OB/GYN Clinical Alert articles from April 2003

OB/GYN Clinical Alert archives from April 2003

International Collaborative Ovarian Neoplasm trial 1 and Adjuvant ChemoTherapy In Ovarian Neoplasm trial.
April 1, 2003... Abstract & Commentary THE INVESTIGATORS OF 2 MAJOR AND PARALLEL EUROPEAN RAN-domized clinical trials focused on early-stage epithelial ovarian cancer (International Collaborative Ovarian Neoplasm 1 [ICON 1] and Adjuvant ChemoTherapy In...

Magnesium sulfate and nimodipine for the prevention of eclampsia.
April 1, 2003... Abstract & Commentary Synopsis: Magnesium sulfate is more effective than nimodipine for prophylaxis against seizures in women with severe preeclampsia. Source: Belfort MA, et al. N Engl J Med. 2003;348: 304-311. THROUGH THE YEARS...

Treatment of sexual dysfunction after menopause.
April 1, 2003... Abstract & Commentary Synopsis: In postmenopausal patients with sexual dysfunction, it is still unclear which, if any, therapy is indicated. Source: Modelska K, Cummings S. Am J Obstet Gynecol. 2003;188:286-293. MODELSKA AND...

Drug treatments to prevent breast cancer.
April 1, 2003... Abstract & Commentary Synopsis: Only tamoxifen has enough evidence to recommend it for the prevention of breast cancer, and its use is limited to very high-risk women with a low risk of side effects. Source: Cuzick J, et al. Lancet....

Increased risk of breast cancer with estrogen-progestin therapy.
April 1, 2003... Abstract & Commentary Synopsis: Postmenopausal estrogen-progestin therapy increased the risk of breast cancer in a population-based cohort in Sweden, and estrogen-only did not. Source: Olsson HL, et al. San Antonio Breast Cancer...

Radical trachelectomy and pelvic lymphadenectomy with uterine preservation in treatment of cervical cancer.
April 1, 2003... Abstract & Commentary Synopsis: Radical trachelectomy combined with pelvic lymphadenectomy can be a feasible method of treatment for early-stage cervical cancer in women who want to preserve their fertility. Source: Schlaerth JB, et...

CME questions.(continuing medical education)(Brief Article)
April 1, 2003... OB/GYN Clinical Alert is changing its testing procedure. You will no longer need to return a Scantron answer sheet to earn credit for the activity Please review the text, answer the following questions, check your answers against the key on the...

Warfarin effectively prevents venous thromboembolism.(Vitamin D Reduces Osteoporotic Fractures)(Adefovir Effective for Hepatitis B Treatment)(Ibuprofen/Aspirin Study Revisited)(ACE Inhibitors Favored in Cardiovascular Care)(Digoxin Dosing and Heart Failure)
April 1, 2003... Low intensity warfarin therapy effectively prevents recurrent venous thromboembolism, according to a recent study in the New England Journal of Medicine. After a median of 6.5 months of full-dose anticoagulation therapy, 508 patients with...

Ice cream-evoked headaches study: a randomized trial of accelerated vs cautious eating.(Brief Article)
April 1, 2003... Source: Kaczorowski M, Kaczorowski J. BMJ. 2002;325:1445-1446. ICE CREAM HEADACHE (ICH) IS A COMMON-place phenomenon induced by ingestion of cold substances, of which ice cream is but one of many potential precipitants. The limited...

Treatment of antidepressant-associated sexual dysfunction with sildenafil.(Brief Article)
April 1, 2003... Source: Nurnberg HG, et al. JAMA. 2003;289:56-64. SEXUAL DYSFUNCTION (SXD), WEIGHT gain, and sleep disturbance comprise as much as 75% of the adverse events that ultimately lead to antidepressant medication discontinuation. Of course,...

Prophylactic treatment of migraine with an angiotensin II receptor blocker.(candesartan compared with placebo)(Brief Article)
April 1, 2003... Source: Tronvik E, et al. JAMA. 2003;289:65-69. DESPITE THE VERY FAVORABLE effect of triptans upon migraine morbidity, a substantial population of persons either does not respond to, or chooses not to use, these agents. Expert advice has...

Syncope, driving recommendations, and clinical reality: survey of patients.(Brief Article)
April 1, 2003... Source: Maas R, et al. BMJ. 2003;326:21. PATIENTS WHO SUFFER SYNCOPE DISORders, similarly to those who have seizures, are at increased risk for themselves and others when driving. Detailed guidance has been devised for clinicians to assist...

ACE inhibitors + ARB for diabetic and hypertensive nephropathy.(angiotensin-converting-enzyme inhibitors and angiotensin-II receptor blockers)
April 1, 2003... Source: Nakao N, et al. Lancet. 2003;361:117-124. ANGIOTENSIN-CONVERTING-enzyme inhibitors (ACE inhibitors) and angiotensin-II receptor blockers (ARB) have been demonstrated to provide significant benefits for persons with both diabetic and...

Action and efficacy of a combination of calcipotriene and betamethasone dipropionate in the treatment of psoriasis.(Brief Article)
April 1, 2003... Source: Papp K, et al. J Am Acad Dermatol. 2003;48:48-54. BOTH CALCIPOTRIENE (DovoNEx[R]) and topical steroids (STR) have been proven effective in management of psoriasis. Calcipotriene (CPT) has been demonstrated to be more effective than...