OB/GYN Clinical Alert articles from January 2002

OB/GYN Clinical Alert archives from January 2002

Tamoxifen and Breast Cancer incidence among women with inherited mutations in BRCA1 and BRCA2.
January 1, 2002... THE RATIONALE FOR THE PRESENT ANALYSIS IS COMPELLING. King and colleagues hypothesized that tamoxifen would protect against the development of breast cancer only in women prone to breast cancers that express estrogen receptors (ER). They note...

Important new monkey study from Tom Clarkson.(tibolone and atherosclerosis)
January 1, 2002... Synopsis: Tibolone treatment does not increase coronary artery atherosclerosis, and an equal reduction in atherosclerosis is seen with unopposed conjugated equine estrogen treatment and with conjugated equine estrogen combined with...

Labor--To wait or not to wait: To push or not to push.
January 1, 2002... Synopsis: This study underscores the need to re-evaluate periodically any concept of obstetrical management, no matter how solid the underlying scientific foundation. Source: Rouse DJ, et al. Obstet Gynecol. 2001;98:550-554. MANY...

Clinical features and risk of recurrence among patients with Vaginal Intraepithelial Neoplasia.
January 1, 2002... Synopsis: Many patients with vaginal intraepithelial neoplasia have recurrence following treatment. Source: Dodge JA, et al. Gynecol Oncol. 2001;83:363-369. PRIMARY NEOPLASIA OF THE VAGINAL EPITHELIUM IS an uncommon condition. Both...

The Phantom hCG Phenomenon. (Special Feature).(false-positive human chorionic gonadotropic)
January 1, 2002... THE ISSUE OF THE FALSE-POSITIVE HUMAN CHORIONIC gonadotropin (hCG), or the so-called "phantom hCG," has received increasing media and scientific attention and scrutiny over the past several months. The Society of Gynecologic Oncologists and the...

Lack of Health Insurance and Decline in Overall Health in late middle age.
January 1, 2002... Source: Baker DW, et al. N Engl J Med. 2001;345:1106-1112. IT IS INTUITIVE THAT UNINSURED AMERicans would use fewer healthcare services. Whether insurance status is related to overall health in late middle age is little studied. As many as...

Long-Term weight loss with Sibutramine.
January 1, 2002... Source: Wirth A, Krause J. JAMA. 2001;286:1331-1339. THE BURGEONING EPIDEMIC OF OBESITY and its consequences shows no signs of diminution. Currently available pharmacotherapy tools have enjoyed only modest use in the clinical setting....

Prediction of all-cause and Cardiovascular Mortality in elderly people from one low Serum Thyrotropin result.
January 1, 2002... Source: Parle JV, et al. Lancet. 2001;358:861-865. SUBCLINICAL HYPERTHYROIDISM (SCH) is defined as a subnormal TSH level accompanied by normal levels of T4 and T3; as is implied in the name designation, persons must also be free of symptoms...

Prevalence of Hereditary Hemochromatosis in late-onset type 1 diabetes mellitus.
January 1, 2002... Source: Ellervik C, et al. Lancet. 2001;358:1405-1409. IT COMES AS A SURPRISE TO MANY CLINIcians that hemochromatosis (HCRM) is literally one of the most common genetic disorders in persons of northern European descent; in America, it has a...

Hormone Replacement Therapy and Dry Eye Syndrome.
January 1, 2002... Source: Schaumberg DA, et al. JAMA. 2001;286:2114-2119. DRY EYE SYNDROME (DES), ALSO known as keratoconjunctivitis sicca, can cause substantial debilitation due to adverse symptoms of dryness and irritation, as well as the morbidity of...

Association between Myeloperoxidase Levels and Risk of Coronary Artery Disease.
January 1, 2002... Source: Zhang R, et al. JAMA. 2001; 286:2136-2142. THE ASSOCIATION BETWEEN INFLAMmatory markers and the presence of atherosclerosis suggests that C-reactive protein, adhesion molecules, and other cytokines are potentially etiologically...