Human Biology articles from February 2007

Human Biology archives from February 2007

Search for hand osteoarthritis susceptibility locus on chromosome 6p12.3-p12.1.(Clinical report)
February 1, 2007... Osteoarthritis is a common age-related degenerative joint disorder with a different incidence among skeletal sites, such as hands, knees, hips, and spine, as well as across sexes and populations. It has been repeatedly reported that the...

Genetic and environmental correlations between bone mineral density and bone size in Caucasians.(Clinical report)
February 1, 2007... Osteoporosis is a skeletal disorder characterized by compromised bone strength, predisposing a person to an increased risk of fracture (NIH Consensus Development Panel on Osteoporosis Prevention, Diagnosis, and Therapy 2001). The most serious...

Evolutionary relationships among prehistoric human populations: an evaluation of relatedness patterns based on facial morphometric data using molecular data.(Report)
February 1, 2007... The study of evolutionary relationships among human populations has a long tradition within physical anthropological research (Buikstra et al. 1990; Larsen 1997). Such relationships mainly represent the apportionment of genetic variation among...

Sex-specific genetic admixture of Mestizos, Amerindian Kichwas, and Afro-Ecuadorans from Ecuador.(Report)
February 1, 2007... Three main ethnic groups live in Ecuador: Mestizos, Amerindian natives, and Afro-Ecuadorans. Mestizos are the most numerous group, with 8 million (or 60% of the total population); they are the Spanish-speaking descendants of Europeans (mostly...

Cystic fibrosis gene variability in two southern Brazilian Amerindian populations: analysis of the [DELTA]F508 mutation and the KM19 and XV2C haplotypes.(Clinical report)
February 1, 2007... Cystic fibrosis (CF) is an autosomal recessive disorder with an incidence of about 1/2,500 live births in European and other European-descended populations; this incidence corresponds to a carrier frequency of about 1/25 (Welsh et al. 1995). In...

Apolipoprotein E polymorphism in Omani dyslipidemic patients with and without coronary artery disease.(Clinical report)
February 1, 2007... Apolipoprotein E (apoE), a plasma protein component of apolipoprotein B-containing lipoproteins, serves as a receptor-binding ligand mediating the clearance of chylomicrons, chylomicron remnants, very low density lipoprotein (VLDL), and...

The common -866G/A polymorphism of the UCP2 gene in healthy Iranians compared with world populations.(Clinical report)
February 1, 2007... Obesity and diabetes are common multifactorial diseases with a major burden on health care systems worldwide. A major focus is the genetics of these complex disorders and the role of single nucleotide polymorphisms (SNPs) on their development...

Association of PPARG2 Pro12Ala variant with larger body mass index in Mestizo and Amerindian populations of Mexico.(Clinical report)
February 1, 2007... Peroxisome proliferator-activated receptor [gamma] (PPARG) is a transcription factor activated by endogenous and pharmacological ligands, such as polyunsaturated fatty acids and thiazolidinediones (Tontonoz et al. 1994; Lehmann et al. 1995)....

Heritability and genetic correlations of metabolic disease-related phenotypes in Mexico: preliminary report from the GEMM Family Study.(Brief Communications)(Genetica de las Enfermedades Metabolicas en Mexico )(Clinical report)
February 1, 2007... Cardiovascular disease (CVD) remains the leading cause of death in adult men and women in the United States and other industrialized nations (Braunwald 1997; National Center for Health Statistics 2000) and is the principal cause of death in...

Glutathione S-transferase M1 and T1 polymorphisms in Brazilian African descendants.(Brief Communications)(Report)
February 1, 2007... Human glutathione S-transferase (GST) is an important enzyme family of phase II of the metabolic process that catalyzes the detoxification of a wide range of carcinogenic compounds and their metabolites (Hayes and Strange 2000). Two polymorphic...