's ataxia (FRDA) is a disease resulting from decreased expression of the mitochondrial protein, frataxin. Results from yeast studies support a hypothesis that FRDA is...

Construction of Inducible Transgenic Mouse Models of Spinocerebellar Ataxia Type 1 (SCA1).
September 22, 2000... The following is an update on research funded by NAF in 1999. Spinocerebellar ataxia type 1 (SCA1) is a dominantly inherited neurodegenerative ataxia caused by an expanded polyglutamine repeat in the SCA1 protein, ataxin-1 (Ref. 1). In...

Giving Twice with One Gift.
September 22, 2000... The National Ataxia Foundation is pleased to announce the establishment of a new company, iGifts-etc.com, which offers quality gifts at discount prices. Gifts-etc.com has made a financial commitment to the National Ataxia Foundation. A...

Identification of Novel ATM Substrates.
September 22, 2000... The following is an update on research funded by NAF in 1999. The genetic disorder Ataxia-Telangiectasia (A-T) is caused due to faulty or absolutely absent function of the ATM protein. The function of ATM is to signal that cells have...

Calcium Release and Cerebellar Purkinje Neurons.
September 22, 2000... The following is an update on research funded by NAF in 1999. A ubiquitous intracellular signaling pathway is the cytosolic free calcium concentration ([[Ca.sup.2]+.sub.i.]) At rest, cells maintain ([[Ca.sup.2]+.sub.i]) low, orders of...

Can IGF-I Help Cerebellar Neuron Survive?
September 22, 2000... The following is an update on research funded by NAF in 1999. From the moment of birth, neurons in the cerebellum require an optimal environment for their growth. In this environment, cerebellar neurons differentiate and migrate to their...

Annual Ataxia Research Drive Begins in October.
September 22, 2000... The National Ataxia Foundation's annual research drive will begin in October 2000. Please look for your letter in the mail and give as generously as you can. The annual ataxia research drive is critical to the success of the research program....

Kim's Korner.
September 22, 2000... Hello again! First of all, I would like to say thank you to everyone who sent his or her condolences on behalf of my husband. I appreciated them all, whether they came via e-mail or the old, but reliable, snail mail. Sometimes just a few...

A Model System to Study the Instability of the GAA Triplet Repeat Expansion in Friedreich Ataxia.
September 22, 2000... The following is an update on research funded by NAF in 1999. Introduction Friedreich ataxia, the most common inherited ataxia, is caused by a deficiency of frataxin. Frataxin is essential for the maintenance of appropriate levels of...

2001 ANNUAL MEETING "Wellness While We Wait".
September 22, 2000... To Be Held In The Land Of 10,000 Lakes Plans are underway for the 2001 National Ataxia Foundation Annual Meeting in Minneapolis, Minnesota April 6th through the 8th. It promises to be the best meeting yet! Next year's get-together...

STOCKing Stuffer.
September 22, 2000... It's never too early to begin making your holiday gift list. One suggestion is to include on your list the National Ataxia Foundation. A gift of stock to the Foundation is a great way to give not only in terms of helping ataxia families...

ADA Anniversary Celebration.
September 22, 2000... The ADA Anniversary Celebration was held July 26 at the Anne Sullivan School in Minneapolis, Minnesota. NAF was among the 50 or so exhibitors, and many people stopped at our table to learn about ataxia. We gave out a lot of information...

Research Update: Ataxia Due to Iron Channel Mutations.
September 22, 2000... The causes of ataxia, and how they effect the approaches to treatment Generally, in the recessive ataxias, there is a deficiency of a protein. The goal in treatment is to replace the protein or replace the deficiency that a protein...

Tenth Anniversary of the Americans with Disabilities Act (ADA).
September 22, 2000... The year 2000 marks the tenth anniversary since the enactment of the Americans with Disabilities Act (ADA). This landmark legislation has protected the civil rights of more than 50 million Americans with physical and mental disabilities. ...

The First International Symposium for Hereditary Spastic Paraplegia.
September 22, 2000... Over a hundred scientists, professionals, and family members converged from all over the world in Ann Arbor, Michigan May 25-27, 2000 for the First International Symposium for Hereditary Spastic Paraplegia. The symposium was beautifully...

Friedreich Ataxia Research Update.
September 22, 2000... I am going to give an overview of Friedreich ataxia over the past year. I also want to mention the important discovery of a new recessive ataxia gene, ARSACS (Autosomal Recessive Spastic Ataxia of Charlevoix Sanguenay). Credit for this...

SCA8.
September 22, 2000... Dr. Day Speaks SCA8 breaks many of the rules that are known for inheritance of dominant forms of ataxia. We are always interested when a disease breaks rules because it will lead us to a deeper level of understanding. This dominantly...

Chapter and Support Group News From Around the Country.
September 22, 2000... Minneapolis Support Group Map #31 by Ginny Cain Minneapolis Area Support Group is growing. Recently, we have had new members attend to learn more about ataxia, and they are getting involved. Two of us will be visiting neurologists in...

Ambassador Listing.
September 22, 2000... Following is a list of NAF ambassadors. Ambassadors are often in areas where there is not a support group for contact information for other ataxia families. Please get to know your ambassadors, and if you would like to become an ambassador...

Memorials and In Your Honor.
September 22, 2000... The National Ataxia Foundation is grateful to those who have made contributions in memory or in honor of their friends and families whose names are listed below. This list reflects contributions made from May 1, 2000 through August 31, 2000....

NAF Chapters and Support Groups.
September 22, 2000... The following is a list of NAF chapters and support groups. The use of these names, addresses, and phone numbers for any purpose other than requesting information regarding NAF or joining a chapter or support group, is strictly prohibited. We...