OB/GYN Clinical Alert articles from January 2003

OB/GYN Clinical Alert archives from January 2003

The WAVE trial--more of the same.(Women's Angiographic Vitamin and Estrogen)
January 1, 2003... ABSTRACT & COMMENTARY THE WOMEN'S ANGIOGRAPHIC VITAMIN AND ESTROGEN (WAVE) Trial was a randomized, controlled secondary prevention study. This study enrolled 423 postmenopausal women with coronary atherosclerosis already established at...

Cyclin E and survival in patients with breast cancer.
January 1, 2003... ABSTRACT & COMMENTARY Synopsis: The hazard ratio for death from breast cancer for patients with high total cyclin E levels as compared with those with low total cyclin E levels was 13.3 to about 8 times as high as the hazard ratios...

Outcomes of endometrial cancer patients undergoing surgery with gynecologic oncology involvement.
January 1, 2003... ABSTRACT & COMMENTARY Synopsis: Involvement of a gynecologic oncologist at the time of primary surgery for endometrial cancer was associated with comparable outcomes in both the university and community hospital setting. Source: Pearl...

Alcohol and hormone therapy increase the risk of breast cancer.
January 1, 2003... ABSTRACT & COMMENTARY Synopsis: The Nurses' Health Study reports an increased incidence of breast cancer with daily alcohol consumption, hormone therapy, and an additive effect with greater drinking. Source: Chen WY, et al. Ann Intern...

Luteal phase sertraline and PMDD.(premenstrual dysphoric disorder)
January 1, 2003... ABSTRACT & COMMENTARY Synopsis: Sertraline was significantly more effective than placebo when taken during the luteal phase for PMDD. Source: Halreich U, et al. Obstet Gynecol. 2002;100: 1219-29. IN A BUSY OFFICE PRACTICE OF...

Maternal diabetes and infant malformations.
January 1, 2003... ABSTRACT & COMMENTARY Synopsis: Women with pregestational diabetes or gestational diabetes plus fasting hyperglycemia have a 3-to 4-fold increased risk of infant malformations, whereas women with mild gestational diabetes have malformation...

Effects of losartan on cardiovascular morbidity and mortality in patients with isolated systolic hypertension and LVH. (Clinical Briefs in Primary Care).(left ventricular hypertrophy)(Brief Article)
January 1, 2003... Source: Kjeldsen SE, et al. JAMA. 2002;1491-1498. SINCE THE EARLY 1990s IT HAS BEEN recognized that left ventricular hypertrophy (LVH) is an important prognostic indicator for cardiovascular morbidity and mortality. More recently, it has...

Increase in nocturnal blood pressure and progression to microalbuminuria in type 1 diabetes. (Clinical Briefs in Primary Care).(Brief Article)
January 1, 2003... Source: Lurbe E, et al. N Engl J Med. 2002;347:797-805. IT HAS BEEN NOTED THAT AMONG persons with type 1 diabetes (DM-1), hypertension (HTN) often develops concomitantly with occurrence of microalbuminuria (MAU). Closer investigation with...

HRT, lipid, and glucose metabolism in diabetic and nondiabetic postmenopausal women. (Clinical Briefs in Primary Care).(hormone replacement therapy)(Brief Article)
January 1, 2003... Source: Crespo CJ, et al. Diabetes Care. 2002;25:1675-1680. LIKE CARDIOVASCULAR DISEASES, type 2 diabetes (DM-2) increases in postmenopausal women. Prospective randomized interventional trials have not shown a benefit for hormone...

Effects of long-term treatment with ACE inhibitors in the presence or absence of aspirin. (Clinical Briefs in Primary Care).(Brief Article)
January 1, 2003... Source: Teo Koon K, et al. Lancet. 2002;360:1037-1043. BOTH ANGIOTENSIN CONVERTING enzyme inhibitors (ACEI) and aspirin (ASA) have a proven valuable track record in a variety of cardiovascular preventive and therapeutic areas. One of the...

Olfactory impairment in older adults. (Clinical Briefs in Primary Care).(Brief Article)
January 1, 2003... Source: Murphy C, et al. JAMA. 2002;288:2307-2312. DESPITE WIDESPREAD ATTENTION to the demographics and management of hearing and visual impairments in older adults, there has been little study of olfactory impairments (OLF). Olfactory...

Long-term risks associated with atrial fibrillation: 20-year follow-up of the Renfrew/Paisley study. (Clinical Briefs in Primary Care).(Brief Article)
January 1, 2003... Source: Simon S, et al. Am J Med. 2002;113:359-364. MOST OF THE STUDIES OF ATRIAL fibrillation (AF) that address cardiovascular (CV) consequences provide only short-term or intermediate-term insight (6 months-24 months). Long-term...

FDA approves Claritin for OTC use for seasonal rhinitis. (Pharmacology Watch).(over the counter)
January 1, 2003... After years of legal wrangling, the FDA has approved loratadine (Claritin, Schering-Plough) as an over-the-counter (OTC) product for the treatment of seasonal rhinitis. Loratadine is considered a nonsedating antihistamine, and its OTC approval...